Amino acid dipepetide frequency for Subtercola vilae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.91AlaAla: 19.91 ± 0.211
0.615AlaCys: 0.615 ± 0.022
7.363AlaAsp: 7.363 ± 0.082
7.347AlaGlu: 7.347 ± 0.105
3.903AlaPhe: 3.903 ± 0.061
12.069AlaGly: 12.069 ± 0.122
2.271AlaHis: 2.271 ± 0.046
5.699AlaIle: 5.699 ± 0.081
2.941AlaLys: 2.941 ± 0.064
13.94AlaLeu: 13.94 ± 0.124
2.352AlaMet: 2.352 ± 0.045
2.92AlaAsn: 2.92 ± 0.054
6.197AlaPro: 6.197 ± 0.09
3.686AlaGln: 3.686 ± 0.056
7.945AlaArg: 7.945 ± 0.101
8.581AlaSer: 8.581 ± 0.104
7.912AlaThr: 7.912 ± 0.111
11.047AlaVal: 11.047 ± 0.112
1.669AlaTrp: 1.669 ± 0.031
2.389AlaTyr: 2.389 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.598CysAla: 0.598 ± 0.023
0.043CysCys: 0.043 ± 0.006
0.307CysAsp: 0.307 ± 0.019
0.228CysGlu: 0.228 ± 0.014
0.169CysPhe: 0.169 ± 0.013
0.534CysGly: 0.534 ± 0.023
0.122CysHis: 0.122 ± 0.009
0.221CysIle: 0.221 ± 0.014
0.069CysLys: 0.069 ± 0.009
0.445CysLeu: 0.445 ± 0.019
0.074CysMet: 0.074 ± 0.008
0.11CysAsn: 0.11 ± 0.009
0.298CysPro: 0.298 ± 0.018
0.117CysGln: 0.117 ± 0.01
0.293CysArg: 0.293 ± 0.016
0.385CysSer: 0.385 ± 0.02
0.337CysThr: 0.337 ± 0.019
0.461CysVal: 0.461 ± 0.021
0.079CysTrp: 0.079 ± 0.009
0.112CysTyr: 0.112 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.756AspAla: 7.756 ± 0.08
0.237AspCys: 0.237 ± 0.014
3.562AspAsp: 3.562 ± 0.061
3.659AspGlu: 3.659 ± 0.073
1.831AspPhe: 1.831 ± 0.042
5.054AspGly: 5.054 ± 0.081
1.132AspHis: 1.132 ± 0.033
2.416AspIle: 2.416 ± 0.051
1.048AspLys: 1.048 ± 0.034
5.655AspLeu: 5.655 ± 0.069
0.709AspMet: 0.709 ± 0.025
1.269AspAsn: 1.269 ± 0.033
3.608AspPro: 3.608 ± 0.055
1.654AspGln: 1.654 ± 0.033
3.577AspArg: 3.577 ± 0.054
3.229AspSer: 3.229 ± 0.054
3.16AspThr: 3.16 ± 0.052
4.749AspVal: 4.749 ± 0.071
0.87AspTrp: 0.87 ± 0.027
1.298AspTyr: 1.298 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
6.126GluAla: 6.126 ± 0.086
0.205GluCys: 0.205 ± 0.015
1.794GluAsp: 1.794 ± 0.043
2.116GluGlu: 2.116 ± 0.05
1.731GluPhe: 1.731 ± 0.042
3.417GluGly: 3.417 ± 0.058
1.368GluHis: 1.368 ± 0.04
2.553GluIle: 2.553 ± 0.054
1.461GluLys: 1.461 ± 0.04
6.36GluLeu: 6.36 ± 0.092
0.886GluMet: 0.886 ± 0.03
1.466GluAsn: 1.466 ± 0.034
2.657GluPro: 2.657 ± 0.052
2.039GluGln: 2.039 ± 0.051
4.121GluArg: 4.121 ± 0.063
2.881GluSer: 2.881 ± 0.049
3.138GluThr: 3.138 ± 0.05
4.098GluVal: 4.098 ± 0.079
0.811GluTrp: 0.811 ± 0.025
1.108GluTyr: 1.108 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
4.503PheAla: 4.503 ± 0.068
0.199PheCys: 0.199 ± 0.013
2.499PheAsp: 2.499 ± 0.052
1.814PheGlu: 1.814 ± 0.05
1.219PhePhe: 1.219 ± 0.039
3.694PheGly: 3.694 ± 0.067
0.569PheHis: 0.569 ± 0.024
1.447PheIle: 1.447 ± 0.038
0.542PheLys: 0.542 ± 0.023
2.777PheLeu: 2.777 ± 0.064
0.505PheMet: 0.505 ± 0.02
0.8PheAsn: 0.8 ± 0.025
1.32PhePro: 1.32 ± 0.034
0.831PheGln: 0.831 ± 0.027
1.685PheArg: 1.685 ± 0.041
2.229PheSer: 2.229 ± 0.043
2.509PheThr: 2.509 ± 0.047
3.096PheVal: 3.096 ± 0.057
0.526PheTrp: 0.526 ± 0.021
0.722PheTyr: 0.722 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
10.586GlyAla: 10.586 ± 0.133
0.559GlyCys: 0.559 ± 0.022
4.566GlyAsp: 4.566 ± 0.068
4.307GlyGlu: 4.307 ± 0.068
3.425GlyPhe: 3.425 ± 0.07
7.562GlyGly: 7.562 ± 0.109
1.977GlyHis: 1.977 ± 0.042
4.764GlyIle: 4.764 ± 0.072
2.151GlyLys: 2.151 ± 0.047
8.664GlyLeu: 8.664 ± 0.101
1.72GlyMet: 1.72 ± 0.044
2.012GlyAsn: 2.012 ± 0.052
3.603GlyPro: 3.603 ± 0.053
2.756GlyGln: 2.756 ± 0.051
5.503GlyArg: 5.503 ± 0.078
6.461GlySer: 6.461 ± 0.085
5.882GlyThr: 5.882 ± 0.091
7.659GlyVal: 7.659 ± 0.084
1.499GlyTrp: 1.499 ± 0.04
2.178GlyTyr: 2.178 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.178HisAla: 2.178 ± 0.042
0.108HisCys: 0.108 ± 0.009
1.283HisAsp: 1.283 ± 0.036
1.085HisGlu: 1.085 ± 0.034
0.649HisPhe: 0.649 ± 0.024
1.74HisGly: 1.74 ± 0.041
0.551HisHis: 0.551 ± 0.022
0.855HisIle: 0.855 ± 0.026
0.271HisLys: 0.271 ± 0.015
2.008HisLeu: 2.008 ± 0.047
0.309HisMet: 0.309 ± 0.016
0.44HisAsn: 0.44 ± 0.02
1.561HisPro: 1.561 ± 0.037
0.571HisGln: 0.571 ± 0.025
1.461HisArg: 1.461 ± 0.035
1.221HisSer: 1.221 ± 0.033
1.172HisThr: 1.172 ± 0.033
1.456HisVal: 1.456 ± 0.034
0.272HisTrp: 0.272 ± 0.015
0.475HisTyr: 0.475 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
6.71IleAla: 6.71 ± 0.084
0.273IleCys: 0.273 ± 0.016
3.546IleAsp: 3.546 ± 0.06
2.87IleGlu: 2.87 ± 0.058
1.392IlePhe: 1.392 ± 0.037
4.65IleGly: 4.65 ± 0.064
0.751IleHis: 0.751 ± 0.027
2.207IleIle: 2.207 ± 0.052
0.941IleLys: 0.941 ± 0.033
3.85IleLeu: 3.85 ± 0.072
0.686IleMet: 0.686 ± 0.023
1.093IleAsn: 1.093 ± 0.032
2.447IlePro: 2.447 ± 0.051
1.084IleGln: 1.084 ± 0.031
2.716IleArg: 2.716 ± 0.05
3.002IleSer: 3.002 ± 0.047
3.213IleThr: 3.213 ± 0.053
4.913IleVal: 4.913 ± 0.074
0.507IleTrp: 0.507 ± 0.022
0.879IleTyr: 0.879 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
2.692LysAla: 2.692 ± 0.055
0.069LysCys: 0.069 ± 0.008
1.08LysAsp: 1.08 ± 0.036
0.885LysGlu: 0.885 ± 0.035
0.654LysPhe: 0.654 ± 0.027
1.618LysGly: 1.618 ± 0.045
0.514LysHis: 0.514 ± 0.022
1.139LysIle: 1.139 ± 0.033
0.866LysLys: 0.866 ± 0.035
2.256LysLeu: 2.256 ± 0.047
0.468LysMet: 0.468 ± 0.018
0.779LysAsn: 0.779 ± 0.031
1.396LysPro: 1.396 ± 0.039
0.786LysGln: 0.786 ± 0.027
1.679LysArg: 1.679 ± 0.039
1.414LysSer: 1.414 ± 0.039
1.637LysThr: 1.637 ± 0.036
1.767LysVal: 1.767 ± 0.044
0.292LysTrp: 0.292 ± 0.017
0.548LysTyr: 0.548 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
14.095LeuAla: 14.095 ± 0.133
0.538LeuCys: 0.538 ± 0.024
6.041LeuAsp: 6.041 ± 0.074
4.873LeuGlu: 4.873 ± 0.076
3.083LeuPhe: 3.083 ± 0.063
9.069LeuGly: 9.069 ± 0.101
1.833LeuHis: 1.833 ± 0.041
4.862LeuIle: 4.862 ± 0.085
2.149LeuLys: 2.149 ± 0.047
10.162LeuLeu: 10.162 ± 0.119
1.646LeuMet: 1.646 ± 0.041
2.362LeuAsn: 2.362 ± 0.042
5.615LeuPro: 5.615 ± 0.074
2.763LeuGln: 2.763 ± 0.048
6.548LeuArg: 6.548 ± 0.09
6.898LeuSer: 6.898 ± 0.087
6.907LeuThr: 6.907 ± 0.077
9.026LeuVal: 9.026 ± 0.105
1.243LeuTrp: 1.243 ± 0.036
1.838LeuTyr: 1.838 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
1.996MetAla: 1.996 ± 0.04
0.092MetCys: 0.092 ± 0.008
0.612MetAsp: 0.612 ± 0.023
0.487MetGlu: 0.487 ± 0.022
0.527MetPhe: 0.527 ± 0.019
1.238MetGly: 1.238 ± 0.033
0.34MetHis: 0.34 ± 0.016
0.893MetIle: 0.893 ± 0.03
0.538MetLys: 0.538 ± 0.024
1.871MetLeu: 1.871 ± 0.046
0.309MetMet: 0.309 ± 0.018
0.608MetAsn: 0.608 ± 0.02
1.126MetPro: 1.126 ± 0.029
0.622MetGln: 0.622 ± 0.025
1.178MetArg: 1.178 ± 0.033
1.387MetSer: 1.387 ± 0.036
1.669MetThr: 1.669 ± 0.038
1.351MetVal: 1.351 ± 0.035
0.175MetTrp: 0.175 ± 0.011
0.255MetTyr: 0.255 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.941AsnAla: 2.941 ± 0.05
0.126AsnCys: 0.126 ± 0.01
1.47AsnAsp: 1.47 ± 0.04
1.161AsnGlu: 1.161 ± 0.033
0.866AsnPhe: 0.866 ± 0.027
2.431AsnGly: 2.431 ± 0.05
0.48AsnHis: 0.48 ± 0.022
1.163AsnIle: 1.163 ± 0.033
0.531AsnLys: 0.531 ± 0.022
2.378AsnLeu: 2.378 ± 0.048
0.391AsnMet: 0.391 ± 0.02
0.69AsnAsn: 0.69 ± 0.029
1.79AsnPro: 1.79 ± 0.041
0.735AsnGln: 0.735 ± 0.027
1.581AsnArg: 1.581 ± 0.037
1.535AsnSer: 1.535 ± 0.041
1.752AsnThr: 1.752 ± 0.048
2.05AsnVal: 2.05 ± 0.041
0.397AsnTrp: 0.397 ± 0.021
0.636AsnTyr: 0.636 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.195ProAla: 7.195 ± 0.103
0.184ProCys: 0.184 ± 0.012
3.432ProAsp: 3.432 ± 0.055
3.192ProGlu: 3.192 ± 0.051
1.736ProPhe: 1.736 ± 0.038
4.902ProGly: 4.902 ± 0.067
1.062ProHis: 1.062 ± 0.033
2.181ProIle: 2.181 ± 0.041
1.162ProLys: 1.162 ± 0.034
4.919ProLeu: 4.919 ± 0.073
0.818ProMet: 0.818 ± 0.025
1.404ProAsn: 1.404 ± 0.036
2.204ProPro: 2.204 ± 0.06
1.466ProGln: 1.466 ± 0.032
2.893ProArg: 2.893 ± 0.057
3.52ProSer: 3.52 ± 0.053
3.866ProThr: 3.866 ± 0.076
4.739ProVal: 4.739 ± 0.07
0.765ProTrp: 0.765 ± 0.026
1.055ProTyr: 1.055 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.575GlnAla: 3.575 ± 0.067
0.145GlnCys: 0.145 ± 0.013
0.962GlnAsp: 0.962 ± 0.029
0.938GlnGlu: 0.938 ± 0.032
1.058GlnPhe: 1.058 ± 0.032
2.074GlnGly: 2.074 ± 0.045
0.661GlnHis: 0.661 ± 0.023
1.664GlnIle: 1.664 ± 0.039
0.887GlnLys: 0.887 ± 0.03
3.591GlnLeu: 3.591 ± 0.054
0.527GlnMet: 0.527 ± 0.024
0.999GlnAsn: 0.999 ± 0.032
1.652GlnPro: 1.652 ± 0.036
1.303GlnGln: 1.303 ± 0.037
2.085GlnArg: 2.085 ± 0.04
1.969GlnSer: 1.969 ± 0.044
1.917GlnThr: 1.917 ± 0.041
2.49GlnVal: 2.49 ± 0.057
0.484GlnTrp: 0.484 ± 0.023
0.739GlnTyr: 0.739 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
7.621ArgAla: 7.621 ± 0.109
0.27ArgCys: 0.27 ± 0.016
3.394ArgAsp: 3.394 ± 0.064
3.557ArgGlu: 3.557 ± 0.064
2.303ArgPhe: 2.303 ± 0.049
4.747ArgGly: 4.747 ± 0.073
1.378ArgHis: 1.378 ± 0.039
3.107ArgIle: 3.107 ± 0.052
1.32ArgLys: 1.32 ± 0.039
6.703ArgLeu: 6.703 ± 0.092
1.462ArgMet: 1.462 ± 0.036
1.396ArgAsn: 1.396 ± 0.032
3.162ArgPro: 3.162 ± 0.061
2.149ArgGln: 2.149 ± 0.049
5.292ArgArg: 5.292 ± 0.081
4.128ArgSer: 4.128 ± 0.066
3.756ArgThr: 3.756 ± 0.062
5.427ArgVal: 5.427 ± 0.075
0.906ArgTrp: 0.906 ± 0.027
1.467ArgTyr: 1.467 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
8.523SerAla: 8.523 ± 0.104
0.325SerCys: 0.325 ± 0.016
3.56SerAsp: 3.56 ± 0.06
2.906SerGlu: 2.906 ± 0.044
2.315SerPhe: 2.315 ± 0.048
6.592SerGly: 6.592 ± 0.084
1.25SerHis: 1.25 ± 0.034
3.325SerIle: 3.325 ± 0.058
1.478SerLys: 1.478 ± 0.041
6.268SerLeu: 6.268 ± 0.08
1.246SerMet: 1.246 ± 0.036
1.693SerAsn: 1.693 ± 0.041
3.588SerPro: 3.588 ± 0.057
1.885SerGln: 1.885 ± 0.038
3.952SerArg: 3.952 ± 0.061
4.857SerSer: 4.857 ± 0.088
5.003SerThr: 5.003 ± 0.081
5.578SerVal: 5.578 ± 0.072
1.005SerTrp: 1.005 ± 0.033
1.432SerTyr: 1.432 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
8.662ThrAla: 8.662 ± 0.126
0.3ThrCys: 0.3 ± 0.015
3.897ThrAsp: 3.897 ± 0.066
2.947ThrGlu: 2.947 ± 0.055
2.227ThrPhe: 2.227 ± 0.043
6.257ThrGly: 6.257 ± 0.086
1.223ThrHis: 1.223 ± 0.03
3.215ThrIle: 3.215 ± 0.051
1.508ThrLys: 1.508 ± 0.043
6.715ThrLeu: 6.715 ± 0.081
1.013ThrMet: 1.013 ± 0.036
1.723ThrAsn: 1.723 ± 0.046
4.304ThrPro: 4.304 ± 0.07
1.677ThrGln: 1.677 ± 0.039
3.439ThrArg: 3.439 ± 0.059
4.447ThrSer: 4.447 ± 0.077
4.575ThrThr: 4.575 ± 0.103
6.328ThrVal: 6.328 ± 0.085
0.866ThrTrp: 0.866 ± 0.029
1.424ThrTyr: 1.424 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
11.187ValAla: 11.187 ± 0.113
0.494ValCys: 0.494 ± 0.023
5.138ValAsp: 5.138 ± 0.069
4.37ValGlu: 4.37 ± 0.073
3.016ValPhe: 3.016 ± 0.058
7.264ValGly: 7.264 ± 0.092
1.521ValHis: 1.521 ± 0.04
4.635ValIle: 4.635 ± 0.075
1.855ValLys: 1.855 ± 0.038
9.113ValLeu: 9.113 ± 0.092
1.494ValMet: 1.494 ± 0.035
2.211ValAsn: 2.211 ± 0.05
4.353ValPro: 4.353 ± 0.06
2.223ValGln: 2.223 ± 0.04
5.056ValArg: 5.056 ± 0.079
6.04ValSer: 6.04 ± 0.075
6.398ValThr: 6.398 ± 0.087
8.502ValVal: 8.502 ± 0.103
1.102ValTrp: 1.102 ± 0.032
1.647ValTyr: 1.647 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.531TrpAla: 1.531 ± 0.039
0.097TrpCys: 0.097 ± 0.009
0.555TrpAsp: 0.555 ± 0.023
0.508TrpGlu: 0.508 ± 0.022
0.554TrpPhe: 0.554 ± 0.02
1.0TrpGly: 1.0 ± 0.034
0.336TrpHis: 0.336 ± 0.017
0.613TrpIle: 0.613 ± 0.022
0.392TrpLys: 0.392 ± 0.018
1.603TrpLeu: 1.603 ± 0.039
0.375TrpMet: 0.375 ± 0.016
0.539TrpAsn: 0.539 ± 0.025
0.722TrpPro: 0.722 ± 0.025
0.699TrpGln: 0.699 ± 0.025
1.035TrpArg: 1.035 ± 0.035
1.112TrpSer: 1.112 ± 0.034
0.609TrpThr: 0.609 ± 0.029
1.22TrpVal: 1.22 ± 0.033
0.313TrpTrp: 0.313 ± 0.017
0.297TrpTyr: 0.297 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.371TyrAla: 2.371 ± 0.042
0.124TyrCys: 0.124 ± 0.011
1.41TyrAsp: 1.41 ± 0.038
1.086TyrGlu: 1.086 ± 0.033
0.826TyrPhe: 0.826 ± 0.027
1.923TyrGly: 1.923 ± 0.042
0.329TyrHis: 0.329 ± 0.018
0.769TyrIle: 0.769 ± 0.028
0.429TyrLys: 0.429 ± 0.021
2.275TyrLeu: 2.275 ± 0.048
0.287TyrMet: 0.287 ± 0.015
0.589TyrAsn: 0.589 ± 0.022
1.09TyrPro: 1.09 ± 0.031
0.675TyrGln: 0.675 ± 0.026
1.505TyrArg: 1.505 ± 0.039
1.482TyrSer: 1.482 ± 0.038
1.335TyrThr: 1.335 ± 0.035
1.665TyrVal: 1.665 ± 0.033
0.33TyrTrp: 0.33 ± 0.017
0.528TyrTyr: 0.528 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3658 proteins (1183075 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski