Amino acid dipepetide frequency for Pseudomonas phage vB_PaeP_Tr60_Ab31

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.685AlaAla: 13.685 ± 1.559
1.069AlaCys: 1.069 ± 0.367
5.203AlaAsp: 5.203 ± 0.655
9.765AlaGlu: 9.765 ± 1.597
3.849AlaPhe: 3.849 ± 0.644
6.985AlaGly: 6.985 ± 0.761
0.998AlaHis: 0.998 ± 0.258
5.132AlaIle: 5.132 ± 0.671
4.633AlaLys: 4.633 ± 0.731
9.694AlaLeu: 9.694 ± 1.075
3.421AlaMet: 3.421 ± 0.524
4.205AlaAsn: 4.205 ± 0.614
3.421AlaPro: 3.421 ± 0.557
6.13AlaGln: 6.13 ± 0.878
7.983AlaArg: 7.983 ± 1.132
5.702AlaSer: 5.702 ± 0.661
5.773AlaThr: 5.773 ± 0.737
6.557AlaVal: 6.557 ± 0.656
2.423AlaTrp: 2.423 ± 0.457
3.136AlaTyr: 3.136 ± 0.588
0.0AlaXaa: 0.0 ± 0.0
Cys
1.354CysAla: 1.354 ± 0.304
0.214CysCys: 0.214 ± 0.124
0.927CysAsp: 0.927 ± 0.308
1.426CysGlu: 1.426 ± 0.329
0.285CysPhe: 0.285 ± 0.135
1.354CysGly: 1.354 ± 0.372
0.071CysHis: 0.071 ± 0.074
0.57CysIle: 0.57 ± 0.176
1.069CysLys: 1.069 ± 0.283
0.855CysLeu: 0.855 ± 0.22
0.143CysMet: 0.143 ± 0.109
0.356CysAsn: 0.356 ± 0.165
0.57CysPro: 0.57 ± 0.229
0.499CysGln: 0.499 ± 0.18
0.57CysArg: 0.57 ± 0.188
0.784CysSer: 0.784 ± 0.25
0.428CysThr: 0.428 ± 0.14
0.428CysVal: 0.428 ± 0.157
0.285CysTrp: 0.285 ± 0.133
0.356CysTyr: 0.356 ± 0.137
0.0CysXaa: 0.0 ± 0.0
Asp
6.415AspAla: 6.415 ± 0.847
0.855AspCys: 0.855 ± 0.234
2.851AspAsp: 2.851 ± 0.456
4.49AspGlu: 4.49 ± 0.588
1.853AspPhe: 1.853 ± 0.388
5.631AspGly: 5.631 ± 0.677
1.212AspHis: 1.212 ± 0.325
3.065AspIle: 3.065 ± 0.598
2.423AspLys: 2.423 ± 0.394
5.346AspLeu: 5.346 ± 0.824
1.497AspMet: 1.497 ± 0.302
1.497AspAsn: 1.497 ± 0.327
3.136AspPro: 3.136 ± 0.422
3.136AspGln: 3.136 ± 0.595
2.922AspArg: 2.922 ± 0.426
2.637AspSer: 2.637 ± 0.399
2.21AspThr: 2.21 ± 0.437
3.564AspVal: 3.564 ± 0.534
1.212AspTrp: 1.212 ± 0.342
1.568AspTyr: 1.568 ± 0.285
0.0AspXaa: 0.0 ± 0.0
Glu
8.553GluAla: 8.553 ± 1.219
1.283GluCys: 1.283 ± 0.351
3.493GluAsp: 3.493 ± 0.482
4.205GluGlu: 4.205 ± 0.742
2.78GluPhe: 2.78 ± 0.411
4.633GluGly: 4.633 ± 0.707
1.568GluHis: 1.568 ± 0.354
3.92GluIle: 3.92 ± 0.543
1.996GluLys: 1.996 ± 0.473
7.199GluLeu: 7.199 ± 0.826
2.138GluMet: 2.138 ± 0.361
2.495GluAsn: 2.495 ± 0.414
2.423GluPro: 2.423 ± 0.347
5.274GluGln: 5.274 ± 0.754
6.486GluArg: 6.486 ± 1.112
4.775GluSer: 4.775 ± 0.619
2.281GluThr: 2.281 ± 0.391
3.706GluVal: 3.706 ± 0.632
1.996GluTrp: 1.996 ± 0.413
2.21GluTyr: 2.21 ± 0.348
0.071GluXaa: 0.071 ± 0.074
Phe
2.637PheAla: 2.637 ± 0.451
0.143PheCys: 0.143 ± 0.111
2.922PheAsp: 2.922 ± 0.435
2.138PheGlu: 2.138 ± 0.408
1.212PhePhe: 1.212 ± 0.289
3.279PheGly: 3.279 ± 0.42
0.784PheHis: 0.784 ± 0.206
1.354PheIle: 1.354 ± 0.291
1.711PheLys: 1.711 ± 0.312
1.996PheLeu: 1.996 ± 0.405
0.57PheMet: 0.57 ± 0.189
1.639PheAsn: 1.639 ± 0.387
1.283PhePro: 1.283 ± 0.273
0.784PheGln: 0.784 ± 0.261
2.138PheArg: 2.138 ± 0.504
3.136PheSer: 3.136 ± 0.511
2.067PheThr: 2.067 ± 0.395
2.637PheVal: 2.637 ± 0.347
0.57PheTrp: 0.57 ± 0.169
1.14PheTyr: 1.14 ± 0.267
0.0PheXaa: 0.0 ± 0.0
Gly
7.484GlyAla: 7.484 ± 0.785
0.927GlyCys: 0.927 ± 0.344
4.49GlyAsp: 4.49 ± 0.573
4.847GlyGlu: 4.847 ± 0.708
3.635GlyPhe: 3.635 ± 0.481
5.773GlyGly: 5.773 ± 0.827
1.283GlyHis: 1.283 ± 0.358
4.348GlyIle: 4.348 ± 0.544
4.063GlyLys: 4.063 ± 0.594
6.344GlyLeu: 6.344 ± 0.636
1.924GlyMet: 1.924 ± 0.339
3.35GlyAsn: 3.35 ± 0.624
2.423GlyPro: 2.423 ± 0.384
2.851GlyGln: 2.851 ± 0.541
5.132GlyArg: 5.132 ± 0.716
4.633GlySer: 4.633 ± 0.522
3.35GlyThr: 3.35 ± 0.503
5.56GlyVal: 5.56 ± 0.639
1.639GlyTrp: 1.639 ± 0.352
2.566GlyTyr: 2.566 ± 0.469
0.0GlyXaa: 0.0 ± 0.0
His
1.069HisAla: 1.069 ± 0.236
0.285HisCys: 0.285 ± 0.169
0.998HisAsp: 0.998 ± 0.266
1.497HisGlu: 1.497 ± 0.334
0.356HisPhe: 0.356 ± 0.176
1.14HisGly: 1.14 ± 0.315
0.356HisHis: 0.356 ± 0.172
0.713HisIle: 0.713 ± 0.222
0.641HisLys: 0.641 ± 0.245
0.927HisLeu: 0.927 ± 0.279
0.285HisMet: 0.285 ± 0.13
0.499HisAsn: 0.499 ± 0.171
1.497HisPro: 1.497 ± 0.378
0.998HisGln: 0.998 ± 0.285
1.354HisArg: 1.354 ± 0.306
0.855HisSer: 0.855 ± 0.253
0.428HisThr: 0.428 ± 0.237
1.069HisVal: 1.069 ± 0.299
0.071HisTrp: 0.071 ± 0.063
0.641HisTyr: 0.641 ± 0.181
0.0HisXaa: 0.0 ± 0.0
Ile
5.845IleAla: 5.845 ± 0.73
0.57IleCys: 0.57 ± 0.226
3.35IleAsp: 3.35 ± 0.503
3.564IleGlu: 3.564 ± 0.446
1.426IlePhe: 1.426 ± 0.31
3.92IleGly: 3.92 ± 0.544
0.855IleHis: 0.855 ± 0.243
1.924IleIle: 1.924 ± 0.351
2.067IleLys: 2.067 ± 0.419
3.778IleLeu: 3.778 ± 0.639
0.927IleMet: 0.927 ± 0.225
2.21IleAsn: 2.21 ± 0.407
1.996IlePro: 1.996 ± 0.37
1.711IleGln: 1.711 ± 0.363
4.063IleArg: 4.063 ± 0.476
4.205IleSer: 4.205 ± 0.62
2.851IleThr: 2.851 ± 0.414
3.635IleVal: 3.635 ± 0.51
1.14IleTrp: 1.14 ± 0.276
1.212IleTyr: 1.212 ± 0.309
0.0IleXaa: 0.0 ± 0.0
Lys
5.417LysAla: 5.417 ± 0.796
0.57LysCys: 0.57 ± 0.223
3.279LysAsp: 3.279 ± 0.478
2.851LysGlu: 2.851 ± 0.429
1.283LysPhe: 1.283 ± 0.272
3.136LysGly: 3.136 ± 0.495
0.499LysHis: 0.499 ± 0.19
1.924LysIle: 1.924 ± 0.356
1.782LysLys: 1.782 ± 0.392
3.279LysLeu: 3.279 ± 0.473
0.927LysMet: 0.927 ± 0.282
1.354LysAsn: 1.354 ± 0.311
2.138LysPro: 2.138 ± 0.399
1.711LysGln: 1.711 ± 0.33
3.207LysArg: 3.207 ± 0.491
2.922LysSer: 2.922 ± 0.472
2.352LysThr: 2.352 ± 0.393
2.138LysVal: 2.138 ± 0.419
1.069LysTrp: 1.069 ± 0.232
1.14LysTyr: 1.14 ± 0.285
0.071LysXaa: 0.071 ± 0.062
Leu
9.337LeuAla: 9.337 ± 0.819
0.855LeuCys: 0.855 ± 0.268
3.564LeuAsp: 3.564 ± 0.54
5.773LeuGlu: 5.773 ± 0.57
2.78LeuPhe: 2.78 ± 0.41
6.842LeuGly: 6.842 ± 0.699
1.069LeuHis: 1.069 ± 0.258
3.92LeuIle: 3.92 ± 0.687
3.635LeuLys: 3.635 ± 0.563
6.7LeuLeu: 6.7 ± 0.671
1.711LeuMet: 1.711 ± 0.386
3.564LeuAsn: 3.564 ± 0.772
3.493LeuPro: 3.493 ± 0.438
1.639LeuGln: 1.639 ± 0.396
7.199LeuArg: 7.199 ± 0.786
6.272LeuSer: 6.272 ± 0.629
3.991LeuThr: 3.991 ± 0.623
3.849LeuVal: 3.849 ± 0.54
0.998LeuTrp: 0.998 ± 0.272
2.708LeuTyr: 2.708 ± 0.379
0.0LeuXaa: 0.0 ± 0.0
Met
2.21MetAla: 2.21 ± 0.438
0.214MetCys: 0.214 ± 0.136
1.426MetAsp: 1.426 ± 0.264
1.782MetGlu: 1.782 ± 0.365
0.499MetPhe: 0.499 ± 0.187
1.069MetGly: 1.069 ± 0.29
0.071MetHis: 0.071 ± 0.073
1.283MetIle: 1.283 ± 0.296
1.426MetLys: 1.426 ± 0.306
1.853MetLeu: 1.853 ± 0.285
0.641MetMet: 0.641 ± 0.185
1.069MetAsn: 1.069 ± 0.272
1.497MetPro: 1.497 ± 0.33
1.069MetGln: 1.069 ± 0.349
1.782MetArg: 1.782 ± 0.414
2.637MetSer: 2.637 ± 0.37
2.281MetThr: 2.281 ± 0.392
0.927MetVal: 0.927 ± 0.243
0.071MetTrp: 0.071 ± 0.062
0.784MetTyr: 0.784 ± 0.264
0.0MetXaa: 0.0 ± 0.0
Asn
3.136AsnAla: 3.136 ± 0.559
0.641AsnCys: 0.641 ± 0.201
2.21AsnAsp: 2.21 ± 0.315
2.067AsnGlu: 2.067 ± 0.393
0.855AsnPhe: 0.855 ± 0.238
3.778AsnGly: 3.778 ± 0.509
0.285AsnHis: 0.285 ± 0.135
1.924AsnIle: 1.924 ± 0.354
0.855AsnLys: 0.855 ± 0.238
2.708AsnLeu: 2.708 ± 0.429
0.641AsnMet: 0.641 ± 0.197
0.998AsnAsn: 0.998 ± 0.259
2.708AsnPro: 2.708 ± 0.367
1.711AsnGln: 1.711 ± 0.367
2.21AsnArg: 2.21 ± 0.424
2.352AsnSer: 2.352 ± 0.409
2.138AsnThr: 2.138 ± 0.621
2.281AsnVal: 2.281 ± 0.532
0.428AsnTrp: 0.428 ± 0.156
1.14AsnTyr: 1.14 ± 0.249
0.0AsnXaa: 0.0 ± 0.0
Pro
3.778ProAla: 3.778 ± 0.516
0.713ProCys: 0.713 ± 0.231
3.635ProAsp: 3.635 ± 0.465
4.562ProGlu: 4.562 ± 0.655
1.568ProPhe: 1.568 ± 0.319
3.493ProGly: 3.493 ± 0.535
0.499ProHis: 0.499 ± 0.186
2.637ProIle: 2.637 ± 0.417
1.212ProLys: 1.212 ± 0.306
2.708ProLeu: 2.708 ± 0.534
0.998ProMet: 0.998 ± 0.261
1.354ProAsn: 1.354 ± 0.354
0.855ProPro: 0.855 ± 0.261
2.138ProGln: 2.138 ± 0.387
2.067ProArg: 2.067 ± 0.416
2.495ProSer: 2.495 ± 0.428
2.138ProThr: 2.138 ± 0.332
3.207ProVal: 3.207 ± 0.499
0.57ProTrp: 0.57 ± 0.204
1.069ProTyr: 1.069 ± 0.28
0.0ProXaa: 0.0 ± 0.0
Gln
7.627GlnAla: 7.627 ± 1.243
0.57GlnCys: 0.57 ± 0.205
2.281GlnAsp: 2.281 ± 0.435
2.994GlnGlu: 2.994 ± 0.617
1.354GlnPhe: 1.354 ± 0.314
2.851GlnGly: 2.851 ± 0.642
0.713GlnHis: 0.713 ± 0.238
2.067GlnIle: 2.067 ± 0.531
1.497GlnLys: 1.497 ± 0.327
3.065GlnLeu: 3.065 ± 0.476
1.283GlnMet: 1.283 ± 0.41
1.426GlnAsn: 1.426 ± 0.304
1.782GlnPro: 1.782 ± 0.318
3.35GlnGln: 3.35 ± 0.956
3.706GlnArg: 3.706 ± 0.746
2.78GlnSer: 2.78 ± 0.449
1.497GlnThr: 1.497 ± 0.331
2.495GlnVal: 2.495 ± 0.382
0.784GlnTrp: 0.784 ± 0.245
1.853GlnTyr: 1.853 ± 0.412
0.0GlnXaa: 0.0 ± 0.0
Arg
8.054ArgAla: 8.054 ± 1.004
0.784ArgCys: 0.784 ± 0.314
3.421ArgAsp: 3.421 ± 0.585
6.629ArgGlu: 6.629 ± 0.994
1.568ArgPhe: 1.568 ± 0.326
4.633ArgGly: 4.633 ± 0.659
1.14ArgHis: 1.14 ± 0.262
4.205ArgIle: 4.205 ± 0.532
3.279ArgLys: 3.279 ± 0.5
5.916ArgLeu: 5.916 ± 0.603
2.281ArgMet: 2.281 ± 0.312
1.996ArgAsn: 1.996 ± 0.364
2.78ArgPro: 2.78 ± 0.484
4.205ArgGln: 4.205 ± 0.868
5.916ArgArg: 5.916 ± 0.752
3.778ArgSer: 3.778 ± 0.419
3.136ArgThr: 3.136 ± 0.349
4.775ArgVal: 4.775 ± 0.639
1.283ArgTrp: 1.283 ± 0.292
2.423ArgTyr: 2.423 ± 0.469
0.071ArgXaa: 0.071 ± 0.068
Ser
6.914SerAla: 6.914 ± 0.663
0.784SerCys: 0.784 ± 0.235
4.277SerAsp: 4.277 ± 0.645
3.849SerGlu: 3.849 ± 0.472
2.423SerPhe: 2.423 ± 0.475
6.272SerGly: 6.272 ± 0.729
1.568SerHis: 1.568 ± 0.363
3.849SerIle: 3.849 ± 0.425
2.994SerLys: 2.994 ± 0.428
4.134SerLeu: 4.134 ± 0.48
1.426SerMet: 1.426 ± 0.321
2.067SerAsn: 2.067 ± 0.34
2.637SerPro: 2.637 ± 0.315
1.996SerGln: 1.996 ± 0.406
4.633SerArg: 4.633 ± 0.519
4.348SerSer: 4.348 ± 0.619
4.134SerThr: 4.134 ± 0.623
3.991SerVal: 3.991 ± 0.571
1.497SerTrp: 1.497 ± 0.368
1.426SerTyr: 1.426 ± 0.477
0.0SerXaa: 0.0 ± 0.0
Thr
7.128ThrAla: 7.128 ± 0.68
0.356ThrCys: 0.356 ± 0.198
2.281ThrAsp: 2.281 ± 0.35
2.922ThrGlu: 2.922 ± 0.484
1.924ThrPhe: 1.924 ± 0.373
4.49ThrGly: 4.49 ± 0.623
0.998ThrHis: 0.998 ± 0.224
2.352ThrIle: 2.352 ± 0.61
2.352ThrLys: 2.352 ± 0.512
4.205ThrLeu: 4.205 ± 0.6
1.14ThrMet: 1.14 ± 0.25
1.568ThrAsn: 1.568 ± 0.262
2.566ThrPro: 2.566 ± 0.35
2.138ThrGln: 2.138 ± 0.392
2.922ThrArg: 2.922 ± 0.381
2.281ThrSer: 2.281 ± 0.424
3.991ThrThr: 3.991 ± 0.731
3.493ThrVal: 3.493 ± 0.694
0.641ThrTrp: 0.641 ± 0.191
1.212ThrTyr: 1.212 ± 0.247
0.0ThrXaa: 0.0 ± 0.0
Val
5.702ValAla: 5.702 ± 0.788
0.998ValCys: 0.998 ± 0.305
4.063ValAsp: 4.063 ± 0.553
4.277ValGlu: 4.277 ± 0.474
2.21ValPhe: 2.21 ± 0.416
4.348ValGly: 4.348 ± 0.57
0.784ValHis: 0.784 ± 0.259
3.635ValIle: 3.635 ± 0.625
2.566ValLys: 2.566 ± 0.422
4.704ValLeu: 4.704 ± 0.655
1.069ValMet: 1.069 ± 0.282
1.924ValAsn: 1.924 ± 0.344
3.279ValPro: 3.279 ± 0.599
2.566ValGln: 2.566 ± 0.474
3.849ValArg: 3.849 ± 0.507
5.987ValSer: 5.987 ± 0.78
3.279ValThr: 3.279 ± 0.554
4.49ValVal: 4.49 ± 0.669
0.784ValTrp: 0.784 ± 0.2
1.497ValTyr: 1.497 ± 0.292
0.0ValXaa: 0.0 ± 0.0
Trp
1.283TrpAla: 1.283 ± 0.317
0.428TrpCys: 0.428 ± 0.17
1.069TrpAsp: 1.069 ± 0.282
0.998TrpGlu: 0.998 ± 0.243
1.14TrpPhe: 1.14 ± 0.287
0.927TrpGly: 0.927 ± 0.263
0.428TrpHis: 0.428 ± 0.142
0.784TrpIle: 0.784 ± 0.235
1.568TrpLys: 1.568 ± 0.353
1.996TrpLeu: 1.996 ± 0.352
0.641TrpMet: 0.641 ± 0.237
0.285TrpAsn: 0.285 ± 0.13
0.428TrpPro: 0.428 ± 0.168
0.927TrpGln: 0.927 ± 0.264
1.426TrpArg: 1.426 ± 0.323
1.283TrpSer: 1.283 ± 0.303
0.855TrpThr: 0.855 ± 0.276
1.283TrpVal: 1.283 ± 0.309
0.356TrpTrp: 0.356 ± 0.117
0.285TrpTyr: 0.285 ± 0.121
0.071TrpXaa: 0.071 ± 0.062
Tyr
2.138TyrAla: 2.138 ± 0.289
0.285TyrCys: 0.285 ± 0.133
1.782TyrAsp: 1.782 ± 0.28
2.851TyrGlu: 2.851 ± 0.468
1.14TyrPhe: 1.14 ± 0.312
2.067TyrGly: 2.067 ± 0.247
0.499TyrHis: 0.499 ± 0.183
1.639TyrIle: 1.639 ± 0.456
1.283TyrLys: 1.283 ± 0.291
2.423TyrLeu: 2.423 ± 0.451
0.855TyrMet: 0.855 ± 0.228
1.212TyrAsn: 1.212 ± 0.287
0.713TyrPro: 0.713 ± 0.27
1.14TyrGln: 1.14 ± 0.319
2.708TyrArg: 2.708 ± 0.454
1.354TyrSer: 1.354 ± 0.285
1.711TyrThr: 1.711 ± 0.306
1.924TyrVal: 1.924 ± 0.343
0.641TyrTrp: 0.641 ± 0.213
1.14TyrTyr: 1.14 ± 0.232
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.071XaaLeu: 0.071 ± 0.062
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.071XaaPro: 0.071 ± 0.074
0.071XaaGln: 0.071 ± 0.062
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.071XaaThr: 0.071 ± 0.068
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 69 proteins (14031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski