Amino acid dipepetide frequency for Blacklegged tick phlebovirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.151AlaAla: 9.151 ± 9.414
1.098AlaCys: 1.098 ± 0.391
2.562AlaAsp: 2.562 ± 1.527
6.955AlaGlu: 6.955 ± 5.861
1.83AlaPhe: 1.83 ± 0.035
3.66AlaGly: 3.66 ± 1.918
1.464AlaHis: 1.464 ± 0.711
2.562AlaIle: 2.562 ± 0.604
6.589AlaLys: 6.589 ± 2.344
5.49AlaLeu: 5.49 ± 1.03
1.464AlaMet: 1.464 ± 2.06
4.026AlaAsn: 4.026 ± 1.74
2.562AlaPro: 2.562 ± 0.32
2.196AlaGln: 2.196 ± 0.142
5.124AlaArg: 5.124 ± 2.131
2.928AlaSer: 2.928 ± 0.498
4.758AlaThr: 4.758 ± 0.462
4.026AlaVal: 4.026 ± 3.588
1.098AlaTrp: 1.098 ± 0.533
2.196AlaTyr: 2.196 ± 0.781
0.0AlaXaa: 0.0 ± 0.0
Cys
1.098CysAla: 1.098 ± 0.533
0.0CysCys: 0.0 ± 0.0
1.464CysAsp: 1.464 ± 0.711
0.0CysGlu: 0.0 ± 0.0
0.732CysPhe: 0.732 ± 0.355
0.366CysGly: 0.366 ± 0.178
0.366CysHis: 0.366 ± 0.746
0.0CysIle: 0.0 ± 0.0
1.098CysLys: 1.098 ± 0.533
1.83CysLeu: 1.83 ± 0.888
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.83CysArg: 1.83 ± 0.888
0.366CysSer: 0.366 ± 0.178
0.366CysThr: 0.366 ± 0.178
1.098CysVal: 1.098 ± 0.533
0.0CysTrp: 0.0 ± 0.0
1.098CysTyr: 1.098 ± 0.533
0.0CysXaa: 0.0 ± 0.0
Asp
2.928AspAla: 2.928 ± 0.498
0.366AspCys: 0.366 ± 0.178
4.758AspAsp: 4.758 ± 2.31
4.026AspGlu: 4.026 ± 1.031
1.098AspPhe: 1.098 ± 1.314
0.732AspGly: 0.732 ± 0.568
0.732AspHis: 0.732 ± 0.355
2.928AspIle: 2.928 ± 0.498
2.928AspLys: 2.928 ± 0.498
8.785AspLeu: 8.785 ± 2.417
1.464AspMet: 1.464 ± 0.711
2.562AspAsn: 2.562 ± 0.32
2.562AspPro: 2.562 ± 1.244
3.66AspGln: 3.66 ± 0.071
4.758AspArg: 4.758 ± 0.461
1.464AspSer: 1.464 ± 0.213
1.464AspThr: 1.464 ± 1.137
4.392AspVal: 4.392 ± 0.639
0.732AspTrp: 0.732 ± 0.355
1.83AspTyr: 1.83 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
6.223GluAla: 6.223 ± 4.369
1.098GluCys: 1.098 ± 0.533
5.124GluAsp: 5.124 ± 1.564
10.981GluGlu: 10.981 ± 4.831
5.124GluPhe: 5.124 ± 1.564
4.026GluGly: 4.026 ± 5.435
1.464GluHis: 1.464 ± 0.711
1.464GluIle: 1.464 ± 0.711
6.589GluLys: 6.589 ± 0.427
7.321GluLeu: 7.321 ± 0.141
2.562GluMet: 2.562 ± 0.604
2.196GluAsn: 2.196 ± 1.066
3.294GluPro: 3.294 ± 1.599
4.026GluGln: 4.026 ± 1.74
4.758GluArg: 4.758 ± 1.385
5.124GluSer: 5.124 ± 0.284
4.392GluThr: 4.392 ± 0.285
3.294GluVal: 3.294 ± 1.172
0.732GluTrp: 0.732 ± 0.568
1.83GluTyr: 1.83 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
2.562PheAla: 2.562 ± 0.32
0.366PheCys: 0.366 ± 0.178
2.562PheAsp: 2.562 ± 0.604
0.366PheGlu: 0.366 ± 0.178
1.464PhePhe: 1.464 ± 0.711
1.098PheGly: 1.098 ± 0.533
0.732PheHis: 0.732 ± 0.355
1.83PheIle: 1.83 ± 0.888
2.562PheLys: 2.562 ± 1.244
4.392PheLeu: 4.392 ± 1.208
1.83PheMet: 1.83 ± 0.035
3.294PheAsn: 3.294 ± 0.675
2.562PhePro: 2.562 ± 0.604
1.098PheGln: 1.098 ± 0.391
1.464PheArg: 1.464 ± 0.711
2.928PheSer: 2.928 ± 0.426
3.294PheThr: 3.294 ± 1.599
2.562PheVal: 2.562 ± 0.32
0.366PheTrp: 0.366 ± 0.178
0.732PheTyr: 0.732 ± 0.355
0.0PheXaa: 0.0 ± 0.0
Gly
2.196GlyAla: 2.196 ± 0.781
0.366GlyCys: 0.366 ± 0.178
3.66GlyAsp: 3.66 ± 0.994
2.928GlyGlu: 2.928 ± 0.426
2.562GlyPhe: 2.562 ± 1.527
3.294GlyGly: 3.294 ± 0.248
2.196GlyHis: 2.196 ± 1.066
3.66GlyIle: 3.66 ± 0.853
2.196GlyLys: 2.196 ± 0.781
5.124GlyLeu: 5.124 ± 0.64
2.196GlyMet: 2.196 ± 0.781
1.098GlyAsn: 1.098 ± 0.533
3.66GlyPro: 3.66 ± 1.918
1.83GlyGln: 1.83 ± 0.035
2.562GlyArg: 2.562 ± 1.244
5.124GlySer: 5.124 ± 0.64
2.562GlyThr: 2.562 ± 0.32
4.026GlyVal: 4.026 ± 2.664
1.098GlyTrp: 1.098 ± 0.391
1.464GlyTyr: 1.464 ± 0.213
0.0GlyXaa: 0.0 ± 0.0
His
1.098HisAla: 1.098 ± 0.391
0.732HisCys: 0.732 ± 0.355
0.366HisAsp: 0.366 ± 0.178
2.562HisGlu: 2.562 ± 1.244
1.464HisPhe: 1.464 ± 0.711
1.464HisGly: 1.464 ± 0.711
1.098HisHis: 1.098 ± 0.391
1.098HisIle: 1.098 ± 0.533
1.098HisLys: 1.098 ± 0.533
1.098HisLeu: 1.098 ± 0.533
0.732HisMet: 0.732 ± 0.355
0.732HisAsn: 0.732 ± 0.355
1.464HisPro: 1.464 ± 0.711
0.366HisGln: 0.366 ± 0.746
2.196HisArg: 2.196 ± 0.142
0.732HisSer: 0.732 ± 0.355
0.366HisThr: 0.366 ± 0.178
3.294HisVal: 3.294 ± 0.248
0.366HisTrp: 0.366 ± 0.178
1.464HisTyr: 1.464 ± 0.213
0.0HisXaa: 0.0 ± 0.0
Ile
2.196IleAla: 2.196 ± 1.705
1.098IleCys: 1.098 ± 0.533
2.196IleAsp: 2.196 ± 1.066
1.83IleGlu: 1.83 ± 0.888
1.098IlePhe: 1.098 ± 0.533
2.196IleGly: 2.196 ± 0.781
0.366IleHis: 0.366 ± 0.178
2.196IleIle: 2.196 ± 1.066
2.196IleLys: 2.196 ± 1.066
4.392IleLeu: 4.392 ± 2.132
1.464IleMet: 1.464 ± 0.711
1.098IleAsn: 1.098 ± 1.314
2.196IlePro: 2.196 ± 0.142
1.098IleGln: 1.098 ± 0.391
2.928IleArg: 2.928 ± 0.498
4.026IleSer: 4.026 ± 1.031
2.562IleThr: 2.562 ± 0.32
2.928IleVal: 2.928 ± 1.421
0.732IleTrp: 0.732 ± 0.355
1.464IleTyr: 1.464 ± 0.711
0.0IleXaa: 0.0 ± 0.0
Lys
5.124LysAla: 5.124 ± 2.131
1.098LysCys: 1.098 ± 0.533
1.83LysAsp: 1.83 ± 0.035
4.392LysGlu: 4.392 ± 1.563
2.928LysPhe: 2.928 ± 0.498
2.196LysGly: 2.196 ± 1.705
1.098LysHis: 1.098 ± 0.391
1.83LysIle: 1.83 ± 0.035
5.49LysLys: 5.49 ± 1.953
4.392LysLeu: 4.392 ± 1.208
1.098LysMet: 1.098 ± 0.136
3.294LysAsn: 3.294 ± 0.675
2.928LysPro: 2.928 ± 0.426
3.66LysGln: 3.66 ± 0.071
4.758LysArg: 4.758 ± 0.461
2.928LysSer: 2.928 ± 0.426
4.758LysThr: 4.758 ± 0.462
2.928LysVal: 2.928 ± 0.426
1.098LysTrp: 1.098 ± 0.533
0.732LysTyr: 0.732 ± 0.355
0.0LysXaa: 0.0 ± 0.0
Leu
7.687LeuAla: 7.687 ± 1.884
1.464LeuCys: 1.464 ± 0.711
5.857LeuAsp: 5.857 ± 0.072
8.785LeuGlu: 8.785 ± 0.569
1.098LeuPhe: 1.098 ± 0.533
7.321LeuGly: 7.321 ± 1.706
3.66LeuHis: 3.66 ± 0.071
3.66LeuIle: 3.66 ± 0.853
5.124LeuLys: 5.124 ± 0.284
9.517LeuLeu: 9.517 ± 0.001
3.294LeuMet: 3.294 ± 0.213
1.83LeuAsn: 1.83 ± 0.888
4.026LeuPro: 4.026 ± 0.107
2.562LeuGln: 2.562 ± 0.604
8.785LeuArg: 8.785 ± 3.341
6.589LeuSer: 6.589 ± 2.274
5.49LeuThr: 5.49 ± 0.106
5.49LeuVal: 5.49 ± 1.953
1.098LeuTrp: 1.098 ± 0.533
3.66LeuTyr: 3.66 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.928MetAla: 2.928 ± 1.35
0.0MetCys: 0.0 ± 0.0
2.196MetAsp: 2.196 ± 1.705
2.196MetGlu: 2.196 ± 0.781
1.098MetPhe: 1.098 ± 0.391
1.098MetGly: 1.098 ± 0.533
1.098MetHis: 1.098 ± 0.533
1.83MetIle: 1.83 ± 0.888
1.098MetLys: 1.098 ± 0.391
2.562MetLeu: 2.562 ± 1.244
1.464MetMet: 1.464 ± 0.213
0.732MetAsn: 0.732 ± 0.355
0.732MetPro: 0.732 ± 0.355
1.464MetGln: 1.464 ± 0.711
2.196MetArg: 2.196 ± 0.781
1.464MetSer: 1.464 ± 0.711
4.026MetThr: 4.026 ± 1.031
2.928MetVal: 2.928 ± 0.426
0.0MetTrp: 0.0 ± 0.0
1.098MetTyr: 1.098 ± 0.533
0.0MetXaa: 0.0 ± 0.0
Asn
1.464AsnAla: 1.464 ± 0.213
0.366AsnCys: 0.366 ± 0.178
1.464AsnAsp: 1.464 ± 0.711
1.098AsnGlu: 1.098 ± 0.391
1.83AsnPhe: 1.83 ± 0.035
1.098AsnGly: 1.098 ± 0.533
1.464AsnHis: 1.464 ± 0.711
1.464AsnIle: 1.464 ± 0.213
1.464AsnLys: 1.464 ± 0.711
4.392AsnLeu: 4.392 ± 1.208
0.732AsnMet: 0.732 ± 0.355
1.098AsnAsn: 1.098 ± 0.533
2.928AsnPro: 2.928 ± 0.498
0.732AsnGln: 0.732 ± 0.355
1.83AsnArg: 1.83 ± 0.959
3.66AsnSer: 3.66 ± 1.777
1.098AsnThr: 1.098 ± 0.533
2.562AsnVal: 2.562 ± 1.244
0.732AsnTrp: 0.732 ± 0.568
1.098AsnTyr: 1.098 ± 0.533
0.0AsnXaa: 0.0 ± 0.0
Pro
2.562ProAla: 2.562 ± 3.375
0.0ProCys: 0.0 ± 0.0
2.562ProAsp: 2.562 ± 0.32
4.758ProGlu: 4.758 ± 0.462
2.928ProPhe: 2.928 ± 1.421
4.758ProGly: 4.758 ± 1.385
1.098ProHis: 1.098 ± 0.533
0.732ProIle: 0.732 ± 0.355
2.562ProLys: 2.562 ± 0.32
1.464ProLeu: 1.464 ± 0.711
0.366ProMet: 0.366 ± 0.178
1.098ProAsn: 1.098 ± 0.533
1.098ProPro: 1.098 ± 0.533
2.196ProGln: 2.196 ± 1.066
3.294ProArg: 3.294 ± 2.096
3.66ProSer: 3.66 ± 0.071
4.026ProThr: 4.026 ± 1.74
5.49ProVal: 5.49 ± 0.818
2.196ProTrp: 2.196 ± 1.066
0.366ProTyr: 0.366 ± 0.178
0.0ProXaa: 0.0 ± 0.0
Gln
2.928GlnAla: 2.928 ± 0.498
0.0GlnCys: 0.0 ± 0.0
1.098GlnAsp: 1.098 ± 0.533
2.562GlnGlu: 2.562 ± 0.604
0.366GlnPhe: 0.366 ± 0.178
3.294GlnGly: 3.294 ± 0.675
1.83GlnHis: 1.83 ± 0.035
1.83GlnIle: 1.83 ± 0.035
2.196GlnLys: 2.196 ± 2.629
3.66GlnLeu: 3.66 ± 1.777
1.83GlnMet: 1.83 ± 0.035
0.732GlnAsn: 0.732 ± 0.355
2.562GlnPro: 2.562 ± 1.527
2.196GlnGln: 2.196 ± 0.781
4.026GlnArg: 4.026 ± 2.664
4.026GlnSer: 4.026 ± 0.817
2.562GlnThr: 2.562 ± 0.604
2.196GlnVal: 2.196 ± 0.142
0.732GlnTrp: 0.732 ± 0.568
0.366GlnTyr: 0.366 ± 0.178
0.0GlnXaa: 0.0 ± 0.0
Arg
4.392ArgAla: 4.392 ± 4.334
0.0ArgCys: 0.0 ± 0.0
2.196ArgAsp: 2.196 ± 1.066
9.151ArgGlu: 9.151 ± 2.024
4.026ArgPhe: 4.026 ± 1.031
5.857ArgGly: 5.857 ± 0.852
2.196ArgHis: 2.196 ± 0.142
2.562ArgIle: 2.562 ± 1.244
2.562ArgLys: 2.562 ± 2.451
6.223ArgLeu: 6.223 ± 0.674
1.464ArgMet: 1.464 ± 0.711
1.098ArgAsn: 1.098 ± 0.533
3.294ArgPro: 3.294 ± 0.675
2.196ArgGln: 2.196 ± 2.629
6.589ArgArg: 6.589 ± 1.42
4.026ArgSer: 4.026 ± 1.031
3.294ArgThr: 3.294 ± 0.675
5.49ArgVal: 5.49 ± 0.818
1.83ArgTrp: 1.83 ± 0.888
2.928ArgTyr: 2.928 ± 1.421
0.0ArgXaa: 0.0 ± 0.0
Ser
4.392SerAla: 4.392 ± 2.486
1.098SerCys: 1.098 ± 0.533
4.758SerAsp: 4.758 ± 1.386
5.124SerGlu: 5.124 ± 0.64
2.562SerPhe: 2.562 ± 1.244
2.928SerGly: 2.928 ± 0.498
0.732SerHis: 0.732 ± 0.355
2.928SerIle: 2.928 ± 0.498
2.928SerLys: 2.928 ± 0.498
8.785SerLeu: 8.785 ± 0.354
2.928SerMet: 2.928 ± 0.426
3.294SerAsn: 3.294 ± 1.599
2.562SerPro: 2.562 ± 1.244
2.196SerGln: 2.196 ± 1.066
3.294SerArg: 3.294 ± 0.675
7.687SerSer: 7.687 ± 0.036
4.758SerThr: 4.758 ± 1.386
5.857SerVal: 5.857 ± 0.072
1.464SerTrp: 1.464 ± 0.213
1.464SerTyr: 1.464 ± 0.213
0.0SerXaa: 0.0 ± 0.0
Thr
2.562ThrAla: 2.562 ± 0.604
1.098ThrCys: 1.098 ± 0.533
2.196ThrAsp: 2.196 ± 0.142
4.392ThrGlu: 4.392 ± 0.285
2.196ThrPhe: 2.196 ± 0.142
1.83ThrGly: 1.83 ± 0.888
0.732ThrHis: 0.732 ± 0.355
1.464ThrIle: 1.464 ± 0.711
4.026ThrLys: 4.026 ± 1.031
5.124ThrLeu: 5.124 ± 0.284
4.392ThrMet: 4.392 ± 1.208
1.83ThrAsn: 1.83 ± 0.888
4.758ThrPro: 4.758 ± 3.232
2.562ThrGln: 2.562 ± 0.604
5.124ThrArg: 5.124 ± 0.64
4.758ThrSer: 4.758 ± 1.386
5.124ThrThr: 5.124 ± 1.564
3.294ThrVal: 3.294 ± 1.599
1.464ThrTrp: 1.464 ± 2.06
0.732ThrTyr: 0.732 ± 0.355
0.0ThrXaa: 0.0 ± 0.0
Val
7.687ValAla: 7.687 ± 3.659
0.366ValCys: 0.366 ± 0.178
3.66ValAsp: 3.66 ± 0.071
5.49ValGlu: 5.49 ± 1.03
2.928ValPhe: 2.928 ± 1.421
2.928ValGly: 2.928 ± 1.421
1.098ValHis: 1.098 ± 0.533
3.66ValIle: 3.66 ± 0.994
4.392ValLys: 4.392 ± 0.639
7.687ValLeu: 7.687 ± 1.811
1.83ValMet: 1.83 ± 0.888
1.464ValAsn: 1.464 ± 0.711
2.196ValPro: 2.196 ± 0.142
2.928ValGln: 2.928 ± 1.421
2.928ValArg: 2.928 ± 1.35
8.053ValSer: 8.053 ± 0.71
2.928ValThr: 2.928 ± 0.426
3.294ValVal: 3.294 ± 0.675
1.098ValTrp: 1.098 ± 0.533
1.464ValTyr: 1.464 ± 1.137
0.0ValXaa: 0.0 ± 0.0
Trp
0.732TrpAla: 0.732 ± 0.355
0.366TrpCys: 0.366 ± 0.178
0.732TrpAsp: 0.732 ± 0.568
1.464TrpGlu: 1.464 ± 0.213
0.366TrpPhe: 0.366 ± 0.178
1.098TrpGly: 1.098 ± 0.391
0.0TrpHis: 0.0 ± 0.0
1.464TrpIle: 1.464 ± 0.711
0.732TrpLys: 0.732 ± 0.568
2.928TrpLeu: 2.928 ± 0.498
0.0TrpMet: 0.0 ± 0.0
0.732TrpAsn: 0.732 ± 0.355
0.366TrpPro: 0.366 ± 0.178
1.098TrpGln: 1.098 ± 0.391
1.464TrpArg: 1.464 ± 0.711
0.732TrpSer: 0.732 ± 0.355
1.098TrpThr: 1.098 ± 0.391
1.098TrpVal: 1.098 ± 0.391
0.732TrpTrp: 0.732 ± 0.355
0.732TrpTyr: 0.732 ± 0.355
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.83TyrAla: 1.83 ± 0.035
0.732TyrCys: 0.732 ± 0.355
2.928TyrAsp: 2.928 ± 1.421
2.562TyrGlu: 2.562 ± 0.32
0.366TyrPhe: 0.366 ± 0.178
2.562TyrGly: 2.562 ± 0.32
0.366TyrHis: 0.366 ± 0.178
1.098TyrIle: 1.098 ± 0.533
0.732TyrLys: 0.732 ± 0.568
2.196TyrLeu: 2.196 ± 0.142
0.732TyrMet: 0.732 ± 0.355
0.366TyrAsn: 0.366 ± 0.178
1.464TyrPro: 1.464 ± 0.213
2.928TyrGln: 2.928 ± 2.273
1.464TyrArg: 1.464 ± 0.711
1.464TyrSer: 1.464 ± 0.711
0.732TyrThr: 0.732 ± 0.355
1.83TyrVal: 1.83 ± 0.035
0.366TyrTrp: 0.366 ± 0.178
0.732TyrTyr: 0.732 ± 0.355
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2733 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski