Amino acid dipepetide frequency for Coprobacillus sp. CAG:235

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.115AlaAla: 3.115 ± 0.089
0.909AlaCys: 0.909 ± 0.039
2.324AlaAsp: 2.324 ± 0.066
2.111AlaGlu: 2.111 ± 0.073
2.477AlaPhe: 2.477 ± 0.07
3.786AlaGly: 3.786 ± 0.091
1.173AlaHis: 1.173 ± 0.044
5.38AlaIle: 5.38 ± 0.088
4.811AlaLys: 4.811 ± 0.099
5.97AlaLeu: 5.97 ± 0.104
1.824AlaMet: 1.824 ± 0.054
2.507AlaAsn: 2.507 ± 0.071
1.309AlaPro: 1.309 ± 0.047
1.557AlaGln: 1.557 ± 0.043
1.889AlaArg: 1.889 ± 0.053
3.498AlaSer: 3.498 ± 0.073
2.917AlaThr: 2.917 ± 0.068
3.535AlaVal: 3.535 ± 0.089
0.344AlaTrp: 0.344 ± 0.026
2.57AlaTyr: 2.57 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.763CysAla: 0.763 ± 0.034
0.274CysCys: 0.274 ± 0.024
0.778CysAsp: 0.778 ± 0.037
0.643CysGlu: 0.643 ± 0.03
0.798CysPhe: 0.798 ± 0.036
1.045CysGly: 1.045 ± 0.043
0.428CysHis: 0.428 ± 0.03
1.262CysIle: 1.262 ± 0.045
0.994CysLys: 0.994 ± 0.04
1.499CysLeu: 1.499 ± 0.049
0.419CysMet: 0.419 ± 0.026
0.595CysAsn: 0.595 ± 0.03
0.536CysPro: 0.536 ± 0.026
0.562CysGln: 0.562 ± 0.032
0.398CysArg: 0.398 ± 0.026
0.896CysSer: 0.896 ± 0.045
0.617CysThr: 0.617 ± 0.027
0.921CysVal: 0.921 ± 0.038
0.096CysTrp: 0.096 ± 0.013
0.655CysTyr: 0.655 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
3.096AspAla: 3.096 ± 0.073
0.822AspCys: 0.822 ± 0.038
3.751AspAsp: 3.751 ± 0.082
5.254AspGlu: 5.254 ± 0.097
3.063AspPhe: 3.063 ± 0.063
3.628AspGly: 3.628 ± 0.09
1.542AspHis: 1.542 ± 0.051
5.253AspIle: 5.253 ± 0.093
4.06AspLys: 4.06 ± 0.107
5.859AspLeu: 5.859 ± 0.097
1.574AspMet: 1.574 ± 0.047
2.564AspAsn: 2.564 ± 0.081
1.456AspPro: 1.456 ± 0.046
2.609AspGln: 2.609 ± 0.063
1.747AspArg: 1.747 ± 0.057
2.796AspSer: 2.796 ± 0.07
2.631AspThr: 2.631 ± 0.071
4.186AspVal: 4.186 ± 0.09
0.409AspTrp: 0.409 ± 0.025
3.829AspTyr: 3.829 ± 0.08
0.0AspXaa: 0.0 ± 0.0
Glu
3.888GluAla: 3.888 ± 0.08
0.785GluCys: 0.785 ± 0.033
4.224GluAsp: 4.224 ± 0.087
5.52GluGlu: 5.52 ± 0.107
2.637GluPhe: 2.637 ± 0.065
3.571GluGly: 3.571 ± 0.089
1.316GluHis: 1.316 ± 0.046
6.362GluIle: 6.362 ± 0.103
7.02GluLys: 7.02 ± 0.123
6.339GluLeu: 6.339 ± 0.113
2.43GluMet: 2.43 ± 0.069
5.183GluAsn: 5.183 ± 0.091
1.25GluPro: 1.25 ± 0.051
2.167GluGln: 2.167 ± 0.054
2.302GluArg: 2.302 ± 0.062
3.19GluSer: 3.19 ± 0.072
3.253GluThr: 3.253 ± 0.079
4.569GluVal: 4.569 ± 0.094
0.359GluTrp: 0.359 ± 0.025
3.214GluTyr: 3.214 ± 0.089
0.0GluXaa: 0.0 ± 0.0
Phe
2.269PheAla: 2.269 ± 0.056
0.612PheCys: 0.612 ± 0.028
3.206PheAsp: 3.206 ± 0.08
2.938PheGlu: 2.938 ± 0.069
1.987PhePhe: 1.987 ± 0.065
2.669PheGly: 2.669 ± 0.067
0.894PheHis: 0.894 ± 0.032
4.391PheIle: 4.391 ± 0.103
3.705PheLys: 3.705 ± 0.082
3.77PheLeu: 3.77 ± 0.096
1.163PheMet: 1.163 ± 0.043
2.604PheAsn: 2.604 ± 0.069
1.09PhePro: 1.09 ± 0.039
1.291PheGln: 1.291 ± 0.046
1.017PheArg: 1.017 ± 0.038
2.91PheSer: 2.91 ± 0.073
2.057PheThr: 2.057 ± 0.056
3.162PheVal: 3.162 ± 0.074
0.269PheTrp: 0.269 ± 0.023
2.2PheTyr: 2.2 ± 0.066
0.0PheXaa: 0.0 ± 0.0
Gly
3.554GlyAla: 3.554 ± 0.096
1.037GlyCys: 1.037 ± 0.04
3.028GlyAsp: 3.028 ± 0.075
3.11GlyGlu: 3.11 ± 0.073
2.988GlyPhe: 2.988 ± 0.083
3.858GlyGly: 3.858 ± 0.112
1.4GlyHis: 1.4 ± 0.047
5.641GlyIle: 5.641 ± 0.097
5.151GlyLys: 5.151 ± 0.092
5.48GlyLeu: 5.48 ± 0.094
1.849GlyMet: 1.849 ± 0.061
3.138GlyAsn: 3.138 ± 0.094
1.093GlyPro: 1.093 ± 0.036
1.908GlyGln: 1.908 ± 0.059
2.02GlyArg: 2.02 ± 0.058
3.336GlySer: 3.336 ± 0.079
3.255GlyThr: 3.255 ± 0.073
4.136GlyVal: 4.136 ± 0.081
0.521GlyTrp: 0.521 ± 0.044
3.333GlyTyr: 3.333 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
1.033HisAla: 1.033 ± 0.038
0.379HisCys: 0.379 ± 0.021
1.323HisAsp: 1.323 ± 0.047
1.297HisGlu: 1.297 ± 0.047
1.161HisPhe: 1.161 ± 0.041
1.307HisGly: 1.307 ± 0.051
0.865HisHis: 0.865 ± 0.047
1.927HisIle: 1.927 ± 0.054
1.251HisLys: 1.251 ± 0.045
2.343HisLeu: 2.343 ± 0.056
0.509HisMet: 0.509 ± 0.026
0.868HisAsn: 0.868 ± 0.032
0.885HisPro: 0.885 ± 0.038
1.183HisGln: 1.183 ± 0.044
0.661HisArg: 0.661 ± 0.032
1.043HisSer: 1.043 ± 0.039
0.887HisThr: 0.887 ± 0.039
1.393HisVal: 1.393 ± 0.046
0.153HisTrp: 0.153 ± 0.015
1.259HisTyr: 1.259 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
5.108IleAla: 5.108 ± 0.108
1.484IleCys: 1.484 ± 0.042
6.164IleAsp: 6.164 ± 0.101
6.722IleGlu: 6.722 ± 0.112
3.816IlePhe: 3.816 ± 0.094
5.316IleGly: 5.316 ± 0.101
1.871IleHis: 1.871 ± 0.059
7.765IleIle: 7.765 ± 0.149
7.203IleLys: 7.203 ± 0.118
7.95IleLeu: 7.95 ± 0.146
2.167IleMet: 2.167 ± 0.058
4.761IleAsn: 4.761 ± 0.089
2.854IlePro: 2.854 ± 0.06
3.293IleGln: 3.293 ± 0.071
2.374IleArg: 2.374 ± 0.062
5.652IleSer: 5.652 ± 0.106
4.134IleThr: 4.134 ± 0.071
5.776IleVal: 5.776 ± 0.102
0.41IleTrp: 0.41 ± 0.024
3.841IleTyr: 3.841 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
4.606LysAla: 4.606 ± 0.089
0.828LysCys: 0.828 ± 0.036
5.88LysAsp: 5.88 ± 0.104
9.037LysGlu: 9.037 ± 0.121
2.164LysPhe: 2.164 ± 0.07
4.508LysGly: 4.508 ± 0.093
1.552LysHis: 1.552 ± 0.053
6.665LysIle: 6.665 ± 0.109
8.674LysLys: 8.674 ± 0.132
6.184LysLeu: 6.184 ± 0.102
2.855LysMet: 2.855 ± 0.057
5.493LysAsn: 5.493 ± 0.103
1.946LysPro: 1.946 ± 0.057
3.485LysGln: 3.485 ± 0.083
3.228LysArg: 3.228 ± 0.077
3.776LysSer: 3.776 ± 0.079
4.373LysThr: 4.373 ± 0.109
5.219LysVal: 5.219 ± 0.097
0.581LysTrp: 0.581 ± 0.031
4.329LysTyr: 4.329 ± 0.077
0.0LysXaa: 0.0 ± 0.0
Leu
5.334LeuAla: 5.334 ± 0.109
1.384LeuCys: 1.384 ± 0.049
5.968LeuAsp: 5.968 ± 0.105
6.44LeuGlu: 6.44 ± 0.1
4.308LeuPhe: 4.308 ± 0.091
5.505LeuGly: 5.505 ± 0.104
1.611LeuHis: 1.611 ± 0.055
7.771LeuIle: 7.771 ± 0.141
8.935LeuLys: 8.935 ± 0.114
8.664LeuLeu: 8.664 ± 0.164
2.665LeuMet: 2.665 ± 0.068
5.744LeuAsn: 5.744 ± 0.092
3.065LeuPro: 3.065 ± 0.076
3.056LeuGln: 3.056 ± 0.059
2.616LeuArg: 2.616 ± 0.064
6.38LeuSer: 6.38 ± 0.103
4.671LeuThr: 4.671 ± 0.088
5.617LeuVal: 5.617 ± 0.095
0.482LeuTrp: 0.482 ± 0.029
3.817LeuTyr: 3.817 ± 0.091
0.0LeuXaa: 0.0 ± 0.0
Met
1.754MetAla: 1.754 ± 0.039
0.367MetCys: 0.367 ± 0.024
1.492MetAsp: 1.492 ± 0.052
1.756MetGlu: 1.756 ± 0.049
1.166MetPhe: 1.166 ± 0.043
1.577MetGly: 1.577 ± 0.054
0.477MetHis: 0.477 ± 0.025
2.892MetIle: 2.892 ± 0.072
3.039MetLys: 3.039 ± 0.06
2.442MetLeu: 2.442 ± 0.063
1.135MetMet: 1.135 ± 0.044
1.987MetAsn: 1.987 ± 0.059
0.876MetPro: 0.876 ± 0.039
0.924MetGln: 0.924 ± 0.037
0.717MetArg: 0.717 ± 0.039
1.875MetSer: 1.875 ± 0.045
1.489MetThr: 1.489 ± 0.05
1.647MetVal: 1.647 ± 0.049
0.146MetTrp: 0.146 ± 0.015
1.114MetTyr: 1.114 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
2.795AsnAla: 2.795 ± 0.073
0.73AsnCys: 0.73 ± 0.033
3.667AsnAsp: 3.667 ± 0.081
4.425AsnGlu: 4.425 ± 0.102
1.905AsnPhe: 1.905 ± 0.054
3.419AsnGly: 3.419 ± 0.095
1.518AsnHis: 1.518 ± 0.054
4.885AsnIle: 4.885 ± 0.084
4.966AsnLys: 4.966 ± 0.103
4.305AsnLeu: 4.305 ± 0.082
1.372AsnMet: 1.372 ± 0.048
3.278AsnAsn: 3.278 ± 0.089
1.787AsnPro: 1.787 ± 0.051
2.787AsnGln: 2.787 ± 0.069
1.81AsnArg: 1.81 ± 0.047
2.705AsnSer: 2.705 ± 0.074
2.759AsnThr: 2.759 ± 0.071
3.532AsnVal: 3.532 ± 0.081
0.37AsnTrp: 0.37 ± 0.025
2.895AsnTyr: 2.895 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
1.411ProAla: 1.411 ± 0.057
0.356ProCys: 0.356 ± 0.025
1.388ProAsp: 1.388 ± 0.046
1.883ProGlu: 1.883 ± 0.059
1.433ProPhe: 1.433 ± 0.047
1.474ProGly: 1.474 ± 0.054
0.674ProHis: 0.674 ± 0.032
2.451ProIle: 2.451 ± 0.066
1.768ProLys: 1.768 ± 0.053
2.793ProLeu: 2.793 ± 0.068
0.789ProMet: 0.789 ± 0.037
1.363ProAsn: 1.363 ± 0.047
0.46ProPro: 0.46 ± 0.028
1.135ProGln: 1.135 ± 0.04
0.851ProArg: 0.851 ± 0.035
1.458ProSer: 1.458 ± 0.041
1.586ProThr: 1.586 ± 0.051
1.942ProVal: 1.942 ± 0.055
0.217ProTrp: 0.217 ± 0.021
1.554ProTyr: 1.554 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
2.063GlnAla: 2.063 ± 0.065
0.367GlnCys: 0.367 ± 0.02
2.054GlnAsp: 2.054 ± 0.053
3.131GlnGlu: 3.131 ± 0.076
1.473GlnPhe: 1.473 ± 0.047
2.055GlnGly: 2.055 ± 0.056
0.631GlnHis: 0.631 ± 0.031
3.252GlnIle: 3.252 ± 0.07
3.32GlnLys: 3.32 ± 0.073
3.658GlnLeu: 3.658 ± 0.08
1.191GlnMet: 1.191 ± 0.046
2.156GlnAsn: 2.156 ± 0.059
0.86GlnPro: 0.86 ± 0.038
1.408GlnGln: 1.408 ± 0.05
1.303GlnArg: 1.303 ± 0.048
1.874GlnSer: 1.874 ± 0.052
2.02GlnThr: 2.02 ± 0.059
2.274GlnVal: 2.274 ± 0.056
0.26GlnTrp: 0.26 ± 0.02
1.881GlnTyr: 1.881 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
1.478ArgAla: 1.478 ± 0.046
0.44ArgCys: 0.44 ± 0.027
1.669ArgAsp: 1.669 ± 0.049
2.114ArgGlu: 2.114 ± 0.065
1.542ArgPhe: 1.542 ± 0.054
1.732ArgGly: 1.732 ± 0.046
0.705ArgHis: 0.705 ± 0.029
2.899ArgIle: 2.899 ± 0.066
2.892ArgLys: 2.892 ± 0.065
2.958ArgLeu: 2.958 ± 0.075
0.999ArgMet: 0.999 ± 0.039
1.804ArgAsn: 1.804 ± 0.064
0.866ArgPro: 0.866 ± 0.042
1.132ArgGln: 1.132 ± 0.04
1.213ArgArg: 1.213 ± 0.051
1.467ArgSer: 1.467 ± 0.049
1.421ArgThr: 1.421 ± 0.049
2.032ArgVal: 2.032 ± 0.058
0.202ArgTrp: 0.202 ± 0.017
1.861ArgTyr: 1.861 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
2.858SerAla: 2.858 ± 0.063
0.733SerCys: 0.733 ± 0.031
2.836SerAsp: 2.836 ± 0.073
2.855SerGlu: 2.855 ± 0.08
3.124SerPhe: 3.124 ± 0.07
3.681SerGly: 3.681 ± 0.081
1.297SerHis: 1.297 ± 0.044
5.019SerIle: 5.019 ± 0.104
4.832SerLys: 4.832 ± 0.087
6.285SerLeu: 6.285 ± 0.112
1.596SerMet: 1.596 ± 0.052
3.022SerAsn: 3.022 ± 0.072
1.365SerPro: 1.365 ± 0.044
2.272SerGln: 2.272 ± 0.053
1.908SerArg: 1.908 ± 0.058
3.782SerSer: 3.782 ± 0.106
2.951SerThr: 2.951 ± 0.073
3.292SerVal: 3.292 ± 0.075
0.425SerTrp: 0.425 ± 0.027
2.966SerTyr: 2.966 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
2.511ThrAla: 2.511 ± 0.064
0.711ThrCys: 0.711 ± 0.03
2.285ThrAsp: 2.285 ± 0.081
2.218ThrGlu: 2.218 ± 0.069
2.399ThrPhe: 2.399 ± 0.061
3.429ThrGly: 3.429 ± 0.079
1.031ThrHis: 1.031 ± 0.038
4.813ThrIle: 4.813 ± 0.093
3.787ThrLys: 3.787 ± 0.086
5.3ThrLeu: 5.3 ± 0.089
1.259ThrMet: 1.259 ± 0.044
2.74ThrAsn: 2.74 ± 0.074
1.714ThrPro: 1.714 ± 0.054
1.49ThrGln: 1.49 ± 0.049
1.563ThrArg: 1.563 ± 0.058
3.153ThrSer: 3.153 ± 0.071
2.89ThrThr: 2.89 ± 0.08
3.456ThrVal: 3.456 ± 0.091
0.328ThrTrp: 0.328 ± 0.025
2.61ThrTyr: 2.61 ± 0.078
0.0ThrXaa: 0.0 ± 0.0
Val
3.7ValAla: 3.7 ± 0.089
1.123ValCys: 1.123 ± 0.038
4.397ValAsp: 4.397 ± 0.08
4.804ValGlu: 4.804 ± 0.086
2.861ValPhe: 2.861 ± 0.068
3.913ValGly: 3.913 ± 0.091
1.149ValHis: 1.149 ± 0.04
5.664ValIle: 5.664 ± 0.087
5.027ValLys: 5.027 ± 0.108
6.325ValLeu: 6.325 ± 0.109
1.675ValMet: 1.675 ± 0.05
3.187ValAsn: 3.187 ± 0.071
1.862ValPro: 1.862 ± 0.053
1.85ValGln: 1.85 ± 0.054
1.905ValArg: 1.905 ± 0.058
4.205ValSer: 4.205 ± 0.084
3.287ValThr: 3.287 ± 0.073
4.679ValVal: 4.679 ± 0.094
0.339ValTrp: 0.339 ± 0.022
2.873ValTyr: 2.873 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.329TrpAla: 0.329 ± 0.025
0.121TrpCys: 0.121 ± 0.013
0.316TrpAsp: 0.316 ± 0.022
0.249TrpGlu: 0.249 ± 0.018
0.341TrpPhe: 0.341 ± 0.027
0.463TrpGly: 0.463 ± 0.032
0.136TrpHis: 0.136 ± 0.014
0.572TrpIle: 0.572 ± 0.031
0.466TrpLys: 0.466 ± 0.028
0.664TrpLeu: 0.664 ± 0.037
0.21TrpMet: 0.21 ± 0.017
0.379TrpAsn: 0.379 ± 0.029
0.134TrpPro: 0.134 ± 0.016
0.236TrpGln: 0.236 ± 0.019
0.177TrpArg: 0.177 ± 0.018
0.369TrpSer: 0.369 ± 0.025
0.311TrpThr: 0.311 ± 0.024
0.364TrpVal: 0.364 ± 0.025
0.069TrpTrp: 0.069 ± 0.011
0.415TrpTyr: 0.415 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.34TyrAla: 2.34 ± 0.056
0.714TyrCys: 0.714 ± 0.03
3.379TyrAsp: 3.379 ± 0.12
3.07TyrGlu: 3.07 ± 0.073
2.561TyrPhe: 2.561 ± 0.062
2.899TyrGly: 2.899 ± 0.077
1.456TyrHis: 1.456 ± 0.047
3.801TyrIle: 3.801 ± 0.08
3.479TyrLys: 3.479 ± 0.074
5.247TyrLeu: 5.247 ± 0.089
1.191TyrMet: 1.191 ± 0.048
2.536TyrAsn: 2.536 ± 0.066
1.576TyrPro: 1.576 ± 0.048
2.885TyrGln: 2.885 ± 0.088
1.728TyrArg: 1.728 ± 0.057
2.735TyrSer: 2.735 ± 0.081
2.178TyrThr: 2.178 ± 0.062
3.096TyrVal: 3.096 ± 0.066
0.342TyrTrp: 0.342 ± 0.022
2.699TyrTyr: 2.699 ± 0.102
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2339 proteins (677759 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski