Amino acid dipepetide frequency for Salmonella enterica subsp. enterica serovar Poona

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.441AlaAla: 10.441 ± 0.126	1.234AlaCys: 1.234 ± 0.035	4.994AlaAsp: 4.994 ± 0.068	5.488AlaGlu: 5.488 ± 0.071	3.556AlaPhe: 3.556 ± 0.052	7.913AlaGly: 7.913 ± 0.097	2.001AlaHis: 2.001 ± 0.045	5.891AlaIle: 5.891 ± 0.086	3.85AlaLys: 3.85 ± 0.082	11.77AlaLeu: 11.77 ± 0.127	3.021AlaMet: 3.021 ± 0.057	3.193AlaAsn: 3.193 ± 0.068	3.933AlaPro: 3.933 ± 0.069	4.546AlaGln: 4.546 ± 0.063	6.023AlaArg: 6.023 ± 0.094	5.681AlaSer: 5.681 ± 0.072	4.919AlaThr: 4.919 ± 0.071	6.632AlaVal: 6.632 ± 0.1	1.626AlaTrp: 1.626 ± 0.043	2.015AlaTyr: 2.015 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.111CysAla: 1.111 ± 0.035	0.218CysCys: 0.218 ± 0.014	0.643CysAsp: 0.643 ± 0.025	0.645CysGlu: 0.645 ± 0.026	0.462CysPhe: 0.462 ± 0.021	1.179CysGly: 1.179 ± 0.035	0.356CysHis: 0.356 ± 0.02	0.685CysIle: 0.685 ± 0.028	0.381CysLys: 0.381 ± 0.021	1.184CysLeu: 1.184 ± 0.033	0.267CysMet: 0.267 ± 0.016	0.346CysAsn: 0.346 ± 0.018	0.604CysPro: 0.604 ± 0.026	0.505CysGln: 0.505 ± 0.026	0.751CysArg: 0.751 ± 0.025	0.705CysSer: 0.705 ± 0.023	0.563CysThr: 0.563 ± 0.021	0.848CysVal: 0.848 ± 0.033	0.22CysTrp: 0.22 ± 0.013	0.372CysTyr: 0.372 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.388AspAla: 5.388 ± 0.079	0.527AspCys: 0.527 ± 0.022	2.926AspAsp: 2.926 ± 0.061	3.288AspGlu: 3.288 ± 0.059	1.96AspPhe: 1.96 ± 0.037	3.776AspGly: 3.776 ± 0.064	1.026AspHis: 1.026 ± 0.032	3.579AspIle: 3.579 ± 0.062	2.482AspLys: 2.482 ± 0.043	4.425AspLeu: 4.425 ± 0.065	1.367AspMet: 1.367 ± 0.036	2.244AspAsn: 2.244 ± 0.053	2.191AspPro: 2.191 ± 0.049	1.468AspGln: 1.468 ± 0.038	2.685AspArg: 2.685 ± 0.053	2.909AspSer: 2.909 ± 0.055	2.709AspThr: 2.709 ± 0.051	3.71AspVal: 3.71 ± 0.062	0.758AspTrp: 0.758 ± 0.027	1.858AspTyr: 1.858 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.113GluAla: 5.113 ± 0.082	0.512GluCys: 0.512 ± 0.02	2.337GluAsp: 2.337 ± 0.047	3.227GluGlu: 3.227 ± 0.069	1.667GluPhe: 1.667 ± 0.043	3.636GluGly: 3.636 ± 0.059	1.434GluHis: 1.434 ± 0.035	3.294GluIle: 3.294 ± 0.053	3.193GluLys: 3.193 ± 0.057	5.597GluLeu: 5.597 ± 0.072	1.75GluMet: 1.75 ± 0.033	2.342GluAsn: 2.342 ± 0.048	2.082GluPro: 2.082 ± 0.039	3.157GluGln: 3.157 ± 0.063	3.627GluArg: 3.627 ± 0.061	2.82GluSer: 2.82 ± 0.053	2.997GluThr: 2.997 ± 0.056	3.58GluVal: 3.58 ± 0.052	0.741GluTrp: 0.741 ± 0.026	1.523GluTyr: 1.523 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.541PheAla: 3.541 ± 0.068	0.587PheCys: 0.587 ± 0.022	2.184PheAsp: 2.184 ± 0.049	1.685PheGlu: 1.685 ± 0.038	1.661PhePhe: 1.661 ± 0.047	3.024PheGly: 3.024 ± 0.06	0.813PheHis: 0.813 ± 0.031	2.586PheIle: 2.586 ± 0.054	1.281PheLys: 1.281 ± 0.033	3.33PheLeu: 3.33 ± 0.063	0.972PheMet: 0.972 ± 0.026	1.709PheAsn: 1.709 ± 0.032	1.507PhePro: 1.507 ± 0.037	1.036PheGln: 1.036 ± 0.03	1.848PheArg: 1.848 ± 0.042	3.075PheSer: 3.075 ± 0.059	2.459PheThr: 2.459 ± 0.049	2.426PheVal: 2.426 ± 0.047	0.604PheTrp: 0.604 ± 0.025	1.239PheTyr: 1.239 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	6.77GlyAla: 6.77 ± 0.093	1.16GlyCys: 1.16 ± 0.031	3.791GlyAsp: 3.791 ± 0.063	4.478GlyGlu: 4.478 ± 0.065	3.139GlyPhe: 3.139 ± 0.062	5.912GlyGly: 5.912 ± 0.092	1.688GlyHis: 1.688 ± 0.036	4.967GlyIle: 4.967 ± 0.077	3.788GlyLys: 3.788 ± 0.06	7.292GlyLeu: 7.292 ± 0.094	2.482GlyMet: 2.482 ± 0.053	2.825GlyAsn: 2.825 ± 0.06	2.227GlyPro: 2.227 ± 0.047	2.815GlyGln: 2.815 ± 0.057	3.99GlyArg: 3.99 ± 0.062	4.234GlySer: 4.234 ± 0.071	3.73GlyThr: 3.73 ± 0.067	5.938GlyVal: 5.938 ± 0.078	1.268GlyTrp: 1.268 ± 0.033	2.611GlyTyr: 2.611 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.027HisAla: 2.027 ± 0.047	0.372HisCys: 0.372 ± 0.019	1.177HisAsp: 1.177 ± 0.035	1.146HisGlu: 1.146 ± 0.032	1.06HisPhe: 1.06 ± 0.034	1.752HisGly: 1.752 ± 0.041	0.827HisHis: 0.827 ± 0.026	1.393HisIle: 1.393 ± 0.035	0.8HisLys: 0.8 ± 0.027	2.323HisLeu: 2.323 ± 0.046	0.544HisMet: 0.544 ± 0.02	0.92HisAsn: 0.92 ± 0.029	1.385HisPro: 1.385 ± 0.038	1.173HisGln: 1.173 ± 0.037	1.348HisArg: 1.348 ± 0.037	1.357HisSer: 1.357 ± 0.037	1.166HisThr: 1.166 ± 0.031	1.383HisVal: 1.383 ± 0.042	0.42HisTrp: 0.42 ± 0.017	0.974HisTyr: 0.974 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.565IleAla: 6.565 ± 0.082	0.723IleCys: 0.723 ± 0.025	3.504IleAsp: 3.504 ± 0.062	3.197IleGlu: 3.197 ± 0.064	2.071IlePhe: 2.071 ± 0.051	4.561IleGly: 4.561 ± 0.074	1.278IleHis: 1.278 ± 0.034	3.554IleIle: 3.554 ± 0.061	2.381IleLys: 2.381 ± 0.054	5.092IleLeu: 5.092 ± 0.075	1.337IleMet: 1.337 ± 0.037	2.694IleAsn: 2.694 ± 0.057	2.866IlePro: 2.866 ± 0.054	1.795IleGln: 1.795 ± 0.037	3.103IleArg: 3.103 ± 0.049	3.777IleSer: 3.777 ± 0.056	3.776IleThr: 3.776 ± 0.065	4.012IleVal: 4.012 ± 0.072	0.736IleTrp: 0.736 ± 0.026	1.628IleTyr: 1.628 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.145LysAla: 4.145 ± 0.073	0.361LysCys: 0.361 ± 0.019	1.998LysAsp: 1.998 ± 0.05	2.474LysGlu: 2.474 ± 0.056	1.115LysPhe: 1.115 ± 0.035	2.905LysGly: 2.905 ± 0.058	0.894LysHis: 0.894 ± 0.026	2.437LysIle: 2.437 ± 0.05	2.336LysLys: 2.336 ± 0.056	4.086LysLeu: 4.086 ± 0.068	1.193LysMet: 1.193 ± 0.032	1.771LysAsn: 1.771 ± 0.044	2.082LysPro: 2.082 ± 0.046	1.854LysGln: 1.854 ± 0.042	2.587LysArg: 2.587 ± 0.053	2.275LysSer: 2.275 ± 0.045	2.579LysThr: 2.579 ± 0.046	2.827LysVal: 2.827 ± 0.054	0.454LysTrp: 0.454 ± 0.021	1.248LysTyr: 1.248 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	11.239LeuAla: 11.239 ± 0.121	1.374LeuCys: 1.374 ± 0.032	5.091LeuAsp: 5.091 ± 0.061	5.311LeuGlu: 5.311 ± 0.083	4.196LeuPhe: 4.196 ± 0.069	7.131LeuGly: 7.131 ± 0.094	2.355LeuHis: 2.355 ± 0.05	5.831LeuIle: 5.831 ± 0.086	4.349LeuLys: 4.349 ± 0.061	11.678LeuLeu: 11.678 ± 0.136	2.83LeuMet: 2.83 ± 0.058	4.165LeuAsn: 4.165 ± 0.065	5.689LeuPro: 5.689 ± 0.077	3.987LeuGln: 3.987 ± 0.067	6.424LeuArg: 6.424 ± 0.087	7.173LeuSer: 7.173 ± 0.09	6.493LeuThr: 6.493 ± 0.074	6.809LeuVal: 6.809 ± 0.072	1.358LeuTrp: 1.358 ± 0.035	2.667LeuTyr: 2.667 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.886MetAla: 2.886 ± 0.056	0.257MetCys: 0.257 ± 0.015	1.209MetAsp: 1.209 ± 0.032	1.229MetGlu: 1.229 ± 0.042	0.921MetPhe: 0.921 ± 0.032	1.957MetGly: 1.957 ± 0.044	0.55MetHis: 0.55 ± 0.022	1.456MetIle: 1.456 ± 0.035	1.399MetLys: 1.399 ± 0.04	3.071MetLeu: 3.071 ± 0.052	0.953MetMet: 0.953 ± 0.031	1.119MetAsn: 1.119 ± 0.032	1.427MetPro: 1.427 ± 0.033	1.215MetGln: 1.215 ± 0.033	1.555MetArg: 1.555 ± 0.038	1.812MetSer: 1.812 ± 0.041	1.78MetThr: 1.78 ± 0.04	1.911MetVal: 1.911 ± 0.044	0.284MetTrp: 0.284 ± 0.018	0.533MetTyr: 0.533 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.644AsnAla: 3.644 ± 0.065	0.356AsnCys: 0.356 ± 0.019	2.075AsnAsp: 2.075 ± 0.042	1.969AsnGlu: 1.969 ± 0.045	1.298AsnPhe: 1.298 ± 0.037	3.062AsnGly: 3.062 ± 0.058	0.893AsnHis: 0.893 ± 0.029	2.455AsnIle: 2.455 ± 0.054	1.585AsnLys: 1.585 ± 0.042	3.423AsnLeu: 3.423 ± 0.062	0.944AsnMet: 0.944 ± 0.029	1.618AsnAsn: 1.618 ± 0.047	2.107AsnPro: 2.107 ± 0.047	1.474AsnGln: 1.474 ± 0.038	1.979AsnArg: 1.979 ± 0.042	2.111AsnSer: 2.111 ± 0.052	2.202AsnThr: 2.202 ± 0.048	2.679AsnVal: 2.679 ± 0.054	0.539AsnTrp: 0.539 ± 0.027	1.197AsnTyr: 1.197 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.833ProAla: 4.833 ± 0.067	0.444ProCys: 0.444 ± 0.022	2.83ProAsp: 2.83 ± 0.051	3.227ProGlu: 3.227 ± 0.05	1.814ProPhe: 1.814 ± 0.035	3.76ProGly: 3.76 ± 0.064	1.108ProHis: 1.108 ± 0.035	1.855ProIle: 1.855 ± 0.041	1.465ProLys: 1.465 ± 0.036	5.238ProLeu: 5.238 ± 0.069	1.103ProMet: 1.103 ± 0.03	1.265ProAsn: 1.265 ± 0.034	2.104ProPro: 2.104 ± 0.043	2.226ProGln: 2.226 ± 0.047	2.396ProArg: 2.396 ± 0.056	2.256ProSer: 2.256 ± 0.048	2.247ProThr: 2.247 ± 0.047	4.036ProVal: 4.036 ± 0.07	0.756ProTrp: 0.756 ± 0.031	1.234ProTyr: 1.234 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.548GlnAla: 4.548 ± 0.068	0.429GlnCys: 0.429 ± 0.018	1.759GlnAsp: 1.759 ± 0.046	2.219GlnGlu: 2.219 ± 0.042	1.41GlnPhe: 1.41 ± 0.03	2.969GlnGly: 2.969 ± 0.052	1.225GlnHis: 1.225 ± 0.035	2.22GlnIle: 2.22 ± 0.04	1.795GlnLys: 1.795 ± 0.044	4.67GlnLeu: 4.67 ± 0.072	1.143GlnMet: 1.143 ± 0.031	1.511GlnAsn: 1.511 ± 0.044	2.137GlnPro: 2.137 ± 0.051	2.985GlnGln: 2.985 ± 0.062	3.031GlnArg: 3.031 ± 0.052	2.266GlnSer: 2.266 ± 0.042	2.225GlnThr: 2.225 ± 0.052	2.724GlnVal: 2.724 ± 0.05	0.701GlnTrp: 0.701 ± 0.024	1.221GlnTyr: 1.221 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.014ArgAla: 5.014 ± 0.074	0.729ArgCys: 0.729 ± 0.029	3.095ArgAsp: 3.095 ± 0.053	3.784ArgGlu: 3.784 ± 0.07	2.516ArgPhe: 2.516 ± 0.045	3.75ArgGly: 3.75 ± 0.058	1.755ArgHis: 1.755 ± 0.042	3.497ArgIle: 3.497 ± 0.051	2.401ArgLys: 2.401 ± 0.052	6.488ArgLeu: 6.488 ± 0.095	1.694ArgMet: 1.694 ± 0.035	2.006ArgAsn: 2.006 ± 0.038	2.553ArgPro: 2.553 ± 0.052	3.175ArgGln: 3.175 ± 0.053	4.001ArgArg: 4.001 ± 0.073	2.894ArgSer: 2.894 ± 0.05	2.581ArgThr: 2.581 ± 0.045	3.848ArgVal: 3.848 ± 0.059	0.944ArgTrp: 0.944 ± 0.029	2.173ArgTyr: 2.173 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.836SerAla: 5.836 ± 0.072	0.715SerCys: 0.715 ± 0.024	3.082SerAsp: 3.082 ± 0.051	3.11SerGlu: 3.11 ± 0.05	2.251SerPhe: 2.251 ± 0.042	5.292SerGly: 5.292 ± 0.072	1.506SerHis: 1.506 ± 0.04	3.149SerIle: 3.149 ± 0.059	1.962SerLys: 1.962 ± 0.044	6.655SerLeu: 6.655 ± 0.084	1.454SerMet: 1.454 ± 0.041	1.834SerAsn: 1.834 ± 0.047	2.747SerPro: 2.747 ± 0.055	2.547SerGln: 2.547 ± 0.043	3.543SerArg: 3.543 ± 0.062	3.542SerSer: 3.542 ± 0.061	2.991SerThr: 2.991 ± 0.052	4.317SerVal: 4.317 ± 0.066	0.983SerTrp: 0.983 ± 0.029	1.639SerTyr: 1.639 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.211ThrAla: 5.211 ± 0.077	0.569ThrCys: 0.569 ± 0.023	2.669ThrAsp: 2.669 ± 0.052	2.51ThrGlu: 2.51 ± 0.051	2.091ThrPhe: 2.091 ± 0.046	4.497ThrGly: 4.497 ± 0.074	1.379ThrHis: 1.379 ± 0.035	3.065ThrIle: 3.065 ± 0.058	1.562ThrLys: 1.562 ± 0.037	7.461ThrLeu: 7.461 ± 0.081	1.209ThrMet: 1.209 ± 0.033	1.657ThrAsn: 1.657 ± 0.047	3.457ThrPro: 3.457 ± 0.066	2.252ThrGln: 2.252 ± 0.048	3.196ThrArg: 3.196 ± 0.055	3.005ThrSer: 3.005 ± 0.056	2.982ThrThr: 2.982 ± 0.066	4.009ThrVal: 4.009 ± 0.07	0.85ThrTrp: 0.85 ± 0.032	1.191ThrTyr: 1.191 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	6.846ValAla: 6.846 ± 0.085	0.883ValCys: 0.883 ± 0.033	3.722ValAsp: 3.722 ± 0.059	3.852ValGlu: 3.852 ± 0.061	2.52ValPhe: 2.52 ± 0.052	4.888ValGly: 4.888 ± 0.073	1.238ValHis: 1.238 ± 0.034	4.481ValIle: 4.481 ± 0.068	3.075ValLys: 3.075 ± 0.054	7.117ValLeu: 7.117 ± 0.092	2.19ValMet: 2.19 ± 0.047	2.835ValAsn: 2.835 ± 0.056	3.025ValPro: 3.025 ± 0.051	2.314ValGln: 2.314 ± 0.046	3.75ValArg: 3.75 ± 0.061	4.634ValSer: 4.634 ± 0.077	4.202ValThr: 4.202 ± 0.07	5.521ValVal: 5.521 ± 0.079	0.973ValTrp: 0.973 ± 0.031	1.819ValTyr: 1.819 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.031TrpAla: 1.031 ± 0.034	0.192TrpCys: 0.192 ± 0.013	0.604TrpAsp: 0.604 ± 0.026	0.571TrpGlu: 0.571 ± 0.024	0.68TrpPhe: 0.68 ± 0.024	0.904TrpGly: 0.904 ± 0.031	0.44TrpHis: 0.44 ± 0.02	0.759TrpIle: 0.759 ± 0.025	0.514TrpLys: 0.514 ± 0.023	2.271TrpLeu: 2.271 ± 0.053	0.425TrpMet: 0.425 ± 0.022	0.465TrpAsn: 0.465 ± 0.022	0.689TrpPro: 0.689 ± 0.027	1.129TrpGln: 1.129 ± 0.036	1.189TrpArg: 1.189 ± 0.032	0.828TrpSer: 0.828 ± 0.027	0.597TrpThr: 0.597 ± 0.024	0.945TrpVal: 0.945 ± 0.032	0.229TrpTrp: 0.229 ± 0.014	0.41TrpTyr: 0.41 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.535TyrAla: 2.535 ± 0.049	0.404TyrCys: 0.404 ± 0.02	1.586TyrAsp: 1.586 ± 0.042	1.22TyrGlu: 1.22 ± 0.031	1.177TyrPhe: 1.177 ± 0.032	2.236TyrGly: 2.236 ± 0.052	0.78TyrHis: 0.78 ± 0.032	1.497TyrIle: 1.497 ± 0.037	1.021TyrLys: 1.021 ± 0.033	2.979TyrLeu: 2.979 ± 0.056	0.648TyrMet: 0.648 ± 0.027	1.095TyrAsn: 1.095 ± 0.03	1.385TyrPro: 1.385 ± 0.043	1.532TyrGln: 1.532 ± 0.038	1.874TyrArg: 1.874 ± 0.041	1.802TyrSer: 1.802 ± 0.046	1.623TyrThr: 1.623 ± 0.045	1.729TyrVal: 1.729 ± 0.041	0.429TyrTrp: 0.429 ± 0.017	0.971TyrTyr: 0.971 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5880 proteins (1096837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---