Amino acid dipepetide frequency for Streptococcus phage Javan166

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.347AlaAla: 4.347 ± 1.358
0.6AlaCys: 0.6 ± 0.214
4.422AlaAsp: 4.422 ± 0.607
4.422AlaGlu: 4.422 ± 0.696
3.223AlaPhe: 3.223 ± 0.648
4.572AlaGly: 4.572 ± 1.066
0.375AlaHis: 0.375 ± 0.143
6.071AlaIle: 6.071 ± 1.045
7.045AlaLys: 7.045 ± 0.984
4.497AlaLeu: 4.497 ± 0.548
2.323AlaMet: 2.323 ± 0.593
3.522AlaAsn: 3.522 ± 0.492
1.424AlaPro: 1.424 ± 0.318
2.548AlaGln: 2.548 ± 0.589
2.173AlaArg: 2.173 ± 0.344
4.722AlaSer: 4.722 ± 0.919
4.047AlaThr: 4.047 ± 0.821
4.797AlaVal: 4.797 ± 1.068
0.6AlaTrp: 0.6 ± 0.189
2.248AlaTyr: 2.248 ± 0.378
0.0AlaXaa: 0.0 ± 0.0
Cys
0.3CysAla: 0.3 ± 0.169
0.3CysCys: 0.3 ± 0.161
0.749CysAsp: 0.749 ± 0.207
0.6CysGlu: 0.6 ± 0.221
0.15CysPhe: 0.15 ± 0.116
0.45CysGly: 0.45 ± 0.214
0.225CysHis: 0.225 ± 0.145
0.3CysIle: 0.3 ± 0.132
0.45CysLys: 0.45 ± 0.175
0.45CysLeu: 0.45 ± 0.186
0.225CysMet: 0.225 ± 0.134
0.375CysAsn: 0.375 ± 0.15
0.15CysPro: 0.15 ± 0.11
0.225CysGln: 0.225 ± 0.134
0.3CysArg: 0.3 ± 0.138
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.45CysVal: 0.45 ± 0.179
0.075CysTrp: 0.075 ± 0.073
0.3CysTyr: 0.3 ± 0.139
0.0CysXaa: 0.0 ± 0.0
Asp
2.923AspAla: 2.923 ± 0.432
0.675AspCys: 0.675 ± 0.249
4.272AspAsp: 4.272 ± 0.624
4.122AspGlu: 4.122 ± 0.635
3.597AspPhe: 3.597 ± 0.454
5.846AspGly: 5.846 ± 0.759
1.049AspHis: 1.049 ± 0.267
5.021AspIle: 5.021 ± 0.602
7.27AspLys: 7.27 ± 0.811
6.52AspLeu: 6.52 ± 0.684
1.424AspMet: 1.424 ± 0.357
3.073AspAsn: 3.073 ± 0.562
1.349AspPro: 1.349 ± 0.278
1.649AspGln: 1.649 ± 0.331
2.698AspArg: 2.698 ± 0.46
3.148AspSer: 3.148 ± 0.423
3.672AspThr: 3.672 ± 0.54
4.347AspVal: 4.347 ± 0.549
0.899AspTrp: 0.899 ± 0.307
3.448AspTyr: 3.448 ± 0.521
0.0AspXaa: 0.0 ± 0.0
Glu
5.546GluAla: 5.546 ± 0.67
0.45GluCys: 0.45 ± 0.273
3.223GluAsp: 3.223 ± 0.591
5.696GluGlu: 5.696 ± 0.993
3.522GluPhe: 3.522 ± 0.543
4.047GluGly: 4.047 ± 0.591
1.124GluHis: 1.124 ± 0.286
6.37GluIle: 6.37 ± 0.841
6.82GluLys: 6.82 ± 0.965
7.794GluLeu: 7.794 ± 0.795
2.548GluMet: 2.548 ± 0.547
3.972GluAsn: 3.972 ± 0.569
2.173GluPro: 2.173 ± 0.467
2.998GluGln: 2.998 ± 0.505
3.298GluArg: 3.298 ± 0.517
4.047GluSer: 4.047 ± 0.489
3.373GluThr: 3.373 ± 0.587
4.946GluVal: 4.946 ± 0.769
0.6GluTrp: 0.6 ± 0.241
3.298GluTyr: 3.298 ± 0.562
0.0GluXaa: 0.0 ± 0.0
Phe
2.773PheAla: 2.773 ± 0.499
0.225PheCys: 0.225 ± 0.109
3.522PheAsp: 3.522 ± 0.43
3.148PheGlu: 3.148 ± 0.45
1.724PhePhe: 1.724 ± 0.328
2.923PheGly: 2.923 ± 0.522
0.45PheHis: 0.45 ± 0.171
2.248PheIle: 2.248 ± 0.485
4.572PheLys: 4.572 ± 0.575
2.398PheLeu: 2.398 ± 0.463
1.049PheMet: 1.049 ± 0.278
2.998PheAsn: 2.998 ± 0.434
0.749PhePro: 0.749 ± 0.254
1.199PheGln: 1.199 ± 0.291
2.848PheArg: 2.848 ± 0.456
2.248PheSer: 2.248 ± 0.489
2.473PheThr: 2.473 ± 0.367
2.923PheVal: 2.923 ± 0.418
0.225PheTrp: 0.225 ± 0.115
1.724PheTyr: 1.724 ± 0.408
0.0PheXaa: 0.0 ± 0.0
Gly
4.197GlyAla: 4.197 ± 1.014
0.15GlyCys: 0.15 ± 0.095
4.797GlyAsp: 4.797 ± 0.961
4.422GlyGlu: 4.422 ± 0.588
3.223GlyPhe: 3.223 ± 0.538
4.197GlyGly: 4.197 ± 0.53
0.749GlyHis: 0.749 ± 0.244
4.422GlyIle: 4.422 ± 0.751
6.67GlyLys: 6.67 ± 0.62
5.996GlyLeu: 5.996 ± 0.979
1.949GlyMet: 1.949 ± 0.375
2.998GlyAsn: 2.998 ± 0.469
1.874GlyPro: 1.874 ± 1.502
2.548GlyGln: 2.548 ± 0.613
2.848GlyArg: 2.848 ± 0.472
2.998GlySer: 2.998 ± 0.68
3.822GlyThr: 3.822 ± 0.457
4.272GlyVal: 4.272 ± 0.7
0.675GlyTrp: 0.675 ± 0.21
3.148GlyTyr: 3.148 ± 0.501
0.0GlyXaa: 0.0 ± 0.0
His
1.049HisAla: 1.049 ± 0.247
0.225HisCys: 0.225 ± 0.155
0.6HisAsp: 0.6 ± 0.201
1.049HisGlu: 1.049 ± 0.271
0.45HisPhe: 0.45 ± 0.194
1.124HisGly: 1.124 ± 0.299
0.225HisHis: 0.225 ± 0.112
0.974HisIle: 0.974 ± 0.303
0.899HisLys: 0.899 ± 0.247
0.525HisLeu: 0.525 ± 0.238
0.225HisMet: 0.225 ± 0.125
0.824HisAsn: 0.824 ± 0.254
0.225HisPro: 0.225 ± 0.149
0.45HisGln: 0.45 ± 0.177
0.824HisArg: 0.824 ± 0.239
0.899HisSer: 0.899 ± 0.302
1.049HisThr: 1.049 ± 0.304
0.749HisVal: 0.749 ± 0.21
0.15HisTrp: 0.15 ± 0.1
0.6HisTyr: 0.6 ± 0.218
0.0HisXaa: 0.0 ± 0.0
Ile
4.422IleAla: 4.422 ± 0.743
0.375IleCys: 0.375 ± 0.174
6.595IleAsp: 6.595 ± 0.697
4.797IleGlu: 4.797 ± 0.642
1.649IlePhe: 1.649 ± 0.333
4.422IleGly: 4.422 ± 0.782
1.349IleHis: 1.349 ± 0.311
5.021IleIle: 5.021 ± 0.621
6.595IleLys: 6.595 ± 0.723
4.946IleLeu: 4.946 ± 0.494
1.349IleMet: 1.349 ± 0.274
4.797IleAsn: 4.797 ± 0.635
1.949IlePro: 1.949 ± 0.41
2.098IleGln: 2.098 ± 0.332
2.623IleArg: 2.623 ± 0.442
4.347IleSer: 4.347 ± 0.712
4.871IleThr: 4.871 ± 0.65
3.373IleVal: 3.373 ± 0.544
0.375IleTrp: 0.375 ± 0.15
2.473IleTyr: 2.473 ± 0.441
0.0IleXaa: 0.0 ± 0.0
Lys
5.996LysAla: 5.996 ± 0.548
0.375LysCys: 0.375 ± 0.178
4.946LysAsp: 4.946 ± 0.645
7.345LysGlu: 7.345 ± 0.908
3.148LysPhe: 3.148 ± 0.538
4.122LysGly: 4.122 ± 0.61
1.124LysHis: 1.124 ± 0.268
6.37LysIle: 6.37 ± 0.63
7.869LysLys: 7.869 ± 1.21
8.169LysLeu: 8.169 ± 0.772
2.773LysMet: 2.773 ± 0.44
5.321LysAsn: 5.321 ± 0.551
2.998LysPro: 2.998 ± 0.545
4.871LysGln: 4.871 ± 0.687
3.822LysArg: 3.822 ± 0.587
5.171LysSer: 5.171 ± 0.568
6.595LysThr: 6.595 ± 0.674
5.396LysVal: 5.396 ± 0.716
1.199LysTrp: 1.199 ± 0.254
3.298LysTyr: 3.298 ± 0.55
0.0LysXaa: 0.0 ± 0.0
Leu
5.471LeuAla: 5.471 ± 0.849
0.225LeuCys: 0.225 ± 0.163
7.345LeuAsp: 7.345 ± 0.711
7.944LeuGlu: 7.944 ± 0.775
2.698LeuPhe: 2.698 ± 0.378
5.171LeuGly: 5.171 ± 0.779
0.974LeuHis: 0.974 ± 0.273
4.647LeuIle: 4.647 ± 0.726
7.045LeuLys: 7.045 ± 0.908
7.12LeuLeu: 7.12 ± 0.998
1.799LeuMet: 1.799 ± 0.318
5.696LeuAsn: 5.696 ± 0.635
2.998LeuPro: 2.998 ± 0.469
4.122LeuGln: 4.122 ± 0.601
3.448LeuArg: 3.448 ± 0.589
6.295LeuSer: 6.295 ± 0.618
5.621LeuThr: 5.621 ± 0.595
4.797LeuVal: 4.797 ± 0.488
0.824LeuTrp: 0.824 ± 0.292
1.724LeuTyr: 1.724 ± 0.355
0.0LeuXaa: 0.0 ± 0.0
Met
3.373MetAla: 3.373 ± 0.566
0.15MetCys: 0.15 ± 0.109
1.049MetAsp: 1.049 ± 0.219
1.874MetGlu: 1.874 ± 0.565
1.199MetPhe: 1.199 ± 0.27
1.199MetGly: 1.199 ± 0.295
0.15MetHis: 0.15 ± 0.111
1.574MetIle: 1.574 ± 0.262
1.274MetLys: 1.274 ± 0.318
2.098MetLeu: 2.098 ± 0.373
0.375MetMet: 0.375 ± 0.201
1.649MetAsn: 1.649 ± 0.342
0.675MetPro: 0.675 ± 0.221
1.199MetGln: 1.199 ± 0.319
1.649MetArg: 1.649 ± 0.334
1.649MetSer: 1.649 ± 0.321
2.248MetThr: 2.248 ± 0.416
1.124MetVal: 1.124 ± 0.318
0.075MetTrp: 0.075 ± 0.079
0.525MetTyr: 0.525 ± 0.158
0.0MetXaa: 0.0 ± 0.0
Asn
4.272AsnAla: 4.272 ± 0.533
0.225AsnCys: 0.225 ± 0.153
3.373AsnAsp: 3.373 ± 0.524
4.047AsnGlu: 4.047 ± 0.615
2.398AsnPhe: 2.398 ± 0.469
5.171AsnGly: 5.171 ± 0.518
0.749AsnHis: 0.749 ± 0.252
3.373AsnIle: 3.373 ± 0.512
3.972AsnLys: 3.972 ± 0.698
5.321AsnLeu: 5.321 ± 0.562
1.049AsnMet: 1.049 ± 0.313
3.073AsnAsn: 3.073 ± 0.537
1.649AsnPro: 1.649 ± 0.36
2.173AsnGln: 2.173 ± 0.525
2.173AsnArg: 2.173 ± 0.371
2.323AsnSer: 2.323 ± 0.364
2.098AsnThr: 2.098 ± 0.498
2.998AsnVal: 2.998 ± 0.444
0.974AsnTrp: 0.974 ± 0.268
1.649AsnTyr: 1.649 ± 0.356
0.0AsnXaa: 0.0 ± 0.0
Pro
1.499ProAla: 1.499 ± 0.318
0.225ProCys: 0.225 ± 0.121
1.724ProAsp: 1.724 ± 0.347
2.323ProGlu: 2.323 ± 0.456
1.499ProPhe: 1.499 ± 0.363
1.424ProGly: 1.424 ± 0.423
0.675ProHis: 0.675 ± 0.248
1.874ProIle: 1.874 ± 0.396
2.848ProLys: 2.848 ± 0.516
1.499ProLeu: 1.499 ± 0.379
0.6ProMet: 0.6 ± 0.221
1.274ProAsn: 1.274 ± 0.305
0.899ProPro: 0.899 ± 0.288
1.049ProGln: 1.049 ± 0.382
1.049ProArg: 1.049 ± 0.265
1.649ProSer: 1.649 ± 0.305
1.649ProThr: 1.649 ± 0.362
1.574ProVal: 1.574 ± 0.304
0.0ProTrp: 0.0 ± 0.0
0.974ProTyr: 0.974 ± 0.244
0.0ProXaa: 0.0 ± 0.0
Gln
3.373GlnAla: 3.373 ± 0.759
0.15GlnCys: 0.15 ± 0.103
1.874GlnAsp: 1.874 ± 0.408
2.773GlnGlu: 2.773 ± 0.345
1.274GlnPhe: 1.274 ± 0.323
2.998GlnGly: 2.998 ± 0.466
0.375GlnHis: 0.375 ± 0.16
2.398GlnIle: 2.398 ± 0.481
3.747GlnLys: 3.747 ± 0.463
4.197GlnLeu: 4.197 ± 0.676
0.749GlnMet: 0.749 ± 0.277
1.724GlnAsn: 1.724 ± 0.36
0.899GlnPro: 0.899 ± 0.24
2.473GlnGln: 2.473 ± 0.471
1.349GlnArg: 1.349 ± 0.385
4.871GlnSer: 4.871 ± 0.776
2.623GlnThr: 2.623 ± 0.538
2.323GlnVal: 2.323 ± 0.417
0.3GlnTrp: 0.3 ± 0.169
1.499GlnTyr: 1.499 ± 0.368
0.0GlnXaa: 0.0 ± 0.0
Arg
2.473ArgAla: 2.473 ± 0.407
0.075ArgCys: 0.075 ± 0.077
2.698ArgAsp: 2.698 ± 0.483
3.148ArgGlu: 3.148 ± 0.514
2.098ArgPhe: 2.098 ± 0.364
2.398ArgGly: 2.398 ± 0.755
0.375ArgHis: 0.375 ± 0.152
2.848ArgIle: 2.848 ± 0.561
4.647ArgLys: 4.647 ± 0.736
4.572ArgLeu: 4.572 ± 0.511
1.199ArgMet: 1.199 ± 0.342
2.024ArgAsn: 2.024 ± 0.347
0.974ArgPro: 0.974 ± 0.326
1.724ArgGln: 1.724 ± 0.363
2.173ArgArg: 2.173 ± 0.372
2.098ArgSer: 2.098 ± 0.383
1.874ArgThr: 1.874 ± 0.349
2.473ArgVal: 2.473 ± 0.428
0.525ArgTrp: 0.525 ± 0.218
2.098ArgTyr: 2.098 ± 0.438
0.0ArgXaa: 0.0 ± 0.0
Ser
4.647SerAla: 4.647 ± 1.312
0.6SerCys: 0.6 ± 0.222
3.448SerAsp: 3.448 ± 0.467
4.797SerGlu: 4.797 ± 0.603
3.148SerPhe: 3.148 ± 0.511
3.448SerGly: 3.448 ± 0.757
0.675SerHis: 0.675 ± 0.244
4.197SerIle: 4.197 ± 0.58
4.797SerLys: 4.797 ± 0.57
4.347SerLeu: 4.347 ± 0.658
1.949SerMet: 1.949 ± 0.418
2.473SerAsn: 2.473 ± 0.473
1.124SerPro: 1.124 ± 0.237
3.073SerGln: 3.073 ± 0.667
2.248SerArg: 2.248 ± 0.388
3.747SerSer: 3.747 ± 0.898
3.597SerThr: 3.597 ± 0.588
4.272SerVal: 4.272 ± 0.627
1.049SerTrp: 1.049 ± 0.261
1.874SerTyr: 1.874 ± 0.369
0.0SerXaa: 0.0 ± 0.0
Thr
4.647ThrAla: 4.647 ± 0.816
0.225ThrCys: 0.225 ± 0.185
3.597ThrAsp: 3.597 ± 0.584
4.422ThrGlu: 4.422 ± 0.8
2.773ThrPhe: 2.773 ± 0.483
4.572ThrGly: 4.572 ± 0.897
1.049ThrHis: 1.049 ± 0.299
3.747ThrIle: 3.747 ± 0.486
4.797ThrLys: 4.797 ± 0.681
6.22ThrLeu: 6.22 ± 0.691
1.199ThrMet: 1.199 ± 0.273
2.248ThrAsn: 2.248 ± 0.519
1.799ThrPro: 1.799 ± 0.373
2.623ThrGln: 2.623 ± 0.359
2.248ThrArg: 2.248 ± 0.357
3.597ThrSer: 3.597 ± 0.539
4.272ThrThr: 4.272 ± 0.783
3.672ThrVal: 3.672 ± 0.46
0.675ThrTrp: 0.675 ± 0.238
1.949ThrTyr: 1.949 ± 0.332
0.0ThrXaa: 0.0 ± 0.0
Val
4.122ValAla: 4.122 ± 1.009
0.225ValCys: 0.225 ± 0.151
4.797ValAsp: 4.797 ± 0.709
5.321ValGlu: 5.321 ± 0.726
2.698ValPhe: 2.698 ± 0.501
4.572ValGly: 4.572 ± 0.58
0.6ValHis: 0.6 ± 0.185
3.972ValIle: 3.972 ± 0.5
5.171ValLys: 5.171 ± 0.596
5.246ValLeu: 5.246 ± 0.772
0.974ValMet: 0.974 ± 0.33
2.473ValAsn: 2.473 ± 0.394
1.349ValPro: 1.349 ± 0.313
2.173ValGln: 2.173 ± 0.339
2.773ValArg: 2.773 ± 0.428
3.672ValSer: 3.672 ± 0.579
4.422ValThr: 4.422 ± 0.549
3.672ValVal: 3.672 ± 0.517
0.824ValTrp: 0.824 ± 0.241
1.574ValTyr: 1.574 ± 0.416
0.0ValXaa: 0.0 ± 0.0
Trp
0.6TrpAla: 0.6 ± 0.224
0.225TrpCys: 0.225 ± 0.127
0.899TrpAsp: 0.899 ± 0.264
0.675TrpGlu: 0.675 ± 0.224
0.675TrpPhe: 0.675 ± 0.229
1.049TrpGly: 1.049 ± 0.268
0.225TrpHis: 0.225 ± 0.129
0.749TrpIle: 0.749 ± 0.2
1.274TrpLys: 1.274 ± 0.276
0.899TrpLeu: 0.899 ± 0.261
0.3TrpMet: 0.3 ± 0.137
0.375TrpAsn: 0.375 ± 0.173
0.15TrpPro: 0.15 ± 0.114
0.375TrpGln: 0.375 ± 0.139
0.6TrpArg: 0.6 ± 0.226
0.6TrpSer: 0.6 ± 0.173
0.375TrpThr: 0.375 ± 0.155
0.525TrpVal: 0.525 ± 0.211
0.15TrpTrp: 0.15 ± 0.106
0.075TrpTyr: 0.075 ± 0.076
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.949TyrAla: 1.949 ± 0.362
0.375TyrCys: 0.375 ± 0.159
3.073TyrAsp: 3.073 ± 0.526
2.923TyrGlu: 2.923 ± 0.584
1.274TyrPhe: 1.274 ± 0.3
2.248TyrGly: 2.248 ± 0.393
0.6TyrHis: 0.6 ± 0.213
2.323TyrIle: 2.323 ± 0.395
3.148TyrLys: 3.148 ± 0.576
3.148TyrLeu: 3.148 ± 0.559
0.974TyrMet: 0.974 ± 0.268
2.173TyrAsn: 2.173 ± 0.485
0.899TyrPro: 0.899 ± 0.278
2.398TyrGln: 2.398 ± 0.448
1.349TyrArg: 1.349 ± 0.35
1.424TyrSer: 1.424 ± 0.286
1.649TyrThr: 1.649 ± 0.382
1.949TyrVal: 1.949 ± 0.384
0.6TyrTrp: 0.6 ± 0.197
1.649TyrTyr: 1.649 ± 0.408
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 70 proteins (13344 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski