Amino acid dipepetide frequency for Hubei toti-like virus 18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.555AlaAla: 10.555 ± 3.277
1.564AlaCys: 1.564 ± 0.833
2.737AlaAsp: 2.737 ± 0.871
2.346AlaGlu: 2.346 ± 0.663
1.955AlaPhe: 1.955 ± 0.455
9.382AlaGly: 9.382 ± 1.477
1.564AlaHis: 1.564 ± 0.341
2.346AlaIle: 2.346 ± 0.076
3.518AlaLys: 3.518 ± 1.061
9.773AlaLeu: 9.773 ± 1.685
1.173AlaMet: 1.173 ± 0.625
2.737AlaAsn: 2.737 ± 0.303
5.082AlaPro: 5.082 ± 0.947
4.691AlaGln: 4.691 ± 1.913
8.21AlaArg: 8.21 ± 0.264
5.864AlaSer: 5.864 ± 0.776
5.864AlaThr: 5.864 ± 1.364
7.819AlaVal: 7.819 ± 0.056
3.518AlaTrp: 3.518 ± 0.474
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
1.173CysAla: 1.173 ± 0.038
0.0CysCys: 0.0 ± 0.0
2.346CysAsp: 2.346 ± 1.686
1.173CysGlu: 1.173 ± 0.038
0.391CysPhe: 0.391 ± 0.379
0.391CysGly: 0.391 ± 0.379
0.391CysHis: 0.391 ± 0.208
1.564CysIle: 1.564 ± 0.929
0.0CysLys: 0.0 ± 0.0
1.955CysLeu: 1.955 ± 0.133
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.955CysPro: 1.955 ± 0.133
0.391CysGln: 0.391 ± 0.208
2.346CysArg: 2.346 ± 0.076
1.173CysSer: 1.173 ± 1.137
0.0CysThr: 0.0 ± 0.0
1.173CysVal: 1.173 ± 0.625
0.0CysTrp: 0.0 ± 0.0
0.391CysTyr: 0.391 ± 0.379
0.0CysXaa: 0.0 ± 0.0
Asp
5.473AspAla: 5.473 ± 1.743
0.782AspCys: 0.782 ± 0.417
3.909AspAsp: 3.909 ± 1.496
4.3AspGlu: 4.3 ± 0.057
1.173AspPhe: 1.173 ± 0.038
3.518AspGly: 3.518 ± 0.113
1.564AspHis: 1.564 ± 0.341
1.955AspIle: 1.955 ± 1.895
1.173AspLys: 1.173 ± 0.038
3.127AspLeu: 3.127 ± 0.492
0.0AspMet: 0.0 ± 0.0
3.127AspAsn: 3.127 ± 0.492
3.518AspPro: 3.518 ± 1.288
2.737AspGln: 2.737 ± 0.303
2.346AspArg: 2.346 ± 0.076
3.127AspSer: 3.127 ± 0.682
3.127AspThr: 3.127 ± 0.492
5.864AspVal: 5.864 ± 0.189
1.955AspTrp: 1.955 ± 0.133
2.346AspTyr: 2.346 ± 1.099
0.0AspXaa: 0.0 ± 0.0
Glu
3.909GluAla: 3.909 ± 0.322
0.0GluCys: 0.0 ± 0.0
4.691GluAsp: 4.691 ± 0.436
7.428GluGlu: 7.428 ± 1.327
2.346GluPhe: 2.346 ± 0.076
5.082GluGly: 5.082 ± 0.359
0.782GluHis: 0.782 ± 0.758
1.173GluIle: 1.173 ± 0.625
1.955GluLys: 1.955 ± 0.72
4.3GluLeu: 4.3 ± 0.645
1.173GluMet: 1.173 ± 0.038
1.173GluAsn: 1.173 ± 0.625
2.737GluPro: 2.737 ± 0.303
3.518GluGln: 3.518 ± 0.113
5.473GluArg: 5.473 ± 0.02
2.346GluSer: 2.346 ± 0.663
1.564GluThr: 1.564 ± 0.246
5.473GluVal: 5.473 ± 1.194
1.955GluTrp: 1.955 ± 0.72
1.173GluTyr: 1.173 ± 0.55
0.0GluXaa: 0.0 ± 0.0
Phe
0.391PheAla: 0.391 ± 0.379
1.173PheCys: 1.173 ± 0.625
1.173PheAsp: 1.173 ± 0.55
0.782PheGlu: 0.782 ± 0.417
0.782PhePhe: 0.782 ± 0.171
1.173PheGly: 1.173 ± 0.625
1.173PheHis: 1.173 ± 0.55
0.391PheIle: 0.391 ± 0.379
1.955PheLys: 1.955 ± 0.133
3.909PheLeu: 3.909 ± 0.266
0.0PheMet: 0.0 ± 0.0
0.391PheAsn: 0.391 ± 0.379
0.782PhePro: 0.782 ± 0.417
0.391PheGln: 0.391 ± 0.208
1.564PheArg: 1.564 ± 0.246
2.346PheSer: 2.346 ± 0.512
2.346PheThr: 2.346 ± 0.663
1.173PheVal: 1.173 ± 0.038
0.782PheTrp: 0.782 ± 0.171
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
7.428GlyAla: 7.428 ± 0.435
1.564GlyCys: 1.564 ± 0.929
2.737GlyAsp: 2.737 ± 0.303
4.3GlyGlu: 4.3 ± 1.232
2.346GlyPhe: 2.346 ± 0.512
11.337GlyGly: 11.337 ± 0.757
1.173GlyHis: 1.173 ± 1.137
3.909GlyIle: 3.909 ± 0.322
3.127GlyLys: 3.127 ± 1.857
9.773GlyLeu: 9.773 ± 0.077
1.564GlyMet: 1.564 ± 0.929
2.737GlyAsn: 2.737 ± 1.459
3.909GlyPro: 3.909 ± 0.266
1.955GlyGln: 1.955 ± 0.455
6.646GlyArg: 6.646 ± 0.018
10.555GlySer: 10.555 ± 3.277
4.691GlyThr: 4.691 ± 1.913
5.473GlyVal: 5.473 ± 0.568
1.564GlyTrp: 1.564 ± 0.929
3.909GlyTyr: 3.909 ± 0.853
0.0GlyXaa: 0.0 ± 0.0
His
0.391HisAla: 0.391 ± 0.208
0.391HisCys: 0.391 ± 0.379
0.0HisAsp: 0.0 ± 0.0
1.173HisGlu: 1.173 ± 0.038
0.391HisPhe: 0.391 ± 0.379
1.564HisGly: 1.564 ± 0.929
0.0HisHis: 0.0 ± 0.0
0.391HisIle: 0.391 ± 0.208
1.173HisLys: 1.173 ± 0.55
1.173HisLeu: 1.173 ± 0.038
0.391HisMet: 0.391 ± 0.379
1.173HisAsn: 1.173 ± 0.038
1.564HisPro: 1.564 ± 0.246
1.173HisGln: 1.173 ± 0.038
1.955HisArg: 1.955 ± 1.895
0.782HisSer: 0.782 ± 0.171
0.391HisThr: 0.391 ± 0.379
1.564HisVal: 1.564 ± 0.246
0.0HisTrp: 0.0 ± 0.0
0.782HisTyr: 0.782 ± 0.171
0.0HisXaa: 0.0 ± 0.0
Ile
3.518IleAla: 3.518 ± 0.113
0.0IleCys: 0.0 ± 0.0
1.955IleAsp: 1.955 ± 0.455
1.955IleGlu: 1.955 ± 0.72
0.782IlePhe: 0.782 ± 0.417
3.518IleGly: 3.518 ± 0.701
1.173IleHis: 1.173 ± 0.55
0.391IleIle: 0.391 ± 0.208
1.173IleLys: 1.173 ± 0.55
3.518IleLeu: 3.518 ± 0.474
0.0IleMet: 0.0 ± 0.0
1.173IleAsn: 1.173 ± 0.625
3.909IlePro: 3.909 ± 0.266
1.173IleGln: 1.173 ± 0.038
3.909IleArg: 3.909 ± 0.853
3.127IleSer: 3.127 ± 0.095
1.955IleThr: 1.955 ± 0.455
3.127IleVal: 3.127 ± 1.27
0.782IleTrp: 0.782 ± 0.171
0.391IleTyr: 0.391 ± 0.379
0.0IleXaa: 0.0 ± 0.0
Lys
3.909LysAla: 3.909 ± 0.853
0.391LysCys: 0.391 ± 0.379
2.737LysAsp: 2.737 ± 0.303
3.518LysGlu: 3.518 ± 0.113
0.391LysPhe: 0.391 ± 0.379
2.346LysGly: 2.346 ± 0.076
0.0LysHis: 0.0 ± 0.0
1.173LysIle: 1.173 ± 0.625
2.346LysLys: 2.346 ± 0.512
3.518LysLeu: 3.518 ± 0.113
0.391LysMet: 0.391 ± 0.379
1.564LysAsn: 1.564 ± 0.929
1.564LysPro: 1.564 ± 1.516
1.955LysGln: 1.955 ± 1.308
2.737LysArg: 2.737 ± 1.478
0.782LysSer: 0.782 ± 0.171
2.737LysThr: 2.737 ± 0.891
2.737LysVal: 2.737 ± 0.891
0.0LysTrp: 0.0 ± 0.0
2.346LysTyr: 2.346 ± 0.076
0.0LysXaa: 0.0 ± 0.0
Leu
11.337LeuAla: 11.337 ± 0.418
1.564LeuCys: 1.564 ± 1.516
6.255LeuAsp: 6.255 ± 1.572
3.518LeuGlu: 3.518 ± 0.113
1.173LeuPhe: 1.173 ± 0.038
8.991LeuGly: 8.991 ± 0.094
2.346LeuHis: 2.346 ± 0.512
2.737LeuIle: 2.737 ± 0.284
4.3LeuLys: 4.3 ± 1.232
7.819LeuLeu: 7.819 ± 2.881
0.782LeuMet: 0.782 ± 0.171
3.518LeuAsn: 3.518 ± 0.701
5.864LeuPro: 5.864 ± 0.189
4.691LeuGln: 4.691 ± 0.738
8.21LeuArg: 8.21 ± 0.91
5.473LeuSer: 5.473 ± 0.568
6.646LeuThr: 6.646 ± 0.606
5.082LeuVal: 5.082 ± 0.815
1.564LeuTrp: 1.564 ± 0.341
3.518LeuTyr: 3.518 ± 0.701
0.0LeuXaa: 0.0 ± 0.0
Met
1.564MetAla: 1.564 ± 0.341
0.0MetCys: 0.0 ± 0.0
0.782MetAsp: 0.782 ± 0.758
1.173MetGlu: 1.173 ± 0.55
0.0MetPhe: 0.0 ± 0.0
1.955MetGly: 1.955 ± 0.72
0.0MetHis: 0.0 ± 0.0
0.391MetIle: 0.391 ± 0.208
0.782MetLys: 0.782 ± 0.417
1.173MetLeu: 1.173 ± 0.55
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.391MetPro: 0.391 ± 0.208
0.391MetGln: 0.391 ± 0.379
1.173MetArg: 1.173 ± 0.038
0.391MetSer: 0.391 ± 0.208
1.173MetThr: 1.173 ± 0.038
1.173MetVal: 1.173 ± 0.038
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.564AsnAla: 1.564 ± 0.246
1.173AsnCys: 1.173 ± 0.625
0.782AsnAsp: 0.782 ± 0.171
0.782AsnGlu: 0.782 ± 0.171
0.391AsnPhe: 0.391 ± 0.379
3.518AsnGly: 3.518 ± 1.061
0.391AsnHis: 0.391 ± 0.379
2.346AsnIle: 2.346 ± 0.076
2.737AsnLys: 2.737 ± 0.303
2.737AsnLeu: 2.737 ± 0.284
0.391AsnMet: 0.391 ± 0.208
2.346AsnAsn: 2.346 ± 0.076
1.564AsnPro: 1.564 ± 0.246
0.782AsnGln: 0.782 ± 0.171
2.346AsnArg: 2.346 ± 1.25
1.564AsnSer: 1.564 ± 0.246
1.173AsnThr: 1.173 ± 0.625
3.127AsnVal: 3.127 ± 0.095
1.173AsnTrp: 1.173 ± 0.038
1.955AsnTyr: 1.955 ± 0.133
0.0AsnXaa: 0.0 ± 0.0
Pro
6.255ProAla: 6.255 ± 0.985
0.782ProCys: 0.782 ± 0.758
3.518ProAsp: 3.518 ± 0.113
3.909ProGlu: 3.909 ± 0.322
0.782ProPhe: 0.782 ± 0.171
5.082ProGly: 5.082 ± 0.228
0.391ProHis: 0.391 ± 0.208
3.518ProIle: 3.518 ± 0.113
1.955ProLys: 1.955 ± 0.455
7.819ProLeu: 7.819 ± 2.405
0.782ProMet: 0.782 ± 0.417
1.173ProAsn: 1.173 ± 0.625
6.646ProPro: 6.646 ± 2.955
1.955ProGln: 1.955 ± 0.455
4.691ProArg: 4.691 ± 0.436
4.3ProSer: 4.3 ± 0.53
3.518ProThr: 3.518 ± 0.474
4.691ProVal: 4.691 ± 0.436
0.391ProTrp: 0.391 ± 0.379
1.564ProTyr: 1.564 ± 0.246
0.0ProXaa: 0.0 ± 0.0
Gln
2.346GlnAla: 2.346 ± 0.663
0.0GlnCys: 0.0 ± 0.0
1.564GlnAsp: 1.564 ± 0.246
2.346GlnGlu: 2.346 ± 0.076
1.564GlnPhe: 1.564 ± 0.833
3.909GlnGly: 3.909 ± 0.266
0.391GlnHis: 0.391 ± 0.208
0.782GlnIle: 0.782 ± 0.417
0.782GlnLys: 0.782 ± 0.171
3.518GlnLeu: 3.518 ± 1.061
0.782GlnMet: 0.782 ± 0.308
1.564GlnAsn: 1.564 ± 0.246
3.127GlnPro: 3.127 ± 0.492
2.346GlnGln: 2.346 ± 0.663
3.127GlnArg: 3.127 ± 0.492
2.346GlnSer: 2.346 ± 0.663
1.173GlnThr: 1.173 ± 0.625
1.955GlnVal: 1.955 ± 0.133
0.782GlnTrp: 0.782 ± 0.417
0.782GlnTyr: 0.782 ± 0.758
0.0GlnXaa: 0.0 ± 0.0
Arg
6.646ArgAla: 6.646 ± 1.193
1.955ArgCys: 1.955 ± 0.72
5.864ArgAsp: 5.864 ± 0.776
5.473ArgGlu: 5.473 ± 1.743
1.955ArgPhe: 1.955 ± 0.72
7.819ArgGly: 7.819 ± 1.706
0.391ArgHis: 0.391 ± 0.208
3.518ArgIle: 3.518 ± 1.061
2.737ArgLys: 2.737 ± 0.891
6.255ArgLeu: 6.255 ± 0.19
0.782ArgMet: 0.782 ± 0.758
2.346ArgAsn: 2.346 ± 1.099
4.691ArgPro: 4.691 ± 0.738
1.955ArgGln: 1.955 ± 0.133
7.037ArgArg: 7.037 ± 3.297
5.864ArgSer: 5.864 ± 0.398
6.255ArgThr: 6.255 ± 0.985
4.691ArgVal: 4.691 ± 0.738
3.127ArgTrp: 3.127 ± 1.27
1.173ArgTyr: 1.173 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
5.473SerAla: 5.473 ± 1.155
1.955SerCys: 1.955 ± 0.72
3.518SerAsp: 3.518 ± 0.701
2.737SerGlu: 2.737 ± 0.891
3.127SerPhe: 3.127 ± 0.095
6.255SerGly: 6.255 ± 0.985
0.391SerHis: 0.391 ± 0.379
3.909SerIle: 3.909 ± 0.853
2.346SerLys: 2.346 ± 0.512
8.21SerLeu: 8.21 ± 2.026
0.782SerMet: 0.782 ± 0.171
2.737SerAsn: 2.737 ± 0.303
5.082SerPro: 5.082 ± 0.359
1.955SerGln: 1.955 ± 1.042
5.473SerArg: 5.473 ± 0.02
6.646SerSer: 6.646 ± 1.78
4.691SerThr: 4.691 ± 1.913
3.909SerVal: 3.909 ± 1.496
1.173SerTrp: 1.173 ± 0.55
1.564SerTyr: 1.564 ± 0.341
0.0SerXaa: 0.0 ± 0.0
Thr
6.255ThrAla: 6.255 ± 2.747
0.391ThrCys: 0.391 ± 0.208
4.691ThrAsp: 4.691 ± 0.738
3.518ThrGlu: 3.518 ± 0.474
1.173ThrPhe: 1.173 ± 0.625
6.646ThrGly: 6.646 ± 0.018
2.346ThrHis: 2.346 ± 0.663
1.564ThrIle: 1.564 ± 0.246
1.173ThrLys: 1.173 ± 0.625
3.518ThrLeu: 3.518 ± 0.113
1.173ThrMet: 1.173 ± 0.038
1.173ThrAsn: 1.173 ± 0.038
3.909ThrPro: 3.909 ± 0.909
0.782ThrGln: 0.782 ± 0.171
5.082ThrArg: 5.082 ± 2.121
5.082ThrSer: 5.082 ± 0.947
6.255ThrThr: 6.255 ± 1.572
3.909ThrVal: 3.909 ± 0.322
0.782ThrTrp: 0.782 ± 0.171
1.955ThrTyr: 1.955 ± 0.455
0.0ThrXaa: 0.0 ± 0.0
Val
7.819ValAla: 7.819 ± 1.231
2.737ValCys: 2.737 ± 0.891
3.127ValAsp: 3.127 ± 0.682
3.909ValGlu: 3.909 ± 0.853
1.564ValPhe: 1.564 ± 0.833
4.691ValGly: 4.691 ± 1.326
1.173ValHis: 1.173 ± 0.55
3.518ValIle: 3.518 ± 0.701
1.955ValLys: 1.955 ± 1.308
7.037ValLeu: 7.037 ± 0.948
0.391ValMet: 0.391 ± 0.587
1.955ValAsn: 1.955 ± 0.133
5.473ValPro: 5.473 ± 0.02
0.0ValGln: 0.0 ± 0.0
4.3ValArg: 4.3 ± 0.53
7.037ValSer: 7.037 ± 0.227
5.864ValThr: 5.864 ± 1.364
6.255ValVal: 6.255 ± 0.19
1.564ValTrp: 1.564 ± 0.929
1.564ValTyr: 1.564 ± 0.246
0.0ValXaa: 0.0 ± 0.0
Trp
2.346TrpAla: 2.346 ± 0.512
0.391TrpCys: 0.391 ± 0.379
1.173TrpAsp: 1.173 ± 0.038
2.737TrpGlu: 2.737 ± 0.303
0.0TrpPhe: 0.0 ± 0.0
1.564TrpGly: 1.564 ± 0.341
0.391TrpHis: 0.391 ± 0.208
0.782TrpIle: 0.782 ± 0.758
1.173TrpLys: 1.173 ± 0.55
2.737TrpLeu: 2.737 ± 2.065
0.391TrpMet: 0.391 ± 0.379
0.391TrpAsn: 0.391 ± 0.379
1.173TrpPro: 1.173 ± 0.038
1.173TrpGln: 1.173 ± 0.038
1.564TrpArg: 1.564 ± 0.929
1.564TrpSer: 1.564 ± 0.341
1.173TrpThr: 1.173 ± 0.038
1.564TrpVal: 1.564 ± 0.246
0.782TrpTrp: 0.782 ± 0.171
0.391TrpTyr: 0.391 ± 0.379
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.346TyrAla: 2.346 ± 1.25
0.0TyrCys: 0.0 ± 0.0
1.564TyrAsp: 1.564 ± 0.246
1.173TyrGlu: 1.173 ± 0.55
0.391TyrPhe: 0.391 ± 0.379
1.955TyrGly: 1.955 ± 0.72
0.391TyrHis: 0.391 ± 0.379
1.173TyrIle: 1.173 ± 0.55
0.782TyrLys: 0.782 ± 0.171
3.518TyrLeu: 3.518 ± 1.061
1.173TyrMet: 1.173 ± 0.625
1.564TyrAsn: 1.564 ± 0.341
0.782TyrPro: 0.782 ± 0.417
1.173TyrGln: 1.173 ± 0.038
2.346TyrArg: 2.346 ± 1.099
1.564TyrSer: 1.564 ± 0.246
0.782TyrThr: 0.782 ± 0.417
1.564TyrVal: 1.564 ± 0.341
1.564TyrTrp: 1.564 ± 0.929
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2559 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski