Amino acid dipepetide frequency for Nocardiopsaceae bacterium YIM 96095

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.807AlaAla: 16.807 ± 0.162	0.967AlaCys: 0.967 ± 0.029	7.473AlaAsp: 7.473 ± 0.088	9.272AlaGlu: 9.272 ± 0.099	3.219AlaPhe: 3.219 ± 0.048	11.354AlaGly: 11.354 ± 0.093	2.885AlaHis: 2.885 ± 0.046	3.943AlaIle: 3.943 ± 0.057	1.981AlaLys: 1.981 ± 0.045	13.279AlaLeu: 13.279 ± 0.13	2.568AlaMet: 2.568 ± 0.041	2.123AlaAsn: 2.123 ± 0.034	6.207AlaPro: 6.207 ± 0.08	3.082AlaGln: 3.082 ± 0.043	10.015AlaArg: 10.015 ± 0.097	5.955AlaSer: 5.955 ± 0.07	7.437AlaThr: 7.437 ± 0.076	10.66AlaVal: 10.66 ± 0.096	1.723AlaTrp: 1.723 ± 0.03	2.074AlaTyr: 2.074 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.015CysAla: 1.015 ± 0.029	0.095CysCys: 0.095 ± 0.01	0.521CysAsp: 0.521 ± 0.02	0.447CysGlu: 0.447 ± 0.02	0.225CysPhe: 0.225 ± 0.014	0.92CysGly: 0.92 ± 0.025	0.21CysHis: 0.21 ± 0.013	0.121CysIle: 0.121 ± 0.009	0.076CysLys: 0.076 ± 0.008	0.65CysLeu: 0.65 ± 0.019	0.127CysMet: 0.127 ± 0.009	0.11CysAsn: 0.11 ± 0.009	0.5CysPro: 0.5 ± 0.018	0.186CysGln: 0.186 ± 0.011	0.61CysArg: 0.61 ± 0.024	0.415CysSer: 0.415 ± 0.018	0.394CysThr: 0.394 ± 0.017	0.726CysVal: 0.726 ± 0.02	0.097CysTrp: 0.097 ± 0.008	0.179CysTyr: 0.179 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.843AspAla: 6.843 ± 0.08	0.362AspCys: 0.362 ± 0.016	4.212AspAsp: 4.212 ± 0.064	4.604AspGlu: 4.604 ± 0.071	1.553AspPhe: 1.553 ± 0.036	5.689AspGly: 5.689 ± 0.06	1.663AspHis: 1.663 ± 0.034	2.35AspIle: 2.35 ± 0.042	0.771AspLys: 0.771 ± 0.029	6.237AspLeu: 6.237 ± 0.072	1.002AspMet: 1.002 ± 0.029	1.142AspAsn: 1.142 ± 0.032	4.89AspPro: 4.89 ± 0.066	1.716AspGln: 1.716 ± 0.036	4.926AspArg: 4.926 ± 0.06	3.27AspSer: 3.27 ± 0.042	4.076AspThr: 4.076 ± 0.059	4.946AspVal: 4.946 ± 0.064	0.894AspTrp: 0.894 ± 0.023	1.321AspTyr: 1.321 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.342GluAla: 7.342 ± 0.083	0.453GluCys: 0.453 ± 0.019	3.624GluAsp: 3.624 ± 0.056	5.029GluGlu: 5.029 ± 0.078	1.875GluPhe: 1.875 ± 0.038	5.061GluGly: 5.061 ± 0.067	1.94GluHis: 1.94 ± 0.036	2.75GluIle: 2.75 ± 0.048	1.071GluLys: 1.071 ± 0.033	7.505GluLeu: 7.505 ± 0.085	1.249GluMet: 1.249 ± 0.029	1.397GluAsn: 1.397 ± 0.032	4.046GluPro: 4.046 ± 0.066	2.203GluGln: 2.203 ± 0.04	7.088GluArg: 7.088 ± 0.087	3.515GluSer: 3.515 ± 0.049	3.6GluThr: 3.6 ± 0.056	5.558GluVal: 5.558 ± 0.068	1.0GluTrp: 1.0 ± 0.028	1.343GluTyr: 1.343 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.529PheAla: 3.529 ± 0.055	0.282PheCys: 0.282 ± 0.013	2.097PheAsp: 2.097 ± 0.042	1.587PheGlu: 1.587 ± 0.033	0.854PhePhe: 0.854 ± 0.031	3.113PheGly: 3.113 ± 0.045	0.668PheHis: 0.668 ± 0.023	0.716PheIle: 0.716 ± 0.023	0.334PheLys: 0.334 ± 0.017	2.624PheLeu: 2.624 ± 0.052	0.404PheMet: 0.404 ± 0.017	0.539PheAsn: 0.539 ± 0.018	1.352PhePro: 1.352 ± 0.034	0.655PheGln: 0.655 ± 0.024	1.73PheArg: 1.73 ± 0.033	1.552PheSer: 1.552 ± 0.033	1.925PheThr: 1.925 ± 0.033	2.529PheVal: 2.529 ± 0.043	0.425PheTrp: 0.425 ± 0.019	0.604PheTyr: 0.604 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.431GlyAla: 10.431 ± 0.098	0.79GlyCys: 0.79 ± 0.027	5.525GlyAsp: 5.525 ± 0.073	6.222GlyGlu: 6.222 ± 0.071	2.813GlyPhe: 2.813 ± 0.045	8.514GlyGly: 8.514 ± 0.094	2.436GlyHis: 2.436 ± 0.042	3.554GlyIle: 3.554 ± 0.051	1.678GlyLys: 1.678 ± 0.038	8.719GlyLeu: 8.719 ± 0.099	2.207GlyMet: 2.207 ± 0.046	1.679GlyAsn: 1.679 ± 0.034	4.617GlyPro: 4.617 ± 0.063	2.55GlyGln: 2.55 ± 0.048	7.026GlyArg: 7.026 ± 0.076	5.145GlySer: 5.145 ± 0.07	5.865GlyThr: 5.865 ± 0.063	8.194GlyVal: 8.194 ± 0.082	1.581GlyTrp: 1.581 ± 0.035	2.437GlyTyr: 2.437 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.72HisAla: 2.72 ± 0.04	0.215HisCys: 0.215 ± 0.014	1.515HisAsp: 1.515 ± 0.036	1.44HisGlu: 1.44 ± 0.03	0.587HisPhe: 0.587 ± 0.022	2.437HisGly: 2.437 ± 0.049	0.745HisHis: 0.745 ± 0.025	0.719HisIle: 0.719 ± 0.023	0.277HisLys: 0.277 ± 0.014	2.421HisLeu: 2.421 ± 0.044	0.382HisMet: 0.382 ± 0.015	0.467HisAsn: 0.467 ± 0.018	1.923HisPro: 1.923 ± 0.035	0.749HisGln: 0.749 ± 0.026	2.125HisArg: 2.125 ± 0.043	1.156HisSer: 1.156 ± 0.032	1.466HisThr: 1.466 ± 0.033	1.843HisVal: 1.843 ± 0.034	0.343HisTrp: 0.343 ± 0.016	0.506HisTyr: 0.506 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	4.768IleAla: 4.768 ± 0.063	0.283IleCys: 0.283 ± 0.013	2.487IleAsp: 2.487 ± 0.039	2.262IleGlu: 2.262 ± 0.038	0.748IlePhe: 0.748 ± 0.022	3.532IleGly: 3.532 ± 0.049	0.67IleHis: 0.67 ± 0.023	1.076IleIle: 1.076 ± 0.03	0.527IleLys: 0.527 ± 0.019	2.6IleLeu: 2.6 ± 0.042	0.539IleMet: 0.539 ± 0.021	0.758IleAsn: 0.758 ± 0.024	1.93IlePro: 1.93 ± 0.041	0.737IleGln: 0.737 ± 0.024	2.389IleArg: 2.389 ± 0.038	1.932IleSer: 1.932 ± 0.039	2.37IleThr: 2.37 ± 0.045	3.029IleVal: 3.029 ± 0.05	0.374IleTrp: 0.374 ± 0.016	0.644IleTyr: 0.644 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	1.737LysAla: 1.737 ± 0.036	0.072LysCys: 0.072 ± 0.008	0.799LysAsp: 0.799 ± 0.028	0.989LysGlu: 0.989 ± 0.028	0.34LysPhe: 0.34 ± 0.017	1.336LysGly: 1.336 ± 0.034	0.345LysHis: 0.345 ± 0.017	0.613LysIle: 0.613 ± 0.022	0.432LysLys: 0.432 ± 0.022	1.509LysLeu: 1.509 ± 0.04	0.273LysMet: 0.273 ± 0.014	0.369LysAsn: 0.369 ± 0.016	0.92LysPro: 0.92 ± 0.026	0.437LysGln: 0.437 ± 0.021	1.419LysArg: 1.419 ± 0.039	0.907LysSer: 0.907 ± 0.026	0.873LysThr: 0.873 ± 0.028	1.265LysVal: 1.265 ± 0.032	0.189LysTrp: 0.189 ± 0.011	0.304LysTyr: 0.304 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	14.185LeuAla: 14.185 ± 0.135	0.785LeuCys: 0.785 ± 0.022	6.746LeuAsp: 6.746 ± 0.075	5.298LeuGlu: 5.298 ± 0.065	2.674LeuPhe: 2.674 ± 0.052	9.14LeuGly: 9.14 ± 0.1	2.071LeuHis: 2.071 ± 0.037	3.003LeuIle: 3.003 ± 0.052	1.336LeuLys: 1.336 ± 0.033	10.823LeuLeu: 10.823 ± 0.135	1.642LeuMet: 1.642 ± 0.038	1.792LeuAsn: 1.792 ± 0.036	5.867LeuPro: 5.867 ± 0.071	1.912LeuGln: 1.912 ± 0.035	9.188LeuArg: 9.188 ± 0.086	5.695LeuSer: 5.695 ± 0.067	6.44LeuThr: 6.44 ± 0.075	9.477LeuVal: 9.477 ± 0.101	1.352LeuTrp: 1.352 ± 0.032	1.733LeuTyr: 1.733 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.45MetAla: 2.45 ± 0.039	0.134MetCys: 0.134 ± 0.011	0.959MetAsp: 0.959 ± 0.029	0.928MetGlu: 0.928 ± 0.021	0.595MetPhe: 0.595 ± 0.02	1.555MetGly: 1.555 ± 0.033	0.34MetHis: 0.34 ± 0.014	0.626MetIle: 0.626 ± 0.019	0.282MetLys: 0.282 ± 0.014	1.938MetLeu: 1.938 ± 0.039	0.324MetMet: 0.324 ± 0.018	0.417MetAsn: 0.417 ± 0.017	1.151MetPro: 1.151 ± 0.03	0.387MetGln: 0.387 ± 0.017	1.739MetArg: 1.739 ± 0.035	1.487MetSer: 1.487 ± 0.033	1.477MetThr: 1.477 ± 0.031	1.674MetVal: 1.674 ± 0.03	0.248MetTrp: 0.248 ± 0.013	0.31MetTyr: 0.31 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.253AsnAla: 2.253 ± 0.041	0.151AsnCys: 0.151 ± 0.011	1.146AsnAsp: 1.146 ± 0.028	1.237AsnGlu: 1.237 ± 0.033	0.459AsnPhe: 0.459 ± 0.022	1.992AsnGly: 1.992 ± 0.044	0.445AsnHis: 0.445 ± 0.018	0.675AsnIle: 0.675 ± 0.024	0.304AsnLys: 0.304 ± 0.017	1.71AsnLeu: 1.71 ± 0.038	0.338AsnMet: 0.338 ± 0.016	0.437AsnAsn: 0.437 ± 0.019	1.413AsnPro: 1.413 ± 0.033	0.561AsnGln: 0.561 ± 0.021	1.496AsnArg: 1.496 ± 0.036	0.96AsnSer: 0.96 ± 0.028	1.14AsnThr: 1.14 ± 0.033	1.506AsnVal: 1.506 ± 0.033	0.277AsnTrp: 0.277 ± 0.016	0.432AsnTyr: 0.432 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.751ProAla: 6.751 ± 0.076	0.317ProCys: 0.317 ± 0.016	4.798ProAsp: 4.798 ± 0.057	5.43ProGlu: 5.43 ± 0.073	1.55ProPhe: 1.55 ± 0.035	6.003ProGly: 6.003 ± 0.076	1.513ProHis: 1.513 ± 0.035	1.585ProIle: 1.585 ± 0.038	0.951ProLys: 0.951 ± 0.027	4.99ProLeu: 4.99 ± 0.067	1.082ProMet: 1.082 ± 0.025	1.158ProAsn: 1.158 ± 0.029	3.846ProPro: 3.846 ± 0.08	1.515ProGln: 1.515 ± 0.045	4.258ProArg: 4.258 ± 0.065	3.131ProSer: 3.131 ± 0.051	3.519ProThr: 3.519 ± 0.057	4.924ProVal: 4.924 ± 0.066	0.923ProTrp: 0.923 ± 0.026	1.15ProTyr: 1.15 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	2.909GlnAla: 2.909 ± 0.042	0.159GlnCys: 0.159 ± 0.01	1.13GlnAsp: 1.13 ± 0.029	1.633GlnGlu: 1.633 ± 0.041	0.631GlnPhe: 0.631 ± 0.021	2.031GlnGly: 2.031 ± 0.042	0.641GlnHis: 0.641 ± 0.025	0.991GlnIle: 0.991 ± 0.026	0.388GlnLys: 0.388 ± 0.022	2.941GlnLeu: 2.941 ± 0.048	0.527GlnMet: 0.527 ± 0.019	0.463GlnAsn: 0.463 ± 0.018	1.582GlnPro: 1.582 ± 0.038	1.066GlnGln: 1.066 ± 0.036	2.871GlnArg: 2.871 ± 0.048	1.204GlnSer: 1.204 ± 0.031	1.198GlnThr: 1.198 ± 0.031	2.223GlnVal: 2.223 ± 0.049	0.44GlnTrp: 0.44 ± 0.017	0.51GlnTyr: 0.51 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.823ArgAla: 9.823 ± 0.086	0.618ArgCys: 0.618 ± 0.023	5.103ArgAsp: 5.103 ± 0.062	5.941ArgGlu: 5.941 ± 0.076	2.517ArgPhe: 2.517 ± 0.046	6.251ArgGly: 6.251 ± 0.065	2.231ArgHis: 2.231 ± 0.039	3.177ArgIle: 3.177 ± 0.046	1.336ArgLys: 1.336 ± 0.031	8.609ArgLeu: 8.609 ± 0.104	1.986ArgMet: 1.986 ± 0.038	1.485ArgAsn: 1.485 ± 0.034	4.652ArgPro: 4.652 ± 0.067	2.182ArgGln: 2.182 ± 0.04	7.978ArgArg: 7.978 ± 0.094	4.55ArgSer: 4.55 ± 0.062	4.759ArgThr: 4.759 ± 0.065	7.314ArgVal: 7.314 ± 0.08	1.452ArgTrp: 1.452 ± 0.036	1.896ArgTyr: 1.896 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.652SerAla: 6.652 ± 0.079	0.414SerCys: 0.414 ± 0.018	3.244SerAsp: 3.244 ± 0.047	3.593SerGlu: 3.593 ± 0.052	1.55SerPhe: 1.55 ± 0.038	6.477SerGly: 6.477 ± 0.078	1.181SerHis: 1.181 ± 0.031	1.574SerIle: 1.574 ± 0.033	0.792SerLys: 0.792 ± 0.025	4.942SerLeu: 4.942 ± 0.063	1.171SerMet: 1.171 ± 0.03	0.94SerAsn: 0.94 ± 0.028	3.327SerPro: 3.327 ± 0.062	1.343SerGln: 1.343 ± 0.035	3.951SerArg: 3.951 ± 0.061	3.009SerSer: 3.009 ± 0.054	3.249SerThr: 3.249 ± 0.049	4.595SerVal: 4.595 ± 0.056	0.925SerTrp: 0.925 ± 0.027	1.282SerTyr: 1.282 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	7.532ThrAla: 7.532 ± 0.077	0.435ThrCys: 0.435 ± 0.017	3.594ThrAsp: 3.594 ± 0.054	4.114ThrGlu: 4.114 ± 0.054	1.639ThrPhe: 1.639 ± 0.04	6.367ThrGly: 6.367 ± 0.073	1.335ThrHis: 1.335 ± 0.03	2.044ThrIle: 2.044 ± 0.037	0.923ThrLys: 0.923 ± 0.028	6.044ThrLeu: 6.044 ± 0.067	1.138ThrMet: 1.138 ± 0.028	1.108ThrAsn: 1.108 ± 0.029	4.157ThrPro: 4.157 ± 0.062	1.382ThrGln: 1.382 ± 0.031	4.477ThrArg: 4.477 ± 0.05	3.394ThrSer: 3.394 ± 0.043	3.964ThrThr: 3.964 ± 0.055	5.992ThrVal: 5.992 ± 0.072	0.942ThrTrp: 0.942 ± 0.027	1.119ThrTyr: 1.119 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.354ValAla: 11.354 ± 0.112	0.76ValCys: 0.76 ± 0.025	5.432ValAsp: 5.432 ± 0.061	5.475ValGlu: 5.475 ± 0.064	2.541ValPhe: 2.541 ± 0.048	7.11ValGly: 7.11 ± 0.076	1.901ValHis: 1.901 ± 0.036	3.095ValIle: 3.095 ± 0.052	1.148ValLys: 1.148 ± 0.03	9.448ValLeu: 9.448 ± 0.112	1.533ValMet: 1.533 ± 0.032	1.825ValAsn: 1.825 ± 0.041	5.009ValPro: 5.009 ± 0.062	1.744ValGln: 1.744 ± 0.035	7.221ValArg: 7.221 ± 0.08	4.998ValSer: 4.998 ± 0.055	5.895ValThr: 5.895 ± 0.074	8.547ValVal: 8.547 ± 0.098	1.175ValTrp: 1.175 ± 0.028	1.6ValTyr: 1.6 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.579TrpAla: 1.579 ± 0.039	0.154TrpCys: 0.154 ± 0.009	0.783TrpAsp: 0.783 ± 0.024	0.834TrpGlu: 0.834 ± 0.026	0.523TrpPhe: 0.523 ± 0.022	1.076TrpGly: 1.076 ± 0.026	0.366TrpHis: 0.366 ± 0.017	0.552TrpIle: 0.552 ± 0.022	0.246TrpLys: 0.246 ± 0.013	1.864TrpLeu: 1.864 ± 0.04	0.269TrpMet: 0.269 ± 0.013	0.358TrpAsn: 0.358 ± 0.015	0.859TrpPro: 0.859 ± 0.03	0.497TrpGln: 0.497 ± 0.018	1.532TrpArg: 1.532 ± 0.033	0.939TrpSer: 0.939 ± 0.026	0.838TrpThr: 0.838 ± 0.029	1.145TrpVal: 1.145 ± 0.03	0.382TrpTrp: 0.382 ± 0.017	0.293TrpTyr: 0.293 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.347TyrAla: 2.347 ± 0.037	0.178TyrCys: 0.178 ± 0.012	1.28TyrAsp: 1.28 ± 0.031	1.312TyrGlu: 1.312 ± 0.031	0.626TyrPhe: 0.626 ± 0.022	2.021TyrGly: 2.021 ± 0.038	0.45TyrHis: 0.45 ± 0.016	0.493TyrIle: 0.493 ± 0.018	0.279TyrLys: 0.279 ± 0.014	2.308TyrLeu: 2.308 ± 0.048	0.26TyrMet: 0.26 ± 0.014	0.366TyrAsn: 0.366 ± 0.016	1.145TyrPro: 1.145 ± 0.028	0.631TyrGln: 0.631 ± 0.024	1.819TyrArg: 1.819 ± 0.031	0.997TyrSer: 0.997 ± 0.026	1.213TyrThr: 1.213 ± 0.029	1.663TyrVal: 1.663 ± 0.032	0.349TyrTrp: 0.349 ± 0.016	0.457TyrTyr: 0.457 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4542 proteins (1459053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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