Amino acid dipepetide frequency for Parabacteroides sp. CAG:409

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.469AlaAla: 5.469 ± 0.101	1.156AlaCys: 1.156 ± 0.038	4.338AlaAsp: 4.338 ± 0.063	4.952AlaGlu: 4.952 ± 0.089	3.236AlaPhe: 3.236 ± 0.063	5.122AlaGly: 5.122 ± 0.084	1.265AlaHis: 1.265 ± 0.035	4.724AlaIle: 4.724 ± 0.073	3.906AlaLys: 3.906 ± 0.078	6.952AlaLeu: 6.952 ± 0.092	1.8AlaMet: 1.8 ± 0.047	3.094AlaAsn: 3.094 ± 0.066	2.182AlaPro: 2.182 ± 0.044	2.751AlaGln: 2.751 ± 0.055	3.042AlaArg: 3.042 ± 0.067	4.521AlaSer: 4.521 ± 0.072	3.64AlaThr: 3.64 ± 0.061	4.793AlaVal: 4.793 ± 0.083	0.936AlaTrp: 0.936 ± 0.034	3.065AlaTyr: 3.065 ± 0.063	0.01AlaXaa: 0.01 ± 0.003
Cys	0.749CysAla: 0.749 ± 0.032	0.246CysCys: 0.246 ± 0.017	0.598CysAsp: 0.598 ± 0.029	0.651CysGlu: 0.651 ± 0.027	0.651CysPhe: 0.651 ± 0.027	1.014CysGly: 1.014 ± 0.037	0.31CysHis: 0.31 ± 0.022	0.828CysIle: 0.828 ± 0.029	0.625CysLys: 0.625 ± 0.027	1.251CysLeu: 1.251 ± 0.034	0.36CysMet: 0.36 ± 0.023	0.525CysAsn: 0.525 ± 0.028	0.573CysPro: 0.573 ± 0.029	0.495CysGln: 0.495 ± 0.023	0.594CysArg: 0.594 ± 0.026	0.786CysSer: 0.786 ± 0.031	0.656CysThr: 0.656 ± 0.026	0.764CysVal: 0.764 ± 0.031	0.191CysTrp: 0.191 ± 0.012	0.511CysTyr: 0.511 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.766AspAla: 3.766 ± 0.067	0.6AspCys: 0.6 ± 0.023	2.434AspAsp: 2.434 ± 0.059	3.972AspGlu: 3.972 ± 0.076	2.915AspPhe: 2.915 ± 0.058	3.975AspGly: 3.975 ± 0.089	0.998AspHis: 0.998 ± 0.035	3.824AspIle: 3.824 ± 0.062	3.788AspLys: 3.788 ± 0.062	5.101AspLeu: 5.101 ± 0.073	1.575AspMet: 1.575 ± 0.044	2.394AspAsn: 2.394 ± 0.058	2.178AspPro: 2.178 ± 0.044	1.824AspGln: 1.824 ± 0.047	2.426AspArg: 2.426 ± 0.052	3.068AspSer: 3.068 ± 0.063	2.609AspThr: 2.609 ± 0.049	3.607AspVal: 3.607 ± 0.058	0.914AspTrp: 0.914 ± 0.03	2.862AspTyr: 2.862 ± 0.062	0.003AspXaa: 0.003 ± 0.002
Glu	5.182GluAla: 5.182 ± 0.083	0.56GluCys: 0.56 ± 0.026	3.276GluAsp: 3.276 ± 0.064	5.595GluGlu: 5.595 ± 0.098	2.328GluPhe: 2.328 ± 0.051	4.221GluGly: 4.221 ± 0.078	1.263GluHis: 1.263 ± 0.03	4.756GluIle: 4.756 ± 0.078	5.472GluLys: 5.472 ± 0.082	5.914GluLeu: 5.914 ± 0.088	2.149GluMet: 2.149 ± 0.048	3.522GluAsn: 3.522 ± 0.06	1.814GluPro: 1.814 ± 0.042	3.029GluGln: 3.029 ± 0.064	3.005GluArg: 3.005 ± 0.061	3.371GluSer: 3.371 ± 0.059	3.603GluThr: 3.603 ± 0.056	4.531GluVal: 4.531 ± 0.067	0.91GluTrp: 0.91 ± 0.034	2.593GluTyr: 2.593 ± 0.055	0.005GluXaa: 0.005 ± 0.002
Phe	3.076PheAla: 3.076 ± 0.058	0.648PheCys: 0.648 ± 0.029	2.753PheAsp: 2.753 ± 0.056	2.517PheGlu: 2.517 ± 0.052	2.176PhePhe: 2.176 ± 0.056	3.243PheGly: 3.243 ± 0.061	0.992PheHis: 0.992 ± 0.035	3.196PheIle: 3.196 ± 0.065	2.332PheLys: 2.332 ± 0.054	4.221PheLeu: 4.221 ± 0.076	1.212PheMet: 1.212 ± 0.039	2.151PheAsn: 2.151 ± 0.053	1.896PhePro: 1.896 ± 0.044	1.623PheGln: 1.623 ± 0.038	2.172PheArg: 2.172 ± 0.053	3.317PheSer: 3.317 ± 0.059	2.656PheThr: 2.656 ± 0.054	3.023PheVal: 3.023 ± 0.063	0.625PheTrp: 0.625 ± 0.026	2.017PheTyr: 2.017 ± 0.05	0.002PheXaa: 0.002 ± 0.002
Gly	4.305GlyAla: 4.305 ± 0.084	0.972GlyCys: 0.972 ± 0.034	3.45GlyAsp: 3.45 ± 0.061	4.281GlyGlu: 4.281 ± 0.064	3.318GlyPhe: 3.318 ± 0.054	4.513GlyGly: 4.513 ± 0.093	1.27GlyHis: 1.27 ± 0.042	5.378GlyIle: 5.378 ± 0.095	5.393GlyLys: 5.393 ± 0.092	5.975GlyLeu: 5.975 ± 0.083	2.163GlyMet: 2.163 ± 0.055	3.534GlyAsn: 3.534 ± 0.065	1.467GlyPro: 1.467 ± 0.048	2.152GlyGln: 2.152 ± 0.051	2.736GlyArg: 2.736 ± 0.053	3.984GlySer: 3.984 ± 0.069	3.894GlyThr: 3.894 ± 0.065	4.554GlyVal: 4.554 ± 0.077	1.087GlyTrp: 1.087 ± 0.037	3.291GlyTyr: 3.291 ± 0.064	0.013GlyXaa: 0.013 ± 0.004
His	1.217HisAla: 1.217 ± 0.035	0.298HisCys: 0.298 ± 0.017	0.955HisAsp: 0.955 ± 0.033	1.073HisGlu: 1.073 ± 0.038	1.129HisPhe: 1.129 ± 0.038	1.203HisGly: 1.203 ± 0.046	0.52HisHis: 0.52 ± 0.024	1.598HisIle: 1.598 ± 0.041	0.981HisLys: 0.981 ± 0.031	1.939HisLeu: 1.939 ± 0.051	0.343HisMet: 0.343 ± 0.017	0.817HisAsn: 0.817 ± 0.033	1.129HisPro: 1.129 ± 0.034	0.839HisGln: 0.839 ± 0.032	0.852HisArg: 0.852 ± 0.031	1.144HisSer: 1.144 ± 0.037	1.064HisThr: 1.064 ± 0.039	1.195HisVal: 1.195 ± 0.036	0.307HisTrp: 0.307 ± 0.019	0.949HisTyr: 0.949 ± 0.034	0.002HisXaa: 0.002 ± 0.001
Ile	5.074IleAla: 5.074 ± 0.08	1.024IleCys: 1.024 ± 0.036	4.051IleAsp: 4.051 ± 0.067	4.373IleGlu: 4.373 ± 0.078	2.732IlePhe: 2.732 ± 0.055	4.792IleGly: 4.792 ± 0.086	1.584IleHis: 1.584 ± 0.042	4.143IleIle: 4.143 ± 0.085	3.819IleLys: 3.819 ± 0.063	6.011IleLeu: 6.011 ± 0.095	1.457IleMet: 1.457 ± 0.041	3.108IleAsn: 3.108 ± 0.069	3.301IlePro: 3.301 ± 0.066	2.96IleGln: 2.96 ± 0.063	3.803IleArg: 3.803 ± 0.068	4.581IleSer: 4.581 ± 0.075	3.801IleThr: 3.801 ± 0.061	4.293IleVal: 4.293 ± 0.068	0.74IleTrp: 0.74 ± 0.029	2.78IleTyr: 2.78 ± 0.06	0.006IleXaa: 0.006 ± 0.003
Lys	4.889LysAla: 4.889 ± 0.08	0.464LysCys: 0.464 ± 0.023	4.087LysAsp: 4.087 ± 0.07	5.662LysGlu: 5.662 ± 0.097	1.976LysPhe: 1.976 ± 0.049	4.444LysGly: 4.444 ± 0.069	1.221LysHis: 1.221 ± 0.039	3.947LysIle: 3.947 ± 0.063	4.693LysLys: 4.693 ± 0.082	5.034LysLeu: 5.034 ± 0.072	2.054LysMet: 2.054 ± 0.042	3.274LysAsn: 3.274 ± 0.058	2.333LysPro: 2.333 ± 0.052	2.926LysGln: 2.926 ± 0.056	2.993LysArg: 2.993 ± 0.051	3.106LysSer: 3.106 ± 0.062	3.247LysThr: 3.247 ± 0.058	4.201LysVal: 4.201 ± 0.067	0.763LysTrp: 0.763 ± 0.03	2.897LysTyr: 2.897 ± 0.059	0.001LysXaa: 0.001 ± 0.001
Leu	6.62LeuAla: 6.62 ± 0.087	1.292LeuCys: 1.292 ± 0.042	4.892LeuAsp: 4.892 ± 0.083	5.484LeuGlu: 5.484 ± 0.084	4.724LeuPhe: 4.724 ± 0.08	5.912LeuGly: 5.912 ± 0.087	1.811LeuHis: 1.811 ± 0.049	5.654LeuIle: 5.654 ± 0.092	6.172LeuLys: 6.172 ± 0.069	9.439LeuLeu: 9.439 ± 0.13	2.516LeuMet: 2.516 ± 0.058	4.572LeuAsn: 4.572 ± 0.085	4.262LeuPro: 4.262 ± 0.073	3.736LeuGln: 3.736 ± 0.077	4.028LeuArg: 4.028 ± 0.074	6.576LeuSer: 6.576 ± 0.093	4.986LeuThr: 4.986 ± 0.07	5.495LeuVal: 5.495 ± 0.073	1.054LeuTrp: 1.054 ± 0.033	3.836LeuTyr: 3.836 ± 0.069	0.004LeuXaa: 0.004 ± 0.002
Met	2.141MetAla: 2.141 ± 0.055	0.258MetCys: 0.258 ± 0.016	1.543MetAsp: 1.543 ± 0.043	1.876MetGlu: 1.876 ± 0.042	0.971MetPhe: 0.971 ± 0.03	1.869MetGly: 1.869 ± 0.045	0.438MetHis: 0.438 ± 0.019	1.689MetIle: 1.689 ± 0.049	2.403MetLys: 2.403 ± 0.043	2.556MetLeu: 2.556 ± 0.051	0.8MetMet: 0.8 ± 0.033	1.603MetAsn: 1.603 ± 0.04	1.17MetPro: 1.17 ± 0.035	1.164MetGln: 1.164 ± 0.035	1.217MetArg: 1.217 ± 0.037	1.41MetSer: 1.41 ± 0.043	1.425MetThr: 1.425 ± 0.033	1.507MetVal: 1.507 ± 0.044	0.234MetTrp: 0.234 ± 0.014	0.917MetTyr: 0.917 ± 0.024	0.006MetXaa: 0.006 ± 0.003
Asn	3.198AsnAla: 3.198 ± 0.061	0.485AsnCys: 0.485 ± 0.024	2.398AsnAsp: 2.398 ± 0.058	2.905AsnGlu: 2.905 ± 0.064	2.068AsnPhe: 2.068 ± 0.046	3.639AsnGly: 3.639 ± 0.064	0.925AsnHis: 0.925 ± 0.035	3.349AsnIle: 3.349 ± 0.064	2.986AsnLys: 2.986 ± 0.06	4.194AsnLeu: 4.194 ± 0.072	1.291AsnMet: 1.291 ± 0.035	2.323AsnAsn: 2.323 ± 0.061	2.569AsnPro: 2.569 ± 0.054	2.025AsnGln: 2.025 ± 0.05	2.482AsnArg: 2.482 ± 0.052	2.568AsnSer: 2.568 ± 0.053	2.585AsnThr: 2.585 ± 0.052	2.837AsnVal: 2.837 ± 0.06	0.722AsnTrp: 0.722 ± 0.028	2.275AsnTyr: 2.275 ± 0.062	0.002AsnXaa: 0.002 ± 0.002
Pro	2.932ProAla: 2.932 ± 0.069	0.36ProCys: 0.36 ± 0.017	2.733ProAsp: 2.733 ± 0.056	3.742ProGlu: 3.742 ± 0.064	1.996ProPhe: 1.996 ± 0.047	2.523ProGly: 2.523 ± 0.052	0.725ProHis: 0.725 ± 0.026	2.491ProIle: 2.491 ± 0.048	2.089ProLys: 2.089 ± 0.043	3.364ProLeu: 3.364 ± 0.057	0.955ProMet: 0.955 ± 0.033	1.827ProAsn: 1.827 ± 0.043	0.814ProPro: 0.814 ± 0.033	1.469ProGln: 1.469 ± 0.043	1.236ProArg: 1.236 ± 0.033	2.312ProSer: 2.312 ± 0.048	2.015ProThr: 2.015 ± 0.053	3.188ProVal: 3.188 ± 0.058	0.495ProTrp: 0.495 ± 0.023	1.797ProTyr: 1.797 ± 0.042	0.004ProXaa: 0.004 ± 0.002
Gln	3.103GlnAla: 3.103 ± 0.054	0.331GlnCys: 0.331 ± 0.02	1.834GlnAsp: 1.834 ± 0.043	2.916GlnGlu: 2.916 ± 0.055	1.493GlnPhe: 1.493 ± 0.042	2.236GlnGly: 2.236 ± 0.044	0.792GlnHis: 0.792 ± 0.034	3.0GlnIle: 3.0 ± 0.06	2.645GlnLys: 2.645 ± 0.052	3.848GlnLeu: 3.848 ± 0.067	1.185GlnMet: 1.185 ± 0.033	1.667GlnAsn: 1.667 ± 0.042	1.596GlnPro: 1.596 ± 0.047	2.089GlnGln: 2.089 ± 0.064	1.732GlnArg: 1.732 ± 0.042	2.107GlnSer: 2.107 ± 0.053	2.273GlnThr: 2.273 ± 0.049	2.68GlnVal: 2.68 ± 0.05	0.482GlnTrp: 0.482 ± 0.026	1.622GlnTyr: 1.622 ± 0.045	0.004GlnXaa: 0.004 ± 0.002
Arg	2.635ArgAla: 2.635 ± 0.059	0.467ArgCys: 0.467 ± 0.022	2.12ArgAsp: 2.12 ± 0.049	2.972ArgGlu: 2.972 ± 0.064	2.372ArgPhe: 2.372 ± 0.048	2.267ArgGly: 2.267 ± 0.056	0.852ArgHis: 0.852 ± 0.032	3.735ArgIle: 3.735 ± 0.065	3.286ArgLys: 3.286 ± 0.059	4.565ArgLeu: 4.565 ± 0.08	1.508ArgMet: 1.508 ± 0.04	2.257ArgAsn: 2.257 ± 0.05	1.699ArgPro: 1.699 ± 0.047	2.026ArgGln: 2.026 ± 0.051	2.171ArgArg: 2.171 ± 0.054	2.389ArgSer: 2.389 ± 0.058	2.322ArgThr: 2.322 ± 0.05	2.638ArgVal: 2.638 ± 0.046	0.624ArgTrp: 0.624 ± 0.022	2.132ArgTyr: 2.132 ± 0.048	0.005ArgXaa: 0.005 ± 0.003
Ser	4.147SerAla: 4.147 ± 0.066	0.871SerCys: 0.871 ± 0.037	3.332SerAsp: 3.332 ± 0.063	3.39SerGlu: 3.39 ± 0.059	3.546SerPhe: 3.546 ± 0.071	4.464SerGly: 4.464 ± 0.066	1.144SerHis: 1.144 ± 0.035	4.257SerIle: 4.257 ± 0.073	3.082SerLys: 3.082 ± 0.065	6.29SerLeu: 6.29 ± 0.087	1.539SerMet: 1.539 ± 0.041	2.477SerAsn: 2.477 ± 0.055	2.358SerPro: 2.358 ± 0.054	1.986SerGln: 1.986 ± 0.042	2.588SerArg: 2.588 ± 0.058	3.871SerSer: 3.871 ± 0.076	3.069SerThr: 3.069 ± 0.063	4.225SerVal: 4.225 ± 0.063	0.885SerTrp: 0.885 ± 0.031	2.823SerTyr: 2.823 ± 0.058	0.009SerXaa: 0.009 ± 0.003
Thr	3.976ThrAla: 3.976 ± 0.069	0.606ThrCys: 0.606 ± 0.025	3.317ThrAsp: 3.317 ± 0.052	3.368ThrGlu: 3.368 ± 0.067	2.585ThrPhe: 2.585 ± 0.047	4.253ThrGly: 4.253 ± 0.077	1.044ThrHis: 1.044 ± 0.036	3.773ThrIle: 3.773 ± 0.072	2.625ThrLys: 2.625 ± 0.059	5.002ThrLeu: 5.002 ± 0.078	1.056ThrMet: 1.056 ± 0.034	2.366ThrAsn: 2.366 ± 0.053	2.727ThrPro: 2.727 ± 0.053	1.773ThrGln: 1.773 ± 0.043	2.136ThrArg: 2.136 ± 0.047	3.256ThrSer: 3.256 ± 0.061	3.083ThrThr: 3.083 ± 0.069	3.68ThrVal: 3.68 ± 0.069	0.738ThrTrp: 0.738 ± 0.034	2.46ThrTyr: 2.46 ± 0.055	0.005ThrXaa: 0.005 ± 0.002
Val	4.65ValAla: 4.65 ± 0.073	1.009ValCys: 1.009 ± 0.038	3.588ValAsp: 3.588 ± 0.065	4.091ValGlu: 4.091 ± 0.062	2.882ValPhe: 2.882 ± 0.053	4.12ValGly: 4.12 ± 0.077	1.156ValHis: 1.156 ± 0.032	4.355ValIle: 4.355 ± 0.066	4.286ValLys: 4.286 ± 0.057	5.936ValLeu: 5.936 ± 0.088	1.647ValMet: 1.647 ± 0.043	3.201ValAsn: 3.201 ± 0.053	2.597ValPro: 2.597 ± 0.05	2.195ValGln: 2.195 ± 0.047	3.043ValArg: 3.043 ± 0.055	4.647ValSer: 4.647 ± 0.077	3.633ValThr: 3.633 ± 0.07	4.526ValVal: 4.526 ± 0.081	0.828ValTrp: 0.828 ± 0.031	2.695ValTyr: 2.695 ± 0.05	0.006ValXaa: 0.006 ± 0.002
Trp	0.791TrpAla: 0.791 ± 0.03	0.187TrpCys: 0.187 ± 0.013	0.733TrpAsp: 0.733 ± 0.031	0.857TrpGlu: 0.857 ± 0.031	0.598TrpPhe: 0.598 ± 0.026	0.965TrpGly: 0.965 ± 0.034	0.295TrpHis: 0.295 ± 0.016	0.97TrpIle: 0.97 ± 0.035	1.036TrpLys: 1.036 ± 0.037	1.269TrpLeu: 1.269 ± 0.039	0.479TrpMet: 0.479 ± 0.021	0.846TrpAsn: 0.846 ± 0.033	0.307TrpPro: 0.307 ± 0.019	0.589TrpGln: 0.589 ± 0.023	0.558TrpArg: 0.558 ± 0.027	0.718TrpSer: 0.718 ± 0.031	0.644TrpThr: 0.644 ± 0.027	0.763TrpVal: 0.763 ± 0.029	0.192TrpTrp: 0.192 ± 0.016	0.576TrpTyr: 0.576 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.027TyrAla: 3.027 ± 0.055	0.54TyrCys: 0.54 ± 0.022	2.397TyrAsp: 2.397 ± 0.051	2.419TyrGlu: 2.419 ± 0.047	2.151TyrPhe: 2.151 ± 0.049	2.95TyrGly: 2.95 ± 0.057	0.949TyrHis: 0.949 ± 0.033	2.762TyrIle: 2.762 ± 0.051	2.588TyrLys: 2.588 ± 0.052	4.201TyrLeu: 4.201 ± 0.067	1.102TyrMet: 1.102 ± 0.037	2.267TyrAsn: 2.267 ± 0.066	2.09TyrPro: 2.09 ± 0.05	1.978TyrGln: 1.978 ± 0.051	2.215TyrArg: 2.215 ± 0.057	2.614TyrSer: 2.614 ± 0.057	2.621TyrThr: 2.621 ± 0.056	2.586TyrVal: 2.586 ± 0.058	0.643TyrTrp: 0.643 ± 0.026	2.192TyrTyr: 2.192 ± 0.056	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.007XaaAla: 0.007 ± 0.003	0.003XaaCys: 0.003 ± 0.002	0.001XaaAsp: 0.001 ± 0.001	0.004XaaGlu: 0.004 ± 0.002	0.002XaaPhe: 0.002 ± 0.001	0.007XaaGly: 0.007 ± 0.003	0.001XaaHis: 0.001 ± 0.001	0.004XaaIle: 0.004 ± 0.002	0.006XaaLys: 0.006 ± 0.003	0.005XaaLeu: 0.005 ± 0.003	0.007XaaMet: 0.007 ± 0.003	0.002XaaAsn: 0.002 ± 0.001	0.005XaaPro: 0.005 ± 0.002	0.004XaaGln: 0.004 ± 0.002	0.01XaaArg: 0.01 ± 0.003	0.007XaaSer: 0.007 ± 0.003	0.003XaaThr: 0.003 ± 0.002	0.007XaaVal: 0.007 ± 0.003	0.003XaaTrp: 0.003 ± 0.002	0.0XaaTyr: 0.0 ± 0.0	0.102XaaXaa: 0.102 ± 0.013

Statistics based on 2823 proteins (967119 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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