Amino acid dipepetide frequency for Honeysuckle ringspot virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.224AlaAla: 6.224 ± 0.905
0.83AlaCys: 0.83 ± 0.292
3.32AlaAsp: 3.32 ± 0.762
3.734AlaGlu: 3.734 ± 0.757
5.394AlaPhe: 5.394 ± 1.134
4.149AlaGly: 4.149 ± 0.703
0.0AlaHis: 0.0 ± 0.0
3.32AlaIle: 3.32 ± 1.054
4.149AlaLys: 4.149 ± 1.755
8.299AlaLeu: 8.299 ± 0.764
2.49AlaMet: 2.49 ± 1.049
4.979AlaAsn: 4.979 ± 0.683
5.394AlaPro: 5.394 ± 0.951
4.149AlaGln: 4.149 ± 0.85
3.32AlaArg: 3.32 ± 0.49
2.075AlaSer: 2.075 ± 1.094
3.734AlaThr: 3.734 ± 1.685
3.734AlaVal: 3.734 ± 0.568
2.075AlaTrp: 2.075 ± 0.594
4.149AlaTyr: 4.149 ± 1.189
0.0AlaXaa: 0.0 ± 0.0
Cys
1.245CysAla: 1.245 ± 0.525
0.0CysCys: 0.0 ± 0.0
0.83CysAsp: 0.83 ± 0.292
0.83CysGlu: 0.83 ± 0.292
1.245CysPhe: 1.245 ± 0.525
0.83CysGly: 0.83 ± 0.292
0.0CysHis: 0.0 ± 0.0
1.66CysIle: 1.66 ± 0.585
1.245CysLys: 1.245 ± 0.525
0.83CysLeu: 0.83 ± 0.292
0.83CysMet: 0.83 ± 0.292
0.0CysAsn: 0.0 ± 0.0
0.83CysPro: 0.83 ± 0.292
0.83CysGln: 0.83 ± 0.292
1.66CysArg: 1.66 ± 0.585
1.66CysSer: 1.66 ± 0.496
0.0CysThr: 0.0 ± 0.0
0.83CysVal: 0.83 ± 0.292
0.0CysTrp: 0.0 ± 0.0
2.49CysTyr: 2.49 ± 0.877
0.0CysXaa: 0.0 ± 0.0
Asp
2.49AspAla: 2.49 ± 0.737
2.49AspCys: 2.49 ± 0.877
4.149AspAsp: 4.149 ± 0.65
0.83AspGlu: 0.83 ± 0.292
1.66AspPhe: 1.66 ± 0.496
5.394AspGly: 5.394 ± 1.193
0.0AspHis: 0.0 ± 0.0
1.66AspIle: 1.66 ± 0.585
2.905AspLys: 2.905 ± 0.914
3.734AspLeu: 3.734 ± 1.011
2.49AspMet: 2.49 ± 0.877
0.415AspAsn: 0.415 ± 0.471
2.49AspPro: 2.49 ± 0.751
1.245AspGln: 1.245 ± 0.376
3.734AspArg: 3.734 ± 1.011
2.905AspSer: 2.905 ± 0.637
2.075AspThr: 2.075 ± 1.094
5.809AspVal: 5.809 ± 1.355
0.0AspTrp: 0.0 ± 0.0
3.734AspTyr: 3.734 ± 0.757
0.0AspXaa: 0.0 ± 0.0
Glu
3.734GluAla: 3.734 ± 1.054
0.0GluCys: 0.0 ± 0.0
2.075GluAsp: 2.075 ± 0.594
3.734GluGlu: 3.734 ± 0.757
4.564GluPhe: 4.564 ± 1.27
2.49GluGly: 2.49 ± 0.397
2.49GluHis: 2.49 ± 0.877
0.415GluIle: 0.415 ± 0.471
3.734GluLys: 3.734 ± 0.722
6.224GluLeu: 6.224 ± 1.209
0.0GluMet: 0.0 ± 0.0
0.415GluAsn: 0.415 ± 0.857
2.905GluPro: 2.905 ± 0.776
2.075GluGln: 2.075 ± 0.594
4.564GluArg: 4.564 ± 0.914
3.734GluSer: 3.734 ± 0.961
2.49GluThr: 2.49 ± 1.049
8.714GluVal: 8.714 ± 1.699
0.0GluTrp: 0.0 ± 0.0
2.075GluTyr: 2.075 ± 1.524
0.0GluXaa: 0.0 ± 0.0
Phe
2.075PheAla: 2.075 ± 0.794
3.734PheCys: 3.734 ± 1.011
2.905PheAsp: 2.905 ± 0.702
3.32PheGlu: 3.32 ± 0.49
0.0PhePhe: 0.0 ± 0.0
4.149PheGly: 4.149 ± 0.889
0.0PheHis: 0.0 ± 0.0
3.734PheIle: 3.734 ± 1.246
4.564PheLys: 4.564 ± 0.926
2.075PheLeu: 2.075 ± 0.72
1.245PheMet: 1.245 ± 0.525
2.49PheAsn: 2.49 ± 0.737
0.415PhePro: 0.415 ± 0.471
1.66PheGln: 1.66 ± 0.585
1.66PheArg: 1.66 ± 0.496
1.66PheSer: 1.66 ± 0.585
2.075PheThr: 2.075 ± 0.813
1.66PheVal: 1.66 ± 0.496
0.0PheTrp: 0.0 ± 0.0
2.49PheTyr: 2.49 ± 0.877
0.0PheXaa: 0.0 ± 0.0
Gly
3.32GlyAla: 3.32 ± 2.137
0.83GlyCys: 0.83 ± 0.292
3.734GlyAsp: 3.734 ± 1.011
5.809GlyGlu: 5.809 ± 0.749
2.49GlyPhe: 2.49 ± 0.751
4.979GlyGly: 4.979 ± 1.293
0.83GlyHis: 0.83 ± 0.702
2.49GlyIle: 2.49 ± 0.877
6.224GlyLys: 6.224 ± 1.769
6.224GlyLeu: 6.224 ± 1.209
1.245GlyMet: 1.245 ± 0.63
1.66GlyAsn: 1.66 ± 0.822
2.075GlyPro: 2.075 ± 0.481
0.415GlyGln: 0.415 ± 0.471
3.734GlyArg: 3.734 ± 0.564
2.905GlySer: 2.905 ± 0.948
4.979GlyThr: 4.979 ± 1.13
4.979GlyVal: 4.979 ± 0.522
1.245GlyTrp: 1.245 ± 0.376
1.245GlyTyr: 1.245 ± 0.376
0.0GlyXaa: 0.0 ± 0.0
His
1.245HisAla: 1.245 ± 0.525
0.0HisCys: 0.0 ± 0.0
2.075HisAsp: 2.075 ± 0.594
0.0HisGlu: 0.0 ± 0.0
0.415HisPhe: 0.415 ± 0.471
0.83HisGly: 0.83 ± 0.292
0.0HisHis: 0.0 ± 0.0
0.83HisIle: 0.83 ± 0.292
0.83HisLys: 0.83 ± 0.292
5.394HisLeu: 5.394 ± 1.465
0.0HisMet: 0.0 ± 0.0
0.83HisAsn: 0.83 ± 0.292
2.075HisPro: 2.075 ± 0.594
0.0HisGln: 0.0 ± 0.0
1.245HisArg: 1.245 ± 0.525
2.49HisSer: 2.49 ± 0.877
3.32HisThr: 3.32 ± 1.082
0.83HisVal: 0.83 ± 0.292
0.83HisTrp: 0.83 ± 0.292
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.394IleAla: 5.394 ± 0.742
0.0IleCys: 0.0 ± 0.0
0.415IleAsp: 0.415 ± 0.471
1.66IleGlu: 1.66 ± 0.585
3.32IlePhe: 3.32 ± 1.857
2.49IleGly: 2.49 ± 1.099
1.245IleHis: 1.245 ± 0.376
3.734IleIle: 3.734 ± 1.246
3.734IleLys: 3.734 ± 1.246
1.66IleLeu: 1.66 ± 0.665
0.0IleMet: 0.0 ± 0.0
1.66IleAsn: 1.66 ± 0.822
4.979IlePro: 4.979 ± 0.873
1.245IleGln: 1.245 ± 0.773
2.49IleArg: 2.49 ± 0.877
4.564IleSer: 4.564 ± 1.818
4.564IleThr: 4.564 ± 0.426
1.245IleVal: 1.245 ± 0.525
0.83IleTrp: 0.83 ± 0.292
1.66IleTyr: 1.66 ± 0.665
0.0IleXaa: 0.0 ± 0.0
Lys
5.394LysAla: 5.394 ± 1.666
2.075LysCys: 2.075 ± 0.594
4.149LysAsp: 4.149 ± 1.588
5.809LysGlu: 5.809 ± 0.843
2.075LysPhe: 2.075 ± 0.594
2.905LysGly: 2.905 ± 0.677
2.905LysHis: 2.905 ± 0.776
2.49LysIle: 2.49 ± 0.75
4.979LysLys: 4.979 ± 0.958
4.564LysLeu: 4.564 ± 1.27
3.734LysMet: 3.734 ± 0.982
2.075LysAsn: 2.075 ± 0.594
2.905LysPro: 2.905 ± 0.678
2.905LysGln: 2.905 ± 1.457
1.66LysArg: 1.66 ± 0.822
3.32LysSer: 3.32 ± 1.169
4.149LysThr: 4.149 ± 1.613
5.809LysVal: 5.809 ± 1.94
1.66LysTrp: 1.66 ± 0.665
4.979LysTyr: 4.979 ± 0.794
0.83LysXaa: 0.83 ± 0.292
Leu
12.863LeuAla: 12.863 ± 1.852
1.66LeuCys: 1.66 ± 0.585
3.734LeuAsp: 3.734 ± 1.011
4.564LeuGlu: 4.564 ± 0.894
1.66LeuPhe: 1.66 ± 0.665
4.564LeuGly: 4.564 ± 0.64
0.0LeuHis: 0.0 ± 0.0
3.32LeuIle: 3.32 ± 2.808
6.639LeuLys: 6.639 ± 1.778
8.714LeuLeu: 8.714 ± 2.035
2.49LeuMet: 2.49 ± 0.655
2.49LeuAsn: 2.49 ± 0.397
4.149LeuPro: 4.149 ± 0.85
4.979LeuGln: 4.979 ± 0.873
4.564LeuArg: 4.564 ± 0.64
4.979LeuSer: 4.979 ± 1.882
5.394LeuThr: 5.394 ± 1.251
7.054LeuVal: 7.054 ± 1.25
1.66LeuTrp: 1.66 ± 0.496
1.66LeuTyr: 1.66 ± 0.8
0.0LeuXaa: 0.0 ± 0.0
Met
2.49MetAla: 2.49 ± 0.397
0.0MetCys: 0.0 ± 0.0
1.245MetAsp: 1.245 ± 1.291
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
1.245MetGly: 1.245 ± 0.525
1.245MetHis: 1.245 ± 0.525
2.49MetIle: 2.49 ± 0.877
3.32MetLys: 3.32 ± 1.169
2.905MetLeu: 2.905 ± 0.678
0.0MetMet: 0.0 ± 0.0
0.83MetAsn: 0.83 ± 0.292
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
1.245MetArg: 1.245 ± 0.376
2.49MetSer: 2.49 ± 0.877
1.245MetThr: 1.245 ± 0.812
4.979MetVal: 4.979 ± 1.065
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.075AsnAla: 2.075 ± 0.481
1.66AsnCys: 1.66 ± 0.585
0.0AsnAsp: 0.0 ± 0.0
0.0AsnGlu: 0.0 ± 0.0
2.49AsnPhe: 2.49 ± 1.796
3.32AsnGly: 3.32 ± 0.457
2.075AsnHis: 2.075 ± 0.594
0.0AsnIle: 0.0 ± 0.0
2.905AsnLys: 2.905 ± 0.677
3.32AsnLeu: 3.32 ± 0.812
1.245AsnMet: 1.245 ± 0.525
3.734AsnAsn: 3.734 ± 0.757
0.83AsnPro: 0.83 ± 0.942
2.075AsnGln: 2.075 ± 0.481
1.66AsnArg: 1.66 ± 0.881
5.394AsnSer: 5.394 ± 1.837
2.905AsnThr: 2.905 ± 1.871
3.734AsnVal: 3.734 ± 1.011
0.415AsnTrp: 0.415 ± 0.471
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
1.66ProAla: 1.66 ± 0.585
0.83ProCys: 0.83 ± 0.292
4.564ProAsp: 4.564 ± 0.894
1.66ProGlu: 1.66 ± 0.8
1.245ProPhe: 1.245 ± 0.525
2.49ProGly: 2.49 ± 1.232
0.83ProHis: 0.83 ± 0.292
1.66ProIle: 1.66 ± 0.496
3.32ProLys: 3.32 ± 1.082
4.564ProLeu: 4.564 ± 0.426
0.0ProMet: 0.0 ± 0.0
2.49ProAsn: 2.49 ± 0.397
2.075ProPro: 2.075 ± 0.72
1.66ProGln: 1.66 ± 0.8
3.734ProArg: 3.734 ± 1.127
0.0ProSer: 0.0 ± 0.0
4.149ProThr: 4.149 ± 1.953
4.979ProVal: 4.979 ± 1.133
0.0ProTrp: 0.0 ± 0.0
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
2.905GlnAla: 2.905 ± 0.637
0.0GlnCys: 0.0 ± 0.0
0.83GlnAsp: 0.83 ± 0.292
3.32GlnGlu: 3.32 ± 1.082
1.66GlnPhe: 1.66 ± 0.585
0.0GlnGly: 0.0 ± 0.0
2.075GlnHis: 2.075 ± 0.594
2.49GlnIle: 2.49 ± 0.877
2.905GlnLys: 2.905 ± 1.687
4.564GlnLeu: 4.564 ± 0.426
2.49GlnMet: 2.49 ± 0.549
2.49GlnAsn: 2.49 ± 0.877
2.49GlnPro: 2.49 ± 0.737
1.66GlnGln: 1.66 ± 0.585
0.0GlnArg: 0.0 ± 0.0
3.734GlnSer: 3.734 ± 1.663
0.415GlnThr: 0.415 ± 0.471
1.66GlnVal: 1.66 ± 0.8
1.245GlnTrp: 1.245 ± 0.376
1.66GlnTyr: 1.66 ± 1.404
0.415GlnXaa: 0.415 ± 0.275
Arg
4.979ArgAla: 4.979 ± 0.803
0.0ArgCys: 0.0 ± 0.0
3.734ArgAsp: 3.734 ± 0.961
5.809ArgGlu: 5.809 ± 1.356
4.979ArgPhe: 4.979 ± 1.351
4.564ArgGly: 4.564 ± 1.412
1.245ArgHis: 1.245 ± 0.525
2.49ArgIle: 2.49 ± 1.546
4.149ArgLys: 4.149 ± 1.462
4.979ArgLeu: 4.979 ± 0.794
0.83ArgMet: 0.83 ± 0.292
0.83ArgAsn: 0.83 ± 0.942
1.245ArgPro: 1.245 ± 0.376
0.0ArgGln: 0.0 ± 0.0
5.809ArgArg: 5.809 ± 1.356
2.075ArgSer: 2.075 ± 1.259
4.149ArgThr: 4.149 ± 1.395
7.469ArgVal: 7.469 ± 1.414
0.0ArgTrp: 0.0 ± 0.0
4.149ArgTyr: 4.149 ± 0.962
0.0ArgXaa: 0.0 ± 0.0
Ser
2.905SerAla: 2.905 ± 1.158
0.83SerCys: 0.83 ± 0.292
2.905SerAsp: 2.905 ± 2.053
0.83SerGlu: 0.83 ± 0.942
2.905SerPhe: 2.905 ± 0.702
5.394SerGly: 5.394 ± 1.905
2.075SerHis: 2.075 ± 0.594
4.979SerIle: 4.979 ± 1.878
4.564SerLys: 4.564 ± 0.64
4.149SerLeu: 4.149 ± 0.921
0.83SerMet: 0.83 ± 0.942
1.245SerAsn: 1.245 ± 0.376
1.245SerPro: 1.245 ± 1.413
0.83SerGln: 0.83 ± 0.702
2.075SerArg: 2.075 ± 0.481
2.905SerSer: 2.905 ± 1.158
3.32SerThr: 3.32 ± 0.457
4.979SerVal: 4.979 ± 0.873
3.32SerTrp: 3.32 ± 1.082
1.245SerTyr: 1.245 ± 0.376
0.0SerXaa: 0.0 ± 0.0
Thr
4.149ThrAla: 4.149 ± 1.018
0.0ThrCys: 0.0 ± 0.0
1.245ThrAsp: 1.245 ± 0.376
0.83ThrGlu: 0.83 ± 0.702
2.075ThrPhe: 2.075 ± 0.481
2.905ThrGly: 2.905 ± 0.63
1.245ThrHis: 1.245 ± 0.525
2.075ThrIle: 2.075 ± 0.813
4.979ThrLys: 4.979 ± 0.803
7.054ThrLeu: 7.054 ± 2.847
0.0ThrMet: 0.0 ± 0.0
3.32ThrAsn: 3.32 ± 1.762
3.734ThrPro: 3.734 ± 1.261
3.32ThrGln: 3.32 ± 1.048
5.809ThrArg: 5.809 ± 1.251
1.66ThrSer: 1.66 ± 0.496
6.639ThrThr: 6.639 ± 1.897
8.714ThrVal: 8.714 ± 1.528
1.245ThrTrp: 1.245 ± 0.812
0.83ThrTyr: 0.83 ± 0.99
0.0ThrXaa: 0.0 ± 0.0
Val
7.054ValAla: 7.054 ± 0.921
2.905ValCys: 2.905 ± 0.906
7.054ValAsp: 7.054 ± 0.925
10.788ValGlu: 10.788 ± 2.578
2.905ValPhe: 2.905 ± 0.776
5.394ValGly: 5.394 ± 1.023
4.149ValHis: 4.149 ± 1.189
3.32ValIle: 3.32 ± 1.762
2.075ValLys: 2.075 ± 0.813
3.734ValLeu: 3.734 ± 1.717
2.49ValMet: 2.49 ± 0.877
5.394ValAsn: 5.394 ± 1.295
0.83ValPro: 0.83 ± 0.292
3.32ValGln: 3.32 ± 1.158
8.714ValArg: 8.714 ± 1.277
4.564ValSer: 4.564 ± 1.955
2.49ValThr: 2.49 ± 1.954
10.788ValVal: 10.788 ± 1.856
0.415ValTrp: 0.415 ± 0.471
2.49ValTyr: 2.49 ± 0.75
0.0ValXaa: 0.0 ± 0.0
Trp
1.66TrpAla: 1.66 ± 0.496
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.245TrpGlu: 1.245 ± 0.525
0.0TrpPhe: 0.0 ± 0.0
1.66TrpGly: 1.66 ± 0.585
0.0TrpHis: 0.0 ± 0.0
0.415TrpIle: 0.415 ± 0.471
0.83TrpLys: 0.83 ± 0.702
1.66TrpLeu: 1.66 ± 0.496
0.83TrpMet: 0.83 ± 0.292
0.83TrpAsn: 0.83 ± 0.292
0.0TrpPro: 0.0 ± 0.0
2.49TrpGln: 2.49 ± 0.397
1.66TrpArg: 1.66 ± 0.665
0.0TrpSer: 0.0 ± 0.0
0.83TrpThr: 0.83 ± 0.292
0.415TrpVal: 0.415 ± 0.471
0.0TrpTrp: 0.0 ± 0.0
0.415TrpTyr: 0.415 ± 0.471
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.66TyrAla: 1.66 ± 0.585
0.0TyrCys: 0.0 ± 0.0
1.245TyrAsp: 1.245 ± 0.525
1.66TyrGlu: 1.66 ± 0.8
0.83TyrPhe: 0.83 ± 0.292
0.83TyrGly: 0.83 ± 0.942
0.83TyrHis: 0.83 ± 0.292
3.32TyrIle: 3.32 ± 1.158
2.905TyrLys: 2.905 ± 0.678
2.905TyrLeu: 2.905 ± 0.702
2.075TyrMet: 2.075 ± 0.481
1.66TyrAsn: 1.66 ± 0.665
1.245TyrPro: 1.245 ± 0.525
4.149TyrGln: 4.149 ± 1.33
4.149TyrArg: 4.149 ± 0.703
0.415TyrSer: 0.415 ± 0.471
2.905TyrThr: 2.905 ± 0.63
2.49TyrVal: 2.49 ± 0.751
0.0TyrTrp: 0.0 ± 0.0
0.415TyrTyr: 0.415 ± 0.857
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.83XaaGly: 0.83 ± 0.292
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.415XaaLys: 0.415 ± 0.275
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2411 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski