Amino acid dipepetide frequency for Lysobacter alkalisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.332AlaAla: 16.332 ± 0.168	1.319AlaCys: 1.319 ± 0.039	7.204AlaAsp: 7.204 ± 0.093	7.132AlaGlu: 7.132 ± 0.119	4.102AlaPhe: 4.102 ± 0.065	11.648AlaGly: 11.648 ± 0.14	2.578AlaHis: 2.578 ± 0.053	5.532AlaIle: 5.532 ± 0.074	2.731AlaLys: 2.731 ± 0.075	14.191AlaLeu: 14.191 ± 0.157	3.407AlaMet: 3.407 ± 0.057	2.758AlaAsn: 2.758 ± 0.06	5.786AlaPro: 5.786 ± 0.089	4.149AlaGln: 4.149 ± 0.068	9.862AlaArg: 9.862 ± 0.129	6.519AlaSer: 6.519 ± 0.079	6.338AlaThr: 6.338 ± 0.114	8.705AlaVal: 8.705 ± 0.112	2.011AlaTrp: 2.011 ± 0.045	2.383AlaTyr: 2.383 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.003CysAla: 1.003 ± 0.033	0.124CysCys: 0.124 ± 0.01	0.503CysAsp: 0.503 ± 0.026	0.476CysGlu: 0.476 ± 0.025	0.273CysPhe: 0.273 ± 0.016	0.956CysGly: 0.956 ± 0.035	0.26CysHis: 0.26 ± 0.018	0.368CysIle: 0.368 ± 0.018	0.178CysLys: 0.178 ± 0.013	0.825CysLeu: 0.825 ± 0.029	0.188CysMet: 0.188 ± 0.012	0.243CysAsn: 0.243 ± 0.016	0.416CysPro: 0.416 ± 0.021	0.225CysGln: 0.225 ± 0.013	0.689CysArg: 0.689 ± 0.028	0.504CysSer: 0.504 ± 0.023	0.459CysThr: 0.459 ± 0.027	0.629CysVal: 0.629 ± 0.025	0.133CysTrp: 0.133 ± 0.011	0.179CysTyr: 0.179 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.261AspAla: 8.261 ± 0.103	0.487AspCys: 0.487 ± 0.022	4.011AspAsp: 4.011 ± 0.063	3.742AspGlu: 3.742 ± 0.063	2.139AspPhe: 2.139 ± 0.044	6.566AspGly: 6.566 ± 0.107	1.249AspHis: 1.249 ± 0.033	2.612AspIle: 2.612 ± 0.056	1.501AspLys: 1.501 ± 0.043	5.495AspLeu: 5.495 ± 0.077	1.19AspMet: 1.19 ± 0.031	1.525AspAsn: 1.525 ± 0.046	3.75AspPro: 3.75 ± 0.072	1.499AspGln: 1.499 ± 0.04	4.319AspArg: 4.319 ± 0.077	2.829AspSer: 2.829 ± 0.045	3.101AspThr: 3.101 ± 0.063	4.08AspVal: 4.08 ± 0.064	1.192AspTrp: 1.192 ± 0.034	1.601AspTyr: 1.601 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.562GluAla: 7.562 ± 0.116	0.379GluCys: 0.379 ± 0.023	2.576GluAsp: 2.576 ± 0.05	2.574GluGlu: 2.574 ± 0.055	1.772GluPhe: 1.772 ± 0.044	4.366GluGly: 4.366 ± 0.06	1.478GluHis: 1.478 ± 0.042	2.62GluIle: 2.62 ± 0.051	1.527GluLys: 1.527 ± 0.04	6.252GluLeu: 6.252 ± 0.089	1.203GluMet: 1.203 ± 0.028	1.213GluAsn: 1.213 ± 0.035	2.903GluPro: 2.903 ± 0.056	2.588GluGln: 2.588 ± 0.059	5.515GluArg: 5.515 ± 0.094	2.845GluSer: 2.845 ± 0.058	2.826GluThr: 2.826 ± 0.054	4.307GluVal: 4.307 ± 0.068	0.817GluTrp: 0.817 ± 0.03	1.274GluTyr: 1.274 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.072PheAla: 4.072 ± 0.073	0.339PheCys: 0.339 ± 0.018	2.873PheAsp: 2.873 ± 0.053	2.168PheGlu: 2.168 ± 0.046	1.166PhePhe: 1.166 ± 0.039	3.413PheGly: 3.413 ± 0.062	0.777PheHis: 0.777 ± 0.027	1.328PheIle: 1.328 ± 0.037	0.834PheLys: 0.834 ± 0.03	2.804PheLeu: 2.804 ± 0.053	0.686PheMet: 0.686 ± 0.024	1.131PheAsn: 1.131 ± 0.038	1.393PhePro: 1.393 ± 0.034	0.875PheGln: 0.875 ± 0.027	2.188PheArg: 2.188 ± 0.041	2.004PheSer: 2.004 ± 0.048	1.696PheThr: 1.696 ± 0.046	2.517PheVal: 2.517 ± 0.05	0.525PheTrp: 0.525 ± 0.025	0.777PheTyr: 0.777 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.86GlyAla: 8.86 ± 0.14	0.844GlyCys: 0.844 ± 0.031	5.365GlyAsp: 5.365 ± 0.083	5.364GlyGlu: 5.364 ± 0.07	3.483GlyPhe: 3.483 ± 0.067	7.715GlyGly: 7.715 ± 0.178	2.291GlyHis: 2.291 ± 0.047	4.235GlyIle: 4.235 ± 0.072	2.783GlyLys: 2.783 ± 0.058	9.067GlyLeu: 9.067 ± 0.106	2.381GlyMet: 2.381 ± 0.05	2.666GlyAsn: 2.666 ± 0.07	3.435GlyPro: 3.435 ± 0.062	3.071GlyGln: 3.071 ± 0.056	6.824GlyArg: 6.824 ± 0.099	5.251GlySer: 5.251 ± 0.092	4.869GlyThr: 4.869 ± 0.155	6.507GlyVal: 6.507 ± 0.085	1.754GlyTrp: 1.754 ± 0.04	2.466GlyTyr: 2.466 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	3.215HisAla: 3.215 ± 0.064	0.296HisCys: 0.296 ± 0.016	1.526HisAsp: 1.526 ± 0.042	1.291HisGlu: 1.291 ± 0.039	0.827HisPhe: 0.827 ± 0.026	2.473HisGly: 2.473 ± 0.049	0.661HisHis: 0.661 ± 0.028	0.762HisIle: 0.762 ± 0.031	0.461HisLys: 0.461 ± 0.02	2.202HisLeu: 2.202 ± 0.045	0.421HisMet: 0.421 ± 0.018	0.498HisAsn: 0.498 ± 0.018	1.555HisPro: 1.555 ± 0.041	0.649HisGln: 0.649 ± 0.026	1.849HisArg: 1.849 ± 0.051	1.024HisSer: 1.024 ± 0.033	0.989HisThr: 0.989 ± 0.03	1.746HisVal: 1.746 ± 0.042	0.444HisTrp: 0.444 ± 0.023	0.678HisTyr: 0.678 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.267IleAla: 6.267 ± 0.076	0.389IleCys: 0.389 ± 0.019	3.59IleAsp: 3.59 ± 0.057	3.438IleGlu: 3.438 ± 0.057	1.018IlePhe: 1.018 ± 0.031	4.557IleGly: 4.557 ± 0.076	0.963IleHis: 0.963 ± 0.031	1.343IleIle: 1.343 ± 0.04	1.081IleLys: 1.081 ± 0.036	3.067IleLeu: 3.067 ± 0.06	0.521IleMet: 0.521 ± 0.024	1.247IleAsn: 1.247 ± 0.037	2.079IlePro: 2.079 ± 0.046	1.037IleGln: 1.037 ± 0.032	2.899IleArg: 2.899 ± 0.052	2.078IleSer: 2.078 ± 0.045	2.183IleThr: 2.183 ± 0.049	3.34IleVal: 3.34 ± 0.059	0.48IleTrp: 0.48 ± 0.021	0.833IleTyr: 0.833 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.209LysAla: 3.209 ± 0.081	0.14LysCys: 0.14 ± 0.015	1.313LysAsp: 1.313 ± 0.041	1.118LysGlu: 1.118 ± 0.043	0.689LysPhe: 0.689 ± 0.027	1.897LysGly: 1.897 ± 0.052	0.589LysHis: 0.589 ± 0.026	1.065LysIle: 1.065 ± 0.032	0.951LysLys: 0.951 ± 0.062	2.77LysLeu: 2.77 ± 0.057	0.558LysMet: 0.558 ± 0.024	0.599LysAsn: 0.599 ± 0.026	1.684LysPro: 1.684 ± 0.043	1.014LysGln: 1.014 ± 0.033	1.961LysArg: 1.961 ± 0.043	1.335LysSer: 1.335 ± 0.038	1.404LysThr: 1.404 ± 0.045	2.026LysVal: 2.026 ± 0.044	0.308LysTrp: 0.308 ± 0.016	0.56LysTyr: 0.56 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.496LeuAla: 14.496 ± 0.151	0.872LeuCys: 0.872 ± 0.026	7.034LeuAsp: 7.034 ± 0.093	5.579LeuGlu: 5.579 ± 0.095	3.399LeuPhe: 3.399 ± 0.076	8.569LeuGly: 8.569 ± 0.129	2.435LeuHis: 2.435 ± 0.053	3.856LeuIle: 3.856 ± 0.063	2.768LeuLys: 2.768 ± 0.062	11.29LeuLeu: 11.29 ± 0.163	2.114LeuMet: 2.114 ± 0.046	2.275LeuAsn: 2.275 ± 0.058	6.403LeuPro: 6.403 ± 0.094	3.726LeuGln: 3.726 ± 0.064	8.51LeuArg: 8.51 ± 0.118	5.872LeuSer: 5.872 ± 0.085	4.686LeuThr: 4.686 ± 0.088	7.882LeuVal: 7.882 ± 0.092	1.387LeuTrp: 1.387 ± 0.04	2.209LeuTyr: 2.209 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.742MetAla: 2.742 ± 0.048	0.15MetCys: 0.15 ± 0.011	1.07MetAsp: 1.07 ± 0.032	0.995MetGlu: 0.995 ± 0.032	0.695MetPhe: 0.695 ± 0.027	1.56MetGly: 1.56 ± 0.037	0.492MetHis: 0.492 ± 0.024	0.915MetIle: 0.915 ± 0.028	0.786MetLys: 0.786 ± 0.027	2.496MetLeu: 2.496 ± 0.049	0.468MetMet: 0.468 ± 0.023	0.655MetAsn: 0.655 ± 0.025	1.564MetPro: 1.564 ± 0.038	0.937MetGln: 0.937 ± 0.032	1.821MetArg: 1.821 ± 0.04	1.558MetSer: 1.558 ± 0.034	1.362MetThr: 1.362 ± 0.034	1.538MetVal: 1.538 ± 0.04	0.21MetTrp: 0.21 ± 0.015	0.375MetTyr: 0.375 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.141AsnAla: 3.141 ± 0.058	0.239AsnCys: 0.239 ± 0.016	1.432AsnAsp: 1.432 ± 0.047	1.193AsnGlu: 1.193 ± 0.033	0.898AsnPhe: 0.898 ± 0.034	2.414AsnGly: 2.414 ± 0.065	0.537AsnHis: 0.537 ± 0.021	1.121AsnIle: 1.121 ± 0.038	0.589AsnLys: 0.589 ± 0.024	2.44AsnLeu: 2.44 ± 0.052	0.479AsnMet: 0.479 ± 0.022	0.771AsnAsn: 0.771 ± 0.035	1.726AsnPro: 1.726 ± 0.044	0.704AsnGln: 0.704 ± 0.03	1.84AsnArg: 1.84 ± 0.045	1.181AsnSer: 1.181 ± 0.039	1.393AsnThr: 1.393 ± 0.051	1.83AsnVal: 1.83 ± 0.051	0.405AsnTrp: 0.405 ± 0.022	0.642AsnTyr: 0.642 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.114ProAla: 7.114 ± 0.09	0.361ProCys: 0.361 ± 0.021	3.991ProAsp: 3.991 ± 0.069	3.608ProGlu: 3.608 ± 0.061	1.626ProPhe: 1.626 ± 0.04	5.313ProGly: 5.313 ± 0.08	1.159ProHis: 1.159 ± 0.032	1.858ProIle: 1.858 ± 0.037	1.267ProLys: 1.267 ± 0.035	5.323ProLeu: 5.323 ± 0.078	1.313ProMet: 1.313 ± 0.034	1.186ProAsn: 1.186 ± 0.04	3.024ProPro: 3.024 ± 0.07	1.83ProGln: 1.83 ± 0.039	3.484ProArg: 3.484 ± 0.063	2.701ProSer: 2.701 ± 0.054	2.432ProThr: 2.432 ± 0.051	4.419ProVal: 4.419 ± 0.077	0.83ProTrp: 0.83 ± 0.023	1.144ProTyr: 1.144 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.852GlnAla: 4.852 ± 0.081	0.26GlnCys: 0.26 ± 0.016	1.475GlnAsp: 1.475 ± 0.041	1.356GlnGlu: 1.356 ± 0.042	0.993GlnPhe: 0.993 ± 0.028	2.515GlnGly: 2.515 ± 0.043	0.843GlnHis: 0.843 ± 0.029	1.335GlnIle: 1.335 ± 0.039	0.84GlnLys: 0.84 ± 0.027	3.668GlnLeu: 3.668 ± 0.072	0.8GlnMet: 0.8 ± 0.028	0.658GlnAsn: 0.658 ± 0.024	2.08GlnPro: 2.08 ± 0.038	1.584GlnGln: 1.584 ± 0.052	3.288GlnArg: 3.288 ± 0.064	1.6GlnSer: 1.6 ± 0.043	1.404GlnThr: 1.404 ± 0.032	2.854GlnVal: 2.854 ± 0.049	0.61GlnTrp: 0.61 ± 0.024	0.747GlnTyr: 0.747 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.218ArgAla: 8.218 ± 0.098	0.586ArgCys: 0.586 ± 0.024	4.662ArgAsp: 4.662 ± 0.075	5.071ArgGlu: 5.071 ± 0.08	3.019ArgPhe: 3.019 ± 0.052	5.64ArgGly: 5.64 ± 0.079	2.29ArgHis: 2.29 ± 0.053	4.229ArgIle: 4.229 ± 0.066	2.012ArgLys: 2.012 ± 0.052	8.866ArgLeu: 8.866 ± 0.117	2.017ArgMet: 2.017 ± 0.046	2.033ArgAsn: 2.033 ± 0.042	3.88ArgPro: 3.88 ± 0.071	2.901ArgGln: 2.901 ± 0.065	6.491ArgArg: 6.491 ± 0.109	3.743ArgSer: 3.743 ± 0.061	3.472ArgThr: 3.472 ± 0.054	5.434ArgVal: 5.434 ± 0.081	1.497ArgTrp: 1.497 ± 0.042	2.251ArgTyr: 2.251 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.864SerAla: 5.864 ± 0.082	0.415SerCys: 0.415 ± 0.021	2.888SerAsp: 2.888 ± 0.052	2.624SerGlu: 2.624 ± 0.051	1.906SerPhe: 1.906 ± 0.051	5.809SerGly: 5.809 ± 0.098	1.217SerHis: 1.217 ± 0.033	2.292SerIle: 2.292 ± 0.046	1.319SerLys: 1.319 ± 0.031	5.416SerLeu: 5.416 ± 0.085	1.186SerMet: 1.186 ± 0.033	1.487SerAsn: 1.487 ± 0.044	2.978SerPro: 2.978 ± 0.053	1.683SerGln: 1.683 ± 0.041	3.972SerArg: 3.972 ± 0.064	2.986SerSer: 2.986 ± 0.058	2.876SerThr: 2.876 ± 0.057	3.732SerVal: 3.732 ± 0.07	0.804SerTrp: 0.804 ± 0.027	1.255SerTyr: 1.255 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.91ThrAla: 5.91 ± 0.085	0.444ThrCys: 0.444 ± 0.023	2.715ThrAsp: 2.715 ± 0.059	2.24ThrGlu: 2.24 ± 0.05	1.615ThrPhe: 1.615 ± 0.054	5.047ThrGly: 5.047 ± 0.104	1.122ThrHis: 1.122 ± 0.031	2.079ThrIle: 2.079 ± 0.061	0.841ThrLys: 0.841 ± 0.032	6.165ThrLeu: 6.165 ± 0.136	0.941ThrMet: 0.941 ± 0.034	0.985ThrAsn: 0.985 ± 0.038	3.374ThrPro: 3.374 ± 0.053	1.422ThrGln: 1.422 ± 0.035	3.745ThrArg: 3.745 ± 0.066	2.57ThrSer: 2.57 ± 0.055	2.674ThrThr: 2.674 ± 0.069	4.263ThrVal: 4.263 ± 0.088	0.746ThrTrp: 0.746 ± 0.026	1.122ThrTyr: 1.122 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	9.462ValAla: 9.462 ± 0.113	0.643ValCys: 0.643 ± 0.023	4.703ValAsp: 4.703 ± 0.062	4.863ValGlu: 4.863 ± 0.074	2.532ValPhe: 2.532 ± 0.049	5.611ValGly: 5.611 ± 0.085	1.678ValHis: 1.678 ± 0.041	3.382ValIle: 3.382 ± 0.055	1.738ValLys: 1.738 ± 0.051	8.293ValLeu: 8.293 ± 0.107	1.632ValMet: 1.632 ± 0.037	1.896ValAsn: 1.896 ± 0.055	3.959ValPro: 3.959 ± 0.069	2.314ValGln: 2.314 ± 0.05	5.405ValArg: 5.405 ± 0.081	3.96ValSer: 3.96 ± 0.064	3.822ValThr: 3.822 ± 0.081	6.144ValVal: 6.144 ± 0.092	0.95ValTrp: 0.95 ± 0.031	1.539ValTyr: 1.539 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.356TrpAla: 1.356 ± 0.039	0.16TrpCys: 0.16 ± 0.011	0.698TrpAsp: 0.698 ± 0.027	0.602TrpGlu: 0.602 ± 0.025	0.612TrpPhe: 0.612 ± 0.025	1.012TrpGly: 1.012 ± 0.032	0.445TrpHis: 0.445 ± 0.018	0.695TrpIle: 0.695 ± 0.026	0.456TrpLys: 0.456 ± 0.021	2.323TrpLeu: 2.323 ± 0.056	0.45TrpMet: 0.45 ± 0.021	0.511TrpAsn: 0.511 ± 0.023	0.838TrpPro: 0.838 ± 0.031	0.778TrpGln: 0.778 ± 0.029	1.474TrpArg: 1.474 ± 0.042	0.919TrpSer: 0.919 ± 0.029	0.789TrpThr: 0.789 ± 0.027	0.998TrpVal: 0.998 ± 0.029	0.352TrpTrp: 0.352 ± 0.02	0.38TrpTyr: 0.38 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.748TyrAla: 2.748 ± 0.054	0.189TyrCys: 0.189 ± 0.013	1.518TyrAsp: 1.518 ± 0.082	1.163TyrGlu: 1.163 ± 0.033	0.802TyrPhe: 0.802 ± 0.031	2.151TyrGly: 2.151 ± 0.046	0.5TyrHis: 0.5 ± 0.022	0.785TyrIle: 0.785 ± 0.028	0.529TyrLys: 0.529 ± 0.025	2.409TyrLeu: 2.409 ± 0.051	0.431TyrMet: 0.431 ± 0.021	0.636TyrAsn: 0.636 ± 0.029	1.155TyrPro: 1.155 ± 0.037	0.776TyrGln: 0.776 ± 0.026	2.177TyrArg: 2.177 ± 0.048	1.228TyrSer: 1.228 ± 0.039	1.247TyrThr: 1.247 ± 0.052	1.576TyrVal: 1.576 ± 0.041	0.392TyrTrp: 0.392 ± 0.02	0.672TyrTyr: 0.672 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3262 proteins (1109580 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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