Amino acid dipepetide frequency for Gordonia phage Tangerine

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.914AlaAla: 16.914 ± 1.322
0.873AlaCys: 0.873 ± 0.245
9.112AlaAsp: 9.112 ± 0.929
8.73AlaGlu: 8.73 ± 0.971
3.165AlaPhe: 3.165 ± 0.524
11.894AlaGly: 11.894 ± 1.09
1.964AlaHis: 1.964 ± 0.286
6.493AlaIle: 6.493 ± 0.933
4.038AlaLys: 4.038 ± 0.483
9.985AlaLeu: 9.985 ± 1.101
2.292AlaMet: 2.292 ± 0.284
3.219AlaAsn: 3.219 ± 0.568
6.875AlaPro: 6.875 ± 0.697
5.02AlaGln: 5.02 ± 0.522
8.021AlaArg: 8.021 ± 0.861
6.275AlaSer: 6.275 ± 0.908
6.493AlaThr: 6.493 ± 0.645
8.021AlaVal: 8.021 ± 0.765
2.401AlaTrp: 2.401 ± 0.378
2.401AlaTyr: 2.401 ± 0.37
0.0AlaXaa: 0.0 ± 0.0
Cys
1.309CysAla: 1.309 ± 0.32
0.055CysCys: 0.055 ± 0.067
0.546CysAsp: 0.546 ± 0.208
0.491CysGlu: 0.491 ± 0.176
0.109CysPhe: 0.109 ± 0.08
1.473CysGly: 1.473 ± 0.31
0.327CysHis: 0.327 ± 0.178
0.164CysIle: 0.164 ± 0.121
0.109CysLys: 0.109 ± 0.102
0.382CysLeu: 0.382 ± 0.153
0.055CysMet: 0.055 ± 0.055
0.218CysAsn: 0.218 ± 0.108
0.546CysPro: 0.546 ± 0.178
0.382CysGln: 0.382 ± 0.145
0.491CysArg: 0.491 ± 0.172
0.764CysSer: 0.764 ± 0.188
0.491CysThr: 0.491 ± 0.163
0.382CysVal: 0.382 ± 0.157
0.055CysTrp: 0.055 ± 0.061
0.055CysTyr: 0.055 ± 0.053
0.0CysXaa: 0.0 ± 0.0
Asp
8.839AspAla: 8.839 ± 0.84
0.273AspCys: 0.273 ± 0.125
8.021AspAsp: 8.021 ± 1.064
6.438AspGlu: 6.438 ± 0.876
0.982AspPhe: 0.982 ± 0.301
7.966AspGly: 7.966 ± 0.751
1.582AspHis: 1.582 ± 0.38
1.855AspIle: 1.855 ± 0.283
1.146AspLys: 1.146 ± 0.213
5.183AspLeu: 5.183 ± 0.675
1.746AspMet: 1.746 ± 0.273
2.237AspAsn: 2.237 ± 0.415
7.311AspPro: 7.311 ± 0.831
2.674AspGln: 2.674 ± 0.386
4.965AspArg: 4.965 ± 0.621
2.401AspSer: 2.401 ± 0.345
3.328AspThr: 3.328 ± 0.464
6.165AspVal: 6.165 ± 0.604
1.637AspTrp: 1.637 ± 0.346
1.691AspTyr: 1.691 ± 0.388
0.0AspXaa: 0.0 ± 0.0
Glu
5.674GluAla: 5.674 ± 0.649
0.6GluCys: 0.6 ± 0.204
3.001GluAsp: 3.001 ± 0.449
1.364GluGlu: 1.364 ± 0.315
2.019GluPhe: 2.019 ± 0.322
3.765GluGly: 3.765 ± 0.442
1.746GluHis: 1.746 ± 0.335
2.51GluIle: 2.51 ± 0.28
1.364GluLys: 1.364 ± 0.274
5.129GluLeu: 5.129 ± 0.827
0.873GluMet: 0.873 ± 0.21
1.528GluAsn: 1.528 ± 0.3
3.274GluPro: 3.274 ± 0.545
3.437GluGln: 3.437 ± 0.503
3.765GluArg: 3.765 ± 0.588
2.237GluSer: 2.237 ± 0.492
3.546GluThr: 3.546 ± 0.482
4.638GluVal: 4.638 ± 0.522
1.855GluTrp: 1.855 ± 0.43
2.019GluTyr: 2.019 ± 0.292
0.0GluXaa: 0.0 ± 0.0
Phe
3.546PheAla: 3.546 ± 0.492
0.436PheCys: 0.436 ± 0.172
2.401PheAsp: 2.401 ± 0.344
1.691PheGlu: 1.691 ± 0.383
0.491PhePhe: 0.491 ± 0.192
2.837PheGly: 2.837 ± 0.39
0.546PheHis: 0.546 ± 0.184
1.419PheIle: 1.419 ± 0.267
0.6PheLys: 0.6 ± 0.171
1.691PheLeu: 1.691 ± 0.3
0.436PheMet: 0.436 ± 0.148
0.491PheAsn: 0.491 ± 0.165
0.818PhePro: 0.818 ± 0.214
0.382PheGln: 0.382 ± 0.144
1.146PheArg: 1.146 ± 0.233
1.091PheSer: 1.091 ± 0.232
1.691PheThr: 1.691 ± 0.292
1.855PheVal: 1.855 ± 0.348
0.327PheTrp: 0.327 ± 0.138
0.273PheTyr: 0.273 ± 0.117
0.0PheXaa: 0.0 ± 0.0
Gly
10.421GlyAla: 10.421 ± 1.225
0.764GlyCys: 0.764 ± 0.248
6.329GlyAsp: 6.329 ± 0.701
4.038GlyGlu: 4.038 ± 0.562
2.073GlyPhe: 2.073 ± 0.425
8.239GlyGly: 8.239 ± 1.088
2.346GlyHis: 2.346 ± 0.416
3.874GlyIle: 3.874 ± 0.521
2.51GlyLys: 2.51 ± 0.438
6.002GlyLeu: 6.002 ± 0.871
2.073GlyMet: 2.073 ± 0.317
2.128GlyAsn: 2.128 ± 0.393
4.147GlyPro: 4.147 ± 0.592
3.383GlyGln: 3.383 ± 0.523
7.802GlyArg: 7.802 ± 0.779
5.292GlySer: 5.292 ± 0.612
5.838GlyThr: 5.838 ± 0.771
7.311GlyVal: 7.311 ± 0.604
1.419GlyTrp: 1.419 ± 0.245
2.292GlyTyr: 2.292 ± 0.389
0.0GlyXaa: 0.0 ± 0.0
His
1.582HisAla: 1.582 ± 0.271
0.055HisCys: 0.055 ± 0.053
1.801HisAsp: 1.801 ± 0.324
1.801HisGlu: 1.801 ± 0.359
0.218HisPhe: 0.218 ± 0.119
1.2HisGly: 1.2 ± 0.23
0.436HisHis: 0.436 ± 0.176
0.709HisIle: 0.709 ± 0.181
0.491HisLys: 0.491 ± 0.16
2.019HisLeu: 2.019 ± 0.396
0.764HisMet: 0.764 ± 0.208
0.382HisAsn: 0.382 ± 0.141
1.255HisPro: 1.255 ± 0.259
0.873HisGln: 0.873 ± 0.213
1.746HisArg: 1.746 ± 0.349
0.818HisSer: 0.818 ± 0.257
2.073HisThr: 2.073 ± 0.377
1.91HisVal: 1.91 ± 0.385
0.327HisTrp: 0.327 ± 0.129
0.382HisTyr: 0.382 ± 0.134
0.0HisXaa: 0.0 ± 0.0
Ile
6.056IleAla: 6.056 ± 0.627
0.273IleCys: 0.273 ± 0.114
3.874IleAsp: 3.874 ± 0.363
3.819IleGlu: 3.819 ± 0.454
0.491IlePhe: 0.491 ± 0.242
4.147IleGly: 4.147 ± 0.876
0.655IleHis: 0.655 ± 0.171
2.182IleIle: 2.182 ± 0.405
0.818IleLys: 0.818 ± 0.367
2.237IleLeu: 2.237 ± 0.359
0.655IleMet: 0.655 ± 0.205
0.764IleAsn: 0.764 ± 0.21
3.001IlePro: 3.001 ± 0.349
0.982IleGln: 0.982 ± 0.289
2.783IleArg: 2.783 ± 0.321
2.019IleSer: 2.019 ± 0.421
3.874IleThr: 3.874 ± 0.469
3.819IleVal: 3.819 ± 0.362
0.764IleTrp: 0.764 ± 0.164
0.709IleTyr: 0.709 ± 0.2
0.0IleXaa: 0.0 ± 0.0
Lys
2.946LysAla: 2.946 ± 0.429
0.055LysCys: 0.055 ± 0.058
0.982LysAsp: 0.982 ± 0.213
0.655LysGlu: 0.655 ± 0.17
1.255LysPhe: 1.255 ± 0.289
1.691LysGly: 1.691 ± 0.334
0.436LysHis: 0.436 ± 0.126
1.691LysIle: 1.691 ± 0.324
0.6LysLys: 0.6 ± 0.166
1.691LysLeu: 1.691 ± 0.296
0.491LysMet: 0.491 ± 0.175
0.6LysAsn: 0.6 ± 0.195
1.364LysPro: 1.364 ± 0.256
1.091LysGln: 1.091 ± 0.278
2.073LysArg: 2.073 ± 0.355
1.582LysSer: 1.582 ± 0.371
1.419LysThr: 1.419 ± 0.269
1.801LysVal: 1.801 ± 0.281
0.546LysTrp: 0.546 ± 0.172
0.764LysTyr: 0.764 ± 0.199
0.0LysXaa: 0.0 ± 0.0
Leu
9.712LeuAla: 9.712 ± 0.768
0.928LeuCys: 0.928 ± 0.251
5.784LeuAsp: 5.784 ± 0.707
2.51LeuGlu: 2.51 ± 0.504
2.346LeuPhe: 2.346 ± 0.419
7.257LeuGly: 7.257 ± 1.216
1.801LeuHis: 1.801 ± 0.378
2.674LeuIle: 2.674 ± 0.402
0.982LeuLys: 0.982 ± 0.269
5.456LeuLeu: 5.456 ± 0.685
1.255LeuMet: 1.255 ± 0.251
2.073LeuAsn: 2.073 ± 0.348
4.474LeuPro: 4.474 ± 0.524
3.328LeuGln: 3.328 ± 0.557
6.22LeuArg: 6.22 ± 0.472
3.328LeuSer: 3.328 ± 0.382
5.456LeuThr: 5.456 ± 0.572
6.711LeuVal: 6.711 ± 0.674
1.691LeuTrp: 1.691 ± 0.338
1.419LeuTyr: 1.419 ± 0.317
0.0LeuXaa: 0.0 ± 0.0
Met
1.582MetAla: 1.582 ± 0.282
0.109MetCys: 0.109 ± 0.081
1.091MetAsp: 1.091 ± 0.223
0.655MetGlu: 0.655 ± 0.221
0.546MetPhe: 0.546 ± 0.179
1.473MetGly: 1.473 ± 0.299
0.382MetHis: 0.382 ± 0.16
0.818MetIle: 0.818 ± 0.2
0.6MetLys: 0.6 ± 0.217
2.128MetLeu: 2.128 ± 0.353
0.273MetMet: 0.273 ± 0.131
0.818MetAsn: 0.818 ± 0.222
1.746MetPro: 1.746 ± 0.28
0.982MetGln: 0.982 ± 0.315
1.582MetArg: 1.582 ± 0.299
1.473MetSer: 1.473 ± 0.308
2.946MetThr: 2.946 ± 0.382
1.637MetVal: 1.637 ± 0.285
0.327MetTrp: 0.327 ± 0.124
0.109MetTyr: 0.109 ± 0.073
0.0MetXaa: 0.0 ± 0.0
Asn
3.437AsnAla: 3.437 ± 0.435
0.382AsnCys: 0.382 ± 0.155
2.401AsnAsp: 2.401 ± 0.359
1.037AsnGlu: 1.037 ± 0.315
0.546AsnPhe: 0.546 ± 0.157
3.055AsnGly: 3.055 ± 0.461
0.491AsnHis: 0.491 ± 0.156
0.982AsnIle: 0.982 ± 0.293
0.491AsnLys: 0.491 ± 0.187
1.91AsnLeu: 1.91 ± 0.375
0.764AsnMet: 0.764 ± 0.212
0.709AsnAsn: 0.709 ± 0.168
2.346AsnPro: 2.346 ± 0.396
0.491AsnGln: 0.491 ± 0.149
1.309AsnArg: 1.309 ± 0.317
1.637AsnSer: 1.637 ± 0.29
1.582AsnThr: 1.582 ± 0.292
2.019AsnVal: 2.019 ± 0.268
0.655AsnTrp: 0.655 ± 0.221
0.546AsnTyr: 0.546 ± 0.212
0.0AsnXaa: 0.0 ± 0.0
Pro
7.639ProAla: 7.639 ± 0.732
0.327ProCys: 0.327 ± 0.18
6.111ProAsp: 6.111 ± 0.828
3.928ProGlu: 3.928 ± 0.596
1.582ProPhe: 1.582 ± 0.38
5.292ProGly: 5.292 ± 0.455
1.255ProHis: 1.255 ± 0.237
3.546ProIle: 3.546 ± 0.483
1.473ProLys: 1.473 ± 0.291
4.365ProLeu: 4.365 ± 0.436
1.255ProMet: 1.255 ± 0.279
2.128ProAsn: 2.128 ± 0.344
4.256ProPro: 4.256 ± 0.602
1.582ProGln: 1.582 ± 0.293
3.437ProArg: 3.437 ± 0.458
2.728ProSer: 2.728 ± 0.425
4.038ProThr: 4.038 ± 0.478
5.02ProVal: 5.02 ± 0.613
0.928ProTrp: 0.928 ± 0.22
1.528ProTyr: 1.528 ± 0.29
0.0ProXaa: 0.0 ± 0.0
Gln
5.729GlnAla: 5.729 ± 0.477
0.491GlnCys: 0.491 ± 0.17
0.982GlnAsp: 0.982 ± 0.257
1.2GlnGlu: 1.2 ± 0.224
1.091GlnPhe: 1.091 ± 0.21
1.855GlnGly: 1.855 ± 0.313
0.873GlnHis: 0.873 ± 0.215
1.691GlnIle: 1.691 ± 0.304
0.982GlnLys: 0.982 ± 0.218
3.11GlnLeu: 3.11 ± 0.422
0.928GlnMet: 0.928 ± 0.2
0.873GlnAsn: 0.873 ± 0.229
2.892GlnPro: 2.892 ± 0.403
2.783GlnGln: 2.783 ± 0.42
3.492GlnArg: 3.492 ± 0.512
1.691GlnSer: 1.691 ± 0.33
2.51GlnThr: 2.51 ± 0.375
3.165GlnVal: 3.165 ± 0.406
0.818GlnTrp: 0.818 ± 0.188
0.818GlnTyr: 0.818 ± 0.19
0.0GlnXaa: 0.0 ± 0.0
Arg
9.603ArgAla: 9.603 ± 0.806
0.491ArgCys: 0.491 ± 0.191
5.02ArgAsp: 5.02 ± 0.564
3.437ArgGlu: 3.437 ± 0.432
1.528ArgPhe: 1.528 ± 0.355
4.747ArgGly: 4.747 ± 0.742
1.255ArgHis: 1.255 ± 0.318
3.983ArgIle: 3.983 ± 0.511
2.401ArgLys: 2.401 ± 0.435
5.183ArgLeu: 5.183 ± 0.65
2.401ArgMet: 2.401 ± 0.438
2.455ArgAsn: 2.455 ± 0.333
3.437ArgPro: 3.437 ± 0.496
2.837ArgGln: 2.837 ± 0.435
9.33ArgArg: 9.33 ± 1.249
2.892ArgSer: 2.892 ± 0.453
3.71ArgThr: 3.71 ± 0.548
5.838ArgVal: 5.838 ± 0.704
1.91ArgTrp: 1.91 ± 0.381
2.182ArgTyr: 2.182 ± 0.412
0.0ArgXaa: 0.0 ± 0.0
Ser
6.329SerAla: 6.329 ± 0.832
0.491SerCys: 0.491 ± 0.178
3.11SerAsp: 3.11 ± 0.513
2.019SerGlu: 2.019 ± 0.374
1.091SerPhe: 1.091 ± 0.225
5.238SerGly: 5.238 ± 0.726
1.146SerHis: 1.146 ± 0.228
2.019SerIle: 2.019 ± 0.327
1.2SerLys: 1.2 ± 0.321
3.546SerLeu: 3.546 ± 0.445
1.037SerMet: 1.037 ± 0.264
1.091SerAsn: 1.091 ± 0.31
2.674SerPro: 2.674 ± 0.446
1.582SerGln: 1.582 ± 0.429
3.11SerArg: 3.11 ± 0.442
3.383SerSer: 3.383 ± 0.67
3.71SerThr: 3.71 ± 0.515
4.038SerVal: 4.038 ± 0.41
1.309SerTrp: 1.309 ± 0.359
0.982SerTyr: 0.982 ± 0.236
0.0SerXaa: 0.0 ± 0.0
Thr
8.512ThrAla: 8.512 ± 0.745
0.655ThrCys: 0.655 ± 0.21
5.238ThrAsp: 5.238 ± 0.522
3.219ThrGlu: 3.219 ± 0.373
1.746ThrPhe: 1.746 ± 0.405
5.674ThrGly: 5.674 ± 0.637
1.146ThrHis: 1.146 ± 0.356
2.946ThrIle: 2.946 ± 0.453
1.528ThrLys: 1.528 ± 0.274
5.238ThrLeu: 5.238 ± 0.43
1.419ThrMet: 1.419 ± 0.262
1.855ThrAsn: 1.855 ± 0.323
5.292ThrPro: 5.292 ± 0.578
1.528ThrGln: 1.528 ± 0.242
3.928ThrArg: 3.928 ± 0.538
3.383ThrSer: 3.383 ± 0.488
4.474ThrThr: 4.474 ± 0.542
5.129ThrVal: 5.129 ± 0.638
1.255ThrTrp: 1.255 ± 0.246
1.309ThrTyr: 1.309 ± 0.24
0.0ThrXaa: 0.0 ± 0.0
Val
9.112ValAla: 9.112 ± 0.88
0.818ValCys: 0.818 ± 0.256
7.748ValAsp: 7.748 ± 0.739
4.801ValGlu: 4.801 ± 0.489
1.473ValPhe: 1.473 ± 0.222
7.311ValGly: 7.311 ± 0.592
1.528ValHis: 1.528 ± 0.285
3.001ValIle: 3.001 ± 0.441
1.582ValLys: 1.582 ± 0.21
5.674ValLeu: 5.674 ± 0.62
1.2ValMet: 1.2 ± 0.245
2.292ValAsn: 2.292 ± 0.327
4.201ValPro: 4.201 ± 0.528
3.055ValGln: 3.055 ± 0.288
5.565ValArg: 5.565 ± 0.603
3.765ValSer: 3.765 ± 0.418
5.62ValThr: 5.62 ± 0.58
6.493ValVal: 6.493 ± 0.651
2.073ValTrp: 2.073 ± 0.345
1.91ValTyr: 1.91 ± 0.372
0.0ValXaa: 0.0 ± 0.0
Trp
2.783TrpAla: 2.783 ± 0.462
0.273TrpCys: 0.273 ± 0.127
1.146TrpAsp: 1.146 ± 0.247
1.037TrpGlu: 1.037 ± 0.281
0.709TrpPhe: 0.709 ± 0.201
0.928TrpGly: 0.928 ± 0.224
0.491TrpHis: 0.491 ± 0.189
0.928TrpIle: 0.928 ± 0.203
0.546TrpLys: 0.546 ± 0.19
2.564TrpLeu: 2.564 ± 0.41
0.764TrpMet: 0.764 ± 0.179
0.436TrpAsn: 0.436 ± 0.198
1.255TrpPro: 1.255 ± 0.295
0.928TrpGln: 0.928 ± 0.212
1.855TrpArg: 1.855 ± 0.343
1.364TrpSer: 1.364 ± 0.291
1.037TrpThr: 1.037 ± 0.268
1.255TrpVal: 1.255 ± 0.278
0.436TrpTrp: 0.436 ± 0.18
0.436TrpTyr: 0.436 ± 0.14
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.455TyrAla: 2.455 ± 0.443
0.055TyrCys: 0.055 ± 0.053
1.746TyrAsp: 1.746 ± 0.328
1.473TyrGlu: 1.473 ± 0.279
0.709TyrPhe: 0.709 ± 0.185
2.237TyrGly: 2.237 ± 0.344
0.436TyrHis: 0.436 ± 0.182
0.436TyrIle: 0.436 ± 0.168
0.273TyrLys: 0.273 ± 0.126
1.964TyrLeu: 1.964 ± 0.335
0.546TyrMet: 0.546 ± 0.13
0.491TyrAsn: 0.491 ± 0.212
1.255TyrPro: 1.255 ± 0.292
0.655TyrGln: 0.655 ± 0.198
2.019TyrArg: 2.019 ± 0.336
0.982TyrSer: 0.982 ± 0.185
1.637TyrThr: 1.637 ± 0.299
2.019TyrVal: 2.019 ± 0.34
0.436TyrTrp: 0.436 ± 0.151
0.382TyrTyr: 0.382 ± 0.136
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 85 proteins (18329 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski