human papillomavirus 74

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 10

Average proteome isoelectric point is 6.45

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 8 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|Q8B5W6|Q8B5W6_9PAPI Uncharacterized protein E4 OS=human papillomavirus 74 OX=44028 GN=E4 PE=3 SV=1
MM1 pKa = 7.89DD2 pKa = 7.06LIPIDD7 pKa = 3.77GTIGTTSTSILPVVIAVFVCIVSIVLIIAITDD39 pKa = 3.75FFVYY43 pKa = 10.16TSILVLTLILYY54 pKa = 9.94LLLWLLLTSALQFYY68 pKa = 9.15TLTLCVCYY76 pKa = 10.46LPAFSLHH83 pKa = 7.12LYY85 pKa = 9.37ILHH88 pKa = 6.36NLEE91 pKa = 4.07

Molecular weight: 10.15 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|Q8B5W7|Q8B5W7_9PAPI Regulatory protein E2 OS=human papillomavirus 74 OX=44028 GN=E2 PE=3 SV=1
MM1 pKa = 6.68YY2 pKa = 10.36RR3 pKa = 11.84EE4 pKa = 4.87GIKK7 pKa = 8.85HH8 pKa = 4.66TTQILKK14 pKa = 10.43LRR16 pKa = 11.84LKK18 pKa = 11.14NMGIRR23 pKa = 11.84CSGKK27 pKa = 10.0CVLAAQLYY35 pKa = 9.16VLLHH39 pKa = 6.71LYY41 pKa = 10.33LVLCKK46 pKa = 9.93TYY48 pKa = 10.34PLLGLLHH55 pKa = 6.68TPPPPPLHH63 pKa = 7.01RR64 pKa = 11.84PPQQCPLPPPRR75 pKa = 11.84ITWTRR80 pKa = 11.84RR81 pKa = 11.84PVKK84 pKa = 10.34DD85 pKa = 4.15PEE87 pKa = 4.54DD88 pKa = 3.9VPPTPTPPTTPTTPEE103 pKa = 4.3APCVSQTEE111 pKa = 4.69TPWTVQTTTSSLTITTITKK130 pKa = 10.36DD131 pKa = 3.11GTTVTVEE138 pKa = 3.73LRR140 pKa = 11.84LL141 pKa = 3.72

Molecular weight: 15.72 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

8

0

8

2490

91

640

311.3

34.73

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.185 ± 0.381

2.972 ± 0.717

5.06 ± 0.603

4.578 ± 0.533

3.815 ± 0.628

5.422 ± 0.528

2.892 ± 0.345

5.502 ± 0.72

4.94 ± 0.824

8.956 ± 1.014

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.968 ± 0.18

4.498 ± 0.598

6.787 ± 1.252

4.779 ± 0.428

4.096 ± 0.365

7.229 ± 1.047

8.514 ± 0.822

6.827 ± 0.255

1.446 ± 0.249

3.534 ± 0.452
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski