Amino acid dipepetide frequency for Calothrix brevissima NIES-22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.414AlaAla: 7.414 ± 0.079	0.757AlaCys: 0.757 ± 0.017	4.208AlaAsp: 4.208 ± 0.051	5.238AlaGlu: 5.238 ± 0.059	2.934AlaPhe: 2.934 ± 0.037	5.375AlaGly: 5.375 ± 0.068	1.2AlaHis: 1.2 ± 0.025	7.283AlaIle: 7.283 ± 0.067	4.391AlaLys: 4.391 ± 0.047	8.44AlaLeu: 8.44 ± 0.084	1.504AlaMet: 1.504 ± 0.025	3.942AlaAsn: 3.942 ± 0.05	2.862AlaPro: 2.862 ± 0.041	4.427AlaGln: 4.427 ± 0.055	3.382AlaArg: 3.382 ± 0.045	4.89AlaSer: 4.89 ± 0.05	4.853AlaThr: 4.853 ± 0.059	5.405AlaVal: 5.405 ± 0.05	0.987AlaTrp: 0.987 ± 0.023	2.419AlaTyr: 2.419 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.635CysAla: 0.635 ± 0.014	0.132CysCys: 0.132 ± 0.007	0.543CysAsp: 0.543 ± 0.017	0.501CysGlu: 0.501 ± 0.015	0.401CysPhe: 0.401 ± 0.012	0.729CysGly: 0.729 ± 0.021	0.264CysHis: 0.264 ± 0.011	0.571CysIle: 0.571 ± 0.015	0.341CysLys: 0.341 ± 0.013	1.117CysLeu: 1.117 ± 0.026	0.13CysMet: 0.13 ± 0.008	0.393CysAsn: 0.393 ± 0.013	0.507CysPro: 0.507 ± 0.016	0.6CysGln: 0.6 ± 0.018	0.449CysArg: 0.449 ± 0.014	0.56CysSer: 0.56 ± 0.016	0.431CysThr: 0.431 ± 0.012	0.545CysVal: 0.545 ± 0.017	0.136CysTrp: 0.136 ± 0.008	0.332CysTyr: 0.332 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.717AspAla: 3.717 ± 0.048	0.516AspCys: 0.516 ± 0.016	2.291AspAsp: 2.291 ± 0.044	2.925AspGlu: 2.925 ± 0.043	2.272AspPhe: 2.272 ± 0.037	3.435AspGly: 3.435 ± 0.063	0.553AspHis: 0.553 ± 0.018	3.691AspIle: 3.691 ± 0.044	2.567AspLys: 2.567 ± 0.038	5.485AspLeu: 5.485 ± 0.057	0.743AspMet: 0.743 ± 0.019	2.404AspAsn: 2.404 ± 0.043	2.087AspPro: 2.087 ± 0.037	1.408AspGln: 1.408 ± 0.029	3.206AspArg: 3.206 ± 0.045	2.985AspSer: 2.985 ± 0.04	2.636AspThr: 2.636 ± 0.046	3.024AspVal: 3.024 ± 0.042	0.913AspTrp: 0.913 ± 0.019	1.944AspTyr: 1.944 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.073GluAla: 5.073 ± 0.055	0.455GluCys: 0.455 ± 0.015	2.643GluAsp: 2.643 ± 0.035	3.661GluGlu: 3.661 ± 0.056	2.48GluPhe: 2.48 ± 0.035	2.857GluGly: 2.857 ± 0.034	0.958GluHis: 0.958 ± 0.019	5.153GluIle: 5.153 ± 0.054	3.523GluLys: 3.523 ± 0.046	6.95GluLeu: 6.95 ± 0.07	1.182GluMet: 1.182 ± 0.021	2.876GluAsn: 2.876 ± 0.031	2.241GluPro: 2.241 ± 0.032	3.632GluGln: 3.632 ± 0.05	3.22GluArg: 3.22 ± 0.042	3.339GluSer: 3.339 ± 0.038	3.321GluThr: 3.321 ± 0.045	4.046GluVal: 4.046 ± 0.052	0.741GluTrp: 0.741 ± 0.019	2.025GluTyr: 2.025 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.149PheAla: 3.149 ± 0.04	0.517PheCys: 0.517 ± 0.016	2.18PheAsp: 2.18 ± 0.036	2.003PheGlu: 2.003 ± 0.034	1.625PhePhe: 1.625 ± 0.026	2.777PheGly: 2.777 ± 0.042	0.728PheHis: 0.728 ± 0.018	2.578PheIle: 2.578 ± 0.034	1.57PheLys: 1.57 ± 0.029	4.033PheLeu: 4.033 ± 0.048	0.674PheMet: 0.674 ± 0.017	1.948PheAsn: 1.948 ± 0.034	1.709PhePro: 1.709 ± 0.028	1.858PheGln: 1.858 ± 0.031	1.741PheArg: 1.741 ± 0.029	2.944PheSer: 2.944 ± 0.041	2.506PheThr: 2.506 ± 0.042	2.336PheVal: 2.336 ± 0.029	0.691PheTrp: 0.691 ± 0.017	1.392PheTyr: 1.392 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	4.668GlyAla: 4.668 ± 0.06	0.723GlyCys: 0.723 ± 0.021	3.402GlyAsp: 3.402 ± 0.049	4.005GlyGlu: 4.005 ± 0.048	2.756GlyPhe: 2.756 ± 0.036	4.814GlyGly: 4.814 ± 0.089	1.16GlyHis: 1.16 ± 0.028	5.067GlyIle: 5.067 ± 0.056	4.261GlyLys: 4.261 ± 0.05	6.623GlyLeu: 6.623 ± 0.051	1.338GlyMet: 1.338 ± 0.024	3.628GlyAsn: 3.628 ± 0.095	1.107GlyPro: 1.107 ± 0.023	2.841GlyGln: 2.841 ± 0.04	3.007GlyArg: 3.007 ± 0.042	4.063GlySer: 4.063 ± 0.066	3.908GlyThr: 3.908 ± 0.072	4.411GlyVal: 4.411 ± 0.054	1.048GlyTrp: 1.048 ± 0.021	2.352GlyTyr: 2.352 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	1.015HisAla: 1.015 ± 0.024	0.247HisCys: 0.247 ± 0.01	0.736HisAsp: 0.736 ± 0.018	0.9HisGlu: 0.9 ± 0.02	0.743HisPhe: 0.743 ± 0.02	1.053HisGly: 1.053 ± 0.027	0.604HisHis: 0.604 ± 0.021	1.151HisIle: 1.151 ± 0.021	0.811HisLys: 0.811 ± 0.024	2.131HisLeu: 2.131 ± 0.031	0.215HisMet: 0.215 ± 0.01	0.801HisAsn: 0.801 ± 0.021	1.287HisPro: 1.287 ± 0.026	1.199HisGln: 1.199 ± 0.027	0.998HisArg: 0.998 ± 0.024	1.187HisSer: 1.187 ± 0.026	0.923HisThr: 0.923 ± 0.02	0.747HisVal: 0.747 ± 0.022	0.343HisTrp: 0.343 ± 0.011	0.618HisTyr: 0.618 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.648IleAla: 7.648 ± 0.068	0.757IleCys: 0.757 ± 0.018	3.762IleAsp: 3.762 ± 0.045	4.238IleGlu: 4.238 ± 0.05	2.752IlePhe: 2.752 ± 0.037	4.501IleGly: 4.501 ± 0.049	1.325IleHis: 1.325 ± 0.025	4.188IleIle: 4.188 ± 0.048	3.426IleLys: 3.426 ± 0.046	6.986IleLeu: 6.986 ± 0.062	0.852IleMet: 0.852 ± 0.021	3.719IleAsn: 3.719 ± 0.051	3.671IlePro: 3.671 ± 0.045	3.419IleGln: 3.419 ± 0.043	3.008IleArg: 3.008 ± 0.04	4.838IleSer: 4.838 ± 0.05	4.069IleThr: 4.069 ± 0.055	4.403IleVal: 4.403 ± 0.042	0.988IleTrp: 0.988 ± 0.024	2.211IleTyr: 2.211 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.165LysAla: 4.165 ± 0.053	0.332LysCys: 0.332 ± 0.012	2.291LysAsp: 2.291 ± 0.035	2.799LysGlu: 2.799 ± 0.042	1.99LysPhe: 1.99 ± 0.028	2.667LysGly: 2.667 ± 0.039	0.864LysHis: 0.864 ± 0.021	3.882LysIle: 3.882 ± 0.049	2.459LysLys: 2.459 ± 0.038	5.798LysLeu: 5.798 ± 0.059	0.924LysMet: 0.924 ± 0.021	2.404LysAsn: 2.404 ± 0.037	2.528LysPro: 2.528 ± 0.037	2.975LysGln: 2.975 ± 0.044	2.224LysArg: 2.224 ± 0.036	3.16LysSer: 3.16 ± 0.042	3.044LysThr: 3.044 ± 0.041	3.255LysVal: 3.255 ± 0.036	0.529LysTrp: 0.529 ± 0.014	1.64LysTyr: 1.64 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	9.823LeuAla: 9.823 ± 0.091	0.94LeuCys: 0.94 ± 0.019	5.153LeuAsp: 5.153 ± 0.052	6.991LeuGlu: 6.991 ± 0.068	3.691LeuPhe: 3.691 ± 0.044	7.377LeuGly: 7.377 ± 0.059	1.82LeuHis: 1.82 ± 0.025	6.996LeuIle: 6.996 ± 0.07	5.583LeuLys: 5.583 ± 0.066	11.241LeuLeu: 11.241 ± 0.086	1.929LeuMet: 1.929 ± 0.032	5.062LeuAsn: 5.062 ± 0.063	5.66LeuPro: 5.66 ± 0.058	6.167LeuGln: 6.167 ± 0.07	5.309LeuArg: 5.309 ± 0.052	7.398LeuSer: 7.398 ± 0.06	6.54LeuThr: 6.54 ± 0.073	6.991LeuVal: 6.991 ± 0.061	1.43LeuTrp: 1.43 ± 0.031	2.762LeuTyr: 2.762 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	1.474MetAla: 1.474 ± 0.026	0.108MetCys: 0.108 ± 0.007	0.636MetAsp: 0.636 ± 0.017	0.86MetGlu: 0.86 ± 0.018	0.531MetPhe: 0.531 ± 0.015	1.19MetGly: 1.19 ± 0.024	0.304MetHis: 0.304 ± 0.011	0.984MetIle: 0.984 ± 0.022	0.899MetLys: 0.899 ± 0.018	1.834MetLeu: 1.834 ± 0.03	0.398MetMet: 0.398 ± 0.015	0.822MetAsn: 0.822 ± 0.017	0.851MetPro: 0.851 ± 0.02	0.954MetGln: 0.954 ± 0.023	0.926MetArg: 0.926 ± 0.02	1.277MetSer: 1.277 ± 0.022	1.237MetThr: 1.237 ± 0.024	1.161MetVal: 1.161 ± 0.023	0.156MetTrp: 0.156 ± 0.009	0.361MetTyr: 0.361 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.359AsnAla: 3.359 ± 0.048	0.497AsnCys: 0.497 ± 0.016	1.946AsnAsp: 1.946 ± 0.058	1.982AsnGlu: 1.982 ± 0.032	2.131AsnPhe: 2.131 ± 0.035	2.992AsnGly: 2.992 ± 0.067	0.939AsnHis: 0.939 ± 0.022	3.503AsnIle: 3.503 ± 0.061	1.927AsnLys: 1.927 ± 0.032	6.082AsnLeu: 6.082 ± 0.069	0.649AsnMet: 0.649 ± 0.018	2.647AsnAsn: 2.647 ± 0.05	3.155AsnPro: 3.155 ± 0.045	3.148AsnGln: 3.148 ± 0.047	2.424AsnArg: 2.424 ± 0.03	3.692AsnSer: 3.692 ± 0.057	2.647AsnThr: 2.647 ± 0.042	2.425AsnVal: 2.425 ± 0.038	0.787AsnTrp: 0.787 ± 0.02	1.745AsnTyr: 1.745 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.194ProAla: 3.194 ± 0.036	0.341ProCys: 0.341 ± 0.013	2.848ProAsp: 2.848 ± 0.032	3.762ProGlu: 3.762 ± 0.046	1.645ProPhe: 1.645 ± 0.026	2.932ProGly: 2.932 ± 0.042	0.896ProHis: 0.896 ± 0.02	3.135ProIle: 3.135 ± 0.038	2.267ProLys: 2.267 ± 0.04	4.491ProLeu: 4.491 ± 0.047	0.685ProMet: 0.685 ± 0.015	2.374ProAsn: 2.374 ± 0.039	2.194ProPro: 2.194 ± 0.04	2.816ProGln: 2.816 ± 0.04	1.617ProArg: 1.617 ± 0.027	2.877ProSer: 2.877 ± 0.038	2.899ProThr: 2.899 ± 0.057	3.208ProVal: 3.208 ± 0.047	0.556ProTrp: 0.556 ± 0.016	1.261ProTyr: 1.261 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	5.089GlnAla: 5.089 ± 0.066	0.361GlnCys: 0.361 ± 0.013	2.215GlnAsp: 2.215 ± 0.03	3.699GlnGlu: 3.699 ± 0.045	1.855GlnPhe: 1.855 ± 0.028	3.454GlnGly: 3.454 ± 0.042	0.88GlnHis: 0.88 ± 0.022	4.037GlnIle: 4.037 ± 0.05	2.978GlnLys: 2.978 ± 0.042	6.251GlnLeu: 6.251 ± 0.076	1.028GlnMet: 1.028 ± 0.023	2.427GlnAsn: 2.427 ± 0.033	2.823GlnPro: 2.823 ± 0.037	4.493GlnGln: 4.493 ± 0.075	2.887GlnArg: 2.887 ± 0.037	3.169GlnSer: 3.169 ± 0.048	3.111GlnThr: 3.111 ± 0.041	3.769GlnVal: 3.769 ± 0.049	0.671GlnTrp: 0.671 ± 0.016	1.382GlnTyr: 1.382 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.015ArgAla: 3.015 ± 0.043	0.459ArgCys: 0.459 ± 0.013	2.481ArgAsp: 2.481 ± 0.037	3.1ArgGlu: 3.1 ± 0.046	2.03ArgPhe: 2.03 ± 0.024	2.786ArgGly: 2.786 ± 0.04	0.937ArgHis: 0.937 ± 0.022	3.246ArgIle: 3.246 ± 0.036	2.236ArgLys: 2.236 ± 0.035	5.721ArgLeu: 5.721 ± 0.049	0.902ArgMet: 0.902 ± 0.02	2.198ArgAsn: 2.198 ± 0.031	1.838ArgPro: 1.838 ± 0.033	3.264ArgGln: 3.264 ± 0.043	2.797ArgArg: 2.797 ± 0.041	3.048ArgSer: 3.048 ± 0.036	2.383ArgThr: 2.383 ± 0.034	3.127ArgVal: 3.127 ± 0.037	0.763ArgTrp: 0.763 ± 0.018	1.849ArgTyr: 1.849 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	4.694SerAla: 4.694 ± 0.042	0.586SerCys: 0.586 ± 0.015	3.313SerAsp: 3.313 ± 0.048	3.584SerGlu: 3.584 ± 0.042	2.573SerPhe: 2.573 ± 0.037	4.619SerGly: 4.619 ± 0.06	1.328SerHis: 1.328 ± 0.027	3.97SerIle: 3.97 ± 0.047	2.771SerLys: 2.771 ± 0.037	7.602SerLeu: 7.602 ± 0.071	1.094SerMet: 1.094 ± 0.021	3.048SerAsn: 3.048 ± 0.059	3.437SerPro: 3.437 ± 0.05	4.066SerGln: 4.066 ± 0.046	3.086SerArg: 3.086 ± 0.037	4.537SerSer: 4.537 ± 0.064	3.628SerThr: 3.628 ± 0.043	3.93SerVal: 3.93 ± 0.041	0.918SerTrp: 0.918 ± 0.02	1.891SerTyr: 1.891 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.126ThrAla: 5.126 ± 0.058	0.441ThrCys: 0.441 ± 0.014	2.669ThrAsp: 2.669 ± 0.044	3.308ThrGlu: 3.308 ± 0.039	2.146ThrPhe: 2.146 ± 0.038	4.477ThrGly: 4.477 ± 0.063	0.978ThrHis: 0.978 ± 0.023	4.142ThrIle: 4.142 ± 0.046	2.462ThrLys: 2.462 ± 0.038	6.216ThrLeu: 6.216 ± 0.061	0.76ThrMet: 0.76 ± 0.022	2.604ThrAsn: 2.604 ± 0.05	3.421ThrPro: 3.421 ± 0.06	3.054ThrGln: 3.054 ± 0.04	2.194ThrArg: 2.194 ± 0.031	3.687ThrSer: 3.687 ± 0.048	3.624ThrThr: 3.624 ± 0.057	4.177ThrVal: 4.177 ± 0.064	0.722ThrTrp: 0.722 ± 0.019	1.694ThrTyr: 1.694 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	5.537ValAla: 5.537 ± 0.062	0.61ValCys: 0.61 ± 0.017	3.319ValAsp: 3.319 ± 0.047	4.17ValGlu: 4.17 ± 0.04	2.439ValPhe: 2.439 ± 0.038	4.265ValGly: 4.265 ± 0.048	0.974ValHis: 0.974 ± 0.022	4.453ValIle: 4.453 ± 0.048	3.506ValLys: 3.506 ± 0.035	6.292ValLeu: 6.292 ± 0.054	1.253ValMet: 1.253 ± 0.021	3.352ValAsn: 3.352 ± 0.053	2.722ValPro: 2.722 ± 0.041	2.771ValGln: 2.771 ± 0.034	2.967ValArg: 2.967 ± 0.042	4.159ValSer: 4.159 ± 0.04	3.968ValThr: 3.968 ± 0.052	4.565ValVal: 4.565 ± 0.053	0.794ValTrp: 0.794 ± 0.019	1.866ValTyr: 1.866 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.877TrpAla: 0.877 ± 0.018	0.141TrpCys: 0.141 ± 0.008	0.69TrpAsp: 0.69 ± 0.02	0.961TrpGlu: 0.961 ± 0.02	0.581TrpPhe: 0.581 ± 0.018	0.907TrpGly: 0.907 ± 0.019	0.314TrpHis: 0.314 ± 0.014	0.807TrpIle: 0.807 ± 0.017	0.608TrpLys: 0.608 ± 0.018	1.858TrpLeu: 1.858 ± 0.032	0.287TrpMet: 0.287 ± 0.011	0.658TrpAsn: 0.658 ± 0.016	0.253TrpPro: 0.253 ± 0.01	1.229TrpGln: 1.229 ± 0.025	0.822TrpArg: 0.822 ± 0.02	0.821TrpSer: 0.821 ± 0.022	0.592TrpThr: 0.592 ± 0.016	0.883TrpVal: 0.883 ± 0.022	0.216TrpTrp: 0.216 ± 0.01	0.433TrpTyr: 0.433 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.238TyrAla: 2.238 ± 0.034	0.394TyrCys: 0.394 ± 0.015	1.473TyrAsp: 1.473 ± 0.036	1.689TyrGlu: 1.689 ± 0.029	1.385TyrPhe: 1.385 ± 0.029	1.973TyrGly: 1.973 ± 0.03	0.685TyrHis: 0.685 ± 0.018	1.927TyrIle: 1.927 ± 0.031	1.344TyrLys: 1.344 ± 0.028	3.712TyrLeu: 3.712 ± 0.044	0.415TyrMet: 0.415 ± 0.013	1.369TyrAsn: 1.369 ± 0.029	1.647TyrPro: 1.647 ± 0.027	2.259TyrGln: 2.259 ± 0.039	1.917TyrArg: 1.917 ± 0.03	2.045TyrSer: 2.045 ± 0.029	1.58TyrThr: 1.58 ± 0.038	1.576TyrVal: 1.576 ± 0.026	0.547TyrTrp: 0.547 ± 0.017	1.12TyrTyr: 1.12 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7229 proteins (2460895 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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