Amino acid dipepetide frequency for Streptomyces lunaelactis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.683AlaAla: 20.683 ± 0.138	1.027AlaCys: 1.027 ± 0.022	8.145AlaAsp: 8.145 ± 0.067	8.777AlaGlu: 8.777 ± 0.079	3.475AlaPhe: 3.475 ± 0.038	12.787AlaGly: 12.787 ± 0.099	2.759AlaHis: 2.759 ± 0.04	3.778AlaIle: 3.778 ± 0.049	3.173AlaLys: 3.173 ± 0.046	13.933AlaLeu: 13.933 ± 0.107	2.539AlaMet: 2.539 ± 0.033	2.04AlaAsn: 2.04 ± 0.033	6.765AlaPro: 6.765 ± 0.069	3.939AlaGln: 3.939 ± 0.048	9.717AlaArg: 9.717 ± 0.076	6.089AlaSer: 6.089 ± 0.051	6.879AlaThr: 6.879 ± 0.058	12.073AlaVal: 12.073 ± 0.098	1.812AlaTrp: 1.812 ± 0.03	2.739AlaTyr: 2.739 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.076CysAla: 1.076 ± 0.023	0.105CysCys: 0.105 ± 0.007	0.48CysAsp: 0.48 ± 0.014	0.423CysGlu: 0.423 ± 0.014	0.216CysPhe: 0.216 ± 0.011	0.955CysGly: 0.955 ± 0.021	0.187CysHis: 0.187 ± 0.009	0.208CysIle: 0.208 ± 0.009	0.117CysLys: 0.117 ± 0.006	0.75CysLeu: 0.75 ± 0.018	0.126CysMet: 0.126 ± 0.007	0.145CysAsn: 0.145 ± 0.008	0.49CysPro: 0.49 ± 0.014	0.193CysGln: 0.193 ± 0.009	0.647CysArg: 0.647 ± 0.018	0.454CysSer: 0.454 ± 0.015	0.531CysThr: 0.531 ± 0.017	0.654CysVal: 0.654 ± 0.017	0.128CysTrp: 0.128 ± 0.007	0.157CysTyr: 0.157 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.498AspAla: 7.498 ± 0.062	0.445AspCys: 0.445 ± 0.014	3.462AspAsp: 3.462 ± 0.043	3.999AspGlu: 3.999 ± 0.04	1.66AspPhe: 1.66 ± 0.026	6.113AspGly: 6.113 ± 0.064	1.354AspHis: 1.354 ± 0.025	2.03AspIle: 2.03 ± 0.032	1.3AspLys: 1.3 ± 0.025	5.991AspLeu: 5.991 ± 0.061	0.888AspMet: 0.888 ± 0.019	1.054AspAsn: 1.054 ± 0.02	4.301AspPro: 4.301 ± 0.046	1.608AspGln: 1.608 ± 0.029	4.723AspArg: 4.723 ± 0.048	2.761AspSer: 2.761 ± 0.035	3.079AspThr: 3.079 ± 0.038	4.528AspVal: 4.528 ± 0.045	1.021AspTrp: 1.021 ± 0.021	1.1AspTyr: 1.1 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.31GluAla: 7.31 ± 0.064	0.402GluCys: 0.402 ± 0.013	2.805GluAsp: 2.805 ± 0.041	3.536GluGlu: 3.536 ± 0.046	1.57GluPhe: 1.57 ± 0.03	4.424GluGly: 4.424 ± 0.052	1.486GluHis: 1.486 ± 0.029	2.413GluIle: 2.413 ± 0.033	1.57GluLys: 1.57 ± 0.031	7.192GluLeu: 7.192 ± 0.073	0.931GluMet: 0.931 ± 0.022	1.088GluAsn: 1.088 ± 0.024	3.391GluPro: 3.391 ± 0.04	2.439GluGln: 2.439 ± 0.038	5.494GluArg: 5.494 ± 0.052	2.837GluSer: 2.837 ± 0.035	2.889GluThr: 2.889 ± 0.044	4.471GluVal: 4.471 ± 0.049	0.806GluTrp: 0.806 ± 0.02	1.171GluTyr: 1.171 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.669PheAla: 3.669 ± 0.044	0.281PheCys: 0.281 ± 0.011	1.955PheAsp: 1.955 ± 0.034	1.49PheGlu: 1.49 ± 0.03	0.872PhePhe: 0.872 ± 0.021	2.971PheGly: 2.971 ± 0.043	0.607PheHis: 0.607 ± 0.017	0.861PheIle: 0.861 ± 0.021	0.563PheLys: 0.563 ± 0.014	2.55PheLeu: 2.55 ± 0.035	0.426PheMet: 0.426 ± 0.013	0.611PheAsn: 0.611 ± 0.017	1.414PhePro: 1.414 ± 0.026	0.687PheGln: 0.687 ± 0.016	1.819PheArg: 1.819 ± 0.026	1.559PheSer: 1.559 ± 0.028	2.001PheThr: 2.001 ± 0.029	2.149PheVal: 2.149 ± 0.035	0.426PheTrp: 0.426 ± 0.013	0.569PheTyr: 0.569 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.74GlyAla: 10.74 ± 0.082	0.855GlyCys: 0.855 ± 0.022	5.08GlyAsp: 5.08 ± 0.051	5.211GlyGlu: 5.211 ± 0.05	2.88GlyPhe: 2.88 ± 0.035	8.705GlyGly: 8.705 ± 0.084	2.302GlyHis: 2.302 ± 0.034	3.639GlyIle: 3.639 ± 0.043	2.726GlyLys: 2.726 ± 0.042	9.33GlyLeu: 9.33 ± 0.067	1.976GlyMet: 1.976 ± 0.034	1.821GlyAsn: 1.821 ± 0.035	5.026GlyPro: 5.026 ± 0.046	2.88GlyGln: 2.88 ± 0.042	7.624GlyArg: 7.624 ± 0.063	5.592GlySer: 5.592 ± 0.052	6.151GlyThr: 6.151 ± 0.07	7.147GlyVal: 7.147 ± 0.067	1.71GlyTrp: 1.71 ± 0.03	2.231GlyTyr: 2.231 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.571HisAla: 2.571 ± 0.036	0.225HisCys: 0.225 ± 0.01	1.294HisAsp: 1.294 ± 0.027	1.212HisGlu: 1.212 ± 0.026	0.633HisPhe: 0.633 ± 0.018	2.329HisGly: 2.329 ± 0.032	0.686HisHis: 0.686 ± 0.019	0.744HisIle: 0.744 ± 0.018	0.385HisLys: 0.385 ± 0.012	2.361HisLeu: 2.361 ± 0.034	0.344HisMet: 0.344 ± 0.012	0.383HisAsn: 0.383 ± 0.014	1.724HisPro: 1.724 ± 0.029	0.702HisGln: 0.702 ± 0.018	2.009HisArg: 2.009 ± 0.029	1.103HisSer: 1.103 ± 0.021	1.338HisThr: 1.338 ± 0.029	1.656HisVal: 1.656 ± 0.026	0.364HisTrp: 0.364 ± 0.013	0.465HisTyr: 0.465 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.203IleAla: 5.203 ± 0.056	0.335IleCys: 0.335 ± 0.012	2.36IleAsp: 2.36 ± 0.035	2.273IleGlu: 2.273 ± 0.036	0.809IlePhe: 0.809 ± 0.019	3.797IleGly: 3.797 ± 0.04	0.672IleHis: 0.672 ± 0.017	0.965IleIle: 0.965 ± 0.025	0.816IleLys: 0.816 ± 0.02	2.579IleLeu: 2.579 ± 0.039	0.475IleMet: 0.475 ± 0.014	0.793IleAsn: 0.793 ± 0.02	1.899IlePro: 1.899 ± 0.028	0.817IleGln: 0.817 ± 0.017	2.363IleArg: 2.363 ± 0.037	1.915IleSer: 1.915 ± 0.033	2.375IleThr: 2.375 ± 0.032	2.894IleVal: 2.894 ± 0.04	0.413IleTrp: 0.413 ± 0.014	0.612IleTyr: 0.612 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.142LysAla: 3.142 ± 0.045	0.136LysCys: 0.136 ± 0.009	1.461LysAsp: 1.461 ± 0.034	1.336LysGlu: 1.336 ± 0.028	0.497LysPhe: 0.497 ± 0.015	1.964LysGly: 1.964 ± 0.036	0.476LysHis: 0.476 ± 0.014	0.968LysIle: 0.968 ± 0.022	0.953LysLys: 0.953 ± 0.031	2.213LysLeu: 2.213 ± 0.038	0.41LysMet: 0.41 ± 0.014	0.589LysAsn: 0.589 ± 0.019	1.519LysPro: 1.519 ± 0.027	0.829LysGln: 0.829 ± 0.022	1.602LysArg: 1.602 ± 0.03	1.287LysSer: 1.287 ± 0.024	1.353LysThr: 1.353 ± 0.03	2.011LysVal: 2.011 ± 0.032	0.31LysTrp: 0.31 ± 0.012	0.506LysTyr: 0.506 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	14.754LeuAla: 14.754 ± 0.115	0.837LeuCys: 0.837 ± 0.018	6.473LeuAsp: 6.473 ± 0.058	4.929LeuGlu: 4.929 ± 0.059	2.579LeuPhe: 2.579 ± 0.039	9.127LeuGly: 9.127 ± 0.072	2.279LeuHis: 2.279 ± 0.033	3.591LeuIle: 3.591 ± 0.048	2.21LeuLys: 2.21 ± 0.036	11.228LeuLeu: 11.228 ± 0.092	1.699LeuMet: 1.699 ± 0.031	1.825LeuAsn: 1.825 ± 0.028	6.461LeuPro: 6.461 ± 0.065	2.412LeuGln: 2.412 ± 0.031	8.493LeuArg: 8.493 ± 0.075	5.43LeuSer: 5.43 ± 0.046	6.641LeuThr: 6.641 ± 0.063	8.587LeuVal: 8.587 ± 0.075	1.287LeuTrp: 1.287 ± 0.025	1.816LeuTyr: 1.816 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.283MetAla: 2.283 ± 0.03	0.135MetCys: 0.135 ± 0.008	0.938MetAsp: 0.938 ± 0.021	0.818MetGlu: 0.818 ± 0.021	0.457MetPhe: 0.457 ± 0.014	1.378MetGly: 1.378 ± 0.024	0.38MetHis: 0.38 ± 0.014	0.67MetIle: 0.67 ± 0.018	0.464MetLys: 0.464 ± 0.015	1.772MetLeu: 1.772 ± 0.027	0.31MetMet: 0.31 ± 0.012	0.463MetAsn: 0.463 ± 0.015	1.178MetPro: 1.178 ± 0.021	0.494MetGln: 0.494 ± 0.015	1.47MetArg: 1.47 ± 0.029	1.326MetSer: 1.326 ± 0.02	1.511MetThr: 1.511 ± 0.028	1.315MetVal: 1.315 ± 0.026	0.218MetTrp: 0.218 ± 0.009	0.32MetTyr: 0.32 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.35AsnAla: 2.35 ± 0.036	0.178AsnCys: 0.178 ± 0.007	1.033AsnAsp: 1.033 ± 0.023	0.924AsnGlu: 0.924 ± 0.021	0.533AsnPhe: 0.533 ± 0.016	2.023AsnGly: 2.023 ± 0.037	0.41AsnHis: 0.41 ± 0.013	0.684AsnIle: 0.684 ± 0.017	0.465AsnLys: 0.465 ± 0.017	1.727AsnLeu: 1.727 ± 0.03	0.308AsnMet: 0.308 ± 0.012	0.475AsnAsn: 0.475 ± 0.018	1.425AsnPro: 1.425 ± 0.029	0.568AsnGln: 0.568 ± 0.016	1.352AsnArg: 1.352 ± 0.023	1.049AsnSer: 1.049 ± 0.025	1.201AsnThr: 1.201 ± 0.031	1.397AsnVal: 1.397 ± 0.026	0.32AsnTrp: 0.32 ± 0.012	0.442AsnTyr: 0.442 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	8.28ProAla: 8.28 ± 0.068	0.34ProCys: 0.34 ± 0.012	4.325ProAsp: 4.325 ± 0.047	4.302ProGlu: 4.302 ± 0.05	1.509ProPhe: 1.509 ± 0.027	6.47ProGly: 6.47 ± 0.057	1.29ProHis: 1.29 ± 0.026	1.384ProIle: 1.384 ± 0.026	1.347ProLys: 1.347 ± 0.03	5.293ProLeu: 5.293 ± 0.053	1.036ProMet: 1.036 ± 0.023	0.973ProAsn: 0.973 ± 0.022	3.428ProPro: 3.428 ± 0.054	1.946ProGln: 1.946 ± 0.034	3.827ProArg: 3.827 ± 0.05	3.28ProSer: 3.28 ± 0.041	3.129ProThr: 3.129 ± 0.039	5.464ProVal: 5.464 ± 0.057	0.886ProTrp: 0.886 ± 0.022	1.41ProTyr: 1.41 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.936GlnAla: 3.936 ± 0.043	0.196GlnCys: 0.196 ± 0.008	1.511GlnAsp: 1.511 ± 0.027	1.523GlnGlu: 1.523 ± 0.027	0.751GlnPhe: 0.751 ± 0.018	2.38GlnGly: 2.38 ± 0.039	0.713GlnHis: 0.713 ± 0.017	1.201GlnIle: 1.201 ± 0.022	0.681GlnLys: 0.681 ± 0.021	3.428GlnLeu: 3.428 ± 0.038	0.532GlnMet: 0.532 ± 0.014	0.544GlnAsn: 0.544 ± 0.015	1.902GlnPro: 1.902 ± 0.033	1.48GlnGln: 1.48 ± 0.043	2.491GlnArg: 2.491 ± 0.037	1.45GlnSer: 1.45 ± 0.027	1.387GlnThr: 1.387 ± 0.025	2.463GlnVal: 2.463 ± 0.036	0.501GlnTrp: 0.501 ± 0.014	0.653GlnTyr: 0.653 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.321ArgAla: 9.321 ± 0.078	0.587ArgCys: 0.587 ± 0.019	4.185ArgAsp: 4.185 ± 0.049	4.677ArgGlu: 4.677 ± 0.051	2.305ArgPhe: 2.305 ± 0.034	5.746ArgGly: 5.746 ± 0.06	2.025ArgHis: 2.025 ± 0.033	3.489ArgIle: 3.489 ± 0.04	1.749ArgLys: 1.749 ± 0.029	8.568ArgLeu: 8.568 ± 0.08	1.756ArgMet: 1.756 ± 0.028	1.472ArgAsn: 1.472 ± 0.026	4.715ArgPro: 4.715 ± 0.054	2.376ArgGln: 2.376 ± 0.035	7.389ArgArg: 7.389 ± 0.087	4.23ArgSer: 4.23 ± 0.045	5.451ArgThr: 5.451 ± 0.047	5.503ArgVal: 5.503 ± 0.05	1.352ArgTrp: 1.352 ± 0.024	1.765ArgTyr: 1.765 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.966SerAla: 6.966 ± 0.056	0.435SerCys: 0.435 ± 0.013	2.834SerAsp: 2.834 ± 0.033	2.645SerGlu: 2.645 ± 0.038	1.602SerPhe: 1.602 ± 0.026	6.242SerGly: 6.242 ± 0.066	1.04SerHis: 1.04 ± 0.02	1.63SerIle: 1.63 ± 0.031	1.178SerLys: 1.178 ± 0.023	4.992SerLeu: 4.992 ± 0.044	1.131SerMet: 1.131 ± 0.019	0.986SerAsn: 0.986 ± 0.022	3.312SerPro: 3.312 ± 0.046	1.384SerGln: 1.384 ± 0.026	3.817SerArg: 3.817 ± 0.05	3.048SerSer: 3.048 ± 0.052	3.175SerThr: 3.175 ± 0.04	4.385SerVal: 4.385 ± 0.042	0.933SerTrp: 0.933 ± 0.021	1.247SerTyr: 1.247 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.558ThrAla: 8.558 ± 0.076	0.439ThrCys: 0.439 ± 0.013	3.503ThrAsp: 3.503 ± 0.045	3.366ThrGlu: 3.366 ± 0.041	1.636ThrPhe: 1.636 ± 0.027	6.525ThrGly: 6.525 ± 0.059	1.178ThrHis: 1.178 ± 0.021	1.872ThrIle: 1.872 ± 0.025	1.206ThrLys: 1.206 ± 0.031	5.61ThrLeu: 5.61 ± 0.056	0.998ThrMet: 0.998 ± 0.022	1.051ThrAsn: 1.051 ± 0.023	3.997ThrPro: 3.997 ± 0.049	1.477ThrGln: 1.477 ± 0.026	3.751ThrArg: 3.751 ± 0.042	3.299ThrSer: 3.299 ± 0.041	3.798ThrThr: 3.798 ± 0.057	5.962ThrVal: 5.962 ± 0.048	0.894ThrTrp: 0.894 ± 0.02	1.356ThrTyr: 1.356 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.373ValAla: 10.373 ± 0.08	0.735ValCys: 0.735 ± 0.017	4.771ValAsp: 4.771 ± 0.045	4.676ValGlu: 4.676 ± 0.054	2.339ValPhe: 2.339 ± 0.039	6.374ValGly: 6.374 ± 0.054	1.953ValHis: 1.953 ± 0.029	3.103ValIle: 3.103 ± 0.037	1.852ValLys: 1.852 ± 0.034	9.247ValLeu: 9.247 ± 0.08	1.48ValMet: 1.48 ± 0.025	1.704ValAsn: 1.704 ± 0.032	5.117ValPro: 5.117 ± 0.055	2.207ValGln: 2.207 ± 0.027	6.946ValArg: 6.946 ± 0.055	4.356ValSer: 4.356 ± 0.046	5.379ValThr: 5.379 ± 0.051	7.556ValVal: 7.556 ± 0.077	1.118ValTrp: 1.118 ± 0.022	1.556ValTyr: 1.556 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.641TrpAla: 1.641 ± 0.027	0.166TrpCys: 0.166 ± 0.008	0.85TrpAsp: 0.85 ± 0.022	0.744TrpGlu: 0.744 ± 0.017	0.505TrpPhe: 0.505 ± 0.013	1.037TrpGly: 1.037 ± 0.022	0.363TrpHis: 0.363 ± 0.012	0.583TrpIle: 0.583 ± 0.018	0.381TrpLys: 0.381 ± 0.014	1.797TrpLeu: 1.797 ± 0.027	0.288TrpMet: 0.288 ± 0.01	0.416TrpAsn: 0.416 ± 0.015	0.788TrpPro: 0.788 ± 0.019	0.645TrpGln: 0.645 ± 0.016	1.324TrpArg: 1.324 ± 0.027	0.933TrpSer: 0.933 ± 0.02	1.025TrpThr: 1.025 ± 0.02	0.993TrpVal: 0.993 ± 0.022	0.349TrpTrp: 0.349 ± 0.011	0.36TrpTyr: 0.36 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.78TyrAla: 2.78 ± 0.036	0.181TyrCys: 0.181 ± 0.009	1.448TyrAsp: 1.448 ± 0.031	1.363TyrGlu: 1.363 ± 0.026	0.655TyrPhe: 0.655 ± 0.018	2.283TyrGly: 2.283 ± 0.027	0.367TyrHis: 0.367 ± 0.013	0.549TyrIle: 0.549 ± 0.017	0.428TyrLys: 0.428 ± 0.015	2.097TyrLeu: 2.097 ± 0.031	0.249TyrMet: 0.249 ± 0.01	0.429TyrAsn: 0.429 ± 0.015	1.068TyrPro: 1.068 ± 0.021	0.641TyrGln: 0.641 ± 0.018	1.803TyrArg: 1.803 ± 0.029	0.982TyrSer: 0.982 ± 0.023	1.181TyrThr: 1.181 ± 0.03	1.63TyrVal: 1.63 ± 0.028	0.338TyrTrp: 0.338 ± 0.012	0.445TyrTyr: 0.445 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7136 proteins (2361430 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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