Amino acid dipepetide frequency for Mycoplasma nasistruthionis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.053AlaAla: 3.053 ± 0.167
0.259AlaCys: 0.259 ± 0.042
3.171AlaAsp: 3.171 ± 0.15
3.58AlaGlu: 3.58 ± 0.145
3.035AlaPhe: 3.035 ± 0.138
2.87AlaGly: 2.87 ± 0.141
0.753AlaHis: 0.753 ± 0.063
4.987AlaIle: 4.987 ± 0.169
6.323AlaLys: 6.323 ± 0.293
6.173AlaLeu: 6.173 ± 0.241
0.983AlaMet: 0.983 ± 0.071
4.545AlaAsn: 4.545 ± 0.188
1.567AlaPro: 1.567 ± 0.099
2.526AlaGln: 2.526 ± 0.134
1.929AlaArg: 1.929 ± 0.097
4.272AlaSer: 4.272 ± 0.148
3.402AlaThr: 3.402 ± 0.15
3.369AlaVal: 3.369 ± 0.158
0.494AlaTrp: 0.494 ± 0.045
2.305AlaTyr: 2.305 ± 0.107
0.005AlaXaa: 0.005 ± 0.004
Cys
0.198CysAla: 0.198 ± 0.031
0.042CysCys: 0.042 ± 0.014
0.282CysAsp: 0.282 ± 0.041
0.235CysGlu: 0.235 ± 0.036
0.325CysPhe: 0.325 ± 0.038
0.268CysGly: 0.268 ± 0.039
0.108CysHis: 0.108 ± 0.023
0.292CysIle: 0.292 ± 0.045
0.278CysLys: 0.278 ± 0.04
0.518CysLeu: 0.518 ± 0.053
0.061CysMet: 0.061 ± 0.017
0.268CysAsn: 0.268 ± 0.036
0.151CysPro: 0.151 ± 0.026
0.202CysGln: 0.202 ± 0.034
0.127CysArg: 0.127 ± 0.022
0.278CysSer: 0.278 ± 0.04
0.141CysThr: 0.141 ± 0.023
0.301CysVal: 0.301 ± 0.038
0.047CysTrp: 0.047 ± 0.015
0.136CysTyr: 0.136 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.604AspAla: 3.604 ± 0.204
0.231AspCys: 0.231 ± 0.035
2.842AspAsp: 2.842 ± 0.161
3.839AspGlu: 3.839 ± 0.165
3.792AspPhe: 3.792 ± 0.168
2.423AspGly: 2.423 ± 0.108
0.72AspHis: 0.72 ± 0.058
4.338AspIle: 4.338 ± 0.174
5.594AspLys: 5.594 ± 0.192
6.977AspLeu: 6.977 ± 0.242
0.729AspMet: 0.729 ± 0.061
3.928AspAsn: 3.928 ± 0.188
1.793AspPro: 1.793 ± 0.101
2.258AspGln: 2.258 ± 0.123
1.482AspArg: 1.482 ± 0.08
3.797AspSer: 3.797 ± 0.134
2.781AspThr: 2.781 ± 0.12
3.246AspVal: 3.246 ± 0.148
0.522AspTrp: 0.522 ± 0.052
2.828AspTyr: 2.828 ± 0.129
0.0AspXaa: 0.0 ± 0.0
Glu
3.787GluAla: 3.787 ± 0.185
0.207GluCys: 0.207 ± 0.036
2.409GluAsp: 2.409 ± 0.124
3.562GluGlu: 3.562 ± 0.211
3.74GluPhe: 3.74 ± 0.146
2.484GluGly: 2.484 ± 0.133
0.701GluHis: 0.701 ± 0.056
6.168GluIle: 6.168 ± 0.182
6.036GluLys: 6.036 ± 0.202
7.372GluLeu: 7.372 ± 0.27
1.115GluMet: 1.115 ± 0.08
5.867GluAsn: 5.867 ± 0.173
1.595GluPro: 1.595 ± 0.104
2.922GluGln: 2.922 ± 0.143
1.778GluArg: 1.778 ± 0.088
3.025GluSer: 3.025 ± 0.129
4.004GluThr: 4.004 ± 0.149
4.074GluVal: 4.074 ± 0.182
0.447GluTrp: 0.447 ± 0.044
2.705GluTyr: 2.705 ± 0.122
0.0GluXaa: 0.0 ± 0.0
Phe
3.195PheAla: 3.195 ± 0.139
0.249PheCys: 0.249 ± 0.036
3.952PheAsp: 3.952 ± 0.135
3.444PheGlu: 3.444 ± 0.139
2.169PhePhe: 2.169 ± 0.134
2.785PheGly: 2.785 ± 0.132
0.527PheHis: 0.527 ± 0.047
4.413PheIle: 4.413 ± 0.181
4.987PheLys: 4.987 ± 0.178
4.884PheLeu: 4.884 ± 0.196
0.805PheMet: 0.805 ± 0.054
4.079PheAsn: 4.079 ± 0.155
1.294PhePro: 1.294 ± 0.086
1.435PheGln: 1.435 ± 0.089
1.402PheArg: 1.402 ± 0.074
3.674PheSer: 3.674 ± 0.163
2.828PheThr: 2.828 ± 0.125
3.42PheVal: 3.42 ± 0.144
0.494PheTrp: 0.494 ± 0.053
2.15PheTyr: 2.15 ± 0.124
0.0PheXaa: 0.0 ± 0.0
Gly
2.795GlyAla: 2.795 ± 0.132
0.193GlyCys: 0.193 ± 0.027
2.367GlyAsp: 2.367 ± 0.124
2.254GlyGlu: 2.254 ± 0.103
2.738GlyPhe: 2.738 ± 0.114
2.635GlyGly: 2.635 ± 0.158
0.828GlyHis: 0.828 ± 0.059
3.994GlyIle: 3.994 ± 0.188
3.797GlyLys: 3.797 ± 0.185
4.394GlyLeu: 4.394 ± 0.163
0.819GlyMet: 0.819 ± 0.064
2.541GlyAsn: 2.541 ± 0.122
0.88GlyPro: 0.88 ± 0.07
1.934GlyGln: 1.934 ± 0.089
1.477GlyArg: 1.477 ± 0.092
3.096GlySer: 3.096 ± 0.13
2.625GlyThr: 2.625 ± 0.134
2.818GlyVal: 2.818 ± 0.141
0.423GlyTrp: 0.423 ± 0.045
2.15GlyTyr: 2.15 ± 0.108
0.0GlyXaa: 0.0 ± 0.0
His
0.781HisAla: 0.781 ± 0.06
0.099HisCys: 0.099 ± 0.02
0.776HisAsp: 0.776 ± 0.064
0.767HisGlu: 0.767 ± 0.063
0.875HisPhe: 0.875 ± 0.069
0.781HisGly: 0.781 ± 0.069
0.254HisHis: 0.254 ± 0.037
0.997HisIle: 0.997 ± 0.073
1.195HisLys: 1.195 ± 0.064
1.59HisLeu: 1.59 ± 0.078
0.193HisMet: 0.193 ± 0.031
1.03HisAsn: 1.03 ± 0.079
0.659HisPro: 0.659 ± 0.068
0.499HisGln: 0.499 ± 0.045
0.395HisArg: 0.395 ± 0.049
0.913HisSer: 0.913 ± 0.069
0.659HisThr: 0.659 ± 0.057
0.725HisVal: 0.725 ± 0.054
0.155HisTrp: 0.155 ± 0.03
0.668HisTyr: 0.668 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
4.837IleAla: 4.837 ± 0.176
0.466IleCys: 0.466 ± 0.042
5.495IleAsp: 5.495 ± 0.202
5.246IleGlu: 5.246 ± 0.189
3.905IlePhe: 3.905 ± 0.163
3.75IleGly: 3.75 ± 0.152
1.129IleHis: 1.129 ± 0.077
6.243IleIle: 6.243 ± 0.218
7.937IleLys: 7.937 ± 0.201
6.996IleLeu: 6.996 ± 0.215
1.256IleMet: 1.256 ± 0.101
6.601IleAsn: 6.601 ± 0.263
2.536IlePro: 2.536 ± 0.118
3.195IleGln: 3.195 ± 0.139
2.145IleArg: 2.145 ± 0.113
5.97IleSer: 5.97 ± 0.215
4.686IleThr: 4.686 ± 0.152
4.855IleVal: 4.855 ± 0.182
0.616IleTrp: 0.616 ± 0.061
3.298IleTyr: 3.298 ± 0.138
0.0IleXaa: 0.0 ± 0.0
Lys
5.618LysAla: 5.618 ± 0.255
0.311LysCys: 0.311 ± 0.038
5.458LysAsp: 5.458 ± 0.231
6.38LysGlu: 6.38 ± 0.197
4.211LysPhe: 4.211 ± 0.131
3.242LysGly: 3.242 ± 0.15
1.506LysHis: 1.506 ± 0.074
7.744LysIle: 7.744 ± 0.225
7.062LysLys: 7.062 ± 0.232
9.151LysLeu: 9.151 ± 0.228
1.962LysMet: 1.962 ± 0.118
7.391LysAsn: 7.391 ± 0.224
2.912LysPro: 2.912 ± 0.136
4.982LysGln: 4.982 ± 0.202
2.955LysArg: 2.955 ± 0.124
5.443LysSer: 5.443 ± 0.17
5.881LysThr: 5.881 ± 0.203
5.674LysVal: 5.674 ± 0.17
0.95LysTrp: 0.95 ± 0.067
4.328LysTyr: 4.328 ± 0.16
0.0LysXaa: 0.0 ± 0.0
Leu
5.97LeuAla: 5.97 ± 0.201
0.4LeuCys: 0.4 ± 0.046
5.966LeuAsp: 5.966 ± 0.168
6.281LeuGlu: 6.281 ± 0.212
4.916LeuPhe: 4.916 ± 0.189
3.933LeuGly: 3.933 ± 0.142
1.308LeuHis: 1.308 ± 0.085
8.172LeuIle: 8.172 ± 0.243
9.842LeuLys: 9.842 ± 0.259
8.445LeuLeu: 8.445 ± 0.266
1.534LeuMet: 1.534 ± 0.093
9.367LeuAsn: 9.367 ± 0.304
2.955LeuPro: 2.955 ± 0.11
3.378LeuGln: 3.378 ± 0.137
2.94LeuArg: 2.94 ± 0.122
7.227LeuSer: 7.227 ± 0.211
5.98LeuThr: 5.98 ± 0.199
5.952LeuVal: 5.952 ± 0.189
0.635LeuTrp: 0.635 ± 0.053
3.359LeuTyr: 3.359 ± 0.14
0.0LeuXaa: 0.0 ± 0.0
Met
0.932MetAla: 0.932 ± 0.065
0.089MetCys: 0.089 ± 0.023
0.781MetAsp: 0.781 ± 0.07
0.936MetGlu: 0.936 ± 0.067
0.983MetPhe: 0.983 ± 0.075
0.64MetGly: 0.64 ± 0.054
0.273MetHis: 0.273 ± 0.04
1.35MetIle: 1.35 ± 0.09
1.628MetLys: 1.628 ± 0.105
1.571MetLeu: 1.571 ± 0.101
0.301MetMet: 0.301 ± 0.038
1.209MetAsn: 1.209 ± 0.092
0.64MetPro: 0.64 ± 0.05
0.687MetGln: 0.687 ± 0.059
0.419MetArg: 0.419 ± 0.051
1.129MetSer: 1.129 ± 0.067
0.743MetThr: 0.743 ± 0.059
0.884MetVal: 0.884 ± 0.059
0.113MetTrp: 0.113 ± 0.022
0.588MetTyr: 0.588 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
4.347AsnAla: 4.347 ± 0.233
0.278AsnCys: 0.278 ± 0.042
4.488AsnAsp: 4.488 ± 0.208
4.7AsnGlu: 4.7 ± 0.173
3.811AsnPhe: 3.811 ± 0.152
3.453AsnGly: 3.453 ± 0.174
1.171AsnHis: 1.171 ± 0.072
5.712AsnIle: 5.712 ± 0.184
7.979AsnLys: 7.979 ± 0.229
7.857AsnLeu: 7.857 ± 0.286
1.021AsnMet: 1.021 ± 0.07
6.987AsnAsn: 6.987 ± 0.295
2.846AsnPro: 2.846 ± 0.115
4.39AsnGln: 4.39 ± 0.184
1.934AsnArg: 1.934 ± 0.099
6.008AsnSer: 6.008 ± 0.211
3.933AsnThr: 3.933 ± 0.152
4.338AsnVal: 4.338 ± 0.158
0.819AsnTrp: 0.819 ± 0.072
3.792AsnTyr: 3.792 ± 0.166
0.0AsnXaa: 0.0 ± 0.0
Pro
1.873ProAla: 1.873 ± 0.116
0.094ProCys: 0.094 ± 0.021
1.797ProAsp: 1.797 ± 0.097
2.63ProGlu: 2.63 ± 0.112
1.52ProPhe: 1.52 ± 0.102
1.468ProGly: 1.468 ± 0.102
0.447ProHis: 0.447 ± 0.053
2.122ProIle: 2.122 ± 0.111
2.456ProLys: 2.456 ± 0.111
2.503ProLeu: 2.503 ± 0.107
0.466ProMet: 0.466 ± 0.041
2.55ProAsn: 2.55 ± 0.127
0.48ProPro: 0.48 ± 0.047
1.101ProGln: 1.101 ± 0.072
0.72ProArg: 0.72 ± 0.06
1.816ProSer: 1.816 ± 0.102
1.868ProThr: 1.868 ± 0.121
2.112ProVal: 2.112 ± 0.124
0.221ProTrp: 0.221 ± 0.028
1.171ProTyr: 1.171 ± 0.083
0.0ProXaa: 0.0 ± 0.0
Gln
2.884GlnAla: 2.884 ± 0.166
0.113GlnCys: 0.113 ± 0.022
2.164GlnAsp: 2.164 ± 0.117
2.988GlnGlu: 2.988 ± 0.152
1.83GlnPhe: 1.83 ± 0.096
1.571GlnGly: 1.571 ± 0.083
0.532GlnHis: 0.532 ± 0.048
3.839GlnIle: 3.839 ± 0.183
4.018GlnLys: 4.018 ± 0.158
3.98GlnLeu: 3.98 ± 0.185
0.828GlnMet: 0.828 ± 0.069
3.849GlnAsn: 3.849 ± 0.146
1.219GlnPro: 1.219 ± 0.097
2.122GlnGln: 2.122 ± 0.142
1.233GlnArg: 1.233 ± 0.072
2.291GlnSer: 2.291 ± 0.108
2.414GlnThr: 2.414 ± 0.105
2.145GlnVal: 2.145 ± 0.102
0.358GlnTrp: 0.358 ± 0.041
1.727GlnTyr: 1.727 ± 0.087
0.0GlnXaa: 0.0 ± 0.0
Arg
1.618ArgAla: 1.618 ± 0.088
0.089ArgCys: 0.089 ± 0.02
1.68ArgAsp: 1.68 ± 0.094
1.873ArgGlu: 1.873 ± 0.091
1.59ArgPhe: 1.59 ± 0.087
1.327ArgGly: 1.327 ± 0.09
0.438ArgHis: 0.438 ± 0.043
2.451ArgIle: 2.451 ± 0.132
2.47ArgLys: 2.47 ± 0.123
2.776ArgLeu: 2.776 ± 0.129
0.63ArgMet: 0.63 ± 0.06
2.131ArgAsn: 2.131 ± 0.105
0.823ArgPro: 0.823 ± 0.07
1.336ArgGln: 1.336 ± 0.095
1.124ArgArg: 1.124 ± 0.078
1.524ArgSer: 1.524 ± 0.086
1.506ArgThr: 1.506 ± 0.088
1.793ArgVal: 1.793 ± 0.107
0.221ArgTrp: 0.221 ± 0.028
1.308ArgTyr: 1.308 ± 0.083
0.0ArgXaa: 0.0 ± 0.0
Ser
3.877SerAla: 3.877 ± 0.165
0.409SerCys: 0.409 ± 0.046
4.051SerAsp: 4.051 ± 0.158
4.451SerGlu: 4.451 ± 0.157
3.773SerPhe: 3.773 ± 0.163
3.463SerGly: 3.463 ± 0.155
0.894SerHis: 0.894 ± 0.076
5.194SerIle: 5.194 ± 0.182
6.248SerLys: 6.248 ± 0.176
6.577SerLeu: 6.577 ± 0.215
1.012SerMet: 1.012 ± 0.073
4.973SerAsn: 4.973 ± 0.176
1.755SerPro: 1.755 ± 0.101
2.668SerGln: 2.668 ± 0.096
1.708SerArg: 1.708 ± 0.093
4.672SerSer: 4.672 ± 0.152
3.863SerThr: 3.863 ± 0.157
3.966SerVal: 3.966 ± 0.133
0.696SerTrp: 0.696 ± 0.061
2.893SerTyr: 2.893 ± 0.138
0.0SerXaa: 0.0 ± 0.0
Thr
3.18ThrAla: 3.18 ± 0.14
0.202ThrCys: 0.202 ± 0.031
3.072ThrAsp: 3.072 ± 0.138
3.529ThrGlu: 3.529 ± 0.168
2.879ThrPhe: 2.879 ± 0.128
2.804ThrGly: 2.804 ± 0.121
0.875ThrHis: 0.875 ± 0.065
4.526ThrIle: 4.526 ± 0.143
5.091ThrLys: 5.091 ± 0.132
5.429ThrLeu: 5.429 ± 0.141
0.616ThrMet: 0.616 ± 0.047
4.455ThrAsn: 4.455 ± 0.178
2.042ThrPro: 2.042 ± 0.123
1.976ThrGln: 1.976 ± 0.078
1.567ThrArg: 1.567 ± 0.102
3.839ThrSer: 3.839 ± 0.149
3.797ThrThr: 3.797 ± 0.159
3.486ThrVal: 3.486 ± 0.15
0.494ThrTrp: 0.494 ± 0.048
2.305ThrTyr: 2.305 ± 0.114
0.0ThrXaa: 0.0 ± 0.0
Val
4.131ValAla: 4.131 ± 0.161
0.273ValCys: 0.273 ± 0.037
3.91ValAsp: 3.91 ± 0.137
4.399ValGlu: 4.399 ± 0.211
3.119ValPhe: 3.119 ± 0.142
2.522ValGly: 2.522 ± 0.128
0.79ValHis: 0.79 ± 0.069
4.789ValIle: 4.789 ± 0.166
5.307ValLys: 5.307 ± 0.197
5.872ValLeu: 5.872 ± 0.196
0.861ValMet: 0.861 ± 0.073
4.295ValAsn: 4.295 ± 0.158
1.873ValPro: 1.873 ± 0.094
1.99ValGln: 1.99 ± 0.1
1.656ValArg: 1.656 ± 0.103
4.667ValSer: 4.667 ± 0.143
2.555ValThr: 2.555 ± 0.117
4.088ValVal: 4.088 ± 0.182
0.503ValTrp: 0.503 ± 0.048
2.409ValTyr: 2.409 ± 0.112
0.0ValXaa: 0.0 ± 0.0
Trp
0.461TrpAla: 0.461 ± 0.047
0.052TrpCys: 0.052 ± 0.015
0.536TrpAsp: 0.536 ± 0.049
0.508TrpGlu: 0.508 ± 0.051
0.438TrpPhe: 0.438 ± 0.048
0.39TrpGly: 0.39 ± 0.049
0.122TrpHis: 0.122 ± 0.024
0.866TrpIle: 0.866 ± 0.063
0.79TrpLys: 0.79 ± 0.067
0.809TrpLeu: 0.809 ± 0.07
0.207TrpMet: 0.207 ± 0.03
0.734TrpAsn: 0.734 ± 0.073
0.183TrpPro: 0.183 ± 0.027
0.386TrpGln: 0.386 ± 0.044
0.273TrpArg: 0.273 ± 0.036
0.447TrpSer: 0.447 ± 0.054
0.494TrpThr: 0.494 ± 0.053
0.456TrpVal: 0.456 ± 0.049
0.151TrpTrp: 0.151 ± 0.029
0.508TrpTyr: 0.508 ± 0.055
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.461TyrAla: 2.461 ± 0.114
0.202TyrCys: 0.202 ± 0.031
2.526TyrAsp: 2.526 ± 0.116
2.399TyrGlu: 2.399 ± 0.113
2.536TyrPhe: 2.536 ± 0.126
1.948TyrGly: 1.948 ± 0.113
0.635TyrHis: 0.635 ± 0.062
2.964TyrIle: 2.964 ± 0.117
4.121TyrLys: 4.121 ± 0.15
4.686TyrLeu: 4.686 ± 0.184
0.494TyrMet: 0.494 ± 0.051
3.063TyrAsn: 3.063 ± 0.153
1.214TyrPro: 1.214 ± 0.074
2.117TyrGln: 2.117 ± 0.088
1.444TyrArg: 1.444 ± 0.091
3.053TyrSer: 3.053 ± 0.127
2.009TyrThr: 2.009 ± 0.106
2.31TyrVal: 2.31 ± 0.11
0.452TyrTrp: 0.452 ± 0.066
1.83TyrTyr: 1.83 ± 0.101
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.005XaaTyr: 0.005 ± 0.004
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 565 proteins (212551 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski