Amino acid dipepetide frequency for Marchantia polymorpha subsp. ruderalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.36AlaAla: 9.36 ± 0.065	1.299AlaCys: 1.299 ± 0.015	4.052AlaAsp: 4.052 ± 0.026	5.652AlaGlu: 5.652 ± 0.034	2.83AlaPhe: 2.83 ± 0.023	6.063AlaGly: 6.063 ± 0.036	1.624AlaHis: 1.624 ± 0.014	3.421AlaIle: 3.421 ± 0.026	4.214AlaLys: 4.214 ± 0.03	7.79AlaLeu: 7.79 ± 0.039	1.999AlaMet: 1.999 ± 0.017	2.517AlaAsn: 2.517 ± 0.022	3.946AlaPro: 3.946 ± 0.031	3.034AlaGln: 3.034 ± 0.024	5.058AlaArg: 5.058 ± 0.029	7.056AlaSer: 7.056 ± 0.041	4.383AlaThr: 4.383 ± 0.025	6.024AlaVal: 6.024 ± 0.03	0.946AlaTrp: 0.946 ± 0.012	1.75AlaTyr: 1.75 ± 0.017	0.003AlaXaa: 0.003 ± 0.001
Cys	1.29CysAla: 1.29 ± 0.015	0.433CysCys: 0.433 ± 0.01	0.783CysAsp: 0.783 ± 0.011	0.901CysGlu: 0.901 ± 0.012	0.655CysPhe: 0.655 ± 0.009	1.309CysGly: 1.309 ± 0.015	0.381CysHis: 0.381 ± 0.007	0.706CysIle: 0.706 ± 0.01	0.823CysLys: 0.823 ± 0.01	1.59CysLeu: 1.59 ± 0.017	0.36CysMet: 0.36 ± 0.007	0.583CysAsn: 0.583 ± 0.009	0.903CysPro: 0.903 ± 0.013	0.579CysGln: 0.579 ± 0.009	1.086CysArg: 1.086 ± 0.013	1.553CysSer: 1.553 ± 0.016	0.911CysThr: 0.911 ± 0.011	1.073CysVal: 1.073 ± 0.013	0.245CysTrp: 0.245 ± 0.005	0.394CysTyr: 0.394 ± 0.007	0.001CysXaa: 0.001 ± 0.0
Asp	4.096AspAla: 4.096 ± 0.025	0.902AspCys: 0.902 ± 0.011	3.661AspAsp: 3.661 ± 0.032	4.352AspGlu: 4.352 ± 0.029	2.107AspPhe: 2.107 ± 0.015	4.239AspGly: 4.239 ± 0.03	1.126AspHis: 1.126 ± 0.013	2.452AspIle: 2.452 ± 0.019	2.4AspLys: 2.4 ± 0.022	5.003AspLeu: 5.003 ± 0.029	1.285AspMet: 1.285 ± 0.013	1.68AspAsn: 1.68 ± 0.018	2.637AspPro: 2.637 ± 0.019	1.663AspGln: 1.663 ± 0.016	3.052AspArg: 3.052 ± 0.024	4.338AspSer: 4.338 ± 0.027	2.381AspThr: 2.381 ± 0.019	3.926AspVal: 3.926 ± 0.023	0.79AspTrp: 0.79 ± 0.009	1.352AspTyr: 1.352 ± 0.015	0.001AspXaa: 0.001 ± 0.0
Glu	5.878GluAla: 5.878 ± 0.036	0.901GluCys: 0.901 ± 0.013	4.334GluAsp: 4.334 ± 0.032	7.016GluGlu: 7.016 ± 0.051	2.154GluPhe: 2.154 ± 0.017	4.519GluGly: 4.519 ± 0.026	1.344GluHis: 1.344 ± 0.014	3.13GluIle: 3.13 ± 0.022	4.533GluLys: 4.533 ± 0.038	6.329GluLeu: 6.329 ± 0.037	1.628GluMet: 1.628 ± 0.013	2.407GluAsn: 2.407 ± 0.019	2.486GluPro: 2.486 ± 0.024	2.703GluGln: 2.703 ± 0.02	4.582GluArg: 4.582 ± 0.033	4.898GluSer: 4.898 ± 0.032	3.202GluThr: 3.202 ± 0.025	4.667GluVal: 4.667 ± 0.029	0.828GluTrp: 0.828 ± 0.011	1.493GluTyr: 1.493 ± 0.014	0.002GluXaa: 0.002 ± 0.0
Phe	2.624PheAla: 2.624 ± 0.024	0.734PheCys: 0.734 ± 0.011	1.967PheAsp: 1.967 ± 0.018	2.168PheGlu: 2.168 ± 0.017	1.53PhePhe: 1.53 ± 0.019	2.825PheGly: 2.825 ± 0.025	0.863PheHis: 0.863 ± 0.01	1.42PheIle: 1.42 ± 0.015	1.61PheLys: 1.61 ± 0.015	3.507PheLeu: 3.507 ± 0.025	0.824PheMet: 0.824 ± 0.011	1.254PheAsn: 1.254 ± 0.013	1.754PhePro: 1.754 ± 0.017	1.385PheGln: 1.385 ± 0.013	1.989PheArg: 1.989 ± 0.019	3.149PheSer: 3.149 ± 0.023	1.823PheThr: 1.823 ± 0.019	2.565PheVal: 2.565 ± 0.02	0.513PheTrp: 0.513 ± 0.009	1.017PheTyr: 1.017 ± 0.013	0.001PheXaa: 0.001 ± 0.0
Gly	5.639GlyAla: 5.639 ± 0.038	1.17GlyCys: 1.17 ± 0.014	3.753GlyAsp: 3.753 ± 0.026	4.252GlyGlu: 4.252 ± 0.027	2.663GlyPhe: 2.663 ± 0.024	6.818GlyGly: 6.818 ± 0.055	1.677GlyHis: 1.677 ± 0.017	3.043GlyIle: 3.043 ± 0.022	3.848GlyLys: 3.848 ± 0.025	6.354GlyLeu: 6.354 ± 0.032	1.617GlyMet: 1.617 ± 0.017	2.6GlyAsn: 2.6 ± 0.023	3.348GlyPro: 3.348 ± 0.026	2.559GlyGln: 2.559 ± 0.021	5.114GlyArg: 5.114 ± 0.034	6.428GlySer: 6.428 ± 0.04	3.763GlyThr: 3.763 ± 0.024	4.878GlyVal: 4.878 ± 0.027	1.039GlyTrp: 1.039 ± 0.012	1.767GlyTyr: 1.767 ± 0.02	0.002GlyXaa: 0.002 ± 0.001
His	1.609HisAla: 1.609 ± 0.013	0.449HisCys: 0.449 ± 0.007	1.087HisAsp: 1.087 ± 0.014	1.346HisGlu: 1.346 ± 0.014	0.874HisPhe: 0.874 ± 0.011	1.65HisGly: 1.65 ± 0.016	0.759HisHis: 0.759 ± 0.013	1.003HisIle: 1.003 ± 0.013	0.959HisLys: 0.959 ± 0.01	2.213HisLeu: 2.213 ± 0.02	0.532HisMet: 0.532 ± 0.009	0.727HisAsn: 0.727 ± 0.011	1.28HisPro: 1.28 ± 0.013	0.942HisGln: 0.942 ± 0.012	1.501HisArg: 1.501 ± 0.015	1.834HisSer: 1.834 ± 0.018	1.032HisThr: 1.032 ± 0.012	1.536HisVal: 1.536 ± 0.015	0.338HisTrp: 0.338 ± 0.007	0.587HisTyr: 0.587 ± 0.009	0.001HisXaa: 0.001 ± 0.0
Ile	3.513IleAla: 3.513 ± 0.023	0.821IleCys: 0.821 ± 0.011	2.335IleAsp: 2.335 ± 0.02	2.646IleGlu: 2.646 ± 0.02	1.651IlePhe: 1.651 ± 0.018	2.802IleGly: 2.802 ± 0.02	0.978IleHis: 0.978 ± 0.011	1.871IleIle: 1.871 ± 0.017	1.97IleLys: 1.97 ± 0.018	4.26IleLeu: 4.26 ± 0.026	0.94IleMet: 0.94 ± 0.011	1.416IleAsn: 1.416 ± 0.013	2.509IlePro: 2.509 ± 0.025	1.637IleGln: 1.637 ± 0.015	2.523IleArg: 2.523 ± 0.023	3.555IleSer: 3.555 ± 0.024	2.182IleThr: 2.182 ± 0.02	3.13IleVal: 3.13 ± 0.022	0.566IleTrp: 0.566 ± 0.008	1.055IleTyr: 1.055 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	4.383LysAla: 4.383 ± 0.028	0.724LysCys: 0.724 ± 0.011	3.02LysAsp: 3.02 ± 0.023	4.249LysGlu: 4.249 ± 0.033	1.691LysPhe: 1.691 ± 0.015	3.328LysGly: 3.328 ± 0.026	1.13LysHis: 1.13 ± 0.012	2.253LysIle: 2.253 ± 0.019	3.862LysLys: 3.862 ± 0.035	5.052LysLeu: 5.052 ± 0.028	1.214LysMet: 1.214 ± 0.012	1.837LysAsn: 1.837 ± 0.016	2.383LysPro: 2.383 ± 0.021	2.075LysGln: 2.075 ± 0.017	3.676LysArg: 3.676 ± 0.026	4.103LysSer: 4.103 ± 0.029	2.621LysThr: 2.621 ± 0.023	3.682LysVal: 3.682 ± 0.027	0.693LysTrp: 0.693 ± 0.01	1.371LysTyr: 1.371 ± 0.015	0.001LysXaa: 0.001 ± 0.0
Leu	7.586LeuAla: 7.586 ± 0.032	1.645LeuCys: 1.645 ± 0.014	5.025LeuAsp: 5.025 ± 0.029	6.652LeuGlu: 6.652 ± 0.044	3.137LeuPhe: 3.137 ± 0.024	6.058LeuGly: 6.058 ± 0.034	2.324LeuHis: 2.324 ± 0.02	3.64LeuIle: 3.64 ± 0.029	5.124LeuLys: 5.124 ± 0.03	9.419LeuLeu: 9.419 ± 0.056	2.039LeuMet: 2.039 ± 0.017	3.133LeuAsn: 3.133 ± 0.025	5.139LeuPro: 5.139 ± 0.032	4.605LeuGln: 4.605 ± 0.031	6.283LeuArg: 6.283 ± 0.035	7.692LeuSer: 7.692 ± 0.041	4.722LeuThr: 4.722 ± 0.03	6.321LeuVal: 6.321 ± 0.032	1.272LeuTrp: 1.272 ± 0.015	2.148LeuTyr: 2.148 ± 0.018	0.002LeuXaa: 0.002 ± 0.0
Met	2.257MetAla: 2.257 ± 0.02	0.33MetCys: 0.33 ± 0.006	1.337MetAsp: 1.337 ± 0.013	1.785MetGlu: 1.785 ± 0.015	0.694MetPhe: 0.694 ± 0.009	1.602MetGly: 1.602 ± 0.017	0.497MetHis: 0.497 ± 0.009	0.924MetIle: 0.924 ± 0.011	1.344MetLys: 1.344 ± 0.015	2.011MetLeu: 2.011 ± 0.018	0.629MetMet: 0.629 ± 0.01	0.817MetAsn: 0.817 ± 0.011	1.036MetPro: 1.036 ± 0.013	0.956MetGln: 0.956 ± 0.011	1.413MetArg: 1.413 ± 0.013	1.791MetSer: 1.791 ± 0.015	1.166MetThr: 1.166 ± 0.012	1.537MetVal: 1.537 ± 0.016	0.279MetTrp: 0.279 ± 0.006	0.53MetTyr: 0.53 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.572AsnAla: 2.572 ± 0.02	0.644AsnCys: 0.644 ± 0.01	1.585AsnAsp: 1.585 ± 0.015	1.983AsnGlu: 1.983 ± 0.018	1.493AsnPhe: 1.493 ± 0.016	2.669AsnGly: 2.669 ± 0.023	0.769AsnHis: 0.769 ± 0.01	1.578AsnIle: 1.578 ± 0.014	1.618AsnLys: 1.618 ± 0.017	3.661AsnLeu: 3.661 ± 0.03	0.857AsnMet: 0.857 ± 0.01	1.347AsnAsn: 1.347 ± 0.018	1.884AsnPro: 1.884 ± 0.018	1.262AsnGln: 1.262 ± 0.014	1.932AsnArg: 1.932 ± 0.018	3.028AsnSer: 3.028 ± 0.024	1.606AsnThr: 1.606 ± 0.015	2.506AsnVal: 2.506 ± 0.02	0.542AsnTrp: 0.542 ± 0.01	0.925AsnTyr: 0.925 ± 0.012	0.001AsnXaa: 0.001 ± 0.0
Pro	4.332ProAla: 4.332 ± 0.035	0.719ProCys: 0.719 ± 0.01	2.536ProAsp: 2.536 ± 0.02	3.367ProGlu: 3.367 ± 0.022	1.76ProPhe: 1.76 ± 0.016	3.594ProGly: 3.594 ± 0.027	1.097ProHis: 1.097 ± 0.013	1.974ProIle: 1.974 ± 0.015	2.487ProLys: 2.487 ± 0.02	4.418ProLeu: 4.418 ± 0.027	1.033ProMet: 1.033 ± 0.013	1.67ProAsn: 1.67 ± 0.018	4.247ProPro: 4.247 ± 0.068	1.988ProGln: 1.988 ± 0.022	3.083ProArg: 3.083 ± 0.025	5.4ProSer: 5.4 ± 0.038	2.918ProThr: 2.918 ± 0.021	3.565ProVal: 3.565 ± 0.026	0.63ProTrp: 0.63 ± 0.01	1.161ProTyr: 1.161 ± 0.015	0.001ProXaa: 0.001 ± 0.0
Gln	3.245GlnAla: 3.245 ± 0.026	0.578GlnCys: 0.578 ± 0.009	1.813GlnAsp: 1.813 ± 0.018	2.743GlnGlu: 2.743 ± 0.022	1.283GlnPhe: 1.283 ± 0.012	2.496GlnGly: 2.496 ± 0.019	0.993GlnHis: 0.993 ± 0.014	1.769GlnIle: 1.769 ± 0.017	2.113GlnLys: 2.113 ± 0.018	3.857GlnLeu: 3.857 ± 0.028	0.945GlnMet: 0.945 ± 0.012	1.386GlnAsn: 1.386 ± 0.015	1.911GlnPro: 1.911 ± 0.02	2.688GlnGln: 2.688 ± 0.058	2.696GlnArg: 2.696 ± 0.02	3.101GlnSer: 3.101 ± 0.026	1.902GlnThr: 1.902 ± 0.018	2.666GlnVal: 2.666 ± 0.021	0.501GlnTrp: 0.501 ± 0.008	0.877GlnTyr: 0.877 ± 0.011	0.001GlnXaa: 0.001 ± 0.0
Arg	5.021ArgAla: 5.021 ± 0.035	1.05ArgCys: 1.05 ± 0.013	3.284ArgAsp: 3.284 ± 0.027	4.392ArgGlu: 4.392 ± 0.032	2.114ArgPhe: 2.114 ± 0.018	4.508ArgGly: 4.508 ± 0.033	1.459ArgHis: 1.459 ± 0.015	2.842ArgIle: 2.842 ± 0.022	3.911ArgLys: 3.911 ± 0.027	5.894ArgLeu: 5.894 ± 0.033	1.5ArgMet: 1.5 ± 0.014	2.349ArgAsn: 2.349 ± 0.02	3.155ArgPro: 3.155 ± 0.023	2.409ArgGln: 2.409 ± 0.021	5.648ArgArg: 5.648 ± 0.044	5.539ArgSer: 5.539 ± 0.036	3.234ArgThr: 3.234 ± 0.022	3.995ArgVal: 3.995 ± 0.023	0.9ArgTrp: 0.9 ± 0.012	1.363ArgTyr: 1.363 ± 0.015	0.002ArgXaa: 0.002 ± 0.0
Ser	6.822SerAla: 6.822 ± 0.039	1.463SerCys: 1.463 ± 0.016	4.23SerAsp: 4.23 ± 0.025	5.136SerGlu: 5.136 ± 0.034	3.141SerPhe: 3.141 ± 0.024	6.507SerGly: 6.507 ± 0.04	1.771SerHis: 1.771 ± 0.015	3.507SerIle: 3.507 ± 0.023	4.31SerLys: 4.31 ± 0.029	7.719SerLeu: 7.719 ± 0.039	1.897SerMet: 1.897 ± 0.015	2.979SerAsn: 2.979 ± 0.02	4.943SerPro: 4.943 ± 0.041	3.172SerGln: 3.172 ± 0.026	5.54SerArg: 5.54 ± 0.034	10.336SerSer: 10.336 ± 0.063	4.931SerThr: 4.931 ± 0.026	5.516SerVal: 5.516 ± 0.03	1.144SerTrp: 1.144 ± 0.012	1.834SerTyr: 1.834 ± 0.017	0.002SerXaa: 0.002 ± 0.0
Thr	4.232ThrAla: 4.232 ± 0.025	0.856ThrCys: 0.856 ± 0.012	2.513ThrAsp: 2.513 ± 0.022	3.099ThrGlu: 3.099 ± 0.026	1.974ThrPhe: 1.974 ± 0.02	3.889ThrGly: 3.889 ± 0.027	1.028ThrHis: 1.028 ± 0.011	2.296ThrIle: 2.296 ± 0.018	2.506ThrLys: 2.506 ± 0.021	4.78ThrLeu: 4.78 ± 0.027	1.163ThrMet: 1.163 ± 0.013	1.746ThrAsn: 1.746 ± 0.016	3.018ThrPro: 3.018 ± 0.027	1.716ThrGln: 1.716 ± 0.015	3.015ThrArg: 3.015 ± 0.02	4.917ThrSer: 4.917 ± 0.031	3.056ThrThr: 3.056 ± 0.027	3.676ThrVal: 3.676 ± 0.023	0.68ThrTrp: 0.68 ± 0.012	1.237ThrTyr: 1.237 ± 0.014	0.001ThrXaa: 0.001 ± 0.0
Val	5.917ValAla: 5.917 ± 0.035	1.171ValCys: 1.171 ± 0.013	4.05ValAsp: 4.05 ± 0.026	5.044ValGlu: 5.044 ± 0.033	2.37ValPhe: 2.37 ± 0.02	4.763ValGly: 4.763 ± 0.034	1.546ValHis: 1.546 ± 0.014	2.853ValIle: 2.853 ± 0.022	3.676ValLys: 3.676 ± 0.025	6.58ValLeu: 6.58 ± 0.036	1.538ValMet: 1.538 ± 0.014	2.339ValAsn: 2.339 ± 0.016	3.693ValPro: 3.693 ± 0.024	2.772ValGln: 2.772 ± 0.018	3.956ValArg: 3.956 ± 0.024	5.31ValSer: 5.31 ± 0.033	3.576ValThr: 3.576 ± 0.024	5.582ValVal: 5.582 ± 0.034	0.837ValTrp: 0.837 ± 0.01	1.692ValTyr: 1.692 ± 0.017	0.002ValXaa: 0.002 ± 0.0
Trp	0.947TrpAla: 0.947 ± 0.011	0.23TrpCys: 0.23 ± 0.005	0.724TrpAsp: 0.724 ± 0.011	0.818TrpGlu: 0.818 ± 0.011	0.448TrpPhe: 0.448 ± 0.009	0.863TrpGly: 0.863 ± 0.01	0.317TrpHis: 0.317 ± 0.007	0.623TrpIle: 0.623 ± 0.01	0.836TrpLys: 0.836 ± 0.012	1.226TrpLeu: 1.226 ± 0.014	0.341TrpMet: 0.341 ± 0.007	0.629TrpAsn: 0.629 ± 0.01	0.597TrpPro: 0.597 ± 0.01	0.573TrpGln: 0.573 ± 0.009	1.007TrpArg: 1.007 ± 0.012	1.046TrpSer: 1.046 ± 0.013	0.781TrpThr: 0.781 ± 0.012	0.778TrpVal: 0.778 ± 0.011	0.242TrpTrp: 0.242 ± 0.007	0.314TrpTyr: 0.314 ± 0.007	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.694TyrAla: 1.694 ± 0.015	0.442TyrCys: 0.442 ± 0.009	1.351TyrAsp: 1.351 ± 0.018	1.43TyrGlu: 1.43 ± 0.016	0.953TyrPhe: 0.953 ± 0.012	1.828TyrGly: 1.828 ± 0.02	0.576TyrHis: 0.576 ± 0.008	1.054TyrIle: 1.054 ± 0.012	1.204TyrLys: 1.204 ± 0.016	2.3TyrLeu: 2.3 ± 0.02	0.593TyrMet: 0.593 ± 0.01	1.045TyrAsn: 1.045 ± 0.013	1.108TyrPro: 1.108 ± 0.014	0.846TyrGln: 0.846 ± 0.011	1.413TyrArg: 1.413 ± 0.014	1.823TyrSer: 1.823 ± 0.016	1.206TyrThr: 1.206 ± 0.014	1.644TyrVal: 1.644 ± 0.016	0.356TyrTrp: 0.356 ± 0.008	0.744TyrTyr: 0.744 ± 0.012	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.003XaaGly: 0.003 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.114XaaXaa: 0.114 ± 0.024

Statistics based on 17951 proteins (7780001 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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