Amino acid dipepetide frequency for Klebsiella pneumoniae IS53

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.184AlaAla: 10.184 ± 0.113	1.123AlaCys: 1.123 ± 0.03	5.141AlaAsp: 5.141 ± 0.072	5.843AlaGlu: 5.843 ± 0.081	3.709AlaPhe: 3.709 ± 0.06	7.829AlaGly: 7.829 ± 0.1	1.926AlaHis: 1.926 ± 0.044	6.008AlaIle: 6.008 ± 0.09	3.898AlaLys: 3.898 ± 0.065	11.445AlaLeu: 11.445 ± 0.114	3.098AlaMet: 3.098 ± 0.056	3.029AlaAsn: 3.029 ± 0.054	3.521AlaPro: 3.521 ± 0.056	4.361AlaGln: 4.361 ± 0.071	5.634AlaArg: 5.634 ± 0.068	5.508AlaSer: 5.508 ± 0.075	4.72AlaThr: 4.72 ± 0.07	6.951AlaVal: 6.951 ± 0.082	1.736AlaTrp: 1.736 ± 0.039	2.012AlaTyr: 2.012 ± 0.04	0.003AlaXaa: 0.003 ± 0.002
Cys	1.017CysAla: 1.017 ± 0.031	0.24CysCys: 0.24 ± 0.016	0.56CysAsp: 0.56 ± 0.021	0.584CysGlu: 0.584 ± 0.022	0.487CysPhe: 0.487 ± 0.021	1.065CysGly: 1.065 ± 0.035	0.337CysHis: 0.337 ± 0.018	0.54CysIle: 0.54 ± 0.024	0.337CysLys: 0.337 ± 0.017	1.066CysLeu: 1.066 ± 0.033	0.294CysMet: 0.294 ± 0.014	0.313CysAsn: 0.313 ± 0.018	0.538CysPro: 0.538 ± 0.022	0.451CysGln: 0.451 ± 0.017	0.794CysArg: 0.794 ± 0.028	0.731CysSer: 0.731 ± 0.02	0.495CysThr: 0.495 ± 0.021	0.724CysVal: 0.724 ± 0.026	0.235CysTrp: 0.235 ± 0.012	0.347CysTyr: 0.347 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.039AspAla: 5.039 ± 0.069	0.517AspCys: 0.517 ± 0.02	2.967AspAsp: 2.967 ± 0.057	3.489AspGlu: 3.489 ± 0.06	2.137AspPhe: 2.137 ± 0.052	3.77AspGly: 3.77 ± 0.064	1.077AspHis: 1.077 ± 0.034	3.434AspIle: 3.434 ± 0.048	2.564AspLys: 2.564 ± 0.049	4.692AspLeu: 4.692 ± 0.068	1.367AspMet: 1.367 ± 0.038	2.151AspAsn: 2.151 ± 0.051	2.353AspPro: 2.353 ± 0.045	1.633AspGln: 1.633 ± 0.033	2.895AspArg: 2.895 ± 0.053	2.74AspSer: 2.74 ± 0.055	2.427AspThr: 2.427 ± 0.052	3.673AspVal: 3.673 ± 0.056	0.819AspTrp: 0.819 ± 0.026	1.907AspTyr: 1.907 ± 0.046	0.001AspXaa: 0.001 ± 0.001
Glu	5.345GluAla: 5.345 ± 0.086	0.477GluCys: 0.477 ± 0.023	2.313GluAsp: 2.313 ± 0.051	3.419GluGlu: 3.419 ± 0.08	1.84GluPhe: 1.84 ± 0.041	3.675GluGly: 3.675 ± 0.058	1.369GluHis: 1.369 ± 0.034	3.289GluIle: 3.289 ± 0.055	3.249GluLys: 3.249 ± 0.052	5.574GluLeu: 5.574 ± 0.079	1.887GluMet: 1.887 ± 0.037	2.191GluAsn: 2.191 ± 0.042	1.978GluPro: 1.978 ± 0.043	3.159GluGln: 3.159 ± 0.057	3.57GluArg: 3.57 ± 0.057	2.841GluSer: 2.841 ± 0.048	2.815GluThr: 2.815 ± 0.055	3.691GluVal: 3.691 ± 0.053	0.777GluTrp: 0.777 ± 0.026	1.487GluTyr: 1.487 ± 0.042	0.001GluXaa: 0.001 ± 0.001
Phe	3.859PheAla: 3.859 ± 0.068	0.593PheCys: 0.593 ± 0.026	2.368PheAsp: 2.368 ± 0.052	1.749PheGlu: 1.749 ± 0.04	1.9PhePhe: 1.9 ± 0.051	3.214PheGly: 3.214 ± 0.055	0.902PheHis: 0.902 ± 0.025	2.711PheIle: 2.711 ± 0.054	1.275PheLys: 1.275 ± 0.033	3.477PheLeu: 3.477 ± 0.065	1.087PheMet: 1.087 ± 0.031	1.766PheAsn: 1.766 ± 0.035	1.607PhePro: 1.607 ± 0.033	1.21PheGln: 1.21 ± 0.034	2.027PheArg: 2.027 ± 0.043	3.196PheSer: 3.196 ± 0.052	2.557PheThr: 2.557 ± 0.043	2.666PheVal: 2.666 ± 0.057	0.69PheTrp: 0.69 ± 0.025	1.293PheTyr: 1.293 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.225GlyAla: 6.225 ± 0.079	1.017GlyCys: 1.017 ± 0.033	3.75GlyAsp: 3.75 ± 0.062	4.56GlyGlu: 4.56 ± 0.068	3.405GlyPhe: 3.405 ± 0.062	5.499GlyGly: 5.499 ± 0.077	1.722GlyHis: 1.722 ± 0.043	5.085GlyIle: 5.085 ± 0.075	4.082GlyLys: 4.082 ± 0.073	7.493GlyLeu: 7.493 ± 0.085	2.532GlyMet: 2.532 ± 0.045	2.635GlyAsn: 2.635 ± 0.057	2.08GlyPro: 2.08 ± 0.05	2.877GlyGln: 2.877 ± 0.049	3.934GlyArg: 3.934 ± 0.056	4.147GlySer: 4.147 ± 0.066	3.62GlyThr: 3.62 ± 0.065	5.705GlyVal: 5.705 ± 0.071	1.337GlyTrp: 1.337 ± 0.037	2.718GlyTyr: 2.718 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.907HisAla: 1.907 ± 0.036	0.323HisCys: 0.323 ± 0.018	1.299HisAsp: 1.299 ± 0.039	1.066HisGlu: 1.066 ± 0.03	1.148HisPhe: 1.148 ± 0.031	1.793HisGly: 1.793 ± 0.041	0.923HisHis: 0.923 ± 0.033	1.419HisIle: 1.419 ± 0.036	0.781HisLys: 0.781 ± 0.029	2.363HisLeu: 2.363 ± 0.048	0.588HisMet: 0.588 ± 0.024	0.838HisAsn: 0.838 ± 0.026	1.378HisPro: 1.378 ± 0.036	1.28HisGln: 1.28 ± 0.033	1.415HisArg: 1.415 ± 0.033	1.279HisSer: 1.279 ± 0.035	1.074HisThr: 1.074 ± 0.029	1.336HisVal: 1.336 ± 0.033	0.402HisTrp: 0.402 ± 0.017	0.982HisTyr: 0.982 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.652IleAla: 6.652 ± 0.091	0.725IleCys: 0.725 ± 0.024	3.599IleAsp: 3.599 ± 0.055	3.137IleGlu: 3.137 ± 0.062	2.236IlePhe: 2.236 ± 0.052	4.585IleGly: 4.585 ± 0.08	1.264IleHis: 1.264 ± 0.034	3.549IleIle: 3.549 ± 0.062	2.383IleLys: 2.383 ± 0.047	5.018IleLeu: 5.018 ± 0.08	1.298IleMet: 1.298 ± 0.032	2.642IleAsn: 2.642 ± 0.043	2.858IlePro: 2.858 ± 0.049	1.771IleGln: 1.771 ± 0.036	3.135IleArg: 3.135 ± 0.048	3.718IleSer: 3.718 ± 0.052	3.461IleThr: 3.461 ± 0.063	4.077IleVal: 4.077 ± 0.062	0.72IleTrp: 0.72 ± 0.024	1.614IleTyr: 1.614 ± 0.04	0.002IleXaa: 0.002 ± 0.001
Lys	4.408LysAla: 4.408 ± 0.073	0.295LysCys: 0.295 ± 0.014	2.066LysAsp: 2.066 ± 0.046	2.326LysGlu: 2.326 ± 0.049	1.156LysPhe: 1.156 ± 0.033	2.972LysGly: 2.972 ± 0.049	0.905LysHis: 0.905 ± 0.029	2.414LysIle: 2.414 ± 0.048	2.403LysLys: 2.403 ± 0.045	4.182LysLeu: 4.182 ± 0.064	1.311LysMet: 1.311 ± 0.037	1.771LysAsn: 1.771 ± 0.043	2.099LysPro: 2.099 ± 0.051	1.925LysGln: 1.925 ± 0.037	2.686LysArg: 2.686 ± 0.044	2.336LysSer: 2.336 ± 0.051	2.604LysThr: 2.604 ± 0.043	3.012LysVal: 3.012 ± 0.055	0.465LysTrp: 0.465 ± 0.023	1.191LysTyr: 1.191 ± 0.038	0.002LysXaa: 0.002 ± 0.001
Leu	11.191LeuAla: 11.191 ± 0.121	1.257LeuCys: 1.257 ± 0.033	5.134LeuAsp: 5.134 ± 0.074	5.156LeuGlu: 5.156 ± 0.079	4.437LeuPhe: 4.437 ± 0.073	7.079LeuGly: 7.079 ± 0.076	2.301LeuHis: 2.301 ± 0.047	5.811LeuIle: 5.811 ± 0.08	4.507LeuLys: 4.507 ± 0.067	11.658LeuLeu: 11.658 ± 0.157	3.025LeuMet: 3.025 ± 0.058	4.042LeuAsn: 4.042 ± 0.054	5.467LeuPro: 5.467 ± 0.076	4.329LeuGln: 4.329 ± 0.059	6.245LeuArg: 6.245 ± 0.081	7.219LeuSer: 7.219 ± 0.084	6.219LeuThr: 6.219 ± 0.076	6.884LeuVal: 6.884 ± 0.095	1.429LeuTrp: 1.429 ± 0.037	2.66LeuTyr: 2.66 ± 0.05	0.002LeuXaa: 0.002 ± 0.001
Met	3.103MetAla: 3.103 ± 0.056	0.217MetCys: 0.217 ± 0.014	1.241MetAsp: 1.241 ± 0.036	1.292MetGlu: 1.292 ± 0.033	0.986MetPhe: 0.986 ± 0.035	1.952MetGly: 1.952 ± 0.045	0.586MetHis: 0.586 ± 0.024	1.584MetIle: 1.584 ± 0.037	1.504MetLys: 1.504 ± 0.036	3.29MetLeu: 3.29 ± 0.065	0.946MetMet: 0.946 ± 0.031	1.2MetAsn: 1.2 ± 0.036	1.496MetPro: 1.496 ± 0.033	1.223MetGln: 1.223 ± 0.031	1.617MetArg: 1.617 ± 0.037	1.853MetSer: 1.853 ± 0.041	1.879MetThr: 1.879 ± 0.042	2.068MetVal: 2.068 ± 0.049	0.29MetTrp: 0.29 ± 0.017	0.57MetTyr: 0.57 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.313AsnAla: 3.313 ± 0.053	0.315AsnCys: 0.315 ± 0.015	2.025AsnAsp: 2.025 ± 0.043	1.815AsnGlu: 1.815 ± 0.039	1.366AsnPhe: 1.366 ± 0.041	3.018AsnGly: 3.018 ± 0.059	0.912AsnHis: 0.912 ± 0.028	2.354AsnIle: 2.354 ± 0.047	1.58AsnLys: 1.58 ± 0.04	3.409AsnLeu: 3.409 ± 0.054	0.988AsnMet: 0.988 ± 0.027	1.534AsnAsn: 1.534 ± 0.038	2.087AsnPro: 2.087 ± 0.036	1.511AsnGln: 1.511 ± 0.032	1.927AsnArg: 1.927 ± 0.041	1.935AsnSer: 1.935 ± 0.047	1.929AsnThr: 1.929 ± 0.044	2.488AsnVal: 2.488 ± 0.043	0.562AsnTrp: 0.562 ± 0.02	1.197AsnTyr: 1.197 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.735ProAla: 4.735 ± 0.061	0.4ProCys: 0.4 ± 0.019	2.786ProAsp: 2.786 ± 0.051	3.254ProGlu: 3.254 ± 0.057	1.96ProPhe: 1.96 ± 0.04	3.662ProGly: 3.662 ± 0.063	1.083ProHis: 1.083 ± 0.032	1.862ProIle: 1.862 ± 0.045	1.472ProLys: 1.472 ± 0.035	5.031ProLeu: 5.031 ± 0.073	1.135ProMet: 1.135 ± 0.031	1.226ProAsn: 1.226 ± 0.032	1.795ProPro: 1.795 ± 0.05	2.285ProGln: 2.285 ± 0.047	2.196ProArg: 2.196 ± 0.045	2.261ProSer: 2.261 ± 0.037	2.051ProThr: 2.051 ± 0.045	3.744ProVal: 3.744 ± 0.065	0.775ProTrp: 0.775 ± 0.029	1.213ProTyr: 1.213 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.538GlnAla: 4.538 ± 0.067	0.38GlnCys: 0.38 ± 0.018	1.729GlnAsp: 1.729 ± 0.042	2.126GlnGlu: 2.126 ± 0.046	1.53GlnPhe: 1.53 ± 0.036	3.022GlnGly: 3.022 ± 0.051	1.325GlnHis: 1.325 ± 0.038	2.232GlnIle: 2.232 ± 0.044	1.824GlnLys: 1.824 ± 0.043	4.789GlnLeu: 4.789 ± 0.08	1.275GlnMet: 1.275 ± 0.036	1.424GlnAsn: 1.424 ± 0.037	2.107GlnPro: 2.107 ± 0.047	3.247GlnGln: 3.247 ± 0.078	3.345GlnArg: 3.345 ± 0.067	2.271GlnSer: 2.271 ± 0.048	2.131GlnThr: 2.131 ± 0.046	2.961GlnVal: 2.961 ± 0.042	0.66GlnTrp: 0.66 ± 0.024	1.229GlnTyr: 1.229 ± 0.033	0.001GlnXaa: 0.001 ± 0.001
Arg	4.721ArgAla: 4.721 ± 0.063	0.736ArgCys: 0.736 ± 0.026	3.082ArgAsp: 3.082 ± 0.053	3.787ArgGlu: 3.787 ± 0.063	2.747ArgPhe: 2.747 ± 0.054	3.647ArgGly: 3.647 ± 0.062	1.8ArgHis: 1.8 ± 0.045	3.398ArgIle: 3.398 ± 0.059	2.456ArgLys: 2.456 ± 0.05	6.527ArgLeu: 6.527 ± 0.079	1.861ArgMet: 1.861 ± 0.043	1.968ArgAsn: 1.968 ± 0.044	2.519ArgPro: 2.519 ± 0.05	3.348ArgGln: 3.348 ± 0.065	4.349ArgArg: 4.349 ± 0.089	3.038ArgSer: 3.038 ± 0.061	2.463ArgThr: 2.463 ± 0.051	3.738ArgVal: 3.738 ± 0.061	1.113ArgTrp: 1.113 ± 0.031	2.279ArgTyr: 2.279 ± 0.044	0.001ArgXaa: 0.001 ± 0.001
Ser	5.87SerAla: 5.87 ± 0.082	0.649SerCys: 0.649 ± 0.025	3.042SerAsp: 3.042 ± 0.054	3.046SerGlu: 3.046 ± 0.055	2.347SerPhe: 2.347 ± 0.048	5.247SerGly: 5.247 ± 0.066	1.425SerHis: 1.425 ± 0.034	2.967SerIle: 2.967 ± 0.046	2.015SerLys: 2.015 ± 0.041	6.627SerLeu: 6.627 ± 0.09	1.576SerMet: 1.576 ± 0.039	1.805SerAsn: 1.805 ± 0.037	2.797SerPro: 2.797 ± 0.056	2.44SerGln: 2.44 ± 0.051	3.649SerArg: 3.649 ± 0.054	3.505SerSer: 3.505 ± 0.068	2.934SerThr: 2.934 ± 0.058	4.1SerVal: 4.1 ± 0.063	1.056SerTrp: 1.056 ± 0.028	1.649SerTyr: 1.649 ± 0.04	0.003SerXaa: 0.003 ± 0.002
Thr	5.024ThrAla: 5.024 ± 0.078	0.531ThrCys: 0.531 ± 0.022	2.513ThrAsp: 2.513 ± 0.047	2.5ThrGlu: 2.5 ± 0.042	2.103ThrPhe: 2.103 ± 0.045	4.363ThrGly: 4.363 ± 0.058	1.175ThrHis: 1.175 ± 0.034	2.968ThrIle: 2.968 ± 0.057	1.495ThrLys: 1.495 ± 0.041	7.103ThrLeu: 7.103 ± 0.071	1.232ThrMet: 1.232 ± 0.032	1.484ThrAsn: 1.484 ± 0.043	3.125ThrPro: 3.125 ± 0.058	1.929ThrGln: 1.929 ± 0.046	3.107ThrArg: 3.107 ± 0.05	2.949ThrSer: 2.949 ± 0.058	2.904ThrThr: 2.904 ± 0.064	3.831ThrVal: 3.831 ± 0.062	0.878ThrTrp: 0.878 ± 0.028	1.181ThrTyr: 1.181 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.932ValAla: 6.932 ± 0.082	0.754ValCys: 0.754 ± 0.024	3.796ValAsp: 3.796 ± 0.058	3.966ValGlu: 3.966 ± 0.066	2.646ValPhe: 2.646 ± 0.054	4.862ValGly: 4.862 ± 0.072	1.303ValHis: 1.303 ± 0.034	4.624ValIle: 4.624 ± 0.072	3.185ValLys: 3.185 ± 0.059	6.915ValLeu: 6.915 ± 0.09	2.258ValMet: 2.258 ± 0.045	2.749ValAsn: 2.749 ± 0.048	2.977ValPro: 2.977 ± 0.052	2.376ValGln: 2.376 ± 0.05	3.725ValArg: 3.725 ± 0.068	4.541ValSer: 4.541 ± 0.066	4.0ValThr: 4.0 ± 0.066	5.547ValVal: 5.547 ± 0.074	0.967ValTrp: 0.967 ± 0.028	1.815ValTyr: 1.815 ± 0.039	0.002ValXaa: 0.002 ± 0.001
Trp	1.042TrpAla: 1.042 ± 0.03	0.198TrpCys: 0.198 ± 0.012	0.665TrpAsp: 0.665 ± 0.024	0.589TrpGlu: 0.589 ± 0.024	0.758TrpPhe: 0.758 ± 0.031	0.954TrpGly: 0.954 ± 0.028	0.457TrpHis: 0.457 ± 0.02	0.758TrpIle: 0.758 ± 0.025	0.546TrpLys: 0.546 ± 0.02	2.329TrpLeu: 2.329 ± 0.049	0.485TrpMet: 0.485 ± 0.021	0.517TrpAsn: 0.517 ± 0.021	0.699TrpPro: 0.699 ± 0.027	1.172TrpGln: 1.172 ± 0.034	1.269TrpArg: 1.269 ± 0.037	0.875TrpSer: 0.875 ± 0.028	0.643TrpThr: 0.643 ± 0.023	0.977TrpVal: 0.977 ± 0.029	0.237TrpTrp: 0.237 ± 0.013	0.448TrpTyr: 0.448 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.575TyrAla: 2.575 ± 0.047	0.409TyrCys: 0.409 ± 0.02	1.577TyrAsp: 1.577 ± 0.035	1.241TyrGlu: 1.241 ± 0.036	1.248TyrPhe: 1.248 ± 0.036	2.212TyrGly: 2.212 ± 0.046	0.801TyrHis: 0.801 ± 0.027	1.436TyrIle: 1.436 ± 0.037	0.973TyrLys: 0.973 ± 0.029	3.062TyrLeu: 3.062 ± 0.051	0.652TyrMet: 0.652 ± 0.026	0.982TyrAsn: 0.982 ± 0.031	1.44TyrPro: 1.44 ± 0.041	1.619TyrGln: 1.619 ± 0.04	2.058TyrArg: 2.058 ± 0.048	1.805TyrSer: 1.805 ± 0.04	1.469TyrThr: 1.469 ± 0.042	1.765TyrVal: 1.765 ± 0.035	0.468TyrTrp: 0.468 ± 0.02	1.044TyrTyr: 1.044 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.003XaaVal: 0.003 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.003XaaXaa: 0.003 ± 0.001

Statistics based on 5308 proteins (1145449 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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