Amino acid dipepetide frequency for Actinokineospora auranticolor

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.689AlaAla: 21.689 ± 0.15	1.088AlaCys: 1.088 ± 0.023	9.277AlaAsp: 9.277 ± 0.067	8.844AlaGlu: 8.844 ± 0.079	3.457AlaPhe: 3.457 ± 0.042	12.632AlaGly: 12.632 ± 0.105	3.122AlaHis: 3.122 ± 0.043	4.069AlaIle: 4.069 ± 0.045	2.738AlaLys: 2.738 ± 0.048	14.659AlaLeu: 14.659 ± 0.117	2.289AlaMet: 2.289 ± 0.032	2.368AlaAsn: 2.368 ± 0.039	6.775AlaPro: 6.775 ± 0.07	3.425AlaGln: 3.425 ± 0.039	10.549AlaArg: 10.549 ± 0.084	5.161AlaSer: 5.161 ± 0.053	8.036AlaThr: 8.036 ± 0.072	13.504AlaVal: 13.504 ± 0.108	1.874AlaTrp: 1.874 ± 0.033	2.344AlaTyr: 2.344 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.24CysAla: 1.24 ± 0.02	0.09CysCys: 0.09 ± 0.007	0.487CysAsp: 0.487 ± 0.018	0.35CysGlu: 0.35 ± 0.012	0.192CysPhe: 0.192 ± 0.01	0.917CysGly: 0.917 ± 0.025	0.178CysHis: 0.178 ± 0.008	0.102CysIle: 0.102 ± 0.006	0.102CysLys: 0.102 ± 0.007	0.762CysLeu: 0.762 ± 0.018	0.09CysMet: 0.09 ± 0.006	0.115CysAsn: 0.115 ± 0.007	0.52CysPro: 0.52 ± 0.015	0.179CysGln: 0.179 ± 0.01	0.597CysArg: 0.597 ± 0.018	0.42CysSer: 0.42 ± 0.014	0.422CysThr: 0.422 ± 0.016	0.727CysVal: 0.727 ± 0.019	0.121CysTrp: 0.121 ± 0.007	0.163CysTyr: 0.163 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.609AspAla: 7.609 ± 0.059	0.425AspCys: 0.425 ± 0.014	3.891AspAsp: 3.891 ± 0.047	3.819AspGlu: 3.819 ± 0.042	1.563AspPhe: 1.563 ± 0.028	6.274AspGly: 6.274 ± 0.054	1.652AspHis: 1.652 ± 0.031	1.839AspIle: 1.839 ± 0.029	1.108AspLys: 1.108 ± 0.027	7.362AspLeu: 7.362 ± 0.059	0.709AspMet: 0.709 ± 0.015	1.172AspAsn: 1.172 ± 0.028	4.9AspPro: 4.9 ± 0.052	1.709AspGln: 1.709 ± 0.025	5.692AspArg: 5.692 ± 0.069	2.64AspSer: 2.64 ± 0.042	3.525AspThr: 3.525 ± 0.044	5.034AspVal: 5.034 ± 0.046	0.984AspTrp: 0.984 ± 0.018	1.217AspTyr: 1.217 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.123GluAla: 6.123 ± 0.067	0.366GluCys: 0.366 ± 0.012	2.395GluAsp: 2.395 ± 0.034	2.405GluGlu: 2.405 ± 0.039	1.69GluPhe: 1.69 ± 0.029	3.274GluGly: 3.274 ± 0.041	1.599GluHis: 1.599 ± 0.033	2.119GluIle: 2.119 ± 0.034	0.96GluLys: 0.96 ± 0.028	6.609GluLeu: 6.609 ± 0.064	0.75GluMet: 0.75 ± 0.019	0.885GluAsn: 0.885 ± 0.019	3.527GluPro: 3.527 ± 0.043	1.961GluGln: 1.961 ± 0.033	5.001GluArg: 5.001 ± 0.056	2.646GluSer: 2.646 ± 0.037	2.686GluThr: 2.686 ± 0.039	5.191GluVal: 5.191 ± 0.049	0.767GluTrp: 0.767 ± 0.019	1.007GluTyr: 1.007 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.948PheAla: 3.948 ± 0.045	0.232PheCys: 0.232 ± 0.009	2.226PheAsp: 2.226 ± 0.039	1.283PheGlu: 1.283 ± 0.027	0.804PhePhe: 0.804 ± 0.019	3.041PheGly: 3.041 ± 0.036	0.651PheHis: 0.651 ± 0.018	0.665PheIle: 0.665 ± 0.019	0.382PheLys: 0.382 ± 0.012	2.528PheLeu: 2.528 ± 0.038	0.295PheMet: 0.295 ± 0.01	0.511PheAsn: 0.511 ± 0.015	1.468PhePro: 1.468 ± 0.029	0.6PheGln: 0.6 ± 0.016	1.828PheArg: 1.828 ± 0.024	1.362PheSer: 1.362 ± 0.025	2.18PheThr: 2.18 ± 0.034	2.228PheVal: 2.228 ± 0.033	0.368PheTrp: 0.368 ± 0.013	0.538PheTyr: 0.538 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.882GlyAla: 10.882 ± 0.08	0.796GlyCys: 0.796 ± 0.02	5.32GlyAsp: 5.32 ± 0.053	4.685GlyGlu: 4.685 ± 0.05	2.901GlyPhe: 2.901 ± 0.039	8.337GlyGly: 8.337 ± 0.088	2.158GlyHis: 2.158 ± 0.031	3.149GlyIle: 3.149 ± 0.035	2.266GlyLys: 2.266 ± 0.04	9.402GlyLeu: 9.402 ± 0.079	1.774GlyMet: 1.774 ± 0.027	1.702GlyAsn: 1.702 ± 0.033	4.993GlyPro: 4.993 ± 0.059	2.592GlyGln: 2.592 ± 0.037	7.113GlyArg: 7.113 ± 0.072	4.965GlySer: 4.965 ± 0.064	6.205GlyThr: 6.205 ± 0.066	8.494GlyVal: 8.494 ± 0.074	1.674GlyTrp: 1.674 ± 0.028	2.169GlyTyr: 2.169 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.694HisAla: 2.694 ± 0.037	0.201HisCys: 0.201 ± 0.01	1.396HisAsp: 1.396 ± 0.027	1.084HisGlu: 1.084 ± 0.02	0.569HisPhe: 0.569 ± 0.014	2.206HisGly: 2.206 ± 0.034	0.714HisHis: 0.714 ± 0.022	0.58HisIle: 0.58 ± 0.015	0.311HisLys: 0.311 ± 0.012	2.574HisLeu: 2.574 ± 0.043	0.264HisMet: 0.264 ± 0.011	0.428HisAsn: 0.428 ± 0.015	1.925HisPro: 1.925 ± 0.031	0.637HisGln: 0.637 ± 0.02	2.228HisArg: 2.228 ± 0.034	0.988HisSer: 0.988 ± 0.019	1.355HisThr: 1.355 ± 0.028	1.774HisVal: 1.774 ± 0.028	0.369HisTrp: 0.369 ± 0.013	0.479HisTyr: 0.479 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.862IleAla: 4.862 ± 0.046	0.242IleCys: 0.242 ± 0.011	2.209IleAsp: 2.209 ± 0.033	1.774IleGlu: 1.774 ± 0.031	0.574IlePhe: 0.574 ± 0.016	3.522IleGly: 3.522 ± 0.04	0.585IleHis: 0.585 ± 0.016	0.815IleIle: 0.815 ± 0.02	0.574IleLys: 0.574 ± 0.016	2.1IleLeu: 2.1 ± 0.031	0.361IleMet: 0.361 ± 0.013	0.698IleAsn: 0.698 ± 0.018	1.798IlePro: 1.798 ± 0.027	0.627IleGln: 0.627 ± 0.018	2.233IleArg: 2.233 ± 0.027	1.64IleSer: 1.64 ± 0.025	2.62IleThr: 2.62 ± 0.039	2.475IleVal: 2.475 ± 0.037	0.329IleTrp: 0.329 ± 0.012	0.475IleTyr: 0.475 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.398LysAla: 2.398 ± 0.041	0.102LysCys: 0.102 ± 0.006	0.908LysAsp: 0.908 ± 0.023	0.762LysGlu: 0.762 ± 0.021	0.426LysPhe: 0.426 ± 0.015	1.359LysGly: 1.359 ± 0.027	0.401LysHis: 0.401 ± 0.014	0.692LysIle: 0.692 ± 0.02	0.46LysLys: 0.46 ± 0.019	1.795LysLeu: 1.795 ± 0.034	0.293LysMet: 0.293 ± 0.012	0.384LysAsn: 0.384 ± 0.014	1.38LysPro: 1.38 ± 0.031	0.568LysGln: 0.568 ± 0.017	1.409LysArg: 1.409 ± 0.033	1.057LysSer: 1.057 ± 0.024	1.135LysThr: 1.135 ± 0.022	1.846LysVal: 1.846 ± 0.033	0.263LysTrp: 0.263 ± 0.011	0.365LysTyr: 0.365 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	16.051LeuAla: 16.051 ± 0.13	0.817LeuCys: 0.817 ± 0.021	7.253LeuAsp: 7.253 ± 0.068	3.984LeuGlu: 3.984 ± 0.054	2.612LeuPhe: 2.612 ± 0.034	9.408LeuGly: 9.408 ± 0.081	2.133LeuHis: 2.133 ± 0.032	2.93LeuIle: 2.93 ± 0.039	1.411LeuLys: 1.411 ± 0.029	11.192LeuLeu: 11.192 ± 0.103	1.263LeuMet: 1.263 ± 0.025	1.631LeuAsn: 1.631 ± 0.026	6.636LeuPro: 6.636 ± 0.067	1.659LeuGln: 1.659 ± 0.026	9.459LeuArg: 9.459 ± 0.079	5.392LeuSer: 5.392 ± 0.046	6.91LeuThr: 6.91 ± 0.069	10.447LeuVal: 10.447 ± 0.066	1.333LeuTrp: 1.333 ± 0.027	1.539LeuTyr: 1.539 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.988MetAla: 1.988 ± 0.033	0.098MetCys: 0.098 ± 0.006	0.741MetAsp: 0.741 ± 0.017	0.507MetGlu: 0.507 ± 0.016	0.41MetPhe: 0.41 ± 0.013	1.125MetGly: 1.125 ± 0.02	0.266MetHis: 0.266 ± 0.011	0.564MetIle: 0.564 ± 0.015	0.278MetLys: 0.278 ± 0.012	1.426MetLeu: 1.426 ± 0.025	0.199MetMet: 0.199 ± 0.009	0.331MetAsn: 0.331 ± 0.012	0.93MetPro: 0.93 ± 0.02	0.297MetGln: 0.297 ± 0.011	1.321MetArg: 1.321 ± 0.02	1.224MetSer: 1.224 ± 0.022	1.417MetThr: 1.417 ± 0.025	1.316MetVal: 1.316 ± 0.026	0.159MetTrp: 0.159 ± 0.008	0.232MetTyr: 0.232 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.296AsnAla: 2.296 ± 0.031	0.166AsnCys: 0.166 ± 0.009	0.911AsnAsp: 0.911 ± 0.02	0.72AsnGlu: 0.72 ± 0.019	0.452AsnPhe: 0.452 ± 0.014	1.898AsnGly: 1.898 ± 0.038	0.427AsnHis: 0.427 ± 0.013	0.544AsnIle: 0.544 ± 0.016	0.339AsnLys: 0.339 ± 0.015	1.834AsnLeu: 1.834 ± 0.03	0.244AsnMet: 0.244 ± 0.01	0.491AsnAsn: 0.491 ± 0.023	1.605AsnPro: 1.605 ± 0.03	0.554AsnGln: 0.554 ± 0.017	1.551AsnArg: 1.551 ± 0.024	0.942AsnSer: 0.942 ± 0.025	1.224AsnThr: 1.224 ± 0.031	1.266AsnVal: 1.266 ± 0.026	0.258AsnTrp: 0.258 ± 0.011	0.435AsnTyr: 0.435 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.369ProAla: 8.369 ± 0.083	0.359ProCys: 0.359 ± 0.014	5.03ProAsp: 5.03 ± 0.052	3.975ProGlu: 3.975 ± 0.052	1.572ProPhe: 1.572 ± 0.029	6.648ProGly: 6.648 ± 0.067	1.312ProHis: 1.312 ± 0.028	1.559ProIle: 1.559 ± 0.028	1.066ProLys: 1.066 ± 0.025	5.331ProLeu: 5.331 ± 0.056	0.903ProMet: 0.903 ± 0.02	1.16ProAsn: 1.16 ± 0.027	3.929ProPro: 3.929 ± 0.073	1.414ProGln: 1.414 ± 0.026	4.448ProArg: 4.448 ± 0.049	3.1ProSer: 3.1 ± 0.049	4.126ProThr: 4.126 ± 0.054	5.981ProVal: 5.981 ± 0.059	0.951ProTrp: 0.951 ± 0.024	1.04ProTyr: 1.04 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.503GlnAla: 3.503 ± 0.043	0.177GlnCys: 0.177 ± 0.009	1.184GlnAsp: 1.184 ± 0.025	1.104GlnGlu: 1.104 ± 0.019	0.634GlnPhe: 0.634 ± 0.017	1.891GlnGly: 1.891 ± 0.027	0.544GlnHis: 0.544 ± 0.016	0.856GlnIle: 0.856 ± 0.022	0.411GlnLys: 0.411 ± 0.014	2.587GlnLeu: 2.587 ± 0.037	0.344GlnMet: 0.344 ± 0.011	0.463GlnAsn: 0.463 ± 0.017	1.725GlnPro: 1.725 ± 0.041	0.963GlnGln: 0.963 ± 0.024	2.409GlnArg: 2.409 ± 0.034	1.157GlnSer: 1.157 ± 0.026	1.331GlnThr: 1.331 ± 0.03	2.698GlnVal: 2.698 ± 0.033	0.454GlnTrp: 0.454 ± 0.014	0.485GlnTyr: 0.485 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	11.178ArgAla: 11.178 ± 0.097	0.672ArgCys: 0.672 ± 0.018	4.748ArgAsp: 4.748 ± 0.042	4.521ArgGlu: 4.521 ± 0.054	2.601ArgPhe: 2.601 ± 0.033	6.295ArgGly: 6.295 ± 0.06	2.125ArgHis: 2.125 ± 0.027	2.709ArgIle: 2.709 ± 0.041	1.607ArgLys: 1.607 ± 0.032	8.905ArgLeu: 8.905 ± 0.082	1.667ArgMet: 1.667 ± 0.03	1.345ArgAsn: 1.345 ± 0.026	4.964ArgPro: 4.964 ± 0.065	2.185ArgGln: 2.185 ± 0.034	7.564ArgArg: 7.564 ± 0.079	3.957ArgSer: 3.957 ± 0.043	4.977ArgThr: 4.977 ± 0.053	7.614ArgVal: 7.614 ± 0.07	1.583ArgTrp: 1.583 ± 0.029	1.838ArgTyr: 1.838 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.851SerAla: 6.851 ± 0.056	0.401SerCys: 0.401 ± 0.016	2.606SerAsp: 2.606 ± 0.045	2.044SerGlu: 2.044 ± 0.031	1.4SerPhe: 1.4 ± 0.026	5.649SerGly: 5.649 ± 0.063	0.904SerHis: 0.904 ± 0.019	1.472SerIle: 1.472 ± 0.025	0.831SerLys: 0.831 ± 0.021	4.588SerLeu: 4.588 ± 0.043	0.911SerMet: 0.911 ± 0.018	0.879SerAsn: 0.879 ± 0.021	3.157SerPro: 3.157 ± 0.041	1.128SerGln: 1.128 ± 0.022	3.75SerArg: 3.75 ± 0.042	2.637SerSer: 2.637 ± 0.043	3.577SerThr: 3.577 ± 0.052	4.325SerVal: 4.325 ± 0.046	0.905SerTrp: 0.905 ± 0.019	0.996SerTyr: 0.996 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	9.403ThrAla: 9.403 ± 0.089	0.505ThrCys: 0.505 ± 0.024	3.86ThrAsp: 3.86 ± 0.051	3.244ThrGlu: 3.244 ± 0.043	1.569ThrPhe: 1.569 ± 0.03	6.835ThrGly: 6.835 ± 0.072	1.289ThrHis: 1.289 ± 0.026	2.015ThrIle: 2.015 ± 0.043	1.16ThrLys: 1.16 ± 0.026	5.685ThrLeu: 5.685 ± 0.066	0.892ThrMet: 0.892 ± 0.019	1.162ThrAsn: 1.162 ± 0.028	4.55ThrPro: 4.55 ± 0.057	1.369ThrGln: 1.369 ± 0.026	4.738ThrArg: 4.738 ± 0.052	3.23ThrSer: 3.23 ± 0.054	4.961ThrThr: 4.961 ± 0.109	6.157ThrVal: 6.157 ± 0.085	1.004ThrTrp: 1.004 ± 0.02	1.252ThrTyr: 1.252 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	12.766ValAla: 12.766 ± 0.086	0.722ValCys: 0.722 ± 0.017	6.668ValAsp: 6.668 ± 0.059	5.32ValGlu: 5.32 ± 0.058	2.612ValPhe: 2.612 ± 0.034	7.485ValGly: 7.485 ± 0.057	1.93ValHis: 1.93 ± 0.031	2.954ValIle: 2.954 ± 0.035	1.477ValLys: 1.477 ± 0.032	10.628ValLeu: 10.628 ± 0.077	1.147ValMet: 1.147 ± 0.022	1.732ValAsn: 1.732 ± 0.03	5.501ValPro: 5.501 ± 0.059	1.878ValGln: 1.878 ± 0.029	7.742ValArg: 7.742 ± 0.058	4.604ValSer: 4.604 ± 0.045	5.954ValThr: 5.954 ± 0.087	10.299ValVal: 10.299 ± 0.086	1.176ValTrp: 1.176 ± 0.021	1.464ValTyr: 1.464 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.71TrpAla: 1.71 ± 0.027	0.149TrpCys: 0.149 ± 0.008	0.82TrpAsp: 0.82 ± 0.018	0.619TrpGlu: 0.619 ± 0.016	0.513TrpPhe: 0.513 ± 0.016	1.013TrpGly: 1.013 ± 0.026	0.395TrpHis: 0.395 ± 0.015	0.491TrpIle: 0.491 ± 0.016	0.236TrpLys: 0.236 ± 0.009	1.883TrpLeu: 1.883 ± 0.032	0.248TrpMet: 0.248 ± 0.009	0.314TrpAsn: 0.314 ± 0.013	0.862TrpPro: 0.862 ± 0.02	0.576TrpGln: 0.576 ± 0.017	1.524TrpArg: 1.524 ± 0.03	0.988TrpSer: 0.988 ± 0.02	1.05TrpThr: 1.05 ± 0.022	1.205TrpVal: 1.205 ± 0.026	0.352TrpTrp: 0.352 ± 0.013	0.294TrpTyr: 0.294 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.342TyrAla: 2.342 ± 0.031	0.162TyrCys: 0.162 ± 0.008	1.195TyrAsp: 1.195 ± 0.03	0.917TyrGlu: 0.917 ± 0.02	0.587TyrPhe: 0.587 ± 0.016	1.772TyrGly: 1.772 ± 0.029	0.388TyrHis: 0.388 ± 0.013	0.388TyrIle: 0.388 ± 0.013	0.286TyrLys: 0.286 ± 0.013	2.209TyrLeu: 2.209 ± 0.034	0.184TyrMet: 0.184 ± 0.008	0.387TyrAsn: 0.387 ± 0.015	1.127TyrPro: 1.127 ± 0.022	0.6TyrGln: 0.6 ± 0.018	1.898TyrArg: 1.898 ± 0.03	0.902TyrSer: 0.902 ± 0.022	1.189TyrThr: 1.189 ± 0.029	1.477TyrVal: 1.477 ± 0.025	0.32TyrTrp: 0.32 ± 0.012	0.418TyrTyr: 0.418 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7400 proteins (2468596 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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