Amino acid dipepetide frequency for Blautia sp. CAG:37

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.718AlaAla: 8.718 ± 0.16	1.248AlaCys: 1.248 ± 0.047	4.94AlaAsp: 4.94 ± 0.104	6.602AlaGlu: 6.602 ± 0.122	3.258AlaPhe: 3.258 ± 0.073	6.646AlaGly: 6.646 ± 0.118	1.309AlaHis: 1.309 ± 0.04	4.655AlaIle: 4.655 ± 0.093	5.204AlaLys: 5.204 ± 0.104	7.049AlaLeu: 7.049 ± 0.096	2.582AlaMet: 2.582 ± 0.066	2.392AlaAsn: 2.392 ± 0.054	2.251AlaPro: 2.251 ± 0.064	2.331AlaGln: 2.331 ± 0.065	3.154AlaArg: 3.154 ± 0.078	4.384AlaSer: 4.384 ± 0.089	3.226AlaThr: 3.226 ± 0.074	6.994AlaVal: 6.994 ± 0.106	0.825AlaTrp: 0.825 ± 0.033	2.803AlaTyr: 2.803 ± 0.051	0.004AlaXaa: 0.004 ± 0.002
Cys	1.215CysAla: 1.215 ± 0.051	0.382CysCys: 0.382 ± 0.03	0.866CysAsp: 0.866 ± 0.037	0.944CysGlu: 0.944 ± 0.039	0.753CysPhe: 0.753 ± 0.032	1.592CysGly: 1.592 ± 0.048	0.377CysHis: 0.377 ± 0.024	1.022CysIle: 1.022 ± 0.038	0.76CysLys: 0.76 ± 0.033	1.151CysLeu: 1.151 ± 0.038	0.489CysMet: 0.489 ± 0.028	0.582CysAsn: 0.582 ± 0.029	0.643CysPro: 0.643 ± 0.032	0.487CysGln: 0.487 ± 0.025	0.896CysArg: 0.896 ± 0.036	0.964CysSer: 0.964 ± 0.036	0.786CysThr: 0.786 ± 0.032	1.106CysVal: 1.106 ± 0.04	0.154CysTrp: 0.154 ± 0.013	0.593CysTyr: 0.593 ± 0.032	0.001CysXaa: 0.001 ± 0.001
Asp	4.698AspAla: 4.698 ± 0.082	0.786AspCys: 0.786 ± 0.034	2.779AspAsp: 2.779 ± 0.073	4.476AspGlu: 4.476 ± 0.088	2.502AspPhe: 2.502 ± 0.071	4.763AspGly: 4.763 ± 0.096	1.054AspHis: 1.054 ± 0.041	3.498AspIle: 3.498 ± 0.072	2.583AspLys: 2.583 ± 0.072	5.021AspLeu: 5.021 ± 0.075	1.55AspMet: 1.55 ± 0.043	1.75AspAsn: 1.75 ± 0.055	2.12AspPro: 2.12 ± 0.061	1.559AspGln: 1.559 ± 0.05	2.417AspArg: 2.417 ± 0.059	2.696AspSer: 2.696 ± 0.065	3.193AspThr: 3.193 ± 0.072	3.764AspVal: 3.764 ± 0.069	0.619AspTrp: 0.619 ± 0.031	2.476AspTyr: 2.476 ± 0.069	0.0AspXaa: 0.0 ± 0.0
Glu	6.05GluAla: 6.05 ± 0.115	0.892GluCys: 0.892 ± 0.038	4.142GluAsp: 4.142 ± 0.074	7.807GluGlu: 7.807 ± 0.13	2.464GluPhe: 2.464 ± 0.049	4.484GluGly: 4.484 ± 0.069	1.425GluHis: 1.425 ± 0.047	5.459GluIle: 5.459 ± 0.098	7.163GluLys: 7.163 ± 0.118	6.673GluLeu: 6.673 ± 0.107	2.55GluMet: 2.55 ± 0.058	4.186GluAsn: 4.186 ± 0.091	2.165GluPro: 2.165 ± 0.07	3.352GluGln: 3.352 ± 0.089	3.581GluArg: 3.581 ± 0.074	3.397GluSer: 3.397 ± 0.075	4.525GluThr: 4.525 ± 0.102	4.486GluVal: 4.486 ± 0.077	0.701GluTrp: 0.701 ± 0.032	2.853GluTyr: 2.853 ± 0.069	0.003GluXaa: 0.003 ± 0.002
Phe	3.276PheAla: 3.276 ± 0.072	0.972PheCys: 0.972 ± 0.042	2.424PheAsp: 2.424 ± 0.058	2.487PheGlu: 2.487 ± 0.059	2.038PhePhe: 2.038 ± 0.067	3.308PheGly: 3.308 ± 0.071	1.0PheHis: 1.0 ± 0.042	2.185PheIle: 2.185 ± 0.058	1.567PheLys: 1.567 ± 0.053	4.344PheLeu: 4.344 ± 0.101	1.062PheMet: 1.062 ± 0.039	1.274PheAsn: 1.274 ± 0.043	1.571PhePro: 1.571 ± 0.045	1.538PheGln: 1.538 ± 0.046	1.925PheArg: 1.925 ± 0.051	2.97PheSer: 2.97 ± 0.071	2.25PheThr: 2.25 ± 0.065	2.853PheVal: 2.853 ± 0.064	0.477PheTrp: 0.477 ± 0.027	1.708PheTyr: 1.708 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	5.443GlyAla: 5.443 ± 0.1	1.38GlyCys: 1.38 ± 0.049	3.589GlyAsp: 3.589 ± 0.077	4.991GlyGlu: 4.991 ± 0.096	3.237GlyPhe: 3.237 ± 0.069	5.02GlyGly: 5.02 ± 0.102	1.294GlyHis: 1.294 ± 0.045	6.127GlyIle: 6.127 ± 0.104	5.712GlyLys: 5.712 ± 0.088	5.598GlyLeu: 5.598 ± 0.109	2.681GlyMet: 2.681 ± 0.064	3.059GlyAsn: 3.059 ± 0.066	1.423GlyPro: 1.423 ± 0.049	2.114GlyGln: 2.114 ± 0.049	3.055GlyArg: 3.055 ± 0.065	4.045GlySer: 4.045 ± 0.087	4.817GlyThr: 4.817 ± 0.082	5.314GlyVal: 5.314 ± 0.09	0.817GlyTrp: 0.817 ± 0.044	3.23GlyTyr: 3.23 ± 0.069	0.005GlyXaa: 0.005 ± 0.003
His	1.378HisAla: 1.378 ± 0.046	0.33HisCys: 0.33 ± 0.02	0.944HisAsp: 0.944 ± 0.039	1.119HisGlu: 1.119 ± 0.042	0.908HisPhe: 0.908 ± 0.032	1.451HisGly: 1.451 ± 0.041	0.507HisHis: 0.507 ± 0.04	1.311HisIle: 1.311 ± 0.048	0.855HisLys: 0.855 ± 0.037	1.756HisLeu: 1.756 ± 0.059	0.597HisMet: 0.597 ± 0.03	0.716HisAsn: 0.716 ± 0.03	1.047HisPro: 1.047 ± 0.041	0.667HisGln: 0.667 ± 0.033	0.902HisArg: 0.902 ± 0.035	0.932HisSer: 0.932 ± 0.034	1.054HisThr: 1.054 ± 0.038	1.28HisVal: 1.28 ± 0.04	0.196HisTrp: 0.196 ± 0.017	0.804HisTyr: 0.804 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.611IleAla: 5.611 ± 0.102	1.326IleCys: 1.326 ± 0.048	3.579IleAsp: 3.579 ± 0.068	4.207IleGlu: 4.207 ± 0.078	2.729IlePhe: 2.729 ± 0.066	4.954IleGly: 4.954 ± 0.108	1.435IleHis: 1.435 ± 0.049	3.76IleIle: 3.76 ± 0.076	2.893IleLys: 2.893 ± 0.069	6.866IleLeu: 6.866 ± 0.117	1.716IleMet: 1.716 ± 0.045	2.295IleAsn: 2.295 ± 0.064	3.165IlePro: 3.165 ± 0.062	2.193IleGln: 2.193 ± 0.061	3.744IleArg: 3.744 ± 0.076	4.349IleSer: 4.349 ± 0.075	3.941IleThr: 3.941 ± 0.074	4.56IleVal: 4.56 ± 0.085	0.689IleTrp: 0.689 ± 0.031	2.343IleTyr: 2.343 ± 0.054	0.001IleXaa: 0.001 ± 0.001
Lys	5.078LysAla: 5.078 ± 0.106	0.636LysCys: 0.636 ± 0.033	3.447LysAsp: 3.447 ± 0.073	6.672LysGlu: 6.672 ± 0.117	1.807LysPhe: 1.807 ± 0.047	3.86LysGly: 3.86 ± 0.062	0.839LysHis: 0.839 ± 0.032	4.317LysIle: 4.317 ± 0.089	6.066LysLys: 6.066 ± 0.108	4.804LysLeu: 4.804 ± 0.079	2.369LysMet: 2.369 ± 0.056	3.294LysAsn: 3.294 ± 0.062	2.031LysPro: 2.031 ± 0.051	2.237LysGln: 2.237 ± 0.051	2.963LysArg: 2.963 ± 0.065	2.847LysSer: 2.847 ± 0.06	3.828LysThr: 3.828 ± 0.077	3.945LysVal: 3.945 ± 0.077	0.605LysTrp: 0.605 ± 0.03	2.497LysTyr: 2.497 ± 0.059	0.001LysXaa: 0.001 ± 0.001
Leu	7.551LeuAla: 7.551 ± 0.116	1.606LeuCys: 1.606 ± 0.055	4.83LeuAsp: 4.83 ± 0.088	6.277LeuGlu: 6.277 ± 0.118	4.006LeuPhe: 4.006 ± 0.094	6.012LeuGly: 6.012 ± 0.111	1.789LeuHis: 1.789 ± 0.055	5.541LeuIle: 5.541 ± 0.103	5.476LeuLys: 5.476 ± 0.076	8.918LeuLeu: 8.918 ± 0.143	2.712LeuMet: 2.712 ± 0.061	3.396LeuAsn: 3.396 ± 0.069	3.825LeuPro: 3.825 ± 0.076	3.013LeuGln: 3.013 ± 0.066	3.987LeuArg: 3.987 ± 0.07	6.127LeuSer: 6.127 ± 0.098	5.051LeuThr: 5.051 ± 0.084	5.854LeuVal: 5.854 ± 0.108	0.786LeuTrp: 0.786 ± 0.038	3.314LeuTyr: 3.314 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.641MetAla: 2.641 ± 0.069	0.354MetCys: 0.354 ± 0.022	1.774MetAsp: 1.774 ± 0.044	2.709MetGlu: 2.709 ± 0.066	0.994MetPhe: 0.994 ± 0.035	2.175MetGly: 2.175 ± 0.06	0.524MetHis: 0.524 ± 0.025	2.213MetIle: 2.213 ± 0.051	2.46MetLys: 2.46 ± 0.055	2.607MetLeu: 2.607 ± 0.059	1.108MetMet: 1.108 ± 0.04	1.498MetAsn: 1.498 ± 0.048	1.285MetPro: 1.285 ± 0.041	1.162MetGln: 1.162 ± 0.042	1.433MetArg: 1.433 ± 0.042	1.636MetSer: 1.636 ± 0.047	1.807MetThr: 1.807 ± 0.056	2.123MetVal: 2.123 ± 0.053	0.221MetTrp: 0.221 ± 0.018	0.904MetTyr: 0.904 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.071AsnAla: 3.071 ± 0.073	0.557AsnCys: 0.557 ± 0.03	1.923AsnAsp: 1.923 ± 0.055	2.522AsnGlu: 2.522 ± 0.056	1.587AsnPhe: 1.587 ± 0.047	3.65AsnGly: 3.65 ± 0.072	0.786AsnHis: 0.786 ± 0.034	2.731AsnIle: 2.731 ± 0.057	1.952AsnLys: 1.952 ± 0.063	3.587AsnLeu: 3.587 ± 0.067	1.22AsnMet: 1.22 ± 0.041	1.439AsnAsn: 1.439 ± 0.048	1.948AsnPro: 1.948 ± 0.051	1.379AsnGln: 1.379 ± 0.045	2.007AsnArg: 2.007 ± 0.053	2.037AsnSer: 2.037 ± 0.058	2.202AsnThr: 2.202 ± 0.05	2.783AsnVal: 2.783 ± 0.066	0.407AsnTrp: 0.407 ± 0.025	1.586AsnTyr: 1.586 ± 0.04	0.001AsnXaa: 0.001 ± 0.001
Pro	2.743ProAla: 2.743 ± 0.069	0.455ProCys: 0.455 ± 0.027	2.404ProAsp: 2.404 ± 0.061	4.018ProGlu: 4.018 ± 0.089	1.636ProPhe: 1.636 ± 0.048	2.657ProGly: 2.657 ± 0.068	0.605ProHis: 0.605 ± 0.028	2.061ProIle: 2.061 ± 0.049	1.985ProLys: 1.985 ± 0.054	2.987ProLeu: 2.987 ± 0.075	1.037ProMet: 1.037 ± 0.039	1.234ProAsn: 1.234 ± 0.048	0.712ProPro: 0.712 ± 0.032	1.119ProGln: 1.119 ± 0.04	1.124ProArg: 1.124 ± 0.042	2.027ProSer: 2.027 ± 0.056	1.745ProThr: 1.745 ± 0.07	3.148ProVal: 3.148 ± 0.069	0.415ProTrp: 0.415 ± 0.024	1.46ProTyr: 1.46 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	2.472GlnAla: 2.472 ± 0.067	0.408GlnCys: 0.408 ± 0.026	1.549GlnAsp: 1.549 ± 0.046	2.881GlnGlu: 2.881 ± 0.06	1.154GlnPhe: 1.154 ± 0.04	1.986GlnGly: 1.986 ± 0.053	0.55GlnHis: 0.55 ± 0.03	2.779GlnIle: 2.779 ± 0.062	3.119GlnLys: 3.119 ± 0.07	2.73GlnLeu: 2.73 ± 0.068	1.402GlnMet: 1.402 ± 0.042	1.703GlnAsn: 1.703 ± 0.047	1.014GlnPro: 1.014 ± 0.04	1.302GlnGln: 1.302 ± 0.049	1.449GlnArg: 1.449 ± 0.044	1.599GlnSer: 1.599 ± 0.049	1.827GlnThr: 1.827 ± 0.058	2.141GlnVal: 2.141 ± 0.064	0.305GlnTrp: 0.305 ± 0.018	1.439GlnTyr: 1.439 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	3.023ArgAla: 3.023 ± 0.064	0.655ArgCys: 0.655 ± 0.036	2.273ArgAsp: 2.273 ± 0.067	4.023ArgGlu: 4.023 ± 0.077	1.893ArgPhe: 1.893 ± 0.054	2.62ArgGly: 2.62 ± 0.065	0.902ArgHis: 0.902 ± 0.032	3.465ArgIle: 3.465 ± 0.073	3.621ArgLys: 3.621 ± 0.08	3.819ArgLeu: 3.819 ± 0.078	1.696ArgMet: 1.696 ± 0.053	2.043ArgAsn: 2.043 ± 0.057	1.468ArgPro: 1.468 ± 0.047	1.797ArgGln: 1.797 ± 0.053	2.502ArgArg: 2.502 ± 0.067	2.255ArgSer: 2.255 ± 0.053	2.466ArgThr: 2.466 ± 0.064	2.901ArgVal: 2.901 ± 0.065	0.394ArgTrp: 0.394 ± 0.024	1.832ArgTyr: 1.832 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	4.56SerAla: 4.56 ± 0.09	0.928SerCys: 0.928 ± 0.041	3.104SerAsp: 3.104 ± 0.077	3.843SerGlu: 3.843 ± 0.078	2.627SerPhe: 2.627 ± 0.063	4.917SerGly: 4.917 ± 0.074	1.016SerHis: 1.016 ± 0.035	3.613SerIle: 3.613 ± 0.073	2.83SerLys: 2.83 ± 0.063	5.056SerLeu: 5.056 ± 0.079	1.817SerMet: 1.817 ± 0.059	1.859SerAsn: 1.859 ± 0.044	1.734SerPro: 1.734 ± 0.046	1.695SerGln: 1.695 ± 0.047	2.656SerArg: 2.656 ± 0.055	3.569SerSer: 3.569 ± 0.087	2.77SerThr: 2.77 ± 0.068	4.248SerVal: 4.248 ± 0.079	0.696SerTrp: 0.696 ± 0.036	2.457SerTyr: 2.457 ± 0.056	0.001SerXaa: 0.001 ± 0.001
Thr	4.964ThrAla: 4.964 ± 0.083	0.739ThrCys: 0.739 ± 0.035	3.071ThrAsp: 3.071 ± 0.066	4.22ThrGlu: 4.22 ± 0.083	2.161ThrPhe: 2.161 ± 0.058	4.748ThrGly: 4.748 ± 0.084	0.927ThrHis: 0.927 ± 0.034	3.898ThrIle: 3.898 ± 0.075	3.038ThrLys: 3.038 ± 0.068	4.885ThrLeu: 4.885 ± 0.09	1.638ThrMet: 1.638 ± 0.043	1.904ThrAsn: 1.904 ± 0.053	2.486ThrPro: 2.486 ± 0.071	1.419ThrGln: 1.419 ± 0.037	2.123ThrArg: 2.123 ± 0.049	2.974ThrSer: 2.974 ± 0.074	2.957ThrThr: 2.957 ± 0.078	4.722ThrVal: 4.722 ± 0.091	0.585ThrTrp: 0.585 ± 0.029	2.133ThrTyr: 2.133 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	4.715ValAla: 4.715 ± 0.089	1.354ValCys: 1.354 ± 0.043	3.734ValAsp: 3.734 ± 0.076	4.807ValGlu: 4.807 ± 0.077	3.177ValPhe: 3.177 ± 0.072	4.34ValGly: 4.34 ± 0.074	1.285ValHis: 1.285 ± 0.043	4.852ValIle: 4.852 ± 0.104	4.255ValLys: 4.255 ± 0.068	7.326ValLeu: 7.326 ± 0.123	2.08ValMet: 2.08 ± 0.055	2.709ValAsn: 2.709 ± 0.061	2.869ValPro: 2.869 ± 0.065	2.316ValGln: 2.316 ± 0.057	3.146ValArg: 3.146 ± 0.066	4.579ValSer: 4.579 ± 0.079	4.443ValThr: 4.443 ± 0.087	4.948ValVal: 4.948 ± 0.095	0.68ValTrp: 0.68 ± 0.029	2.709ValTyr: 2.709 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.578TrpAla: 0.578 ± 0.029	0.196TrpCys: 0.196 ± 0.016	0.529TrpAsp: 0.529 ± 0.028	0.713TrpGlu: 0.713 ± 0.036	0.44TrpPhe: 0.44 ± 0.025	0.739TrpGly: 0.739 ± 0.038	0.198TrpHis: 0.198 ± 0.017	0.713TrpIle: 0.713 ± 0.038	0.855TrpLys: 0.855 ± 0.037	0.903TrpLeu: 0.903 ± 0.034	0.367TrpMet: 0.367 ± 0.022	0.575TrpAsn: 0.575 ± 0.029	0.272TrpPro: 0.272 ± 0.02	0.389TrpGln: 0.389 ± 0.023	0.387TrpArg: 0.387 ± 0.021	0.552TrpSer: 0.552 ± 0.029	0.485TrpThr: 0.485 ± 0.025	0.571TrpVal: 0.571 ± 0.028	0.123TrpTrp: 0.123 ± 0.015	0.476TrpTyr: 0.476 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.787TyrAla: 2.787 ± 0.066	0.558TyrCys: 0.558 ± 0.028	2.404TyrAsp: 2.404 ± 0.058	3.04TyrGlu: 3.04 ± 0.075	1.86TyrPhe: 1.86 ± 0.061	3.027TyrGly: 3.027 ± 0.069	0.931TyrHis: 0.931 ± 0.035	2.153TyrIle: 2.153 ± 0.051	1.753TyrLys: 1.753 ± 0.051	3.991TyrLeu: 3.991 ± 0.07	0.956TyrMet: 0.956 ± 0.039	1.466TyrAsn: 1.466 ± 0.045	1.539TyrPro: 1.539 ± 0.05	1.741TyrGln: 1.741 ± 0.045	2.192TyrArg: 2.192 ± 0.06	2.053TyrSer: 2.053 ± 0.059	2.217TyrThr: 2.217 ± 0.062	2.582TyrVal: 2.582 ± 0.062	0.366TyrTrp: 0.366 ± 0.022	1.821TyrTyr: 1.821 ± 0.075	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.004XaaGly: 0.004 ± 0.002	0.003XaaHis: 0.003 ± 0.002	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.003XaaSer: 0.003 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.021XaaXaa: 0.021 ± 0.007

Statistics based on 2353 proteins (754178 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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