Amino acid dipepetide frequency for Schistosoma margrebowiei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.834AlaAla: 3.834 ± 0.041	0.987AlaCys: 0.987 ± 0.013	2.578AlaAsp: 2.578 ± 0.023	2.869AlaGlu: 2.869 ± 0.027	2.099AlaPhe: 2.099 ± 0.021	2.013AlaGly: 2.013 ± 0.024	0.971AlaHis: 0.971 ± 0.015	2.731AlaIle: 2.731 ± 0.022	2.349AlaLys: 2.349 ± 0.023	4.683AlaLeu: 4.683 ± 0.035	0.868AlaMet: 0.868 ± 0.012	2.341AlaAsn: 2.341 ± 0.019	1.852AlaPro: 1.852 ± 0.021	1.708AlaGln: 1.708 ± 0.019	2.612AlaArg: 2.612 ± 0.025	4.149AlaSer: 4.149 ± 0.032	2.694AlaThr: 2.694 ± 0.026	2.971AlaVal: 2.971 ± 0.023	0.424AlaTrp: 0.424 ± 0.009	1.445AlaTyr: 1.445 ± 0.016	0.002AlaXaa: 0.002 ± 0.001
Cys	0.864CysAla: 0.864 ± 0.014	0.489CysCys: 0.489 ± 0.012	0.997CysAsp: 0.997 ± 0.017	1.022CysGlu: 1.022 ± 0.016	0.841CysPhe: 0.841 ± 0.013	0.946CysGly: 0.946 ± 0.014	0.598CysHis: 0.598 ± 0.013	1.536CysIle: 1.536 ± 0.016	1.076CysLys: 1.076 ± 0.015	2.33CysLeu: 2.33 ± 0.022	0.402CysMet: 0.402 ± 0.008	1.153CysAsn: 1.153 ± 0.014	0.946CysPro: 0.946 ± 0.016	0.908CysGln: 0.908 ± 0.013	1.006CysArg: 1.006 ± 0.014	2.005CysSer: 2.005 ± 0.021	1.293CysThr: 1.293 ± 0.014	0.99CysVal: 0.99 ± 0.014	0.224CysTrp: 0.224 ± 0.006	0.698CysTyr: 0.698 ± 0.01	0.001CysXaa: 0.001 ± 0.0
Asp	2.234AspAla: 2.234 ± 0.022	0.92AspCys: 0.92 ± 0.012	4.1AspAsp: 4.1 ± 0.048	3.447AspGlu: 3.447 ± 0.028	2.054AspPhe: 2.054 ± 0.016	2.509AspGly: 2.509 ± 0.026	1.56AspHis: 1.56 ± 0.016	3.432AspIle: 3.432 ± 0.025	2.723AspLys: 2.723 ± 0.024	5.356AspLeu: 5.356 ± 0.033	1.051AspMet: 1.051 ± 0.014	3.567AspAsn: 3.567 ± 0.031	2.231AspPro: 2.231 ± 0.021	1.983AspGln: 1.983 ± 0.017	2.378AspArg: 2.378 ± 0.022	4.249AspSer: 4.249 ± 0.031	2.734AspThr: 2.734 ± 0.018	3.345AspVal: 3.345 ± 0.025	0.587AspTrp: 0.587 ± 0.01	1.724AspTyr: 1.724 ± 0.017	0.002AspXaa: 0.002 ± 0.0
Glu	2.926GluAla: 2.926 ± 0.026	0.941GluCys: 0.941 ± 0.015	3.138GluAsp: 3.138 ± 0.026	4.415GluGlu: 4.415 ± 0.047	1.943GluPhe: 1.943 ± 0.019	2.211GluGly: 2.211 ± 0.02	1.417GluHis: 1.417 ± 0.016	3.602GluIle: 3.602 ± 0.026	3.907GluLys: 3.907 ± 0.031	5.544GluLeu: 5.544 ± 0.038	1.356GluMet: 1.356 ± 0.016	3.839GluAsn: 3.839 ± 0.028	1.626GluPro: 1.626 ± 0.016	2.568GluGln: 2.568 ± 0.024	3.052GluArg: 3.052 ± 0.028	4.352GluSer: 4.352 ± 0.027	3.567GluThr: 3.567 ± 0.025	2.783GluVal: 2.783 ± 0.021	0.622GluTrp: 0.622 ± 0.009	1.703GluTyr: 1.703 ± 0.015	0.003GluXaa: 0.003 ± 0.001
Phe	1.709PheAla: 1.709 ± 0.017	0.77PheCys: 0.77 ± 0.012	2.109PheAsp: 2.109 ± 0.019	1.71PheGlu: 1.71 ± 0.019	1.306PhePhe: 1.306 ± 0.016	1.72PheGly: 1.72 ± 0.019	1.168PheHis: 1.168 ± 0.015	2.849PheIle: 2.849 ± 0.03	2.079PheLys: 2.079 ± 0.019	3.466PheLeu: 3.466 ± 0.028	0.798PheMet: 0.798 ± 0.011	2.758PheAsn: 2.758 ± 0.024	1.624PhePro: 1.624 ± 0.019	1.503PheGln: 1.503 ± 0.016	1.768PheArg: 1.768 ± 0.018	3.239PheSer: 3.239 ± 0.027	2.724PheThr: 2.724 ± 0.019	2.144PheVal: 2.144 ± 0.02	0.351PheTrp: 0.351 ± 0.007	1.341PheTyr: 1.341 ± 0.015	0.001PheXaa: 0.001 ± 0.0
Gly	1.882GlyAla: 1.882 ± 0.023	0.886GlyCys: 0.886 ± 0.013	2.086GlyAsp: 2.086 ± 0.021	2.489GlyGlu: 2.489 ± 0.028	2.063GlyPhe: 2.063 ± 0.02	3.042GlyGly: 3.042 ± 0.032	1.339GlyHis: 1.339 ± 0.014	3.073GlyIle: 3.073 ± 0.022	3.119GlyLys: 3.119 ± 0.026	4.298GlyLeu: 4.298 ± 0.034	0.869GlyMet: 0.869 ± 0.013	2.37GlyAsn: 2.37 ± 0.018	1.728GlyPro: 1.728 ± 0.044	1.783GlyGln: 1.783 ± 0.018	2.6GlyArg: 2.6 ± 0.021	4.402GlySer: 4.402 ± 0.031	2.511GlyThr: 2.511 ± 0.023	2.556GlyVal: 2.556 ± 0.022	0.66GlyTrp: 0.66 ± 0.01	1.464GlyTyr: 1.464 ± 0.019	0.001GlyXaa: 0.001 ± 0.0
His	0.901HisAla: 0.901 ± 0.011	0.631HisCys: 0.631 ± 0.011	1.261HisAsp: 1.261 ± 0.012	1.608HisGlu: 1.608 ± 0.017	1.056HisPhe: 1.056 ± 0.014	1.539HisGly: 1.539 ± 0.015	1.741HisHis: 1.741 ± 0.029	1.792HisIle: 1.792 ± 0.018	1.928HisLys: 1.928 ± 0.021	2.927HisLeu: 2.927 ± 0.025	0.578HisMet: 0.578 ± 0.009	1.751HisAsn: 1.751 ± 0.021	1.215HisPro: 1.215 ± 0.013	1.343HisGln: 1.343 ± 0.017	1.404HisArg: 1.404 ± 0.015	2.68HisSer: 2.68 ± 0.025	1.845HisThr: 1.845 ± 0.022	1.26HisVal: 1.26 ± 0.015	0.536HisTrp: 0.536 ± 0.01	1.013HisTyr: 1.013 ± 0.013	0.001HisXaa: 0.001 ± 0.0
Ile	2.704IleAla: 2.704 ± 0.022	1.403IleCys: 1.403 ± 0.017	3.979IleAsp: 3.979 ± 0.03	3.487IleGlu: 3.487 ± 0.029	2.414IlePhe: 2.414 ± 0.024	3.099IleGly: 3.099 ± 0.025	2.39IleHis: 2.39 ± 0.021	5.051IleIle: 5.051 ± 0.044	4.102IleLys: 4.102 ± 0.027	5.977IleLeu: 5.977 ± 0.039	1.427IleMet: 1.427 ± 0.015	4.987IleAsn: 4.987 ± 0.041	3.087IlePro: 3.087 ± 0.026	3.384IleGln: 3.384 ± 0.028	3.268IleArg: 3.268 ± 0.023	6.214IleSer: 6.214 ± 0.036	4.549IleThr: 4.549 ± 0.028	3.043IleVal: 3.043 ± 0.026	0.822IleTrp: 0.822 ± 0.012	2.004IleTyr: 2.004 ± 0.021	0.003IleXaa: 0.003 ± 0.001
Lys	3.534LysAla: 3.534 ± 0.03	1.306LysCys: 1.306 ± 0.016	2.542LysAsp: 2.542 ± 0.022	3.714LysGlu: 3.714 ± 0.034	2.122LysPhe: 2.122 ± 0.021	1.97LysGly: 1.97 ± 0.027	1.854LysHis: 1.854 ± 0.019	3.739LysIle: 3.739 ± 0.026	4.02LysLys: 4.02 ± 0.04	5.722LysLeu: 5.722 ± 0.036	1.367LysMet: 1.367 ± 0.014	3.497LysAsn: 3.497 ± 0.028	2.4LysPro: 2.4 ± 0.024	3.081LysGln: 3.081 ± 0.025	3.647LysArg: 3.647 ± 0.032	5.566LysSer: 5.566 ± 0.037	4.217LysThr: 4.217 ± 0.03	3.021LysVal: 3.021 ± 0.024	0.674LysTrp: 0.674 ± 0.011	2.019LysTyr: 2.019 ± 0.021	0.003LysXaa: 0.003 ± 0.001
Leu	4.488LeuAla: 4.488 ± 0.033	2.07LeuCys: 2.07 ± 0.022	5.131LeuAsp: 5.131 ± 0.032	4.677LeuGlu: 4.677 ± 0.04	3.678LeuPhe: 3.678 ± 0.03	4.005LeuGly: 4.005 ± 0.025	2.515LeuHis: 2.515 ± 0.021	5.822LeuIle: 5.822 ± 0.043	5.771LeuLys: 5.771 ± 0.035	10.059LeuLeu: 10.059 ± 0.102	2.12LeuMet: 2.12 ± 0.019	6.632LeuAsn: 6.632 ± 0.04	4.701LeuPro: 4.701 ± 0.033	4.102LeuGln: 4.102 ± 0.029	5.387LeuArg: 5.387 ± 0.037	9.451LeuSer: 9.451 ± 0.04	5.614LeuThr: 5.614 ± 0.031	4.906LeuVal: 4.906 ± 0.034	1.08LeuTrp: 1.08 ± 0.014	2.936LeuTyr: 2.936 ± 0.024	0.005LeuXaa: 0.005 ± 0.001
Met	0.98MetAla: 0.98 ± 0.014	0.347MetCys: 0.347 ± 0.007	1.055MetAsp: 1.055 ± 0.014	1.475MetGlu: 1.475 ± 0.018	0.739MetPhe: 0.739 ± 0.01	0.988MetGly: 0.988 ± 0.014	0.479MetHis: 0.479 ± 0.009	1.238MetIle: 1.238 ± 0.015	1.97MetLys: 1.97 ± 0.018	2.107MetLeu: 2.107 ± 0.019	0.658MetMet: 0.658 ± 0.022	1.964MetAsn: 1.964 ± 0.019	0.751MetPro: 0.751 ± 0.012	1.094MetGln: 1.094 ± 0.015	1.058MetArg: 1.058 ± 0.012	1.586MetSer: 1.586 ± 0.015	1.106MetThr: 1.106 ± 0.014	1.195MetVal: 1.195 ± 0.015	0.251MetTrp: 0.251 ± 0.006	0.604MetTyr: 0.604 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.574AsnAla: 2.574 ± 0.021	1.357AsnCys: 1.357 ± 0.016	3.991AsnAsp: 3.991 ± 0.035	3.935AsnGlu: 3.935 ± 0.035	2.069AsnPhe: 2.069 ± 0.019	2.702AsnGly: 2.702 ± 0.028	2.075AsnHis: 2.075 ± 0.023	5.179AsnIle: 5.179 ± 0.032	4.117AsnLys: 4.117 ± 0.035	5.472AsnLeu: 5.472 ± 0.036	1.327AsnMet: 1.327 ± 0.015	9.637AsnAsn: 9.637 ± 0.119	2.936AsnPro: 2.936 ± 0.02	3.302AsnGln: 3.302 ± 0.028	2.969AsnArg: 2.969 ± 0.022	7.288AsnSer: 7.288 ± 0.055	4.882AsnThr: 4.882 ± 0.045	3.354AsnVal: 3.354 ± 0.022	0.841AsnTrp: 0.841 ± 0.011	2.177AsnTyr: 2.177 ± 0.023	0.002AsnXaa: 0.002 ± 0.001
Pro	1.802ProAla: 1.802 ± 0.018	0.84ProCys: 0.84 ± 0.014	2.388ProAsp: 2.388 ± 0.02	2.236ProGlu: 2.236 ± 0.02	1.529ProPhe: 1.529 ± 0.017	2.268ProGly: 2.268 ± 0.046	1.181ProHis: 1.181 ± 0.015	3.151ProIle: 3.151 ± 0.024	2.162ProLys: 2.162 ± 0.022	3.551ProLeu: 3.551 ± 0.026	0.861ProMet: 0.861 ± 0.011	2.676ProAsn: 2.676 ± 0.022	2.657ProPro: 2.657 ± 0.038	1.457ProGln: 1.457 ± 0.02	1.863ProArg: 1.863 ± 0.019	4.455ProSer: 4.455 ± 0.038	3.042ProThr: 3.042 ± 0.021	2.906ProVal: 2.906 ± 0.024	0.354ProTrp: 0.354 ± 0.007	1.313ProTyr: 1.313 ± 0.016	0.001ProXaa: 0.001 ± 0.0
Gln	2.006GlnAla: 2.006 ± 0.022	0.986GlnCys: 0.986 ± 0.013	1.541GlnAsp: 1.541 ± 0.014	2.274GlnGlu: 2.274 ± 0.021	1.624GlnPhe: 1.624 ± 0.017	1.652GlnGly: 1.652 ± 0.018	1.289GlnHis: 1.289 ± 0.019	2.911GlnIle: 2.911 ± 0.024	2.193GlnLys: 2.193 ± 0.019	5.454GlnLeu: 5.454 ± 0.038	1.252GlnMet: 1.252 ± 0.015	2.602GlnAsn: 2.602 ± 0.026	1.744GlnPro: 1.744 ± 0.02	3.533GlnGln: 3.533 ± 0.051	2.14GlnArg: 2.14 ± 0.021	4.103GlnSer: 4.103 ± 0.03	2.508GlnThr: 2.508 ± 0.024	2.062GlnVal: 2.062 ± 0.02	0.629GlnTrp: 0.629 ± 0.011	1.358GlnTyr: 1.358 ± 0.014	0.001GlnXaa: 0.001 ± 0.0
Arg	2.171ArgAla: 2.171 ± 0.018	0.955ArgCys: 0.955 ± 0.014	2.03ArgAsp: 2.03 ± 0.019	2.578ArgGlu: 2.578 ± 0.024	2.037ArgPhe: 2.037 ± 0.021	2.012ArgGly: 2.012 ± 0.025	1.576ArgHis: 1.576 ± 0.017	3.805ArgIle: 3.805 ± 0.027	3.848ArgLys: 3.848 ± 0.037	5.056ArgLeu: 5.056 ± 0.04	1.326ArgMet: 1.326 ± 0.015	3.056ArgAsn: 3.056 ± 0.026	2.231ArgPro: 2.231 ± 0.018	2.581ArgGln: 2.581 ± 0.023	3.909ArgArg: 3.909 ± 0.04	4.122ArgSer: 4.122 ± 0.033	3.406ArgThr: 3.406 ± 0.025	2.367ArgVal: 2.367 ± 0.023	0.757ArgTrp: 0.757 ± 0.013	1.676ArgTyr: 1.676 ± 0.016	0.001ArgXaa: 0.001 ± 0.001
Ser	3.846SerAla: 3.846 ± 0.029	2.062SerCys: 2.062 ± 0.021	4.927SerAsp: 4.927 ± 0.029	4.681SerGlu: 4.681 ± 0.031	3.622SerPhe: 3.622 ± 0.026	4.523SerGly: 4.523 ± 0.03	2.555SerHis: 2.555 ± 0.021	6.466SerIle: 6.466 ± 0.04	5.22SerLys: 5.22 ± 0.031	8.01SerLeu: 8.01 ± 0.043	1.983SerMet: 1.983 ± 0.015	7.453SerAsn: 7.453 ± 0.048	4.145SerPro: 4.145 ± 0.037	3.671SerGln: 3.671 ± 0.026	4.403SerArg: 4.403 ± 0.033	13.0SerSer: 13.0 ± 0.124	7.08SerThr: 7.08 ± 0.046	5.492SerVal: 5.492 ± 0.036	0.798SerTrp: 0.798 ± 0.013	2.568SerTyr: 2.568 ± 0.021	0.002SerXaa: 0.002 ± 0.001
Thr	3.199ThrAla: 3.199 ± 0.027	1.278ThrCys: 1.278 ± 0.015	3.262ThrAsp: 3.262 ± 0.023	3.379ThrGlu: 3.379 ± 0.026	2.103ThrPhe: 2.103 ± 0.016	2.929ThrGly: 2.929 ± 0.027	1.6ThrHis: 1.6 ± 0.02	4.564ThrIle: 4.564 ± 0.032	3.536ThrLys: 3.536 ± 0.025	5.583ThrLeu: 5.583 ± 0.029	1.43ThrMet: 1.43 ± 0.015	5.383ThrAsn: 5.383 ± 0.049	2.587ThrPro: 2.587 ± 0.028	2.311ThrGln: 2.311 ± 0.022	2.944ThrArg: 2.944 ± 0.024	7.087ThrSer: 7.087 ± 0.045	8.049ThrThr: 8.049 ± 0.178	3.645ThrVal: 3.645 ± 0.025	0.905ThrTrp: 0.905 ± 0.013	1.908ThrTyr: 1.908 ± 0.02	0.003ThrXaa: 0.003 ± 0.001
Val	2.819ValAla: 2.819 ± 0.025	1.182ValCys: 1.182 ± 0.014	2.92ValAsp: 2.92 ± 0.024	2.969ValGlu: 2.969 ± 0.026	2.033ValPhe: 2.033 ± 0.019	3.069ValGly: 3.069 ± 0.024	1.449ValHis: 1.449 ± 0.015	3.425ValIle: 3.425 ± 0.024	3.425ValLys: 3.425 ± 0.028	5.149ValLeu: 5.149 ± 0.03	1.007ValMet: 1.007 ± 0.013	3.292ValAsn: 3.292 ± 0.021	2.298ValPro: 2.298 ± 0.022	1.984ValGln: 1.984 ± 0.017	2.797ValArg: 2.797 ± 0.024	4.897ValSer: 4.897 ± 0.034	3.137ValThr: 3.137 ± 0.024	3.173ValVal: 3.173 ± 0.026	0.525ValTrp: 0.525 ± 0.009	1.628ValTyr: 1.628 ± 0.017	0.004ValXaa: 0.004 ± 0.001
Trp	0.35TrpAla: 0.35 ± 0.008	0.204TrpCys: 0.204 ± 0.006	0.501TrpAsp: 0.501 ± 0.009	0.735TrpGlu: 0.735 ± 0.012	0.426TrpPhe: 0.426 ± 0.009	0.324TrpGly: 0.324 ± 0.008	0.22TrpHis: 0.22 ± 0.006	1.116TrpIle: 1.116 ± 0.014	1.01TrpLys: 1.01 ± 0.014	0.956TrpLeu: 0.956 ± 0.015	0.314TrpMet: 0.314 ± 0.007	1.047TrpAsn: 1.047 ± 0.012	0.57TrpPro: 0.57 ± 0.009	0.285TrpGln: 0.285 ± 0.006	0.792TrpArg: 0.792 ± 0.013	0.849TrpSer: 0.849 ± 0.013	0.978TrpThr: 0.978 ± 0.013	0.44TrpVal: 0.44 ± 0.009	0.132TrpTrp: 0.132 ± 0.005	0.28TrpTyr: 0.28 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.355TyrAla: 1.355 ± 0.016	0.71TyrCys: 0.71 ± 0.013	1.652TyrAsp: 1.652 ± 0.017	1.813TyrGlu: 1.813 ± 0.016	1.376TyrPhe: 1.376 ± 0.017	1.697TyrGly: 1.697 ± 0.021	1.031TyrHis: 1.031 ± 0.013	1.905TyrIle: 1.905 ± 0.021	1.458TyrLys: 1.458 ± 0.016	3.448TyrLeu: 3.448 ± 0.025	0.648TyrMet: 0.648 ± 0.011	2.183TyrAsn: 2.183 ± 0.022	1.364TyrPro: 1.364 ± 0.017	1.277TyrGln: 1.277 ± 0.015	1.503TyrArg: 1.503 ± 0.017	2.813TyrSer: 2.813 ± 0.023	1.743TyrThr: 1.743 ± 0.017	1.524TyrVal: 1.524 ± 0.016	0.357TyrTrp: 0.357 ± 0.008	1.175TyrTyr: 1.175 ± 0.02	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.003XaaIle: 0.003 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.003XaaLeu: 0.003 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.002XaaVal: 0.002 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 25527 proteins (6596622 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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