Amino acid dipepetide frequency for Lactobacillus phage Sabazios

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.44AlaAla: 9.44 ± 2.932
0.337AlaCys: 0.337 ± 0.16
5.31AlaAsp: 5.31 ± 0.705
4.636AlaGlu: 4.636 ± 0.722
3.203AlaPhe: 3.203 ± 0.489
7.839AlaGly: 7.839 ± 1.797
1.686AlaHis: 1.686 ± 0.336
5.563AlaIle: 5.563 ± 1.118
5.479AlaLys: 5.479 ± 0.655
6.49AlaLeu: 6.49 ± 0.644
3.877AlaMet: 3.877 ± 0.938
4.804AlaAsn: 4.804 ± 0.688
2.276AlaPro: 2.276 ± 0.411
2.866AlaGln: 2.866 ± 0.644
2.866AlaArg: 2.866 ± 0.409
4.804AlaSer: 4.804 ± 0.912
4.804AlaThr: 4.804 ± 0.879
6.575AlaVal: 6.575 ± 0.774
1.264AlaTrp: 1.264 ± 0.321
3.119AlaTyr: 3.119 ± 0.507
0.0AlaXaa: 0.0 ± 0.0
Cys
0.169CysAla: 0.169 ± 0.132
0.253CysCys: 0.253 ± 0.148
0.674CysAsp: 0.674 ± 0.266
0.337CysGlu: 0.337 ± 0.188
0.0CysPhe: 0.0 ± 0.0
0.253CysGly: 0.253 ± 0.119
0.084CysHis: 0.084 ± 0.086
0.421CysIle: 0.421 ± 0.215
0.084CysLys: 0.084 ± 0.087
0.084CysLeu: 0.084 ± 0.088
0.421CysMet: 0.421 ± 0.17
0.337CysAsn: 0.337 ± 0.156
0.253CysPro: 0.253 ± 0.144
0.169CysGln: 0.169 ± 0.111
0.421CysArg: 0.421 ± 0.184
0.421CysSer: 0.421 ± 0.189
0.253CysThr: 0.253 ± 0.144
0.421CysVal: 0.421 ± 0.178
0.084CysTrp: 0.084 ± 0.086
0.506CysTyr: 0.506 ± 0.179
0.0CysXaa: 0.0 ± 0.0
Asp
5.647AspAla: 5.647 ± 0.645
0.59AspCys: 0.59 ± 0.206
5.057AspAsp: 5.057 ± 0.903
4.299AspGlu: 4.299 ± 0.59
2.192AspPhe: 2.192 ± 0.459
7.67AspGly: 7.67 ± 0.629
0.759AspHis: 0.759 ± 0.246
3.54AspIle: 3.54 ± 0.476
5.647AspLys: 5.647 ± 0.724
5.984AspLeu: 5.984 ± 0.568
2.444AspMet: 2.444 ± 0.58
4.552AspAsn: 4.552 ± 0.657
1.77AspPro: 1.77 ± 0.397
2.192AspGln: 2.192 ± 0.509
2.276AspArg: 2.276 ± 0.497
3.877AspSer: 3.877 ± 0.545
4.299AspThr: 4.299 ± 0.689
3.962AspVal: 3.962 ± 0.538
0.843AspTrp: 0.843 ± 0.355
2.782AspTyr: 2.782 ± 0.54
0.0AspXaa: 0.0 ± 0.0
Glu
3.709GluAla: 3.709 ± 0.674
0.253GluCys: 0.253 ± 0.193
3.793GluAsp: 3.793 ± 0.566
4.214GluGlu: 4.214 ± 0.804
2.36GluPhe: 2.36 ± 0.535
2.697GluGly: 2.697 ± 0.615
1.349GluHis: 1.349 ± 0.359
4.299GluIle: 4.299 ± 0.526
3.456GluLys: 3.456 ± 0.657
5.479GluLeu: 5.479 ± 0.696
2.276GluMet: 2.276 ± 0.339
2.697GluAsn: 2.697 ± 0.465
1.264GluPro: 1.264 ± 0.384
2.107GluGln: 2.107 ± 0.416
3.119GluArg: 3.119 ± 0.664
3.709GluSer: 3.709 ± 0.494
4.13GluThr: 4.13 ± 0.661
2.782GluVal: 2.782 ± 0.415
0.421GluTrp: 0.421 ± 0.175
3.962GluTyr: 3.962 ± 0.685
0.0GluXaa: 0.0 ± 0.0
Phe
2.276PheAla: 2.276 ± 0.401
0.084PheCys: 0.084 ± 0.08
3.456PheAsp: 3.456 ± 0.601
2.276PheGlu: 2.276 ± 0.448
1.264PhePhe: 1.264 ± 0.31
3.203PheGly: 3.203 ± 0.581
0.506PheHis: 0.506 ± 0.183
2.192PheIle: 2.192 ± 0.367
2.95PheLys: 2.95 ± 0.477
2.444PheLeu: 2.444 ± 0.465
0.927PheMet: 0.927 ± 0.274
2.444PheAsn: 2.444 ± 0.476
1.096PhePro: 1.096 ± 0.286
0.759PheGln: 0.759 ± 0.202
1.264PheArg: 1.264 ± 0.318
2.782PheSer: 2.782 ± 0.439
4.046PheThr: 4.046 ± 0.629
2.444PheVal: 2.444 ± 0.412
0.253PheTrp: 0.253 ± 0.142
2.107PheTyr: 2.107 ± 0.435
0.0PheXaa: 0.0 ± 0.0
Gly
5.057GlyAla: 5.057 ± 1.554
0.169GlyCys: 0.169 ± 0.122
5.984GlyAsp: 5.984 ± 0.968
5.057GlyGlu: 5.057 ± 0.713
3.709GlyPhe: 3.709 ± 0.599
4.214GlyGly: 4.214 ± 0.566
0.506GlyHis: 0.506 ± 0.201
4.973GlyIle: 4.973 ± 0.993
5.984GlyLys: 5.984 ± 0.807
4.889GlyLeu: 4.889 ± 0.847
2.023GlyMet: 2.023 ± 0.566
4.552GlyAsn: 4.552 ± 0.633
1.011GlyPro: 1.011 ± 0.411
2.697GlyGln: 2.697 ± 0.676
3.372GlyArg: 3.372 ± 0.512
5.394GlySer: 5.394 ± 0.596
4.973GlyThr: 4.973 ± 0.638
5.647GlyVal: 5.647 ± 0.65
0.59GlyTrp: 0.59 ± 0.22
3.877GlyTyr: 3.877 ± 0.622
0.0GlyXaa: 0.0 ± 0.0
His
1.18HisAla: 1.18 ± 0.253
0.169HisCys: 0.169 ± 0.131
1.264HisAsp: 1.264 ± 0.284
1.18HisGlu: 1.18 ± 0.289
0.421HisPhe: 0.421 ± 0.29
0.927HisGly: 0.927 ± 0.282
0.337HisHis: 0.337 ± 0.177
0.759HisIle: 0.759 ± 0.248
1.18HisLys: 1.18 ± 0.298
0.759HisLeu: 0.759 ± 0.245
0.253HisMet: 0.253 ± 0.124
0.674HisAsn: 0.674 ± 0.203
0.674HisPro: 0.674 ± 0.255
0.506HisGln: 0.506 ± 0.168
0.843HisArg: 0.843 ± 0.273
1.096HisSer: 1.096 ± 0.269
0.759HisThr: 0.759 ± 0.284
1.096HisVal: 1.096 ± 0.26
0.169HisTrp: 0.169 ± 0.123
0.759HisTyr: 0.759 ± 0.294
0.0HisXaa: 0.0 ± 0.0
Ile
6.406IleAla: 6.406 ± 1.029
0.253IleCys: 0.253 ± 0.153
4.889IleAsp: 4.889 ± 0.825
4.467IleGlu: 4.467 ± 0.763
1.433IlePhe: 1.433 ± 0.328
3.54IleGly: 3.54 ± 0.98
0.759IleHis: 0.759 ± 0.224
3.709IleIle: 3.709 ± 0.562
5.563IleLys: 5.563 ± 0.708
2.782IleLeu: 2.782 ± 0.439
2.023IleMet: 2.023 ± 0.417
4.467IleAsn: 4.467 ± 0.678
1.517IlePro: 1.517 ± 0.359
1.096IleGln: 1.096 ± 0.272
1.349IleArg: 1.349 ± 0.404
3.456IleSer: 3.456 ± 0.496
5.563IleThr: 5.563 ± 0.602
4.72IleVal: 4.72 ± 0.73
0.421IleTrp: 0.421 ± 0.151
2.529IleTyr: 2.529 ± 0.437
0.0IleXaa: 0.0 ± 0.0
Lys
6.743LysAla: 6.743 ± 0.73
0.506LysCys: 0.506 ± 0.196
3.203LysAsp: 3.203 ± 0.524
4.13LysGlu: 4.13 ± 0.663
3.372LysPhe: 3.372 ± 0.547
4.214LysGly: 4.214 ± 0.875
1.264LysHis: 1.264 ± 0.315
2.95LysIle: 2.95 ± 0.525
4.636LysLys: 4.636 ± 0.814
6.996LysLeu: 6.996 ± 0.729
2.613LysMet: 2.613 ± 0.497
4.383LysAsn: 4.383 ± 0.694
2.36LysPro: 2.36 ± 0.45
3.034LysGln: 3.034 ± 0.596
3.624LysArg: 3.624 ± 0.656
3.962LysSer: 3.962 ± 0.637
4.636LysThr: 4.636 ± 0.596
3.372LysVal: 3.372 ± 0.592
0.506LysTrp: 0.506 ± 0.215
3.119LysTyr: 3.119 ± 0.523
0.0LysXaa: 0.0 ± 0.0
Leu
5.9LeuAla: 5.9 ± 0.823
0.506LeuCys: 0.506 ± 0.168
5.226LeuAsp: 5.226 ± 0.775
3.709LeuGlu: 3.709 ± 0.689
2.613LeuPhe: 2.613 ± 0.496
4.13LeuGly: 4.13 ± 0.529
1.601LeuHis: 1.601 ± 0.336
4.804LeuIle: 4.804 ± 0.645
6.322LeuLys: 6.322 ± 0.74
6.322LeuLeu: 6.322 ± 0.718
2.023LeuMet: 2.023 ± 0.393
4.383LeuAsn: 4.383 ± 0.568
3.54LeuPro: 3.54 ± 0.432
2.866LeuGln: 2.866 ± 0.472
2.192LeuArg: 2.192 ± 0.39
4.804LeuSer: 4.804 ± 0.648
6.575LeuThr: 6.575 ± 0.785
4.72LeuVal: 4.72 ± 0.756
1.011LeuTrp: 1.011 ± 0.287
3.203LeuTyr: 3.203 ± 0.532
0.0LeuXaa: 0.0 ± 0.0
Met
3.709MetAla: 3.709 ± 0.617
0.337MetCys: 0.337 ± 0.161
1.686MetAsp: 1.686 ± 0.371
1.18MetGlu: 1.18 ± 0.368
1.18MetPhe: 1.18 ± 0.294
1.77MetGly: 1.77 ± 0.547
0.253MetHis: 0.253 ± 0.14
1.77MetIle: 1.77 ± 0.477
1.854MetLys: 1.854 ± 0.348
3.034MetLeu: 3.034 ± 0.561
1.011MetMet: 1.011 ± 0.313
1.517MetAsn: 1.517 ± 0.32
0.59MetPro: 0.59 ± 0.201
1.433MetGln: 1.433 ± 0.412
1.601MetArg: 1.601 ± 0.435
1.601MetSer: 1.601 ± 0.386
2.866MetThr: 2.866 ± 0.438
1.686MetVal: 1.686 ± 0.436
0.253MetTrp: 0.253 ± 0.144
1.011MetTyr: 1.011 ± 0.364
0.0MetXaa: 0.0 ± 0.0
Asn
5.226AsnAla: 5.226 ± 0.623
0.506AsnCys: 0.506 ± 0.197
3.54AsnAsp: 3.54 ± 0.528
3.119AsnGlu: 3.119 ± 0.659
1.77AsnPhe: 1.77 ± 0.336
6.912AsnGly: 6.912 ± 0.886
1.18AsnHis: 1.18 ± 0.359
3.034AsnIle: 3.034 ± 0.391
4.72AsnLys: 4.72 ± 0.599
3.456AsnLeu: 3.456 ± 0.503
1.601AsnMet: 1.601 ± 0.441
3.203AsnAsn: 3.203 ± 0.468
0.927AsnPro: 0.927 ± 0.296
1.264AsnGln: 1.264 ± 0.239
1.77AsnArg: 1.77 ± 0.36
3.287AsnSer: 3.287 ± 0.555
3.372AsnThr: 3.372 ± 0.501
3.962AsnVal: 3.962 ± 0.639
0.927AsnTrp: 0.927 ± 0.254
2.107AsnTyr: 2.107 ± 0.477
0.0AsnXaa: 0.0 ± 0.0
Pro
2.866ProAla: 2.866 ± 0.436
0.169ProCys: 0.169 ± 0.108
2.444ProAsp: 2.444 ± 0.469
1.686ProGlu: 1.686 ± 0.35
1.517ProPhe: 1.517 ± 0.353
1.854ProGly: 1.854 ± 0.432
0.084ProHis: 0.084 ± 0.076
1.601ProIle: 1.601 ± 0.354
1.854ProLys: 1.854 ± 0.462
2.192ProLeu: 2.192 ± 0.381
0.506ProMet: 0.506 ± 0.183
1.349ProAsn: 1.349 ± 0.346
0.337ProPro: 0.337 ± 0.18
1.601ProGln: 1.601 ± 0.343
0.927ProArg: 0.927 ± 0.275
1.939ProSer: 1.939 ± 0.582
1.601ProThr: 1.601 ± 0.366
2.276ProVal: 2.276 ± 0.361
0.421ProTrp: 0.421 ± 0.156
1.433ProTyr: 1.433 ± 0.402
0.0ProXaa: 0.0 ± 0.0
Gln
4.552GlnAla: 4.552 ± 0.667
0.0GlnCys: 0.0 ± 0.0
1.264GlnAsp: 1.264 ± 0.399
1.433GlnGlu: 1.433 ± 0.319
1.011GlnPhe: 1.011 ± 0.307
2.866GlnGly: 2.866 ± 0.502
0.59GlnHis: 0.59 ± 0.171
1.854GlnIle: 1.854 ± 0.422
1.686GlnLys: 1.686 ± 0.427
3.287GlnLeu: 3.287 ± 0.462
1.18GlnMet: 1.18 ± 0.288
1.517GlnAsn: 1.517 ± 0.369
1.18GlnPro: 1.18 ± 0.357
1.77GlnGln: 1.77 ± 0.304
1.264GlnArg: 1.264 ± 0.273
2.107GlnSer: 2.107 ± 0.365
2.192GlnThr: 2.192 ± 0.393
2.95GlnVal: 2.95 ± 0.559
0.253GlnTrp: 0.253 ± 0.146
1.349GlnTyr: 1.349 ± 0.312
0.0GlnXaa: 0.0 ± 0.0
Arg
3.624ArgAla: 3.624 ± 0.496
0.169ArgCys: 0.169 ± 0.104
2.95ArgAsp: 2.95 ± 0.37
2.107ArgGlu: 2.107 ± 0.552
2.95ArgPhe: 2.95 ± 0.559
2.529ArgGly: 2.529 ± 0.416
0.59ArgHis: 0.59 ± 0.231
2.782ArgIle: 2.782 ± 0.592
2.192ArgLys: 2.192 ± 0.444
4.214ArgLeu: 4.214 ± 0.681
0.674ArgMet: 0.674 ± 0.215
1.939ArgAsn: 1.939 ± 0.466
1.18ArgPro: 1.18 ± 0.406
0.843ArgGln: 0.843 ± 0.243
2.023ArgArg: 2.023 ± 0.463
1.517ArgSer: 1.517 ± 0.397
2.023ArgThr: 2.023 ± 0.431
3.034ArgVal: 3.034 ± 0.637
0.506ArgTrp: 0.506 ± 0.2
1.686ArgTyr: 1.686 ± 0.38
0.0ArgXaa: 0.0 ± 0.0
Ser
5.057SerAla: 5.057 ± 1.039
0.169SerCys: 0.169 ± 0.114
5.31SerAsp: 5.31 ± 0.767
3.372SerGlu: 3.372 ± 0.496
2.36SerPhe: 2.36 ± 0.451
6.153SerGly: 6.153 ± 1.081
1.096SerHis: 1.096 ± 0.2
4.046SerIle: 4.046 ± 0.581
3.456SerLys: 3.456 ± 0.513
4.804SerLeu: 4.804 ± 0.574
2.023SerMet: 2.023 ± 0.275
3.203SerAsn: 3.203 ± 0.485
1.77SerPro: 1.77 ± 0.326
2.529SerGln: 2.529 ± 0.383
1.77SerArg: 1.77 ± 0.4
5.563SerSer: 5.563 ± 1.018
3.203SerThr: 3.203 ± 0.436
4.636SerVal: 4.636 ± 0.628
0.421SerTrp: 0.421 ± 0.158
2.192SerTyr: 2.192 ± 0.424
0.0SerXaa: 0.0 ± 0.0
Thr
6.322ThrAla: 6.322 ± 0.823
0.421ThrCys: 0.421 ± 0.17
5.226ThrAsp: 5.226 ± 0.743
3.119ThrGlu: 3.119 ± 0.465
2.866ThrPhe: 2.866 ± 0.41
5.984ThrGly: 5.984 ± 0.841
0.59ThrHis: 0.59 ± 0.247
4.299ThrIle: 4.299 ± 0.564
2.529ThrLys: 2.529 ± 0.353
5.563ThrLeu: 5.563 ± 0.846
1.264ThrMet: 1.264 ± 0.296
2.95ThrAsn: 2.95 ± 0.58
3.119ThrPro: 3.119 ± 0.574
2.529ThrGln: 2.529 ± 0.429
3.034ThrArg: 3.034 ± 0.534
4.13ThrSer: 4.13 ± 0.813
4.383ThrThr: 4.383 ± 0.813
5.142ThrVal: 5.142 ± 0.772
0.843ThrTrp: 0.843 ± 0.276
3.793ThrTyr: 3.793 ± 0.445
0.0ThrXaa: 0.0 ± 0.0
Val
6.069ValAla: 6.069 ± 0.94
0.337ValCys: 0.337 ± 0.206
4.636ValAsp: 4.636 ± 0.644
3.877ValGlu: 3.877 ± 0.628
2.192ValPhe: 2.192 ± 0.458
4.046ValGly: 4.046 ± 0.603
0.927ValHis: 0.927 ± 0.31
4.72ValIle: 4.72 ± 0.5
5.394ValLys: 5.394 ± 0.635
4.13ValLeu: 4.13 ± 0.654
1.517ValMet: 1.517 ± 0.312
3.287ValAsn: 3.287 ± 0.519
2.192ValPro: 2.192 ± 0.578
2.023ValGln: 2.023 ± 0.394
3.54ValArg: 3.54 ± 0.621
5.394ValSer: 5.394 ± 0.811
4.636ValThr: 4.636 ± 0.565
4.13ValVal: 4.13 ± 0.727
0.927ValTrp: 0.927 ± 0.275
3.034ValTyr: 3.034 ± 0.699
0.0ValXaa: 0.0 ± 0.0
Trp
0.674TrpAla: 0.674 ± 0.221
0.0TrpCys: 0.0 ± 0.0
0.927TrpAsp: 0.927 ± 0.223
0.506TrpGlu: 0.506 ± 0.192
0.337TrpPhe: 0.337 ± 0.162
0.506TrpGly: 0.506 ± 0.193
0.337TrpHis: 0.337 ± 0.175
0.759TrpIle: 0.759 ± 0.286
0.59TrpLys: 0.59 ± 0.248
1.433TrpLeu: 1.433 ± 0.342
0.0TrpMet: 0.0 ± 0.0
0.759TrpAsn: 0.759 ± 0.241
0.084TrpPro: 0.084 ± 0.076
0.253TrpGln: 0.253 ± 0.133
0.337TrpArg: 0.337 ± 0.168
1.011TrpSer: 1.011 ± 0.219
0.674TrpThr: 0.674 ± 0.213
0.674TrpVal: 0.674 ± 0.218
0.169TrpTrp: 0.169 ± 0.115
0.674TrpTyr: 0.674 ± 0.252
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.613TyrAla: 2.613 ± 0.429
0.421TyrCys: 0.421 ± 0.151
3.54TyrAsp: 3.54 ± 0.524
3.372TyrGlu: 3.372 ± 0.589
2.023TyrPhe: 2.023 ± 0.409
3.372TyrGly: 3.372 ± 0.462
0.506TyrHis: 0.506 ± 0.232
2.866TyrIle: 2.866 ± 0.529
4.13TyrLys: 4.13 ± 0.682
2.107TyrLeu: 2.107 ± 0.392
1.601TyrMet: 1.601 ± 0.291
2.866TyrAsn: 2.866 ± 0.523
1.517TyrPro: 1.517 ± 0.363
1.77TyrGln: 1.77 ± 0.429
1.939TyrArg: 1.939 ± 0.481
2.276TyrSer: 2.276 ± 0.414
3.119TyrThr: 3.119 ± 0.705
2.782TyrVal: 2.782 ± 0.467
0.421TyrTrp: 0.421 ± 0.172
2.276TyrTyr: 2.276 ± 0.504
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (11865 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski