Amino acid dipepetide frequency for Sanxia picorna-like virus 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.645AlaAla: 3.645 ± 1.523
0.405AlaCys: 0.405 ± 0.475
2.835AlaAsp: 2.835 ± 0.113
2.835AlaGlu: 2.835 ± 0.8
4.86AlaPhe: 4.86 ± 0.886
7.695AlaGly: 7.695 ± 0.773
2.43AlaHis: 2.43 ± 0.099
2.43AlaIle: 2.43 ± 0.786
1.62AlaLys: 1.62 ± 0.163
5.67AlaLeu: 5.67 ± 0.913
1.62AlaMet: 1.62 ± 0.524
2.025AlaAsn: 2.025 ± 0.312
3.24AlaPro: 3.24 ± 1.049
1.62AlaGln: 1.62 ± 0.524
2.025AlaArg: 2.025 ± 0.312
5.67AlaSer: 5.67 ± 0.226
4.05AlaThr: 4.05 ± 2.685
7.29AlaVal: 7.29 ± 0.389
1.215AlaTrp: 1.215 ± 0.05
3.24AlaTyr: 3.24 ± 0.326
0.0AlaXaa: 0.0 ± 0.0
Cys
1.62CysAla: 1.62 ± 0.163
0.405CysCys: 0.405 ± 0.212
2.025CysAsp: 2.025 ± 0.375
0.405CysGlu: 0.405 ± 0.475
0.405CysPhe: 0.405 ± 0.212
0.81CysGly: 0.81 ± 0.425
0.0CysHis: 0.0 ± 0.0
1.215CysIle: 1.215 ± 0.637
0.81CysLys: 0.81 ± 0.425
0.405CysLeu: 0.405 ± 0.475
1.215CysMet: 1.215 ± 0.637
0.81CysAsn: 0.81 ± 0.425
0.405CysPro: 0.405 ± 0.475
0.405CysGln: 0.405 ± 0.212
0.405CysArg: 0.405 ± 0.212
1.215CysSer: 1.215 ± 0.05
0.405CysThr: 0.405 ± 0.212
2.835CysVal: 2.835 ± 0.574
0.0CysTrp: 0.0 ± 0.0
0.81CysTyr: 0.81 ± 0.425
0.0CysXaa: 0.0 ± 0.0
Asp
2.43AspAla: 2.43 ± 0.588
0.405AspCys: 0.405 ± 0.212
4.05AspAsp: 4.05 ± 0.75
3.24AspGlu: 3.24 ± 0.326
6.075AspPhe: 6.075 ± 1.813
3.645AspGly: 3.645 ± 0.149
0.0AspHis: 0.0 ± 0.0
6.075AspIle: 6.075 ± 0.248
3.645AspLys: 3.645 ± 1.225
3.645AspLeu: 3.645 ± 1.225
2.835AspMet: 2.835 ± 0.113
0.405AspAsn: 0.405 ± 0.212
2.43AspPro: 2.43 ± 1.473
1.62AspGln: 1.62 ± 0.163
2.43AspArg: 2.43 ± 1.275
1.62AspSer: 1.62 ± 0.163
2.43AspThr: 2.43 ± 0.786
3.645AspVal: 3.645 ± 1.523
0.405AspTrp: 0.405 ± 0.212
2.835AspTyr: 2.835 ± 1.487
0.0AspXaa: 0.0 ± 0.0
Glu
2.025GluAla: 2.025 ± 0.375
0.81GluCys: 0.81 ± 0.425
1.62GluAsp: 1.62 ± 0.163
0.81GluGlu: 0.81 ± 0.425
2.43GluPhe: 2.43 ± 1.275
1.62GluGly: 1.62 ± 0.163
1.62GluHis: 1.62 ± 0.524
4.05GluIle: 4.05 ± 0.75
3.24GluLys: 3.24 ± 1.013
4.86GluLeu: 4.86 ± 0.886
1.62GluMet: 1.62 ± 0.163
2.43GluAsn: 2.43 ± 0.099
2.835GluPro: 2.835 ± 0.8
1.62GluGln: 1.62 ± 0.163
2.835GluArg: 2.835 ± 0.8
2.835GluSer: 2.835 ± 0.8
1.62GluThr: 1.62 ± 0.163
2.025GluVal: 2.025 ± 0.312
0.405GluTrp: 0.405 ± 0.212
2.025GluTyr: 2.025 ± 0.375
0.0GluXaa: 0.0 ± 0.0
Phe
2.43PheAla: 2.43 ± 0.099
0.81PheCys: 0.81 ± 0.425
2.835PheAsp: 2.835 ± 0.574
2.43PheGlu: 2.43 ± 0.099
2.43PhePhe: 2.43 ± 0.588
1.62PheGly: 1.62 ± 0.524
2.43PheHis: 2.43 ± 0.786
5.67PheIle: 5.67 ± 0.226
1.62PheLys: 1.62 ± 0.163
4.05PheLeu: 4.05 ± 1.438
0.405PheMet: 0.405 ± 0.212
4.05PheAsn: 4.05 ± 1.438
5.265PhePro: 5.265 ± 1.36
1.62PheGln: 1.62 ± 0.524
3.645PheArg: 3.645 ± 0.538
8.505PheSer: 8.505 ± 1.026
3.645PheThr: 3.645 ± 0.149
3.24PheVal: 3.24 ± 1.049
0.81PheTrp: 0.81 ± 0.262
3.24PheTyr: 3.24 ± 1.013
0.0PheXaa: 0.0 ± 0.0
Gly
6.075GlyAla: 6.075 ± 1.813
1.62GlyCys: 1.62 ± 1.211
6.075GlyAsp: 6.075 ± 1.813
4.455GlyGlu: 4.455 ± 1.65
4.86GlyPhe: 4.86 ± 0.199
4.05GlyGly: 4.05 ± 0.75
1.62GlyHis: 1.62 ± 0.85
2.835GlyIle: 2.835 ± 1.948
4.455GlyLys: 4.455 ± 1.65
4.05GlyLeu: 4.05 ± 0.75
2.43GlyMet: 2.43 ± 0.099
1.215GlyAsn: 1.215 ± 0.737
1.62GlyPro: 1.62 ± 0.85
1.215GlyGln: 1.215 ± 0.737
2.025GlyArg: 2.025 ± 1.686
5.67GlySer: 5.67 ± 1.835
4.86GlyThr: 4.86 ± 1.573
5.67GlyVal: 5.67 ± 2.522
0.405GlyTrp: 0.405 ± 0.475
1.62GlyTyr: 1.62 ± 0.163
0.0GlyXaa: 0.0 ± 0.0
His
1.215HisAla: 1.215 ± 0.737
0.0HisCys: 0.0 ± 0.0
0.81HisAsp: 0.81 ± 0.262
0.0HisGlu: 0.0 ± 0.0
1.215HisPhe: 1.215 ± 0.637
1.62HisGly: 1.62 ± 0.524
0.0HisHis: 0.0 ± 0.0
2.43HisIle: 2.43 ± 0.588
0.0HisLys: 0.0 ± 0.0
2.43HisLeu: 2.43 ± 1.275
0.0HisMet: 0.0 ± 0.0
1.215HisAsn: 1.215 ± 0.05
0.405HisPro: 0.405 ± 0.475
0.81HisGln: 0.81 ± 0.262
2.835HisArg: 2.835 ± 1.261
3.645HisSer: 3.645 ± 1.912
0.81HisThr: 0.81 ± 0.949
1.215HisVal: 1.215 ± 0.05
0.405HisTrp: 0.405 ± 0.212
0.405HisTyr: 0.405 ± 0.475
0.0HisXaa: 0.0 ± 0.0
Ile
3.645IleAla: 3.645 ± 0.149
0.0IleCys: 0.0 ± 0.0
3.645IleAsp: 3.645 ± 0.836
2.835IleGlu: 2.835 ± 0.574
6.075IlePhe: 6.075 ± 0.439
5.265IleGly: 5.265 ± 0.673
0.0IleHis: 0.0 ± 0.0
2.835IleIle: 2.835 ± 0.8
1.62IleLys: 1.62 ± 0.163
7.29IleLeu: 7.29 ± 0.389
1.215IleMet: 1.215 ± 0.637
4.455IleAsn: 4.455 ± 0.411
2.43IlePro: 2.43 ± 0.588
1.215IleGln: 1.215 ± 0.05
2.835IleArg: 2.835 ± 1.261
8.505IleSer: 8.505 ± 1.035
3.24IleThr: 3.24 ± 0.361
4.86IleVal: 4.86 ± 0.488
0.81IleTrp: 0.81 ± 0.262
2.43IleTyr: 2.43 ± 0.588
0.0IleXaa: 0.0 ± 0.0
Lys
2.025LysAla: 2.025 ± 0.375
0.81LysCys: 0.81 ± 0.262
0.405LysAsp: 0.405 ± 0.212
2.025LysGlu: 2.025 ± 0.375
5.265LysPhe: 5.265 ± 0.014
2.025LysGly: 2.025 ± 1.062
0.81LysHis: 0.81 ± 0.262
3.645LysIle: 3.645 ± 0.538
2.025LysLys: 2.025 ± 0.375
3.645LysLeu: 3.645 ± 1.225
0.405LysMet: 0.405 ± 0.212
2.43LysAsn: 2.43 ± 0.588
2.835LysPro: 2.835 ± 0.113
0.81LysGln: 0.81 ± 0.262
2.835LysArg: 2.835 ± 0.8
5.265LysSer: 5.265 ± 1.388
2.43LysThr: 2.43 ± 1.275
5.265LysVal: 5.265 ± 2.762
0.0LysTrp: 0.0 ± 0.0
2.025LysTyr: 2.025 ± 1.062
0.0LysXaa: 0.0 ± 0.0
Leu
9.316LeuAla: 9.316 ± 0.61
2.025LeuCys: 2.025 ± 0.375
6.885LeuAsp: 6.885 ± 1.551
4.05LeuGlu: 4.05 ± 0.063
3.645LeuPhe: 3.645 ± 1.523
2.835LeuGly: 2.835 ± 0.574
2.835LeuHis: 2.835 ± 0.8
3.24LeuIle: 3.24 ± 1.7
4.05LeuLys: 4.05 ± 1.438
5.67LeuLeu: 5.67 ± 1.6
1.62LeuMet: 1.62 ± 0.163
4.86LeuAsn: 4.86 ± 0.488
4.455LeuPro: 4.455 ± 0.276
2.43LeuGln: 2.43 ± 0.588
4.86LeuArg: 4.86 ± 0.886
4.05LeuSer: 4.05 ± 2.125
6.48LeuThr: 6.48 ± 0.723
6.48LeuVal: 6.48 ± 0.036
1.62LeuTrp: 1.62 ± 0.85
2.025LeuTyr: 2.025 ± 0.375
0.0LeuXaa: 0.0 ± 0.0
Met
1.215MetAla: 1.215 ± 0.05
0.81MetCys: 0.81 ± 0.262
0.81MetAsp: 0.81 ± 0.425
1.215MetGlu: 1.215 ± 0.637
1.62MetPhe: 1.62 ± 0.163
1.62MetGly: 1.62 ± 0.163
0.405MetHis: 0.405 ± 0.212
1.62MetIle: 1.62 ± 0.163
2.025MetLys: 2.025 ± 0.375
1.215MetLeu: 1.215 ± 0.637
0.405MetMet: 0.405 ± 0.212
0.81MetAsn: 0.81 ± 0.262
1.62MetPro: 1.62 ± 0.163
1.215MetGln: 1.215 ± 0.05
2.025MetArg: 2.025 ± 0.375
1.62MetSer: 1.62 ± 1.211
1.62MetThr: 1.62 ± 0.524
2.43MetVal: 2.43 ± 0.588
0.405MetTrp: 0.405 ± 0.212
1.215MetTyr: 1.215 ± 0.05
0.0MetXaa: 0.0 ± 0.0
Asn
2.43AsnAla: 2.43 ± 0.786
0.81AsnCys: 0.81 ± 0.425
1.62AsnAsp: 1.62 ± 0.163
2.025AsnGlu: 2.025 ± 0.375
2.835AsnPhe: 2.835 ± 0.113
4.05AsnGly: 4.05 ± 0.063
0.81AsnHis: 0.81 ± 0.262
2.835AsnIle: 2.835 ± 0.574
2.835AsnLys: 2.835 ± 0.8
5.67AsnLeu: 5.67 ± 0.913
1.215AsnMet: 1.215 ± 0.153
3.24AsnAsn: 3.24 ± 0.326
4.05AsnPro: 4.05 ± 1.311
0.81AsnGln: 0.81 ± 0.262
1.215AsnArg: 1.215 ± 0.737
2.835AsnSer: 2.835 ± 0.113
2.835AsnThr: 2.835 ± 0.574
3.24AsnVal: 3.24 ± 0.361
1.215AsnTrp: 1.215 ± 0.637
2.025AsnTyr: 2.025 ± 0.312
0.0AsnXaa: 0.0 ± 0.0
Pro
2.835ProAla: 2.835 ± 1.948
0.405ProCys: 0.405 ± 0.212
3.645ProAsp: 3.645 ± 0.149
2.43ProGlu: 2.43 ± 1.275
4.05ProPhe: 4.05 ± 1.998
3.24ProGly: 3.24 ± 1.013
0.81ProHis: 0.81 ± 0.262
3.645ProIle: 3.645 ± 0.836
1.215ProLys: 1.215 ± 0.05
7.695ProLeu: 7.695 ± 0.601
1.62ProMet: 1.62 ± 0.524
2.835ProAsn: 2.835 ± 1.948
2.025ProPro: 2.025 ± 0.375
1.215ProGln: 1.215 ± 0.05
2.025ProArg: 2.025 ± 0.312
4.05ProSer: 4.05 ± 0.624
2.025ProThr: 2.025 ± 0.312
2.835ProVal: 2.835 ± 0.574
0.405ProTrp: 0.405 ± 0.475
3.24ProTyr: 3.24 ± 2.423
0.0ProXaa: 0.0 ± 0.0
Gln
0.81GlnAla: 0.81 ± 0.425
0.405GlnCys: 0.405 ± 0.212
1.215GlnAsp: 1.215 ± 0.637
0.81GlnGlu: 0.81 ± 0.425
2.025GlnPhe: 2.025 ± 0.312
1.215GlnGly: 1.215 ± 0.737
0.81GlnHis: 0.81 ± 0.262
0.81GlnIle: 0.81 ± 0.425
1.62GlnLys: 1.62 ± 0.85
0.81GlnLeu: 0.81 ± 0.425
0.81GlnMet: 0.81 ± 0.262
1.215GlnAsn: 1.215 ± 0.05
0.81GlnPro: 0.81 ± 0.262
0.0GlnGln: 0.0 ± 0.0
0.81GlnArg: 0.81 ± 0.262
4.05GlnSer: 4.05 ± 1.311
1.62GlnThr: 1.62 ± 0.524
0.81GlnVal: 0.81 ± 0.262
0.0GlnTrp: 0.0 ± 0.0
1.62GlnTyr: 1.62 ± 1.211
0.0GlnXaa: 0.0 ± 0.0
Arg
5.265ArgAla: 5.265 ± 0.014
2.025ArgCys: 2.025 ± 1.062
2.025ArgAsp: 2.025 ± 0.312
2.835ArgGlu: 2.835 ± 0.113
1.62ArgPhe: 1.62 ± 0.524
3.645ArgGly: 3.645 ± 2.897
0.81ArgHis: 0.81 ± 0.262
4.86ArgIle: 4.86 ± 0.199
1.62ArgLys: 1.62 ± 0.85
4.455ArgLeu: 4.455 ± 1.098
2.43ArgMet: 2.43 ± 1.275
2.025ArgAsn: 2.025 ± 0.312
2.43ArgPro: 2.43 ± 0.786
0.405ArgGln: 0.405 ± 0.212
3.24ArgArg: 3.24 ± 1.013
2.835ArgSer: 2.835 ± 0.8
2.835ArgThr: 2.835 ± 0.113
4.05ArgVal: 4.05 ± 0.75
0.405ArgTrp: 0.405 ± 0.212
2.835ArgTyr: 2.835 ± 0.574
0.0ArgXaa: 0.0 ± 0.0
Ser
4.455SerAla: 4.455 ± 3.159
1.62SerCys: 1.62 ± 0.163
4.455SerAsp: 4.455 ± 0.411
3.24SerGlu: 3.24 ± 0.361
3.645SerPhe: 3.645 ± 0.538
9.316SerGly: 9.316 ± 0.077
2.025SerHis: 2.025 ± 1.062
4.455SerIle: 4.455 ± 1.098
3.24SerLys: 3.24 ± 1.7
10.531SerLeu: 10.531 ± 2.089
2.025SerMet: 2.025 ± 0.312
5.67SerAsn: 5.67 ± 0.226
5.67SerPro: 5.67 ± 1.835
1.215SerGln: 1.215 ± 0.05
3.645SerArg: 3.645 ± 0.836
10.126SerSer: 10.126 ± 1.189
2.025SerThr: 2.025 ± 0.312
6.48SerVal: 6.48 ± 0.036
1.62SerTrp: 1.62 ± 0.524
2.835SerTyr: 2.835 ± 0.8
0.0SerXaa: 0.0 ± 0.0
Thr
4.05ThrAla: 4.05 ± 3.372
0.81ThrCys: 0.81 ± 0.425
3.645ThrAsp: 3.645 ± 1.225
0.81ThrGlu: 0.81 ± 0.262
1.215ThrPhe: 1.215 ± 0.05
3.645ThrGly: 3.645 ± 0.538
2.025ThrHis: 2.025 ± 0.375
4.86ThrIle: 4.86 ± 1.573
2.43ThrLys: 2.43 ± 1.275
4.86ThrLeu: 4.86 ± 2.26
0.405ThrMet: 0.405 ± 0.279
4.05ThrAsn: 4.05 ± 1.311
2.835ThrPro: 2.835 ± 2.635
2.43ThrGln: 2.43 ± 0.786
1.215ThrArg: 1.215 ± 0.637
4.05ThrSer: 4.05 ± 2.685
4.455ThrThr: 4.455 ± 1.098
4.455ThrVal: 4.455 ± 0.411
0.405ThrTrp: 0.405 ± 0.212
3.645ThrTyr: 3.645 ± 0.538
0.0ThrXaa: 0.0 ± 0.0
Val
7.29ValAla: 7.29 ± 1.076
1.215ValCys: 1.215 ± 0.05
2.835ValAsp: 2.835 ± 0.113
2.43ValGlu: 2.43 ± 0.099
2.835ValPhe: 2.835 ± 0.8
5.67ValGly: 5.67 ± 0.461
0.81ValHis: 0.81 ± 0.262
4.86ValIle: 4.86 ± 0.886
5.265ValLys: 5.265 ± 0.673
3.645ValLeu: 3.645 ± 1.523
1.62ValMet: 1.62 ± 0.163
3.24ValAsn: 3.24 ± 0.326
4.86ValPro: 4.86 ± 0.886
0.81ValGln: 0.81 ± 0.262
5.67ValArg: 5.67 ± 1.6
8.505ValSer: 8.505 ± 1.722
4.86ValThr: 4.86 ± 1.573
4.86ValVal: 4.86 ± 1.573
0.81ValTrp: 0.81 ± 0.425
2.43ValTyr: 2.43 ± 0.588
0.0ValXaa: 0.0 ± 0.0
Trp
1.215TrpAla: 1.215 ± 0.05
0.81TrpCys: 0.81 ± 0.425
1.62TrpAsp: 1.62 ± 0.163
0.81TrpGlu: 0.81 ± 0.425
0.405TrpPhe: 0.405 ± 0.212
0.0TrpGly: 0.0 ± 0.0
0.81TrpHis: 0.81 ± 0.262
0.0TrpIle: 0.0 ± 0.0
0.405TrpLys: 0.405 ± 0.475
0.405TrpLeu: 0.405 ± 0.212
0.0TrpMet: 0.0 ± 0.0
0.81TrpAsn: 0.81 ± 0.425
0.0TrpPro: 0.0 ± 0.0
0.81TrpGln: 0.81 ± 0.425
2.43TrpArg: 2.43 ± 0.099
0.405TrpSer: 0.405 ± 0.212
0.81TrpThr: 0.81 ± 0.262
0.405TrpVal: 0.405 ± 0.475
0.0TrpTrp: 0.0 ± 0.0
0.405TrpTyr: 0.405 ± 0.212
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.43TyrAla: 2.43 ± 0.588
0.405TyrCys: 0.405 ± 0.212
0.81TyrAsp: 0.81 ± 0.425
3.645TyrGlu: 3.645 ± 1.225
3.24TyrPhe: 3.24 ± 0.326
3.24TyrGly: 3.24 ± 0.326
0.405TyrHis: 0.405 ± 0.475
2.835TyrIle: 2.835 ± 0.8
3.24TyrLys: 3.24 ± 0.326
2.43TyrLeu: 2.43 ± 0.588
1.62TyrMet: 1.62 ± 0.163
1.215TyrAsn: 1.215 ± 0.05
2.025TyrPro: 2.025 ± 0.375
0.0TyrGln: 0.0 ± 0.0
3.645TyrArg: 3.645 ± 0.149
2.835TyrSer: 2.835 ± 0.574
3.24TyrThr: 3.24 ± 1.049
2.43TyrVal: 2.43 ± 0.099
1.215TyrTrp: 1.215 ± 0.05
0.81TyrTyr: 0.81 ± 0.425
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2470 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski