Amino acid dipepetide frequency for Desulfuromonas thiophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.885AlaAla: 14.885 ± 0.218
1.68AlaCys: 1.68 ± 0.055
6.383AlaAsp: 6.383 ± 0.129
7.364AlaGlu: 7.364 ± 0.119
3.567AlaPhe: 3.567 ± 0.076
9.759AlaGly: 9.759 ± 0.124
1.756AlaHis: 1.756 ± 0.048
4.971AlaIle: 4.971 ± 0.088
2.422AlaLys: 2.422 ± 0.064
15.141AlaLeu: 15.141 ± 0.208
2.247AlaMet: 2.247 ± 0.064
2.379AlaAsn: 2.379 ± 0.073
4.755AlaPro: 4.755 ± 0.088
5.03AlaGln: 5.03 ± 0.088
7.669AlaArg: 7.669 ± 0.144
5.647AlaSer: 5.647 ± 0.089
5.208AlaThr: 5.208 ± 0.111
7.891AlaVal: 7.891 ± 0.102
1.065AlaTrp: 1.065 ± 0.041
2.2AlaTyr: 2.2 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.433CysAla: 1.433 ± 0.047
0.367CysCys: 0.367 ± 0.023
0.919CysAsp: 0.919 ± 0.037
0.621CysGlu: 0.621 ± 0.027
0.577CysPhe: 0.577 ± 0.032
1.548CysGly: 1.548 ± 0.049
0.732CysHis: 0.732 ± 0.056
0.532CysIle: 0.532 ± 0.027
0.266CysLys: 0.266 ± 0.019
1.728CysLeu: 1.728 ± 0.053
0.247CysMet: 0.247 ± 0.018
0.344CysAsn: 0.344 ± 0.021
0.847CysPro: 0.847 ± 0.036
0.841CysGln: 0.841 ± 0.034
1.321CysArg: 1.321 ± 0.043
0.815CysSer: 0.815 ± 0.035
0.433CysThr: 0.433 ± 0.025
0.741CysVal: 0.741 ± 0.031
0.201CysTrp: 0.201 ± 0.015
0.393CysTyr: 0.393 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
5.405AspAla: 5.405 ± 0.103
0.953AspCys: 0.953 ± 0.041
2.858AspAsp: 2.858 ± 0.127
3.3AspGlu: 3.3 ± 0.08
2.413AspPhe: 2.413 ± 0.059
4.424AspGly: 4.424 ± 0.128
1.11AspHis: 1.11 ± 0.044
2.723AspIle: 2.723 ± 0.076
1.666AspLys: 1.666 ± 0.052
6.675AspLeu: 6.675 ± 0.123
0.932AspMet: 0.932 ± 0.033
1.647AspAsn: 1.647 ± 0.067
2.604AspPro: 2.604 ± 0.057
2.377AspGln: 2.377 ± 0.06
3.481AspArg: 3.481 ± 0.076
3.169AspSer: 3.169 ± 0.077
2.073AspThr: 2.073 ± 0.102
3.183AspVal: 3.183 ± 0.084
0.908AspTrp: 0.908 ± 0.035
1.783AspTyr: 1.783 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
6.05GluAla: 6.05 ± 0.099
0.417GluCys: 0.417 ± 0.024
2.571GluAsp: 2.571 ± 0.062
3.565GluGlu: 3.565 ± 0.069
1.632GluPhe: 1.632 ± 0.047
3.773GluGly: 3.773 ± 0.091
1.087GluHis: 1.087 ± 0.037
3.306GluIle: 3.306 ± 0.068
2.375GluLys: 2.375 ± 0.073
7.317GluLeu: 7.317 ± 0.104
1.298GluMet: 1.298 ± 0.041
1.652GluAsn: 1.652 ± 0.047
2.44GluPro: 2.44 ± 0.062
4.373GluGln: 4.373 ± 0.089
4.817GluArg: 4.817 ± 0.093
2.211GluSer: 2.211 ± 0.053
2.965GluThr: 2.965 ± 0.064
3.987GluVal: 3.987 ± 0.079
0.425GluTrp: 0.425 ± 0.026
1.099GluTyr: 1.099 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.661PheAla: 3.661 ± 0.072
0.696PheCys: 0.696 ± 0.029
2.552PheAsp: 2.552 ± 0.064
1.974PheGlu: 1.974 ± 0.045
1.568PhePhe: 1.568 ± 0.054
2.988PheGly: 2.988 ± 0.077
0.723PheHis: 0.723 ± 0.032
1.717PheIle: 1.717 ± 0.05
1.02PheLys: 1.02 ± 0.039
3.465PheLeu: 3.465 ± 0.08
0.739PheMet: 0.739 ± 0.031
1.129PheAsn: 1.129 ± 0.04
1.412PhePro: 1.412 ± 0.052
1.048PheGln: 1.048 ± 0.035
2.051PheArg: 2.051 ± 0.059
2.688PheSer: 2.688 ± 0.066
1.745PheThr: 1.745 ± 0.053
2.72PheVal: 2.72 ± 0.06
0.468PheTrp: 0.468 ± 0.028
1.088PheTyr: 1.088 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
7.108GlyAla: 7.108 ± 0.128
1.462GlyCys: 1.462 ± 0.051
4.025GlyAsp: 4.025 ± 0.15
4.132GlyGlu: 4.132 ± 0.078
2.938GlyPhe: 2.938 ± 0.061
5.864GlyGly: 5.864 ± 0.15
1.704GlyHis: 1.704 ± 0.045
4.053GlyIle: 4.053 ± 0.081
2.735GlyLys: 2.735 ± 0.074
9.35GlyLeu: 9.35 ± 0.13
1.702GlyMet: 1.702 ± 0.046
2.116GlyAsn: 2.116 ± 0.105
2.641GlyPro: 2.641 ± 0.065
4.024GlyGln: 4.024 ± 0.071
5.676GlyArg: 5.676 ± 0.105
4.338GlySer: 4.338 ± 0.117
3.627GlyThr: 3.627 ± 0.107
5.096GlyVal: 5.096 ± 0.091
0.967GlyTrp: 0.967 ± 0.041
2.418GlyTyr: 2.418 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.689HisAla: 1.689 ± 0.045
0.487HisCys: 0.487 ± 0.027
1.105HisAsp: 1.105 ± 0.039
1.062HisGlu: 1.062 ± 0.037
0.95HisPhe: 0.95 ± 0.036
1.58HisGly: 1.58 ± 0.044
0.609HisHis: 0.609 ± 0.033
0.918HisIle: 0.918 ± 0.033
0.563HisLys: 0.563 ± 0.026
2.736HisLeu: 2.736 ± 0.066
0.334HisMet: 0.334 ± 0.022
0.682HisAsn: 0.682 ± 0.029
1.293HisPro: 1.293 ± 0.043
1.334HisGln: 1.334 ± 0.039
1.497HisArg: 1.497 ± 0.051
1.388HisSer: 1.388 ± 0.045
0.673HisThr: 0.673 ± 0.028
1.071HisVal: 1.071 ± 0.034
0.364HisTrp: 0.364 ± 0.021
0.694HisTyr: 0.694 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.322IleAla: 5.322 ± 0.092
0.692IleCys: 0.692 ± 0.03
3.626IleAsp: 3.626 ± 0.099
3.487IleGlu: 3.487 ± 0.075
1.599IlePhe: 1.599 ± 0.043
4.168IleGly: 4.168 ± 0.082
1.029IleHis: 1.029 ± 0.038
2.177IleIle: 2.177 ± 0.065
1.617IleLys: 1.617 ± 0.052
4.641IleLeu: 4.641 ± 0.076
0.72IleMet: 0.72 ± 0.032
1.621IleAsn: 1.621 ± 0.055
2.006IlePro: 2.006 ± 0.055
1.486IleGln: 1.486 ± 0.047
3.266IleArg: 3.266 ± 0.072
2.785IleSer: 2.785 ± 0.062
2.213IleThr: 2.213 ± 0.088
3.23IleVal: 3.23 ± 0.065
0.366IleTrp: 0.366 ± 0.023
1.139IleTyr: 1.139 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
2.935LysAla: 2.935 ± 0.076
0.238LysCys: 0.238 ± 0.021
1.501LysAsp: 1.501 ± 0.051
1.86LysGlu: 1.86 ± 0.057
0.765LysPhe: 0.765 ± 0.033
2.17LysGly: 2.17 ± 0.059
0.509LysHis: 0.509 ± 0.024
1.825LysIle: 1.825 ± 0.059
1.771LysLys: 1.771 ± 0.061
2.864LysLeu: 2.864 ± 0.069
0.719LysMet: 0.719 ± 0.031
1.052LysAsn: 1.052 ± 0.039
1.424LysPro: 1.424 ± 0.045
1.435LysGln: 1.435 ± 0.045
1.903LysArg: 1.903 ± 0.058
1.559LysSer: 1.559 ± 0.046
1.802LysThr: 1.802 ± 0.052
1.893LysVal: 1.893 ± 0.065
0.216LysTrp: 0.216 ± 0.016
0.716LysTyr: 0.716 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
15.822LeuAla: 15.822 ± 0.217
2.108LeuCys: 2.108 ± 0.065
6.239LeuAsp: 6.239 ± 0.11
6.888LeuGlu: 6.888 ± 0.103
4.603LeuPhe: 4.603 ± 0.09
8.461LeuGly: 8.461 ± 0.116
2.694LeuHis: 2.694 ± 0.062
5.306LeuIle: 5.306 ± 0.094
3.553LeuLys: 3.553 ± 0.072
17.885LeuLeu: 17.885 ± 0.325
2.123LeuMet: 2.123 ± 0.055
2.953LeuAsn: 2.953 ± 0.07
6.947LeuPro: 6.947 ± 0.13
7.454LeuGln: 7.454 ± 0.134
9.55LeuArg: 9.55 ± 0.148
6.779LeuSer: 6.779 ± 0.092
6.428LeuThr: 6.428 ± 0.127
9.066LeuVal: 9.066 ± 0.131
1.526LeuTrp: 1.526 ± 0.056
2.97LeuTyr: 2.97 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.534MetAla: 2.534 ± 0.063
0.145MetCys: 0.145 ± 0.016
0.943MetAsp: 0.943 ± 0.034
1.203MetGlu: 1.203 ± 0.036
0.492MetPhe: 0.492 ± 0.027
1.316MetGly: 1.316 ± 0.047
0.328MetHis: 0.328 ± 0.021
0.928MetIle: 0.928 ± 0.035
0.915MetLys: 0.915 ± 0.037
1.989MetLeu: 1.989 ± 0.049
0.4MetMet: 0.4 ± 0.024
0.727MetAsn: 0.727 ± 0.029
0.981MetPro: 0.981 ± 0.037
0.751MetGln: 0.751 ± 0.031
1.158MetArg: 1.158 ± 0.037
1.04MetSer: 1.04 ± 0.037
1.306MetThr: 1.306 ± 0.036
1.344MetVal: 1.344 ± 0.043
0.097MetTrp: 0.097 ± 0.011
0.303MetTyr: 0.303 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.622AsnAla: 2.622 ± 0.066
0.343AsnCys: 0.343 ± 0.02
1.51AsnAsp: 1.51 ± 0.078
1.281AsnGlu: 1.281 ± 0.041
0.85AsnPhe: 0.85 ± 0.031
1.999AsnGly: 1.999 ± 0.071
0.598AsnHis: 0.598 ± 0.026
1.539AsnIle: 1.539 ± 0.057
0.821AsnLys: 0.821 ± 0.037
3.44AsnLeu: 3.44 ± 0.083
0.543AsnMet: 0.543 ± 0.026
0.84AsnAsn: 0.84 ± 0.043
1.728AsnPro: 1.728 ± 0.049
1.162AsnGln: 1.162 ± 0.043
2.108AsnArg: 2.108 ± 0.055
1.456AsnSer: 1.456 ± 0.046
1.069AsnThr: 1.069 ± 0.044
1.566AsnVal: 1.566 ± 0.063
0.306AsnTrp: 0.306 ± 0.021
0.751AsnTyr: 0.751 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
6.956ProAla: 6.956 ± 0.123
0.62ProCys: 0.62 ± 0.029
2.721ProAsp: 2.721 ± 0.062
3.1ProGlu: 3.1 ± 0.063
1.806ProPhe: 1.806 ± 0.051
3.564ProGly: 3.564 ± 0.068
0.983ProHis: 0.983 ± 0.041
1.473ProIle: 1.473 ± 0.047
0.981ProLys: 0.981 ± 0.033
6.659ProLeu: 6.659 ± 0.117
0.874ProMet: 0.874 ± 0.036
0.887ProAsn: 0.887 ± 0.034
2.669ProPro: 2.669 ± 0.087
2.999ProGln: 2.999 ± 0.073
2.665ProArg: 2.665 ± 0.063
1.994ProSer: 1.994 ± 0.049
2.061ProThr: 2.061 ± 0.054
3.873ProVal: 3.873 ± 0.074
0.633ProTrp: 0.633 ± 0.03
1.122ProTyr: 1.122 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
6.424GlnAla: 6.424 ± 0.108
0.546GlnCys: 0.546 ± 0.024
2.055GlnAsp: 2.055 ± 0.055
2.418GlnGlu: 2.418 ± 0.064
1.316GlnPhe: 1.316 ± 0.038
3.618GlnGly: 3.618 ± 0.066
1.212GlnHis: 1.212 ± 0.044
2.593GlnIle: 2.593 ± 0.052
1.363GlnLys: 1.363 ± 0.05
8.276GlnLeu: 8.276 ± 0.159
1.015GlnMet: 1.015 ± 0.035
1.106GlnAsn: 1.106 ± 0.045
3.021GlnPro: 3.021 ± 0.082
5.208GlnGln: 5.208 ± 0.152
4.95GlnArg: 4.95 ± 0.108
1.958GlnSer: 1.958 ± 0.052
2.329GlnThr: 2.329 ± 0.04
3.904GlnVal: 3.904 ± 0.073
0.524GlnTrp: 0.524 ± 0.027
0.826GlnTyr: 0.826 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
6.035ArgAla: 6.035 ± 0.1
1.241ArgCys: 1.241 ± 0.041
3.516ArgAsp: 3.516 ± 0.079
3.939ArgGlu: 3.939 ± 0.091
2.944ArgPhe: 2.944 ± 0.072
4.061ArgGly: 4.061 ± 0.072
1.992ArgHis: 1.992 ± 0.055
3.926ArgIle: 3.926 ± 0.079
2.03ArgLys: 2.03 ± 0.056
10.558ArgLeu: 10.558 ± 0.191
1.38ArgMet: 1.38 ± 0.044
1.856ArgAsn: 1.856 ± 0.055
3.642ArgPro: 3.642 ± 0.086
6.08ArgGln: 6.08 ± 0.133
5.9ArgArg: 5.9 ± 0.115
3.406ArgSer: 3.406 ± 0.07
2.603ArgThr: 2.603 ± 0.058
4.375ArgVal: 4.375 ± 0.089
1.073ArgTrp: 1.073 ± 0.047
2.161ArgTyr: 2.161 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
5.9SerAla: 5.9 ± 0.107
0.905SerCys: 0.905 ± 0.036
2.848SerAsp: 2.848 ± 0.081
2.621SerGlu: 2.621 ± 0.056
2.081SerPhe: 2.081 ± 0.054
5.102SerGly: 5.102 ± 0.112
1.149SerHis: 1.149 ± 0.042
2.218SerIle: 2.218 ± 0.058
1.222SerLys: 1.222 ± 0.039
7.043SerLeu: 7.043 ± 0.112
1.023SerMet: 1.023 ± 0.035
1.342SerAsn: 1.342 ± 0.053
2.415SerPro: 2.415 ± 0.055
2.325SerGln: 2.325 ± 0.059
3.744SerArg: 3.744 ± 0.071
3.024SerSer: 3.024 ± 0.074
2.28SerThr: 2.28 ± 0.07
3.155SerVal: 3.155 ± 0.066
0.731SerTrp: 0.731 ± 0.031
1.431SerTyr: 1.431 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
6.007ThrAla: 6.007 ± 0.12
0.546ThrCys: 0.546 ± 0.029
2.602ThrAsp: 2.602 ± 0.095
2.542ThrGlu: 2.542 ± 0.057
1.632ThrPhe: 1.632 ± 0.044
4.246ThrGly: 4.246 ± 0.115
0.706ThrHis: 0.706 ± 0.028
2.282ThrIle: 2.282 ± 0.095
0.987ThrLys: 0.987 ± 0.036
6.218ThrLeu: 6.218 ± 0.143
0.719ThrMet: 0.719 ± 0.031
1.135ThrAsn: 1.135 ± 0.048
2.629ThrPro: 2.629 ± 0.06
1.502ThrGln: 1.502 ± 0.046
2.741ThrArg: 2.741 ± 0.064
2.623ThrSer: 2.623 ± 0.072
2.585ThrThr: 2.585 ± 0.08
3.187ThrVal: 3.187 ± 0.081
0.396ThrTrp: 0.396 ± 0.023
0.967ThrTyr: 0.967 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.068ValAla: 8.068 ± 0.115
0.939ValCys: 0.939 ± 0.04
3.748ValAsp: 3.748 ± 0.091
4.38ValGlu: 4.38 ± 0.071
2.248ValPhe: 2.248 ± 0.06
4.605ValGly: 4.605 ± 0.079
1.179ValHis: 1.179 ± 0.037
3.355ValIle: 3.355 ± 0.077
1.967ValLys: 1.967 ± 0.057
8.377ValLeu: 8.377 ± 0.111
1.342ValMet: 1.342 ± 0.046
1.982ValAsn: 1.982 ± 0.069
3.214ValPro: 3.214 ± 0.072
2.711ValGln: 2.711 ± 0.059
4.902ValArg: 4.902 ± 0.088
3.621ValSer: 3.621 ± 0.076
3.528ValThr: 3.528 ± 0.09
5.266ValVal: 5.266 ± 0.1
0.638ValTrp: 0.638 ± 0.027
1.529ValTyr: 1.529 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.806TrpAla: 0.806 ± 0.033
0.159TrpCys: 0.159 ± 0.015
0.476TrpAsp: 0.476 ± 0.021
0.455TrpGlu: 0.455 ± 0.024
0.44TrpPhe: 0.44 ± 0.023
0.682TrpGly: 0.682 ± 0.028
0.333TrpHis: 0.333 ± 0.019
0.435TrpIle: 0.435 ± 0.024
0.259TrpLys: 0.259 ± 0.018
1.852TrpLeu: 1.852 ± 0.061
0.185TrpMet: 0.185 ± 0.016
0.298TrpAsn: 0.298 ± 0.017
0.766TrpPro: 0.766 ± 0.033
1.164TrpGln: 1.164 ± 0.049
1.124TrpArg: 1.124 ± 0.049
0.554TrpSer: 0.554 ± 0.025
0.389TrpThr: 0.389 ± 0.021
0.539TrpVal: 0.539 ± 0.027
0.215TrpTrp: 0.215 ± 0.018
0.272TrpTyr: 0.272 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.361TyrAla: 2.361 ± 0.05
0.36TyrCys: 0.36 ± 0.02
1.49TyrAsp: 1.49 ± 0.054
1.167TyrGlu: 1.167 ± 0.041
1.032TyrPhe: 1.032 ± 0.037
2.049TyrGly: 2.049 ± 0.056
0.598TyrHis: 0.598 ± 0.029
0.912TyrIle: 0.912 ± 0.035
0.626TyrLys: 0.626 ± 0.03
3.139TyrLeu: 3.139 ± 0.067
0.36TyrMet: 0.36 ± 0.021
0.787TyrAsn: 0.787 ± 0.033
1.2TyrPro: 1.2 ± 0.042
1.362TyrGln: 1.362 ± 0.038
2.193TyrArg: 2.193 ± 0.058
1.499TyrSer: 1.499 ± 0.044
0.934TyrThr: 0.934 ± 0.043
1.51TyrVal: 1.51 ± 0.043
0.282TyrTrp: 0.282 ± 0.018
0.752TyrTyr: 0.752 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2471 proteins (839046 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski