Amino acid dipepetide frequency for Sphingomonas gellani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.731AlaAla: 20.731 ± 0.22	1.067AlaCys: 1.067 ± 0.036	8.379AlaAsp: 8.379 ± 0.09	7.391AlaGlu: 7.391 ± 0.104	4.145AlaPhe: 4.145 ± 0.069	12.687AlaGly: 12.687 ± 0.114	2.387AlaHis: 2.387 ± 0.041	6.455AlaIle: 6.455 ± 0.096	3.489AlaLys: 3.489 ± 0.064	14.166AlaLeu: 14.166 ± 0.135	3.981AlaMet: 3.981 ± 0.066	3.229AlaAsn: 3.229 ± 0.056	6.766AlaPro: 6.766 ± 0.105	4.424AlaGln: 4.424 ± 0.078	10.711AlaArg: 10.711 ± 0.122	6.742AlaSer: 6.742 ± 0.08	7.87AlaThr: 7.87 ± 0.096	9.643AlaVal: 9.643 ± 0.103	1.749AlaTrp: 1.749 ± 0.044	2.512AlaTyr: 2.512 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.03	0.083CysCys: 0.083 ± 0.009	0.476CysAsp: 0.476 ± 0.02	0.336CysGlu: 0.336 ± 0.017	0.267CysPhe: 0.267 ± 0.015	0.801CysGly: 0.801 ± 0.029	0.186CysHis: 0.186 ± 0.013	0.292CysIle: 0.292 ± 0.017	0.117CysLys: 0.117 ± 0.011	0.624CysLeu: 0.624 ± 0.024	0.136CysMet: 0.136 ± 0.009	0.156CysAsn: 0.156 ± 0.012	0.427CysPro: 0.427 ± 0.02	0.181CysGln: 0.181 ± 0.014	0.598CysArg: 0.598 ± 0.025	0.394CysSer: 0.394 ± 0.022	0.412CysThr: 0.412 ± 0.021	0.583CysVal: 0.583 ± 0.023	0.106CysTrp: 0.106 ± 0.01	0.156CysTyr: 0.156 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.904AspAla: 8.904 ± 0.101	0.404AspCys: 0.404 ± 0.02	3.517AspAsp: 3.517 ± 0.063	3.047AspGlu: 3.047 ± 0.066	1.897AspPhe: 1.897 ± 0.045	6.086AspGly: 6.086 ± 0.078	1.383AspHis: 1.383 ± 0.036	2.474AspIle: 2.474 ± 0.057	1.446AspLys: 1.446 ± 0.036	5.926AspLeu: 5.926 ± 0.072	1.367AspMet: 1.367 ± 0.035	1.268AspAsn: 1.268 ± 0.04	4.017AspPro: 4.017 ± 0.062	1.963AspGln: 1.963 ± 0.042	5.642AspArg: 5.642 ± 0.083	2.119AspSer: 2.119 ± 0.044	3.228AspThr: 3.228 ± 0.051	4.365AspVal: 4.365 ± 0.063	1.132AspTrp: 1.132 ± 0.037	1.525AspTyr: 1.525 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.161GluAla: 7.161 ± 0.098	0.252GluCys: 0.252 ± 0.017	2.444GluAsp: 2.444 ± 0.052	2.466GluGlu: 2.466 ± 0.058	1.185GluPhe: 1.185 ± 0.031	4.106GluGly: 4.106 ± 0.062	1.046GluHis: 1.046 ± 0.031	2.063GluIle: 2.063 ± 0.049	1.414GluLys: 1.414 ± 0.042	4.253GluLeu: 4.253 ± 0.077	1.126GluMet: 1.126 ± 0.037	1.075GluAsn: 1.075 ± 0.033	2.497GluPro: 2.497 ± 0.052	2.003GluGln: 2.003 ± 0.045	4.999GluArg: 4.999 ± 0.088	1.818GluSer: 1.818 ± 0.045	2.671GluThr: 2.671 ± 0.05	3.621GluVal: 3.621 ± 0.062	0.684GluTrp: 0.684 ± 0.024	0.834GluTyr: 0.834 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.713PheAla: 4.713 ± 0.069	0.292PheCys: 0.292 ± 0.017	2.676PheAsp: 2.676 ± 0.05	1.649PheGlu: 1.649 ± 0.039	1.197PhePhe: 1.197 ± 0.036	3.528PheGly: 3.528 ± 0.07	0.685PheHis: 0.685 ± 0.027	1.174PheIle: 1.174 ± 0.036	0.696PheLys: 0.696 ± 0.027	2.833PheLeu: 2.833 ± 0.054	0.657PheMet: 0.657 ± 0.028	0.962PheAsn: 0.962 ± 0.03	1.461PhePro: 1.461 ± 0.037	0.888PheGln: 0.888 ± 0.029	2.373PheArg: 2.373 ± 0.049	1.781PheSer: 1.781 ± 0.044	1.968PheThr: 1.968 ± 0.04	2.589PheVal: 2.589 ± 0.05	0.47PheTrp: 0.47 ± 0.022	0.84PheTyr: 0.84 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.686GlyAla: 10.686 ± 0.119	0.835GlyCys: 0.835 ± 0.026	5.369GlyAsp: 5.369 ± 0.08	4.517GlyGlu: 4.517 ± 0.067	3.593GlyPhe: 3.593 ± 0.061	8.64GlyGly: 8.64 ± 0.118	1.926GlyHis: 1.926 ± 0.046	4.172GlyIle: 4.172 ± 0.07	2.718GlyLys: 2.718 ± 0.059	8.611GlyLeu: 8.611 ± 0.096	2.298GlyMet: 2.298 ± 0.048	2.327GlyAsn: 2.327 ± 0.059	3.79GlyPro: 3.79 ± 0.069	3.189GlyGln: 3.189 ± 0.057	7.586GlyArg: 7.586 ± 0.082	4.958GlySer: 4.958 ± 0.071	5.53GlyThr: 5.53 ± 0.084	6.872GlyVal: 6.872 ± 0.077	1.852GlyTrp: 1.852 ± 0.043	2.378GlyTyr: 2.378 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.682HisAla: 2.682 ± 0.057	0.19HisCys: 0.19 ± 0.014	1.317HisAsp: 1.317 ± 0.036	0.86HisGlu: 0.86 ± 0.026	0.696HisPhe: 0.696 ± 0.023	2.053HisGly: 2.053 ± 0.04	0.587HisHis: 0.587 ± 0.025	0.723HisIle: 0.723 ± 0.025	0.358HisLys: 0.358 ± 0.021	1.924HisLeu: 1.924 ± 0.044	0.395HisMet: 0.395 ± 0.017	0.447HisAsn: 0.447 ± 0.02	1.352HisPro: 1.352 ± 0.039	0.555HisGln: 0.555 ± 0.024	1.642HisArg: 1.642 ± 0.045	0.842HisSer: 0.842 ± 0.032	0.72HisThr: 0.72 ± 0.026	1.59HisVal: 1.59 ± 0.042	0.369HisTrp: 0.369 ± 0.019	0.481HisTyr: 0.481 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.335IleAla: 7.335 ± 0.082	0.329IleCys: 0.329 ± 0.019	3.738IleAsp: 3.738 ± 0.062	2.702IleGlu: 2.702 ± 0.05	1.158IlePhe: 1.158 ± 0.032	5.02IleGly: 5.02 ± 0.079	0.8IleHis: 0.8 ± 0.031	1.482IleIle: 1.482 ± 0.039	0.962IleLys: 0.962 ± 0.03	3.331IleLeu: 3.331 ± 0.056	0.756IleMet: 0.756 ± 0.028	1.118IleAsn: 1.118 ± 0.033	1.949IlePro: 1.949 ± 0.047	1.08IleGln: 1.08 ± 0.035	3.149IleArg: 3.149 ± 0.053	2.02IleSer: 2.02 ± 0.048	2.266IleThr: 2.266 ± 0.048	3.848IleVal: 3.848 ± 0.065	0.545IleTrp: 0.545 ± 0.024	0.838IleTyr: 0.838 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.363LysAla: 3.363 ± 0.059	0.102LysCys: 0.102 ± 0.01	1.314LysAsp: 1.314 ± 0.032	0.901LysGlu: 0.901 ± 0.034	0.61LysPhe: 0.61 ± 0.026	2.303LysGly: 2.303 ± 0.051	0.425LysHis: 0.425 ± 0.018	0.966LysIle: 0.966 ± 0.032	0.815LysLys: 0.815 ± 0.031	2.565LysLeu: 2.565 ± 0.056	0.566LysMet: 0.566 ± 0.021	0.591LysAsn: 0.591 ± 0.025	1.743LysPro: 1.743 ± 0.046	0.776LysGln: 0.776 ± 0.027	2.04LysArg: 2.04 ± 0.042	1.284LysSer: 1.284 ± 0.037	1.401LysThr: 1.401 ± 0.036	1.874LysVal: 1.874 ± 0.044	0.301LysTrp: 0.301 ± 0.016	0.464LysTyr: 0.464 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.167LeuAla: 14.167 ± 0.134	0.728LeuCys: 0.728 ± 0.026	6.375LeuAsp: 6.375 ± 0.085	4.008LeuGlu: 4.008 ± 0.071	3.591LeuPhe: 3.591 ± 0.068	8.23LeuGly: 8.23 ± 0.088	1.905LeuHis: 1.905 ± 0.043	4.419LeuIle: 4.419 ± 0.067	2.562LeuLys: 2.562 ± 0.052	9.326LeuLeu: 9.326 ± 0.117	1.942LeuMet: 1.942 ± 0.043	2.334LeuAsn: 2.334 ± 0.052	5.794LeuPro: 5.794 ± 0.075	2.38LeuGln: 2.38 ± 0.048	6.953LeuArg: 6.953 ± 0.081	6.173LeuSer: 6.173 ± 0.086	5.729LeuThr: 5.729 ± 0.081	7.627LeuVal: 7.627 ± 0.083	1.189LeuTrp: 1.189 ± 0.034	1.898LeuTyr: 1.898 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.2MetAla: 3.2 ± 0.062	0.129MetCys: 0.129 ± 0.01	1.04MetAsp: 1.04 ± 0.035	0.899MetGlu: 0.899 ± 0.029	0.621MetPhe: 0.621 ± 0.024	1.735MetGly: 1.735 ± 0.038	0.378MetHis: 0.378 ± 0.02	1.197MetIle: 1.197 ± 0.033	0.737MetLys: 0.737 ± 0.024	2.539MetLeu: 2.539 ± 0.053	0.575MetMet: 0.575 ± 0.024	0.584MetAsn: 0.584 ± 0.021	1.441MetPro: 1.441 ± 0.038	0.66MetGln: 0.66 ± 0.029	1.865MetArg: 1.865 ± 0.043	1.341MetSer: 1.341 ± 0.037	1.773MetThr: 1.773 ± 0.043	1.617MetVal: 1.617 ± 0.036	0.234MetTrp: 0.234 ± 0.014	0.258MetTyr: 0.258 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.182AsnAla: 3.182 ± 0.052	0.195AsnCys: 0.195 ± 0.015	1.4AsnAsp: 1.4 ± 0.032	0.941AsnGlu: 0.941 ± 0.032	0.83AsnPhe: 0.83 ± 0.035	2.605AsnGly: 2.605 ± 0.063	0.478AsnHis: 0.478 ± 0.02	1.11AsnIle: 1.11 ± 0.031	0.557AsnLys: 0.557 ± 0.023	2.306AsnLeu: 2.306 ± 0.052	0.475AsnMet: 0.475 ± 0.018	0.691AsnAsn: 0.691 ± 0.034	1.701AsnPro: 1.701 ± 0.044	0.725AsnGln: 0.725 ± 0.026	1.86AsnArg: 1.86 ± 0.035	1.222AsnSer: 1.222 ± 0.042	1.295AsnThr: 1.295 ± 0.048	1.763AsnVal: 1.763 ± 0.047	0.393AsnTrp: 0.393 ± 0.019	0.677AsnTyr: 0.677 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	8.131ProAla: 8.131 ± 0.109	0.363ProCys: 0.363 ± 0.018	4.242ProAsp: 4.242 ± 0.06	2.861ProGlu: 2.861 ± 0.048	2.002ProPhe: 2.002 ± 0.044	5.055ProGly: 5.055 ± 0.07	1.117ProHis: 1.117 ± 0.036	2.396ProIle: 2.396 ± 0.045	1.264ProLys: 1.264 ± 0.038	5.043ProLeu: 5.043 ± 0.077	1.099ProMet: 1.099 ± 0.035	1.37ProAsn: 1.37 ± 0.036	2.992ProPro: 2.992 ± 0.072	1.707ProGln: 1.707 ± 0.042	3.403ProArg: 3.403 ± 0.058	2.97ProSer: 2.97 ± 0.053	2.983ProThr: 2.983 ± 0.056	4.631ProVal: 4.631 ± 0.063	0.736ProTrp: 0.736 ± 0.028	1.106ProTyr: 1.106 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.472GlnAla: 4.472 ± 0.071	0.177GlnCys: 0.177 ± 0.013	1.471GlnAsp: 1.471 ± 0.034	1.144GlnGlu: 1.144 ± 0.032	0.983GlnPhe: 0.983 ± 0.037	2.635GlnGly: 2.635 ± 0.05	0.584GlnHis: 0.584 ± 0.02	1.472GlnIle: 1.472 ± 0.038	0.71GlnLys: 0.71 ± 0.029	3.059GlnLeu: 3.059 ± 0.049	0.721GlnMet: 0.721 ± 0.025	0.728GlnAsn: 0.728 ± 0.03	2.135GlnPro: 2.135 ± 0.046	1.277GlnGln: 1.277 ± 0.042	2.672GlnArg: 2.672 ± 0.056	1.641GlnSer: 1.641 ± 0.041	1.706GlnThr: 1.706 ± 0.047	2.605GlnVal: 2.605 ± 0.056	0.424GlnTrp: 0.424 ± 0.018	0.569GlnTyr: 0.569 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.846ArgAla: 9.846 ± 0.088	0.529ArgCys: 0.529 ± 0.022	4.671ArgAsp: 4.671 ± 0.071	3.893ArgGlu: 3.893 ± 0.074	3.383ArgPhe: 3.383 ± 0.052	5.74ArgGly: 5.74 ± 0.079	1.842ArgHis: 1.842 ± 0.039	4.053ArgIle: 4.053 ± 0.064	1.661ArgLys: 1.661 ± 0.039	8.831ArgLeu: 8.831 ± 0.101	2.139ArgMet: 2.139 ± 0.044	1.826ArgAsn: 1.826 ± 0.038	4.413ArgPro: 4.413 ± 0.068	2.758ArgGln: 2.758 ± 0.051	6.859ArgArg: 6.859 ± 0.109	3.926ArgSer: 3.926 ± 0.059	3.929ArgThr: 3.929 ± 0.059	5.789ArgVal: 5.789 ± 0.071	1.423ArgTrp: 1.423 ± 0.035	2.035ArgTyr: 2.035 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.63SerAla: 6.63 ± 0.098	0.354SerCys: 0.354 ± 0.019	3.128SerAsp: 3.128 ± 0.051	2.079SerGlu: 2.079 ± 0.039	1.971SerPhe: 1.971 ± 0.039	5.566SerGly: 5.566 ± 0.072	0.909SerHis: 0.909 ± 0.028	2.437SerIle: 2.437 ± 0.051	1.157SerLys: 1.157 ± 0.031	4.777SerLeu: 4.777 ± 0.072	1.113SerMet: 1.113 ± 0.033	1.355SerAsn: 1.355 ± 0.043	2.957SerPro: 2.957 ± 0.067	1.46SerGln: 1.46 ± 0.035	3.683SerArg: 3.683 ± 0.061	2.734SerSer: 2.734 ± 0.067	2.917SerThr: 2.917 ± 0.061	3.911SerVal: 3.911 ± 0.057	0.782SerTrp: 0.782 ± 0.029	1.339SerTyr: 1.339 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	7.101ThrAla: 7.101 ± 0.089	0.397ThrCys: 0.397 ± 0.021	3.179ThrAsp: 3.179 ± 0.054	2.19ThrGlu: 2.19 ± 0.046	1.829ThrPhe: 1.829 ± 0.044	5.794ThrGly: 5.794 ± 0.089	0.982ThrHis: 0.982 ± 0.033	2.885ThrIle: 2.885 ± 0.055	1.107ThrLys: 1.107 ± 0.033	6.405ThrLeu: 6.405 ± 0.087	1.168ThrMet: 1.168 ± 0.036	1.326ThrAsn: 1.326 ± 0.034	3.859ThrPro: 3.859 ± 0.077	1.564ThrGln: 1.564 ± 0.039	4.141ThrArg: 4.141 ± 0.059	2.887ThrSer: 2.887 ± 0.063	3.106ThrThr: 3.106 ± 0.074	4.679ThrVal: 4.679 ± 0.064	0.691ThrTrp: 0.691 ± 0.025	1.281ThrTyr: 1.281 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	11.106ValAla: 11.106 ± 0.101	0.518ValCys: 0.518 ± 0.021	4.684ValAsp: 4.684 ± 0.068	4.399ValGlu: 4.399 ± 0.071	2.149ValPhe: 2.149 ± 0.047	6.167ValGly: 6.167 ± 0.077	1.316ValHis: 1.316 ± 0.039	3.352ValIle: 3.352 ± 0.057	1.76ValLys: 1.76 ± 0.04	7.1ValLeu: 7.1 ± 0.086	1.595ValMet: 1.595 ± 0.04	1.941ValAsn: 1.941 ± 0.044	4.359ValPro: 4.359 ± 0.064	2.238ValGln: 2.238 ± 0.042	5.821ValArg: 5.821 ± 0.079	4.317ValSer: 4.317 ± 0.069	5.06ValThr: 5.06 ± 0.074	6.138ValVal: 6.138 ± 0.09	0.865ValTrp: 0.865 ± 0.03	1.351ValTyr: 1.351 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.451TrpAla: 1.451 ± 0.039	0.13TrpCys: 0.13 ± 0.011	0.703TrpAsp: 0.703 ± 0.027	0.498TrpGlu: 0.498 ± 0.023	0.591TrpPhe: 0.591 ± 0.025	0.992TrpGly: 0.992 ± 0.033	0.37TrpHis: 0.37 ± 0.018	0.626TrpIle: 0.626 ± 0.022	0.38TrpLys: 0.38 ± 0.016	1.724TrpLeu: 1.724 ± 0.039	0.347TrpMet: 0.347 ± 0.017	0.465TrpAsn: 0.465 ± 0.023	0.763TrpPro: 0.763 ± 0.029	0.651TrpGln: 0.651 ± 0.026	1.52TrpArg: 1.52 ± 0.037	0.941TrpSer: 0.941 ± 0.029	0.954TrpThr: 0.954 ± 0.031	0.86TrpVal: 0.86 ± 0.027	0.301TrpTrp: 0.301 ± 0.017	0.302TrpTyr: 0.302 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.73TyrAla: 2.73 ± 0.058	0.191TyrCys: 0.191 ± 0.014	1.585TyrAsp: 1.585 ± 0.043	0.937TyrGlu: 0.937 ± 0.027	0.733TyrPhe: 0.733 ± 0.024	2.104TyrGly: 2.104 ± 0.045	0.477TyrHis: 0.477 ± 0.022	0.677TyrIle: 0.677 ± 0.023	0.497TyrLys: 0.497 ± 0.021	1.988TyrLeu: 1.988 ± 0.04	0.366TyrMet: 0.366 ± 0.019	0.614TyrAsn: 0.614 ± 0.031	1.054TyrPro: 1.054 ± 0.032	0.705TyrGln: 0.705 ± 0.027	2.029TyrArg: 2.029 ± 0.053	1.147TyrSer: 1.147 ± 0.036	1.056TyrThr: 1.056 ± 0.036	1.632TyrVal: 1.632 ± 0.038	0.323TyrTrp: 0.323 ± 0.02	0.646TyrTyr: 0.646 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3624 proteins (1151458 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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