Amino acid dipepetide frequency for Mucilaginibacter hurinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.201AlaAla: 7.201 ± 0.105	0.759AlaCys: 0.759 ± 0.028	5.049AlaAsp: 5.049 ± 0.074	4.662AlaGlu: 4.662 ± 0.078	3.525AlaPhe: 3.525 ± 0.058	6.652AlaGly: 6.652 ± 0.102	1.305AlaHis: 1.305 ± 0.037	5.588AlaIle: 5.588 ± 0.083	4.795AlaLys: 4.795 ± 0.069	7.205AlaLeu: 7.205 ± 0.098	1.786AlaMet: 1.786 ± 0.041	3.867AlaAsn: 3.867 ± 0.067	2.529AlaPro: 2.529 ± 0.051	2.907AlaGln: 2.907 ± 0.043	2.941AlaArg: 2.941 ± 0.056	4.427AlaSer: 4.427 ± 0.071	4.379AlaThr: 4.379 ± 0.086	5.418AlaVal: 5.418 ± 0.079	0.832AlaTrp: 0.832 ± 0.027	2.999AlaTyr: 2.999 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.571CysAla: 0.571 ± 0.023	0.129CysCys: 0.129 ± 0.01	0.425CysAsp: 0.425 ± 0.022	0.385CysGlu: 0.385 ± 0.019	0.418CysPhe: 0.418 ± 0.02	0.665CysGly: 0.665 ± 0.026	0.22CysHis: 0.22 ± 0.014	0.615CysIle: 0.615 ± 0.022	0.474CysLys: 0.474 ± 0.022	0.757CysLeu: 0.757 ± 0.027	0.184CysMet: 0.184 ± 0.014	0.402CysAsn: 0.402 ± 0.021	0.313CysPro: 0.313 ± 0.017	0.199CysGln: 0.199 ± 0.014	0.335CysArg: 0.335 ± 0.019	0.528CysSer: 0.528 ± 0.025	0.482CysThr: 0.482 ± 0.022	0.474CysVal: 0.474 ± 0.019	0.085CysTrp: 0.085 ± 0.009	0.307CysTyr: 0.307 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.221AspAla: 4.221 ± 0.066	0.366AspCys: 0.366 ± 0.017	2.888AspAsp: 2.888 ± 0.056	3.525AspGlu: 3.525 ± 0.064	2.924AspPhe: 2.924 ± 0.05	4.006AspGly: 4.006 ± 0.101	0.987AspHis: 0.987 ± 0.028	4.357AspIle: 4.357 ± 0.076	4.008AspLys: 4.008 ± 0.068	4.54AspLeu: 4.54 ± 0.076	1.269AspMet: 1.269 ± 0.034	3.055AspAsn: 3.055 ± 0.056	2.124AspPro: 2.124 ± 0.043	1.501AspGln: 1.501 ± 0.042	2.178AspArg: 2.178 ± 0.049	2.933AspSer: 2.933 ± 0.062	2.955AspThr: 2.955 ± 0.055	3.8AspVal: 3.8 ± 0.06	0.735AspTrp: 0.735 ± 0.027	2.555AspTyr: 2.555 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.25GluAla: 4.25 ± 0.066	0.333GluCys: 0.333 ± 0.016	2.751GluAsp: 2.751 ± 0.052	3.371GluGlu: 3.371 ± 0.077	2.379GluPhe: 2.379 ± 0.05	3.388GluGly: 3.388 ± 0.058	1.114GluHis: 1.114 ± 0.037	3.988GluIle: 3.988 ± 0.069	4.324GluLys: 4.324 ± 0.081	5.456GluLeu: 5.456 ± 0.089	1.425GluMet: 1.425 ± 0.037	2.899GluAsn: 2.899 ± 0.061	1.783GluPro: 1.783 ± 0.047	2.419GluGln: 2.419 ± 0.056	2.62GluArg: 2.62 ± 0.059	2.549GluSer: 2.549 ± 0.047	2.769GluThr: 2.769 ± 0.05	3.842GluVal: 3.842 ± 0.065	0.64GluTrp: 0.64 ± 0.024	2.126GluTyr: 2.126 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.517PheAla: 3.517 ± 0.058	0.47PheCys: 0.47 ± 0.022	2.929PheAsp: 2.929 ± 0.052	2.614PheGlu: 2.614 ± 0.054	2.457PhePhe: 2.457 ± 0.054	3.359PheGly: 3.359 ± 0.057	0.76PheHis: 0.76 ± 0.025	3.596PheIle: 3.596 ± 0.065	3.34PheLys: 3.34 ± 0.063	3.929PheLeu: 3.929 ± 0.073	1.056PheMet: 1.056 ± 0.029	3.042PheAsn: 3.042 ± 0.058	1.64PhePro: 1.64 ± 0.04	1.135PheGln: 1.135 ± 0.033	1.82PheArg: 1.82 ± 0.045	3.409PheSer: 3.409 ± 0.061	3.356PheThr: 3.356 ± 0.066	2.856PheVal: 2.856 ± 0.05	0.555PheTrp: 0.555 ± 0.025	2.113PheTyr: 2.113 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.953GlyAla: 4.953 ± 0.083	0.643GlyCys: 0.643 ± 0.025	3.754GlyAsp: 3.754 ± 0.07	3.551GlyGlu: 3.551 ± 0.057	3.619GlyPhe: 3.619 ± 0.062	5.127GlyGly: 5.127 ± 0.089	1.291GlyHis: 1.291 ± 0.036	5.429GlyIle: 5.429 ± 0.078	5.18GlyLys: 5.18 ± 0.083	6.347GlyLeu: 6.347 ± 0.082	1.689GlyMet: 1.689 ± 0.045	3.867GlyAsn: 3.867 ± 0.081	1.796GlyPro: 1.796 ± 0.045	2.254GlyGln: 2.254 ± 0.044	2.967GlyArg: 2.967 ± 0.05	4.382GlySer: 4.382 ± 0.082	4.462GlyThr: 4.462 ± 0.085	4.756GlyVal: 4.756 ± 0.071	0.995GlyTrp: 0.995 ± 0.035	3.303GlyTyr: 3.303 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.341HisAla: 1.341 ± 0.034	0.195HisCys: 0.195 ± 0.014	0.978HisAsp: 0.978 ± 0.028	1.042HisGlu: 1.042 ± 0.034	1.079HisPhe: 1.079 ± 0.033	1.252HisGly: 1.252 ± 0.035	0.589HisHis: 0.589 ± 0.031	1.435HisIle: 1.435 ± 0.042	1.067HisLys: 1.067 ± 0.03	1.845HisLeu: 1.845 ± 0.047	0.388HisMet: 0.388 ± 0.017	1.015HisAsn: 1.015 ± 0.028	1.075HisPro: 1.075 ± 0.031	0.702HisGln: 0.702 ± 0.028	0.787HisArg: 0.787 ± 0.026	0.971HisSer: 0.971 ± 0.031	1.073HisThr: 1.073 ± 0.03	1.064HisVal: 1.064 ± 0.034	0.234HisTrp: 0.234 ± 0.013	0.871HisTyr: 0.871 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.982IleAla: 5.982 ± 0.083	0.659IleCys: 0.659 ± 0.025	4.251IleAsp: 4.251 ± 0.066	4.071IleGlu: 4.071 ± 0.062	3.098IlePhe: 3.098 ± 0.06	4.78IleGly: 4.78 ± 0.073	1.225IleHis: 1.225 ± 0.034	5.139IleIle: 5.139 ± 0.078	5.006IleLys: 5.006 ± 0.068	5.911IleLeu: 5.911 ± 0.073	1.384IleMet: 1.384 ± 0.033	4.511IleAsn: 4.511 ± 0.068	3.042IlePro: 3.042 ± 0.056	2.134IleGln: 2.134 ± 0.043	2.88IleArg: 2.88 ± 0.053	4.717IleSer: 4.717 ± 0.071	4.997IleThr: 4.997 ± 0.081	4.409IleVal: 4.409 ± 0.073	0.697IleTrp: 0.697 ± 0.028	2.747IleTyr: 2.747 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	5.329LysAla: 5.329 ± 0.08	0.326LysCys: 0.326 ± 0.017	3.681LysAsp: 3.681 ± 0.067	3.887LysGlu: 3.887 ± 0.069	2.681LysPhe: 2.681 ± 0.05	4.413LysGly: 4.413 ± 0.068	1.356LysHis: 1.356 ± 0.036	4.793LysIle: 4.793 ± 0.072	5.206LysLys: 5.206 ± 0.085	6.355LysLeu: 6.355 ± 0.079	1.72LysMet: 1.72 ± 0.04	3.989LysAsn: 3.989 ± 0.069	3.006LysPro: 3.006 ± 0.066	2.777LysGln: 2.777 ± 0.058	2.866LysArg: 2.866 ± 0.051	3.612LysSer: 3.612 ± 0.065	3.976LysThr: 3.976 ± 0.063	4.436LysVal: 4.436 ± 0.064	0.758LysTrp: 0.758 ± 0.023	2.814LysTyr: 2.814 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	7.095LeuAla: 7.095 ± 0.087	0.786LeuCys: 0.786 ± 0.029	4.512LeuAsp: 4.512 ± 0.072	4.354LeuGlu: 4.354 ± 0.091	4.511LeuPhe: 4.511 ± 0.077	5.654LeuGly: 5.654 ± 0.089	1.802LeuHis: 1.802 ± 0.043	6.212LeuIle: 6.212 ± 0.088	6.789LeuLys: 6.789 ± 0.089	9.077LeuLeu: 9.077 ± 0.117	2.151LeuMet: 2.151 ± 0.039	5.52LeuAsn: 5.52 ± 0.085	4.145LeuPro: 4.145 ± 0.068	3.642LeuGln: 3.642 ± 0.06	3.818LeuArg: 3.818 ± 0.059	6.317LeuSer: 6.317 ± 0.078	5.715LeuThr: 5.715 ± 0.086	5.662LeuVal: 5.662 ± 0.076	0.955LeuTrp: 0.955 ± 0.033	3.39LeuTyr: 3.39 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.976MetAla: 1.976 ± 0.044	0.139MetCys: 0.139 ± 0.012	1.218MetAsp: 1.218 ± 0.038	1.188MetGlu: 1.188 ± 0.034	0.857MetPhe: 0.857 ± 0.034	1.536MetGly: 1.536 ± 0.038	0.465MetHis: 0.465 ± 0.019	1.435MetIle: 1.435 ± 0.041	1.665MetLys: 1.665 ± 0.041	2.277MetLeu: 2.277 ± 0.049	0.527MetMet: 0.527 ± 0.022	1.109MetAsn: 1.109 ± 0.03	1.156MetPro: 1.156 ± 0.029	0.986MetGln: 0.986 ± 0.029	1.055MetArg: 1.055 ± 0.033	1.314MetSer: 1.314 ± 0.035	1.045MetThr: 1.045 ± 0.035	1.551MetVal: 1.551 ± 0.041	0.191MetTrp: 0.191 ± 0.014	0.691MetTyr: 0.691 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	4.213AsnAla: 4.213 ± 0.071	0.391AsnCys: 0.391 ± 0.019	2.98AsnAsp: 2.98 ± 0.05	2.908AsnGlu: 2.908 ± 0.058	2.702AsnPhe: 2.702 ± 0.052	4.044AsnGly: 4.044 ± 0.082	0.955AsnHis: 0.955 ± 0.03	4.276AsnIle: 4.276 ± 0.07	3.691AsnLys: 3.691 ± 0.054	4.841AsnLeu: 4.841 ± 0.068	1.22AsnMet: 1.22 ± 0.035	3.397AsnAsn: 3.397 ± 0.07	2.664AsnPro: 2.664 ± 0.044	1.936AsnGln: 1.936 ± 0.045	2.454AsnArg: 2.454 ± 0.048	3.208AsnSer: 3.208 ± 0.062	3.5AsnThr: 3.5 ± 0.071	3.456AsnVal: 3.456 ± 0.071	0.747AsnTrp: 0.747 ± 0.025	2.582AsnTyr: 2.582 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	3.801ProAla: 3.801 ± 0.07	0.226ProCys: 0.226 ± 0.015	2.791ProAsp: 2.791 ± 0.047	2.836ProGlu: 2.836 ± 0.05	1.944ProPhe: 1.944 ± 0.044	3.231ProGly: 3.231 ± 0.064	0.796ProHis: 0.796 ± 0.024	2.137ProIle: 2.137 ± 0.043	2.124ProLys: 2.124 ± 0.049	3.422ProLeu: 3.422 ± 0.054	0.716ProMet: 0.716 ± 0.029	1.88ProAsn: 1.88 ± 0.043	1.235ProPro: 1.235 ± 0.046	1.473ProGln: 1.473 ± 0.034	1.243ProArg: 1.243 ± 0.037	2.107ProSer: 2.107 ± 0.046	1.899ProThr: 1.899 ± 0.045	3.671ProVal: 3.671 ± 0.06	0.412ProTrp: 0.412 ± 0.019	1.585ProTyr: 1.585 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.728GlnAla: 2.728 ± 0.055	0.208GlnCys: 0.208 ± 0.015	1.554GlnAsp: 1.554 ± 0.039	1.785GlnGlu: 1.785 ± 0.039	1.534GlnPhe: 1.534 ± 0.041	2.131GlnGly: 2.131 ± 0.046	0.837GlnHis: 0.837 ± 0.031	2.27GlnIle: 2.27 ± 0.047	2.507GlnLys: 2.507 ± 0.055	3.761GlnLeu: 3.761 ± 0.065	0.865GlnMet: 0.865 ± 0.03	1.941GlnAsn: 1.941 ± 0.046	1.567GlnPro: 1.567 ± 0.038	2.066GlnGln: 2.066 ± 0.067	1.694GlnArg: 1.694 ± 0.047	2.082GlnSer: 2.082 ± 0.045	2.007GlnThr: 2.007 ± 0.046	2.436GlnVal: 2.436 ± 0.041	0.413GlnTrp: 0.413 ± 0.022	1.487GlnTyr: 1.487 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.664ArgAla: 2.664 ± 0.053	0.257ArgCys: 0.257 ± 0.015	2.266ArgAsp: 2.266 ± 0.044	2.371ArgGlu: 2.371 ± 0.05	2.284ArgPhe: 2.284 ± 0.048	2.41ArgGly: 2.41 ± 0.048	0.799ArgHis: 0.799 ± 0.031	3.108ArgIle: 3.108 ± 0.056	2.899ArgLys: 2.899 ± 0.05	4.131ArgLeu: 4.131 ± 0.067	1.069ArgMet: 1.069 ± 0.031	2.315ArgAsn: 2.315 ± 0.047	1.481ArgPro: 1.481 ± 0.037	1.647ArgGln: 1.647 ± 0.044	1.861ArgArg: 1.861 ± 0.056	2.34ArgSer: 2.34 ± 0.05	2.154ArgThr: 2.154 ± 0.046	2.8ArgVal: 2.8 ± 0.044	0.545ArgTrp: 0.545 ± 0.023	1.942ArgTyr: 1.942 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.964SerAla: 4.964 ± 0.073	0.537SerCys: 0.537 ± 0.02	2.988SerAsp: 2.988 ± 0.057	2.745SerGlu: 2.745 ± 0.056	3.184SerPhe: 3.184 ± 0.062	4.985SerGly: 4.985 ± 0.082	1.039SerHis: 1.039 ± 0.031	4.317SerIle: 4.317 ± 0.066	3.626SerLys: 3.626 ± 0.059	5.517SerLeu: 5.517 ± 0.067	1.219SerMet: 1.219 ± 0.034	3.091SerAsn: 3.091 ± 0.059	2.408SerPro: 2.408 ± 0.052	1.932SerGln: 1.932 ± 0.047	2.504SerArg: 2.504 ± 0.055	3.708SerSer: 3.708 ± 0.077	3.371SerThr: 3.371 ± 0.059	4.254SerVal: 4.254 ± 0.073	0.688SerTrp: 0.688 ± 0.025	2.546SerTyr: 2.546 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	5.058ThrAla: 5.058 ± 0.084	0.411ThrCys: 0.411 ± 0.019	3.489ThrAsp: 3.489 ± 0.054	3.105ThrGlu: 3.105 ± 0.054	2.751ThrPhe: 2.751 ± 0.053	5.265ThrGly: 5.265 ± 0.085	1.086ThrHis: 1.086 ± 0.027	4.337ThrIle: 4.337 ± 0.084	3.016ThrLys: 3.016 ± 0.055	5.32ThrLeu: 5.32 ± 0.075	1.036ThrMet: 1.036 ± 0.027	2.936ThrAsn: 2.936 ± 0.069	2.842ThrPro: 2.842 ± 0.061	1.921ThrGln: 1.921 ± 0.041	2.292ThrArg: 2.292 ± 0.047	3.463ThrSer: 3.463 ± 0.071	3.607ThrThr: 3.607 ± 0.078	4.419ThrVal: 4.419 ± 0.089	0.673ThrTrp: 0.673 ± 0.027	2.473ThrTyr: 2.473 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	5.233ValAla: 5.233 ± 0.084	0.637ValCys: 0.637 ± 0.023	3.623ValAsp: 3.623 ± 0.058	3.446ValGlu: 3.446 ± 0.058	3.24ValPhe: 3.24 ± 0.051	3.768ValGly: 3.768 ± 0.07	1.175ValHis: 1.175 ± 0.032	5.091ValIle: 5.091 ± 0.071	4.869ValLys: 4.869 ± 0.071	6.281ValLeu: 6.281 ± 0.076	1.585ValMet: 1.585 ± 0.04	4.011ValAsn: 4.011 ± 0.072	2.647ValPro: 2.647 ± 0.058	2.101ValGln: 2.101 ± 0.047	2.474ValArg: 2.474 ± 0.047	4.364ValSer: 4.364 ± 0.067	4.473ValThr: 4.473 ± 0.093	4.62ValVal: 4.62 ± 0.075	0.73ValTrp: 0.73 ± 0.024	2.749ValTyr: 2.749 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.781TrpAla: 0.781 ± 0.029	0.125TrpCys: 0.125 ± 0.011	0.651TrpAsp: 0.651 ± 0.025	0.623TrpGlu: 0.623 ± 0.027	0.581TrpPhe: 0.581 ± 0.026	0.85TrpGly: 0.85 ± 0.03	0.3TrpHis: 0.3 ± 0.019	0.732TrpIle: 0.732 ± 0.027	0.694TrpLys: 0.694 ± 0.027	1.222TrpLeu: 1.222 ± 0.036	0.341TrpMet: 0.341 ± 0.021	0.587TrpAsn: 0.587 ± 0.027	0.404TrpPro: 0.404 ± 0.02	0.556TrpGln: 0.556 ± 0.024	0.534TrpArg: 0.534 ± 0.022	0.576TrpSer: 0.576 ± 0.023	0.618TrpThr: 0.618 ± 0.025	0.774TrpVal: 0.774 ± 0.032	0.195TrpTrp: 0.195 ± 0.013	0.47TrpTyr: 0.47 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.948TyrAla: 2.948 ± 0.059	0.372TyrCys: 0.372 ± 0.018	2.149TyrAsp: 2.149 ± 0.041	1.958TyrGlu: 1.958 ± 0.039	2.186TyrPhe: 2.186 ± 0.044	2.847TyrGly: 2.847 ± 0.054	0.902TyrHis: 0.902 ± 0.029	2.784TyrIle: 2.784 ± 0.047	2.704TyrLys: 2.704 ± 0.054	3.911TyrLeu: 3.911 ± 0.066	0.75TyrMet: 0.75 ± 0.024	2.729TyrAsn: 2.729 ± 0.059	1.671TyrPro: 1.671 ± 0.042	1.587TyrGln: 1.587 ± 0.043	2.02TyrArg: 2.02 ± 0.045	2.614TyrSer: 2.614 ± 0.053	2.664TyrThr: 2.664 ± 0.059	2.418TyrVal: 2.418 ± 0.053	0.536TyrTrp: 0.536 ± 0.022	1.908TyrTyr: 1.908 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3344 proteins (1161225 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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