Amino acid dipepetide frequency for Formosa sediminum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.167AlaAla: 4.167 ± 0.084	0.558AlaCys: 0.558 ± 0.023	3.203AlaAsp: 3.203 ± 0.05	3.986AlaGlu: 3.986 ± 0.07	3.462AlaPhe: 3.462 ± 0.052	3.756AlaGly: 3.756 ± 0.063	1.216AlaHis: 1.216 ± 0.034	5.569AlaIle: 5.569 ± 0.079	4.757AlaLys: 4.757 ± 0.076	6.833AlaLeu: 6.833 ± 0.094	1.438AlaMet: 1.438 ± 0.039	3.56AlaAsn: 3.56 ± 0.05	1.884AlaPro: 1.884 ± 0.048	2.43AlaGln: 2.43 ± 0.053	1.833AlaArg: 1.833 ± 0.042	4.194AlaSer: 4.194 ± 0.069	3.788AlaThr: 3.788 ± 0.073	4.065AlaVal: 4.065 ± 0.071	0.66AlaTrp: 0.66 ± 0.025	2.777AlaTyr: 2.777 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.453CysAla: 0.453 ± 0.021	0.111CysCys: 0.111 ± 0.009	0.376CysAsp: 0.376 ± 0.02	0.469CysGlu: 0.469 ± 0.022	0.458CysPhe: 0.458 ± 0.021	0.558CysGly: 0.558 ± 0.029	0.176CysHis: 0.176 ± 0.015	0.664CysIle: 0.664 ± 0.021	0.508CysLys: 0.508 ± 0.021	0.703CysLeu: 0.703 ± 0.026	0.163CysMet: 0.163 ± 0.013	0.432CysAsn: 0.432 ± 0.021	0.277CysPro: 0.277 ± 0.019	0.192CysGln: 0.192 ± 0.012	0.187CysArg: 0.187 ± 0.012	0.507CysSer: 0.507 ± 0.025	0.426CysThr: 0.426 ± 0.02	0.47CysVal: 0.47 ± 0.021	0.068CysTrp: 0.068 ± 0.007	0.314CysTyr: 0.314 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.949AspAla: 3.949 ± 0.069	0.431AspCys: 0.431 ± 0.02	3.099AspAsp: 3.099 ± 0.061	3.546AspGlu: 3.546 ± 0.062	3.495AspPhe: 3.495 ± 0.054	3.503AspGly: 3.503 ± 0.068	0.969AspHis: 0.969 ± 0.025	4.707AspIle: 4.707 ± 0.057	3.942AspLys: 3.942 ± 0.06	5.508AspLeu: 5.508 ± 0.07	1.154AspMet: 1.154 ± 0.034	3.17AspAsn: 3.17 ± 0.071	1.601AspPro: 1.601 ± 0.039	1.579AspGln: 1.579 ± 0.041	1.778AspArg: 1.778 ± 0.04	3.322AspSer: 3.322 ± 0.058	3.182AspThr: 3.182 ± 0.055	3.972AspVal: 3.972 ± 0.06	0.721AspTrp: 0.721 ± 0.028	3.098AspTyr: 3.098 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	4.718GluAla: 4.718 ± 0.068	0.329GluCys: 0.329 ± 0.023	3.967GluAsp: 3.967 ± 0.07	4.022GluGlu: 4.022 ± 0.069	2.942GluPhe: 2.942 ± 0.054	3.604GluGly: 3.604 ± 0.064	1.421GluHis: 1.421 ± 0.037	5.129GluIle: 5.129 ± 0.068	4.673GluLys: 4.673 ± 0.073	5.976GluLeu: 5.976 ± 0.078	1.318GluMet: 1.318 ± 0.032	4.266GluAsn: 4.266 ± 0.074	1.522GluPro: 1.522 ± 0.043	2.322GluGln: 2.322 ± 0.047	2.377GluArg: 2.377 ± 0.05	3.417GluSer: 3.417 ± 0.057	4.151GluThr: 4.151 ± 0.061	4.046GluVal: 4.046 ± 0.063	0.579GluTrp: 0.579 ± 0.024	2.452GluTyr: 2.452 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	2.703PheAla: 2.703 ± 0.053	0.425PheCys: 0.425 ± 0.02	2.886PheAsp: 2.886 ± 0.059	3.334PheGlu: 3.334 ± 0.054	2.539PhePhe: 2.539 ± 0.058	3.538PheGly: 3.538 ± 0.064	0.786PheHis: 0.786 ± 0.024	4.032PheIle: 4.032 ± 0.071	4.3PheLys: 4.3 ± 0.068	4.514PheLeu: 4.514 ± 0.063	1.085PheMet: 1.085 ± 0.033	3.765PheAsn: 3.765 ± 0.067	1.546PhePro: 1.546 ± 0.039	1.468PheGln: 1.468 ± 0.037	1.436PheArg: 1.436 ± 0.037	3.947PheSer: 3.947 ± 0.068	3.158PheThr: 3.158 ± 0.058	2.929PheVal: 2.929 ± 0.057	0.557PheTrp: 0.557 ± 0.025	2.245PheTyr: 2.245 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.137GlyAla: 4.137 ± 0.063	0.536GlyCys: 0.536 ± 0.025	3.315GlyAsp: 3.315 ± 0.052	3.557GlyGlu: 3.557 ± 0.06	3.519GlyPhe: 3.519 ± 0.063	4.276GlyGly: 4.276 ± 0.077	1.163GlyHis: 1.163 ± 0.034	5.193GlyIle: 5.193 ± 0.065	4.391GlyLys: 4.391 ± 0.067	5.808GlyLeu: 5.808 ± 0.071	1.435GlyMet: 1.435 ± 0.039	3.268GlyAsn: 3.268 ± 0.063	1.338GlyPro: 1.338 ± 0.035	1.839GlyGln: 1.839 ± 0.041	1.903GlyArg: 1.903 ± 0.047	3.765GlySer: 3.765 ± 0.071	3.976GlyThr: 3.976 ± 0.073	4.418GlyVal: 4.418 ± 0.068	0.715GlyTrp: 0.715 ± 0.024	2.925GlyTyr: 2.925 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.128HisAla: 1.128 ± 0.032	0.178HisCys: 0.178 ± 0.013	0.972HisAsp: 0.972 ± 0.027	0.964HisGlu: 0.964 ± 0.027	1.175HisPhe: 1.175 ± 0.029	1.123HisGly: 1.123 ± 0.036	0.507HisHis: 0.507 ± 0.022	1.625HisIle: 1.625 ± 0.043	1.271HisLys: 1.271 ± 0.034	1.999HisLeu: 1.999 ± 0.046	0.38HisMet: 0.38 ± 0.018	1.166HisAsn: 1.166 ± 0.038	0.918HisPro: 0.918 ± 0.029	0.657HisGln: 0.657 ± 0.024	0.648HisArg: 0.648 ± 0.026	1.132HisSer: 1.132 ± 0.036	1.175HisThr: 1.175 ± 0.033	1.143HisVal: 1.143 ± 0.031	0.225HisTrp: 0.225 ± 0.014	0.903HisTyr: 0.903 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.584IleAla: 5.584 ± 0.084	0.661IleCys: 0.661 ± 0.026	5.001IleAsp: 5.001 ± 0.076	5.527IleGlu: 5.527 ± 0.079	3.566IlePhe: 3.566 ± 0.057	5.002IleGly: 5.002 ± 0.072	1.441IleHis: 1.441 ± 0.035	6.433IleIle: 6.433 ± 0.089	6.089IleLys: 6.089 ± 0.074	7.282IleLeu: 7.282 ± 0.096	1.475IleMet: 1.475 ± 0.034	4.966IleAsn: 4.966 ± 0.069	3.313IlePro: 3.313 ± 0.055	2.647IleGln: 2.647 ± 0.045	2.335IleArg: 2.335 ± 0.046	5.931IleSer: 5.931 ± 0.08	5.324IleThr: 5.324 ± 0.081	4.905IleVal: 4.905 ± 0.057	0.68IleTrp: 0.68 ± 0.026	2.946IleTyr: 2.946 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	5.256LysAla: 5.256 ± 0.073	0.326LysCys: 0.326 ± 0.019	4.578LysAsp: 4.578 ± 0.06	4.977LysGlu: 4.977 ± 0.08	2.852LysPhe: 2.852 ± 0.045	4.156LysGly: 4.156 ± 0.069	1.806LysHis: 1.806 ± 0.044	5.898LysIle: 5.898 ± 0.079	5.936LysLys: 5.936 ± 0.08	6.666LysLeu: 6.666 ± 0.081	1.802LysMet: 1.802 ± 0.038	4.981LysAsn: 4.981 ± 0.086	2.603LysPro: 2.603 ± 0.049	3.082LysGln: 3.082 ± 0.048	2.888LysArg: 2.888 ± 0.059	4.73LysSer: 4.73 ± 0.072	5.428LysThr: 5.428 ± 0.081	4.329LysVal: 4.329 ± 0.075	0.709LysTrp: 0.709 ± 0.024	2.986LysTyr: 2.986 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	5.687LeuAla: 5.687 ± 0.08	0.742LeuCys: 0.742 ± 0.026	5.502LeuAsp: 5.502 ± 0.06	6.478LeuGlu: 6.478 ± 0.082	4.77LeuPhe: 4.77 ± 0.071	5.97LeuGly: 5.97 ± 0.089	1.696LeuHis: 1.696 ± 0.038	7.432LeuIle: 7.432 ± 0.095	8.374LeuLys: 8.374 ± 0.097	8.717LeuLeu: 8.717 ± 0.121	1.974LeuMet: 1.974 ± 0.042	6.298LeuAsn: 6.298 ± 0.084	3.477LeuPro: 3.477 ± 0.063	3.368LeuGln: 3.368 ± 0.056	2.959LeuArg: 2.959 ± 0.054	6.432LeuSer: 6.432 ± 0.083	5.368LeuThr: 5.368 ± 0.073	5.439LeuVal: 5.439 ± 0.073	0.756LeuTrp: 0.756 ± 0.028	3.336LeuTyr: 3.336 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.515MetAla: 1.515 ± 0.04	0.165MetCys: 0.165 ± 0.012	1.034MetAsp: 1.034 ± 0.033	1.145MetGlu: 1.145 ± 0.032	0.914MetPhe: 0.914 ± 0.028	1.22MetGly: 1.22 ± 0.033	0.426MetHis: 0.426 ± 0.02	1.44MetIle: 1.44 ± 0.035	2.031MetLys: 2.031 ± 0.039	2.012MetLeu: 2.012 ± 0.042	0.52MetMet: 0.52 ± 0.022	1.199MetAsn: 1.199 ± 0.029	0.833MetPro: 0.833 ± 0.029	0.81MetGln: 0.81 ± 0.028	0.775MetArg: 0.775 ± 0.026	1.483MetSer: 1.483 ± 0.036	1.124MetThr: 1.124 ± 0.031	1.291MetVal: 1.291 ± 0.036	0.179MetTrp: 0.179 ± 0.013	0.781MetTyr: 0.781 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.966AsnAla: 3.966 ± 0.06	0.412AsnCys: 0.412 ± 0.025	3.192AsnAsp: 3.192 ± 0.061	3.566AsnGlu: 3.566 ± 0.058	3.005AsnPhe: 3.005 ± 0.06	3.75AsnGly: 3.75 ± 0.07	1.14AsnHis: 1.14 ± 0.038	5.373AsnIle: 5.373 ± 0.089	4.413AsnLys: 4.413 ± 0.068	5.68AsnLeu: 5.68 ± 0.089	1.321AsnMet: 1.321 ± 0.036	3.936AsnAsn: 3.936 ± 0.077	2.632AsnPro: 2.632 ± 0.054	2.189AsnGln: 2.189 ± 0.045	2.029AsnArg: 2.029 ± 0.043	3.86AsnSer: 3.86 ± 0.065	4.54AsnThr: 4.54 ± 0.087	3.601AsnVal: 3.601 ± 0.049	0.745AsnTrp: 0.745 ± 0.025	3.09AsnTyr: 3.09 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	1.737ProAla: 1.737 ± 0.045	0.205ProCys: 0.205 ± 0.014	2.023ProAsp: 2.023 ± 0.044	3.058ProGlu: 3.058 ± 0.048	1.86ProPhe: 1.86 ± 0.039	1.768ProGly: 1.768 ± 0.042	0.62ProHis: 0.62 ± 0.025	2.778ProIle: 2.778 ± 0.054	2.618ProLys: 2.618 ± 0.049	3.047ProLeu: 3.047 ± 0.053	0.688ProMet: 0.688 ± 0.026	2.287ProAsn: 2.287 ± 0.05	0.723ProPro: 0.723 ± 0.029	1.058ProGln: 1.058 ± 0.031	0.868ProArg: 0.868 ± 0.028	2.022ProSer: 2.022 ± 0.042	2.028ProThr: 2.028 ± 0.048	2.187ProVal: 2.187 ± 0.042	0.34ProTrp: 0.34 ± 0.017	1.408ProTyr: 1.408 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.14GlnAla: 2.14 ± 0.049	0.189GlnCys: 0.189 ± 0.013	2.054GlnAsp: 2.054 ± 0.051	2.191GlnGlu: 2.191 ± 0.046	1.752GlnPhe: 1.752 ± 0.041	1.832GlnGly: 1.832 ± 0.04	0.756GlnHis: 0.756 ± 0.025	2.689GlnIle: 2.689 ± 0.048	2.425GlnLys: 2.425 ± 0.049	3.576GlnLeu: 3.576 ± 0.063	0.714GlnMet: 0.714 ± 0.024	2.16GlnAsn: 2.16 ± 0.048	1.102GlnPro: 1.102 ± 0.034	1.324GlnGln: 1.324 ± 0.04	1.081GlnArg: 1.081 ± 0.038	2.052GlnSer: 2.052 ± 0.044	2.086GlnThr: 2.086 ± 0.041	1.994GlnVal: 1.994 ± 0.043	0.346GlnTrp: 0.346 ± 0.015	1.371GlnTyr: 1.371 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.117ArgAla: 2.117 ± 0.05	0.203ArgCys: 0.203 ± 0.012	1.655ArgAsp: 1.655 ± 0.041	1.857ArgGlu: 1.857 ± 0.041	1.78ArgPhe: 1.78 ± 0.04	1.851ArgGly: 1.851 ± 0.042	0.644ArgHis: 0.644 ± 0.025	2.702ArgIle: 2.702 ± 0.049	2.314ArgLys: 2.314 ± 0.049	3.163ArgLeu: 3.163 ± 0.054	0.778ArgMet: 0.778 ± 0.026	1.784ArgAsn: 1.784 ± 0.042	1.057ArgPro: 1.057 ± 0.033	1.038ArgGln: 1.038 ± 0.035	1.154ArgArg: 1.154 ± 0.039	1.76ArgSer: 1.76 ± 0.044	1.892ArgThr: 1.892 ± 0.038	2.027ArgVal: 2.027 ± 0.039	0.376ArgTrp: 0.376 ± 0.017	1.486ArgTyr: 1.486 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.732SerAla: 3.732 ± 0.067	0.666SerCys: 0.666 ± 0.024	3.786SerAsp: 3.786 ± 0.068	4.331SerGlu: 4.331 ± 0.06	3.458SerPhe: 3.458 ± 0.062	4.523SerGly: 4.523 ± 0.071	1.173SerHis: 1.173 ± 0.034	5.291SerIle: 5.291 ± 0.077	5.209SerLys: 5.209 ± 0.073	5.824SerLeu: 5.824 ± 0.082	1.266SerMet: 1.266 ± 0.04	3.919SerAsn: 3.919 ± 0.068	2.041SerPro: 2.041 ± 0.047	2.132SerGln: 2.132 ± 0.042	2.024SerArg: 2.024 ± 0.04	4.31SerSer: 4.31 ± 0.086	3.774SerThr: 3.774 ± 0.073	4.032SerVal: 4.032 ± 0.068	0.668SerTrp: 0.668 ± 0.024	2.813SerTyr: 2.813 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	4.037ThrAla: 4.037 ± 0.069	0.394ThrCys: 0.394 ± 0.02	3.603ThrAsp: 3.603 ± 0.068	3.761ThrGlu: 3.761 ± 0.056	3.182ThrPhe: 3.182 ± 0.058	3.982ThrGly: 3.982 ± 0.067	1.257ThrHis: 1.257 ± 0.034	5.374ThrIle: 5.374 ± 0.093	4.113ThrLys: 4.113 ± 0.061	6.349ThrLeu: 6.349 ± 0.081	1.011ThrMet: 1.011 ± 0.03	3.599ThrAsn: 3.599 ± 0.07	2.579ThrPro: 2.579 ± 0.053	2.099ThrGln: 2.099 ± 0.05	1.643ThrArg: 1.643 ± 0.042	4.125ThrSer: 4.125 ± 0.073	4.162ThrThr: 4.162 ± 0.088	3.986ThrVal: 3.986 ± 0.08	0.654ThrTrp: 0.654 ± 0.026	2.804ThrTyr: 2.804 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	3.967ValAla: 3.967 ± 0.063	0.539ValCys: 0.539 ± 0.024	3.526ValAsp: 3.526 ± 0.06	3.647ValGlu: 3.647 ± 0.064	3.498ValPhe: 3.498 ± 0.066	3.698ValGly: 3.698 ± 0.069	1.024ValHis: 1.024 ± 0.031	4.921ValIle: 4.921 ± 0.067	4.484ValLys: 4.484 ± 0.071	6.256ValLeu: 6.256 ± 0.078	1.303ValMet: 1.303 ± 0.033	3.802ValAsn: 3.802 ± 0.061	2.077ValPro: 2.077 ± 0.047	1.715ValGln: 1.715 ± 0.046	1.886ValArg: 1.886 ± 0.043	4.569ValSer: 4.569 ± 0.069	3.839ValThr: 3.839 ± 0.071	4.164ValVal: 4.164 ± 0.068	0.595ValTrp: 0.595 ± 0.023	2.463ValTyr: 2.463 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.553TrpAla: 0.553 ± 0.024	0.112TrpCys: 0.112 ± 0.01	0.622TrpAsp: 0.622 ± 0.025	0.624TrpGlu: 0.624 ± 0.025	0.545TrpPhe: 0.545 ± 0.023	0.663TrpGly: 0.663 ± 0.027	0.231TrpHis: 0.231 ± 0.014	0.731TrpIle: 0.731 ± 0.025	0.739TrpLys: 0.739 ± 0.028	0.972TrpLeu: 0.972 ± 0.029	0.29TrpMet: 0.29 ± 0.016	0.677TrpAsn: 0.677 ± 0.024	0.259TrpPro: 0.259 ± 0.018	0.385TrpGln: 0.385 ± 0.02	0.38TrpArg: 0.38 ± 0.018	0.675TrpSer: 0.675 ± 0.028	0.581TrpThr: 0.581 ± 0.027	0.583TrpVal: 0.583 ± 0.023	0.128TrpTrp: 0.128 ± 0.011	0.423TrpTyr: 0.423 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.591TyrAla: 2.591 ± 0.053	0.332TyrCys: 0.332 ± 0.017	2.331TyrAsp: 2.331 ± 0.048	2.192TyrGlu: 2.192 ± 0.049	2.42TyrPhe: 2.42 ± 0.053	2.704TyrGly: 2.704 ± 0.048	0.837TyrHis: 0.837 ± 0.032	3.126TyrIle: 3.126 ± 0.052	3.403TyrLys: 3.403 ± 0.062	3.888TyrLeu: 3.888 ± 0.067	0.778TyrMet: 0.778 ± 0.026	3.208TyrAsn: 3.208 ± 0.061	1.541TyrPro: 1.541 ± 0.035	1.499TyrGln: 1.499 ± 0.039	1.454TyrArg: 1.454 ± 0.035	2.737TyrSer: 2.737 ± 0.053	2.712TyrThr: 2.712 ± 0.06	2.393TyrVal: 2.393 ± 0.049	0.474TyrTrp: 0.474 ± 0.023	1.982TyrTyr: 1.982 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3315 proteins (1148853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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