Amino acid dipepetide frequency for Rhodanobacter fulvus Jip2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.16AlaAla: 17.16 ± 0.189
1.192AlaCys: 1.192 ± 0.037
7.15AlaAsp: 7.15 ± 0.088
6.337AlaGlu: 6.337 ± 0.083
4.014AlaPhe: 4.014 ± 0.061
10.661AlaGly: 10.661 ± 0.142
2.791AlaHis: 2.791 ± 0.056
5.484AlaIle: 5.484 ± 0.079
3.408AlaLys: 3.408 ± 0.066
15.038AlaLeu: 15.038 ± 0.14
3.472AlaMet: 3.472 ± 0.061
3.087AlaAsn: 3.087 ± 0.052
5.947AlaPro: 5.947 ± 0.09
5.267AlaGln: 5.267 ± 0.073
8.727AlaArg: 8.727 ± 0.115
6.924AlaSer: 6.924 ± 0.083
6.581AlaThr: 6.581 ± 0.096
8.749AlaVal: 8.749 ± 0.103
1.967AlaTrp: 1.967 ± 0.05
2.504AlaTyr: 2.504 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.07CysAla: 1.07 ± 0.031
0.113CysCys: 0.113 ± 0.011
0.473CysAsp: 0.473 ± 0.022
0.437CysGlu: 0.437 ± 0.021
0.298CysPhe: 0.298 ± 0.017
0.867CysGly: 0.867 ± 0.029
0.294CysHis: 0.294 ± 0.021
0.329CysIle: 0.329 ± 0.019
0.187CysLys: 0.187 ± 0.014
0.823CysLeu: 0.823 ± 0.032
0.187CysMet: 0.187 ± 0.014
0.218CysAsn: 0.218 ± 0.014
0.397CysPro: 0.397 ± 0.023
0.227CysGln: 0.227 ± 0.015
0.515CysArg: 0.515 ± 0.024
0.443CysSer: 0.443 ± 0.023
0.429CysThr: 0.429 ± 0.019
0.647CysVal: 0.647 ± 0.026
0.13CysTrp: 0.13 ± 0.01
0.208CysTyr: 0.208 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
8.107AspAla: 8.107 ± 0.093
0.426AspCys: 0.426 ± 0.021
3.654AspAsp: 3.654 ± 0.068
3.225AspGlu: 3.225 ± 0.062
2.205AspPhe: 2.205 ± 0.045
5.742AspGly: 5.742 ± 0.091
1.461AspHis: 1.461 ± 0.035
2.531AspIle: 2.531 ± 0.06
1.702AspLys: 1.702 ± 0.047
5.479AspLeu: 5.479 ± 0.08
1.233AspMet: 1.233 ± 0.032
1.52AspAsn: 1.52 ± 0.041
3.271AspPro: 3.271 ± 0.055
1.854AspGln: 1.854 ± 0.045
3.697AspArg: 3.697 ± 0.055
2.626AspSer: 2.626 ± 0.047
2.964AspThr: 2.964 ± 0.05
4.536AspVal: 4.536 ± 0.07
1.06AspTrp: 1.06 ± 0.031
1.751AspTyr: 1.751 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
6.129GluAla: 6.129 ± 0.089
0.335GluCys: 0.335 ± 0.021
2.11GluAsp: 2.11 ± 0.045
2.052GluGlu: 2.052 ± 0.057
1.54GluPhe: 1.54 ± 0.038
3.501GluGly: 3.501 ± 0.064
1.489GluHis: 1.489 ± 0.038
2.254GluIle: 2.254 ± 0.044
1.752GluLys: 1.752 ± 0.045
5.981GluLeu: 5.981 ± 0.086
1.032GluMet: 1.032 ± 0.031
1.298GluAsn: 1.298 ± 0.03
2.386GluPro: 2.386 ± 0.048
2.544GluGln: 2.544 ± 0.05
4.462GluArg: 4.462 ± 0.079
2.538GluSer: 2.538 ± 0.059
2.433GluThr: 2.433 ± 0.045
3.55GluVal: 3.55 ± 0.059
0.65GluTrp: 0.65 ± 0.024
1.062GluTyr: 1.062 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
4.296PheAla: 4.296 ± 0.075
0.317PheCys: 0.317 ± 0.017
2.608PheAsp: 2.608 ± 0.046
1.789PheGlu: 1.789 ± 0.042
1.255PhePhe: 1.255 ± 0.037
3.423PheGly: 3.423 ± 0.056
0.821PheHis: 0.821 ± 0.028
1.364PheIle: 1.364 ± 0.036
0.966PheLys: 0.966 ± 0.033
2.951PheLeu: 2.951 ± 0.056
0.721PheMet: 0.721 ± 0.025
1.134PheAsn: 1.134 ± 0.035
1.468PhePro: 1.468 ± 0.032
1.025PheGln: 1.025 ± 0.029
2.059PheArg: 2.059 ± 0.038
2.049PheSer: 2.049 ± 0.047
1.848PheThr: 1.848 ± 0.044
2.632PheVal: 2.632 ± 0.052
0.446PheTrp: 0.446 ± 0.024
0.903PheTyr: 0.903 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
9.129GlyAla: 9.129 ± 0.148
0.791GlyCys: 0.791 ± 0.027
4.9GlyAsp: 4.9 ± 0.071
4.581GlyGlu: 4.581 ± 0.067
3.269GlyPhe: 3.269 ± 0.056
6.997GlyGly: 6.997 ± 0.128
2.173GlyHis: 2.173 ± 0.043
4.058GlyIle: 4.058 ± 0.061
3.407GlyLys: 3.407 ± 0.062
8.266GlyLeu: 8.266 ± 0.103
2.415GlyMet: 2.415 ± 0.051
2.558GlyAsn: 2.558 ± 0.062
2.88GlyPro: 2.88 ± 0.056
3.259GlyGln: 3.259 ± 0.063
5.448GlyArg: 5.448 ± 0.075
4.982GlySer: 4.982 ± 0.088
4.473GlyThr: 4.473 ± 0.109
6.6GlyVal: 6.6 ± 0.081
1.649GlyTrp: 1.649 ± 0.035
2.446GlyTyr: 2.446 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
3.334HisAla: 3.334 ± 0.048
0.273HisCys: 0.273 ± 0.016
1.56HisAsp: 1.56 ± 0.041
1.223HisGlu: 1.223 ± 0.037
0.96HisPhe: 0.96 ± 0.031
2.599HisGly: 2.599 ± 0.054
0.726HisHis: 0.726 ± 0.027
0.959HisIle: 0.959 ± 0.027
0.546HisLys: 0.546 ± 0.02
2.3HisLeu: 2.3 ± 0.044
0.583HisMet: 0.583 ± 0.022
0.555HisAsn: 0.555 ± 0.023
1.615HisPro: 1.615 ± 0.041
0.83HisGln: 0.83 ± 0.026
1.732HisArg: 1.732 ± 0.044
1.135HisSer: 1.135 ± 0.037
1.141HisThr: 1.141 ± 0.033
1.862HisVal: 1.862 ± 0.043
0.459HisTrp: 0.459 ± 0.021
0.802HisTyr: 0.802 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.04IleAla: 6.04 ± 0.076
0.377IleCys: 0.377 ± 0.019
3.635IleAsp: 3.635 ± 0.054
2.94IleGlu: 2.94 ± 0.065
1.252IlePhe: 1.252 ± 0.034
4.492IleGly: 4.492 ± 0.07
1.017IleHis: 1.017 ± 0.032
1.551IleIle: 1.551 ± 0.045
1.291IleLys: 1.291 ± 0.038
3.125IleLeu: 3.125 ± 0.061
0.615IleMet: 0.615 ± 0.025
1.426IleAsn: 1.426 ± 0.04
2.049IlePro: 2.049 ± 0.046
1.13IleGln: 1.13 ± 0.032
2.643IleArg: 2.643 ± 0.049
2.365IleSer: 2.365 ± 0.047
2.451IleThr: 2.451 ± 0.055
3.367IleVal: 3.367 ± 0.057
0.486IleTrp: 0.486 ± 0.024
0.988IleTyr: 0.988 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.543LysAla: 3.543 ± 0.066
0.134LysCys: 0.134 ± 0.012
1.47LysAsp: 1.47 ± 0.042
1.175LysGlu: 1.175 ± 0.034
0.823LysPhe: 0.823 ± 0.028
2.11LysGly: 2.11 ± 0.054
0.775LysHis: 0.775 ± 0.025
1.284LysIle: 1.284 ± 0.036
1.074LysLys: 1.074 ± 0.041
3.491LysLeu: 3.491 ± 0.062
0.626LysMet: 0.626 ± 0.025
0.787LysAsn: 0.787 ± 0.026
2.094LysPro: 2.094 ± 0.048
1.255LysGln: 1.255 ± 0.035
2.157LysArg: 2.157 ± 0.049
1.572LysSer: 1.572 ± 0.034
1.618LysThr: 1.618 ± 0.038
2.289LysVal: 2.289 ± 0.054
0.308LysTrp: 0.308 ± 0.018
0.655LysTyr: 0.655 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
15.067LeuAla: 15.067 ± 0.132
0.994LeuCys: 0.994 ± 0.032
6.761LeuAsp: 6.761 ± 0.095
4.829LeuGlu: 4.829 ± 0.066
3.465LeuPhe: 3.465 ± 0.064
8.827LeuGly: 8.827 ± 0.103
2.666LeuHis: 2.666 ± 0.054
4.458LeuIle: 4.458 ± 0.065
3.382LeuLys: 3.382 ± 0.063
12.344LeuLeu: 12.344 ± 0.174
2.217LeuMet: 2.217 ± 0.058
2.591LeuAsn: 2.591 ± 0.052
6.543LeuPro: 6.543 ± 0.093
4.172LeuGln: 4.172 ± 0.065
8.16LeuArg: 8.16 ± 0.1
6.042LeuSer: 6.042 ± 0.074
5.387LeuThr: 5.387 ± 0.097
7.511LeuVal: 7.511 ± 0.09
1.384LeuTrp: 1.384 ± 0.041
2.298LeuTyr: 2.298 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.834MetAla: 2.834 ± 0.055
0.144MetCys: 0.144 ± 0.012
1.228MetAsp: 1.228 ± 0.038
0.969MetGlu: 0.969 ± 0.028
0.694MetPhe: 0.694 ± 0.026
1.605MetGly: 1.605 ± 0.04
0.605MetHis: 0.605 ± 0.024
0.938MetIle: 0.938 ± 0.03
0.873MetLys: 0.873 ± 0.029
2.705MetLeu: 2.705 ± 0.05
0.468MetMet: 0.468 ± 0.024
0.745MetAsn: 0.745 ± 0.027
1.429MetPro: 1.429 ± 0.041
1.042MetGln: 1.042 ± 0.028
1.681MetArg: 1.681 ± 0.039
1.535MetSer: 1.535 ± 0.038
1.374MetThr: 1.374 ± 0.035
1.615MetVal: 1.615 ± 0.046
0.219MetTrp: 0.219 ± 0.013
0.41MetTyr: 0.41 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.393AsnAla: 3.393 ± 0.06
0.199AsnCys: 0.199 ± 0.015
1.583AsnAsp: 1.583 ± 0.04
1.2AsnGlu: 1.2 ± 0.034
0.925AsnPhe: 0.925 ± 0.028
2.604AsnGly: 2.604 ± 0.072
0.64AsnHis: 0.64 ± 0.024
1.169AsnIle: 1.169 ± 0.032
0.683AsnLys: 0.683 ± 0.024
2.695AsnLeu: 2.695 ± 0.051
0.487AsnMet: 0.487 ± 0.022
0.803AsnAsn: 0.803 ± 0.032
1.735AsnPro: 1.735 ± 0.039
0.929AsnGln: 0.929 ± 0.031
1.762AsnArg: 1.762 ± 0.043
1.233AsnSer: 1.233 ± 0.044
1.416AsnThr: 1.416 ± 0.042
1.971AsnVal: 1.971 ± 0.042
0.423AsnTrp: 0.423 ± 0.022
0.775AsnTyr: 0.775 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
7.157ProAla: 7.157 ± 0.097
0.341ProCys: 0.341 ± 0.019
3.467ProAsp: 3.467 ± 0.062
2.756ProGlu: 2.756 ± 0.053
1.681ProPhe: 1.681 ± 0.044
4.521ProGly: 4.521 ± 0.066
1.186ProHis: 1.186 ± 0.036
1.957ProIle: 1.957 ± 0.041
1.313ProLys: 1.313 ± 0.035
5.545ProLeu: 5.545 ± 0.087
1.297ProMet: 1.297 ± 0.039
1.272ProAsn: 1.272 ± 0.032
2.878ProPro: 2.878 ± 0.071
2.162ProGln: 2.162 ± 0.049
3.276ProArg: 3.276 ± 0.062
2.777ProSer: 2.777 ± 0.047
2.608ProThr: 2.608 ± 0.052
4.034ProVal: 4.034 ± 0.059
0.914ProTrp: 0.914 ± 0.031
1.221ProTyr: 1.221 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
5.07GlnAla: 5.07 ± 0.07
0.254GlnCys: 0.254 ± 0.016
1.464GlnAsp: 1.464 ± 0.035
1.347GlnGlu: 1.347 ± 0.037
1.171GlnPhe: 1.171 ± 0.033
2.731GlnGly: 2.731 ± 0.043
1.146GlnHis: 1.146 ± 0.032
1.63GlnIle: 1.63 ± 0.04
1.002GlnLys: 1.002 ± 0.034
4.79GlnLeu: 4.79 ± 0.073
0.891GlnMet: 0.891 ± 0.029
0.853GlnAsn: 0.853 ± 0.03
2.474GlnPro: 2.474 ± 0.049
2.185GlnGln: 2.185 ± 0.053
3.743GlnArg: 3.743 ± 0.066
2.032GlnSer: 2.032 ± 0.043
1.815GlnThr: 1.815 ± 0.043
2.883GlnVal: 2.883 ± 0.051
0.675GlnTrp: 0.675 ± 0.025
0.817GlnTyr: 0.817 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
7.802ArgAla: 7.802 ± 0.112
0.57ArgCys: 0.57 ± 0.025
4.346ArgAsp: 4.346 ± 0.064
4.22ArgGlu: 4.22 ± 0.074
2.704ArgPhe: 2.704 ± 0.048
5.023ArgGly: 5.023 ± 0.068
2.154ArgHis: 2.154 ± 0.045
3.554ArgIle: 3.554 ± 0.061
2.117ArgLys: 2.117 ± 0.051
7.948ArgLeu: 7.948 ± 0.113
1.863ArgMet: 1.863 ± 0.037
1.839ArgAsn: 1.839 ± 0.039
3.098ArgPro: 3.098 ± 0.055
3.121ArgGln: 3.121 ± 0.061
5.662ArgArg: 5.662 ± 0.091
3.509ArgSer: 3.509 ± 0.059
3.162ArgThr: 3.162 ± 0.056
5.018ArgVal: 5.018 ± 0.077
1.336ArgTrp: 1.336 ± 0.036
2.147ArgTyr: 2.147 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
6.439SerAla: 6.439 ± 0.08
0.408SerCys: 0.408 ± 0.019
2.927SerAsp: 2.927 ± 0.049
2.393SerGlu: 2.393 ± 0.054
2.013SerPhe: 2.013 ± 0.045
5.247SerGly: 5.247 ± 0.093
1.326SerHis: 1.326 ± 0.035
2.345SerIle: 2.345 ± 0.045
1.445SerLys: 1.445 ± 0.031
5.699SerLeu: 5.699 ± 0.08
1.35SerMet: 1.35 ± 0.036
1.417SerAsn: 1.417 ± 0.042
2.822SerPro: 2.822 ± 0.047
1.862SerGln: 1.862 ± 0.039
3.641SerArg: 3.641 ± 0.057
3.244SerSer: 3.244 ± 0.06
3.029SerThr: 3.029 ± 0.06
4.02SerVal: 4.02 ± 0.057
0.874SerTrp: 0.874 ± 0.03
1.48SerTyr: 1.48 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
6.145ThrAla: 6.145 ± 0.084
0.371ThrCys: 0.371 ± 0.02
2.917ThrAsp: 2.917 ± 0.053
2.243ThrGlu: 2.243 ± 0.039
1.72ThrPhe: 1.72 ± 0.037
4.648ThrGly: 4.648 ± 0.103
1.264ThrHis: 1.264 ± 0.032
2.268ThrIle: 2.268 ± 0.049
1.044ThrLys: 1.044 ± 0.033
6.582ThrLeu: 6.582 ± 0.121
1.008ThrMet: 1.008 ± 0.03
1.151ThrAsn: 1.151 ± 0.037
3.442ThrPro: 3.442 ± 0.062
1.761ThrGln: 1.761 ± 0.041
3.457ThrArg: 3.457 ± 0.064
2.664ThrSer: 2.664 ± 0.054
2.977ThrThr: 2.977 ± 0.074
4.27ThrVal: 4.27 ± 0.072
0.696ThrTrp: 0.696 ± 0.024
1.15ThrTyr: 1.15 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
9.399ValAla: 9.399 ± 0.09
0.703ValCys: 0.703 ± 0.025
4.733ValAsp: 4.733 ± 0.065
3.81ValGlu: 3.81 ± 0.064
2.572ValPhe: 2.572 ± 0.051
5.579ValGly: 5.579 ± 0.069
1.652ValHis: 1.652 ± 0.048
3.563ValIle: 3.563 ± 0.063
1.919ValLys: 1.919 ± 0.05
8.346ValLeu: 8.346 ± 0.106
1.776ValMet: 1.776 ± 0.045
2.142ValAsn: 2.142 ± 0.046
3.768ValPro: 3.768 ± 0.06
2.543ValGln: 2.543 ± 0.05
5.01ValArg: 5.01 ± 0.075
4.188ValSer: 4.188 ± 0.071
4.065ValThr: 4.065 ± 0.077
6.068ValVal: 6.068 ± 0.086
0.92ValTrp: 0.92 ± 0.028
1.603ValTyr: 1.603 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.313TrpAla: 1.313 ± 0.033
0.155TrpCys: 0.155 ± 0.012
0.651TrpAsp: 0.651 ± 0.026
0.493TrpGlu: 0.493 ± 0.021
0.602TrpPhe: 0.602 ± 0.027
0.912TrpGly: 0.912 ± 0.031
0.449TrpHis: 0.449 ± 0.019
0.693TrpIle: 0.693 ± 0.025
0.485TrpLys: 0.485 ± 0.02
2.339TrpLeu: 2.339 ± 0.057
0.432TrpMet: 0.432 ± 0.022
0.548TrpAsn: 0.548 ± 0.023
0.796TrpPro: 0.796 ± 0.027
0.846TrpGln: 0.846 ± 0.03
1.355TrpArg: 1.355 ± 0.036
0.896TrpSer: 0.896 ± 0.032
0.711TrpThr: 0.711 ± 0.026
0.952TrpVal: 0.952 ± 0.035
0.295TrpTrp: 0.295 ± 0.02
0.397TrpTyr: 0.397 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.031TyrAla: 3.031 ± 0.06
0.195TyrCys: 0.195 ± 0.013
1.408TyrAsp: 1.408 ± 0.035
1.078TyrGlu: 1.078 ± 0.029
0.913TyrPhe: 0.913 ± 0.028
2.19TyrGly: 2.19 ± 0.052
0.556TyrHis: 0.556 ± 0.023
0.852TyrIle: 0.852 ± 0.022
0.641TyrLys: 0.641 ± 0.022
2.655TyrLeu: 2.655 ± 0.056
0.442TyrMet: 0.442 ± 0.02
0.683TyrAsn: 0.683 ± 0.029
1.27TyrPro: 1.27 ± 0.036
0.958TyrGln: 0.958 ± 0.029
2.004TyrArg: 2.004 ± 0.044
1.227TyrSer: 1.227 ± 0.034
1.299TyrThr: 1.299 ± 0.04
1.785TyrVal: 1.785 ± 0.044
0.428TyrTrp: 0.428 ± 0.02
0.668TyrTyr: 0.668 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3400 proteins (1141324 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski