Amino acid dipepetide frequency for Streptococcus satellite phage Javan438

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.917AlaAla: 0.917 ± 0.613
0.0AlaCys: 0.0 ± 0.0
3.972AlaAsp: 3.972 ± 1.121
6.722AlaGlu: 6.722 ± 1.797
2.75AlaPhe: 2.75 ± 1.171
3.666AlaGly: 3.666 ± 1.251
0.611AlaHis: 0.611 ± 0.413
4.583AlaIle: 4.583 ± 1.24
5.194AlaLys: 5.194 ± 1.055
4.277AlaLeu: 4.277 ± 1.189
1.528AlaMet: 1.528 ± 0.864
3.055AlaAsn: 3.055 ± 0.771
1.222AlaPro: 1.222 ± 0.497
3.055AlaGln: 3.055 ± 0.88
2.444AlaArg: 2.444 ± 0.74
3.055AlaSer: 3.055 ± 0.909
5.805AlaThr: 5.805 ± 1.259
2.75AlaVal: 2.75 ± 0.651
0.917AlaTrp: 0.917 ± 0.4
1.833AlaTyr: 1.833 ± 0.579
0.0AlaXaa: 0.0 ± 0.0
Cys
0.306CysAla: 0.306 ± 0.278
0.0CysCys: 0.0 ± 0.0
1.222CysAsp: 1.222 ± 0.57
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.306CysIle: 0.306 ± 0.287
0.306CysLys: 0.306 ± 0.322
0.306CysLeu: 0.306 ± 0.296
0.306CysMet: 0.306 ± 0.332
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.306CysArg: 0.306 ± 0.25
0.306CysSer: 0.306 ± 0.25
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.611AspAla: 0.611 ± 0.375
0.306AspCys: 0.306 ± 0.287
3.972AspAsp: 3.972 ± 0.936
3.972AspGlu: 3.972 ± 1.245
4.583AspPhe: 4.583 ± 1.155
2.75AspGly: 2.75 ± 0.834
0.306AspHis: 0.306 ± 0.321
6.722AspIle: 6.722 ± 1.528
4.888AspLys: 4.888 ± 0.96
5.5AspLeu: 5.5 ± 1.037
2.139AspMet: 2.139 ± 0.67
3.972AspAsn: 3.972 ± 1.162
0.306AspPro: 0.306 ± 0.321
1.222AspGln: 1.222 ± 0.818
3.055AspArg: 3.055 ± 1.088
4.277AspSer: 4.277 ± 1.317
3.666AspThr: 3.666 ± 1.018
3.666AspVal: 3.666 ± 0.885
0.306AspTrp: 0.306 ± 0.296
4.888AspTyr: 4.888 ± 1.43
0.0AspXaa: 0.0 ± 0.0
Glu
4.277GluAla: 4.277 ± 0.908
0.306GluCys: 0.306 ± 0.278
3.972GluAsp: 3.972 ± 1.106
7.333GluGlu: 7.333 ± 1.512
2.139GluPhe: 2.139 ± 0.763
2.75GluGly: 2.75 ± 0.904
0.917GluHis: 0.917 ± 0.421
7.027GluIle: 7.027 ± 1.67
6.416GluLys: 6.416 ± 0.911
8.86GluLeu: 8.86 ± 0.918
1.833GluMet: 1.833 ± 0.721
5.194GluAsn: 5.194 ± 1.081
3.666GluPro: 3.666 ± 1.288
2.75GluGln: 2.75 ± 1.063
7.027GluArg: 7.027 ± 1.813
3.972GluSer: 3.972 ± 1.385
4.583GluThr: 4.583 ± 1.293
6.416GluVal: 6.416 ± 1.757
0.0GluTrp: 0.0 ± 0.0
4.583GluTyr: 4.583 ± 1.106
0.0GluXaa: 0.0 ± 0.0
Phe
1.833PheAla: 1.833 ± 0.888
0.0PheCys: 0.0 ± 0.0
3.972PheAsp: 3.972 ± 0.955
4.277PheGlu: 4.277 ± 1.24
1.833PhePhe: 1.833 ± 0.716
3.055PheGly: 3.055 ± 1.007
0.611PheHis: 0.611 ± 0.384
2.139PheIle: 2.139 ± 0.725
3.361PheLys: 3.361 ± 1.088
5.5PheLeu: 5.5 ± 1.173
0.917PheMet: 0.917 ± 0.561
1.222PheAsn: 1.222 ± 0.71
0.611PhePro: 0.611 ± 0.541
1.833PheGln: 1.833 ± 0.673
2.75PheArg: 2.75 ± 0.792
2.444PheSer: 2.444 ± 0.584
2.139PheThr: 2.139 ± 0.87
1.222PheVal: 1.222 ± 0.57
0.611PheTrp: 0.611 ± 0.464
2.444PheTyr: 2.444 ± 0.739
0.0PheXaa: 0.0 ± 0.0
Gly
2.444GlyAla: 2.444 ± 1.027
0.306GlyCys: 0.306 ± 0.25
3.666GlyAsp: 3.666 ± 1.052
4.277GlyGlu: 4.277 ± 0.954
4.277GlyPhe: 4.277 ± 0.825
1.833GlyGly: 1.833 ± 0.624
0.917GlyHis: 0.917 ± 0.468
3.055GlyIle: 3.055 ± 0.839
3.666GlyLys: 3.666 ± 1.047
5.194GlyLeu: 5.194 ± 1.175
2.139GlyMet: 2.139 ± 0.847
1.833GlyAsn: 1.833 ± 0.663
0.0GlyPro: 0.0 ± 0.0
3.055GlyGln: 3.055 ± 0.868
1.833GlyArg: 1.833 ± 0.534
1.528GlySer: 1.528 ± 0.672
2.75GlyThr: 2.75 ± 1.085
3.361GlyVal: 3.361 ± 0.768
0.306GlyTrp: 0.306 ± 0.272
2.75GlyTyr: 2.75 ± 0.71
0.0GlyXaa: 0.0 ± 0.0
His
1.222HisAla: 1.222 ± 0.654
0.0HisCys: 0.0 ± 0.0
0.306HisAsp: 0.306 ± 0.278
0.611HisGlu: 0.611 ± 0.33
0.917HisPhe: 0.917 ± 0.551
1.833HisGly: 1.833 ± 0.729
0.306HisHis: 0.306 ± 0.272
0.917HisIle: 0.917 ± 0.551
1.528HisLys: 1.528 ± 0.732
1.528HisLeu: 1.528 ± 0.477
0.0HisMet: 0.0 ± 0.0
0.306HisAsn: 0.306 ± 0.294
0.306HisPro: 0.306 ± 0.292
0.306HisGln: 0.306 ± 0.296
1.528HisArg: 1.528 ± 0.653
1.528HisSer: 1.528 ± 0.652
0.611HisThr: 0.611 ± 0.384
0.306HisVal: 0.306 ± 0.272
0.306HisTrp: 0.306 ± 0.272
0.917HisTyr: 0.917 ± 0.606
0.0HisXaa: 0.0 ± 0.0
Ile
4.583IleAla: 4.583 ± 1.081
0.611IleCys: 0.611 ± 0.437
6.111IleAsp: 6.111 ± 1.35
5.805IleGlu: 5.805 ± 1.422
2.444IlePhe: 2.444 ± 0.844
3.055IleGly: 3.055 ± 0.805
0.917IleHis: 0.917 ± 0.518
3.361IleIle: 3.361 ± 0.963
7.333IleLys: 7.333 ± 1.193
5.805IleLeu: 5.805 ± 0.867
1.528IleMet: 1.528 ± 0.611
2.75IleAsn: 2.75 ± 1.089
2.139IlePro: 2.139 ± 0.68
3.361IleGln: 3.361 ± 0.795
2.444IleArg: 2.444 ± 0.892
5.805IleSer: 5.805 ± 1.555
5.5IleThr: 5.5 ± 1.044
1.833IleVal: 1.833 ± 0.762
1.528IleTrp: 1.528 ± 0.605
3.055IleTyr: 3.055 ± 0.772
0.0IleXaa: 0.0 ± 0.0
Lys
8.86LysAla: 8.86 ± 1.87
0.0LysCys: 0.0 ± 0.0
5.5LysAsp: 5.5 ± 1.415
7.944LysGlu: 7.944 ± 1.144
2.444LysPhe: 2.444 ± 0.717
4.888LysGly: 4.888 ± 1.376
3.666LysHis: 3.666 ± 1.032
8.86LysIle: 8.86 ± 1.718
7.333LysLys: 7.333 ± 1.656
5.805LysLeu: 5.805 ± 2.023
1.222LysMet: 1.222 ± 0.465
3.666LysAsn: 3.666 ± 1.196
3.666LysPro: 3.666 ± 1.027
4.888LysGln: 4.888 ± 1.087
7.333LysArg: 7.333 ± 1.128
4.583LysSer: 4.583 ± 1.453
6.111LysThr: 6.111 ± 1.253
5.805LysVal: 5.805 ± 1.073
0.917LysTrp: 0.917 ± 0.527
1.222LysTyr: 1.222 ± 0.568
0.0LysXaa: 0.0 ± 0.0
Leu
7.944LeuAla: 7.944 ± 1.372
0.306LeuCys: 0.306 ± 0.294
8.249LeuAsp: 8.249 ± 2.029
10.694LeuGlu: 10.694 ± 1.561
3.972LeuPhe: 3.972 ± 1.073
2.444LeuGly: 2.444 ± 0.916
0.917LeuHis: 0.917 ± 0.413
4.277LeuIle: 4.277 ± 0.877
10.082LeuLys: 10.082 ± 1.874
9.777LeuLeu: 9.777 ± 2.016
0.917LeuMet: 0.917 ± 0.553
6.111LeuAsn: 6.111 ± 1.649
3.972LeuPro: 3.972 ± 1.387
3.666LeuGln: 3.666 ± 0.904
2.75LeuArg: 2.75 ± 1.034
3.972LeuSer: 3.972 ± 0.961
7.027LeuThr: 7.027 ± 1.531
4.583LeuVal: 4.583 ± 1.098
0.611LeuTrp: 0.611 ± 0.37
3.666LeuTyr: 3.666 ± 1.091
0.0LeuXaa: 0.0 ± 0.0
Met
2.444MetAla: 2.444 ± 0.662
0.0MetCys: 0.0 ± 0.0
2.139MetAsp: 2.139 ± 0.761
1.833MetGlu: 1.833 ± 0.8
0.917MetPhe: 0.917 ± 0.565
1.833MetGly: 1.833 ± 0.555
0.0MetHis: 0.0 ± 0.0
2.75MetIle: 2.75 ± 0.927
1.833MetLys: 1.833 ± 1.066
1.222MetLeu: 1.222 ± 0.423
0.306MetMet: 0.306 ± 0.359
2.75MetAsn: 2.75 ± 0.686
0.0MetPro: 0.0 ± 0.0
1.528MetGln: 1.528 ± 0.589
0.917MetArg: 0.917 ± 0.408
0.917MetSer: 0.917 ± 0.531
3.972MetThr: 3.972 ± 1.257
0.917MetVal: 0.917 ± 0.522
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.444AsnAla: 2.444 ± 0.654
0.0AsnCys: 0.0 ± 0.0
2.139AsnAsp: 2.139 ± 0.872
2.75AsnGlu: 2.75 ± 0.613
1.833AsnPhe: 1.833 ± 0.788
3.055AsnGly: 3.055 ± 0.971
0.917AsnHis: 0.917 ± 0.434
1.528AsnIle: 1.528 ± 0.644
3.972AsnLys: 3.972 ± 0.797
5.5AsnLeu: 5.5 ± 1.151
2.75AsnMet: 2.75 ± 1.017
2.139AsnAsn: 2.139 ± 0.87
3.361AsnPro: 3.361 ± 1.25
1.528AsnGln: 1.528 ± 0.719
1.833AsnArg: 1.833 ± 0.636
3.972AsnSer: 3.972 ± 1.271
2.139AsnThr: 2.139 ± 0.82
2.75AsnVal: 2.75 ± 0.805
0.611AsnTrp: 0.611 ± 0.398
2.75AsnTyr: 2.75 ± 0.903
0.0AsnXaa: 0.0 ± 0.0
Pro
2.139ProAla: 2.139 ± 0.541
0.306ProCys: 0.306 ± 0.25
1.833ProAsp: 1.833 ± 0.59
3.666ProGlu: 3.666 ± 1.306
1.528ProPhe: 1.528 ± 0.91
0.306ProGly: 0.306 ± 0.272
0.306ProHis: 0.306 ± 0.294
1.833ProIle: 1.833 ± 0.574
2.444ProLys: 2.444 ± 0.753
2.75ProLeu: 2.75 ± 0.836
1.222ProMet: 1.222 ± 0.619
2.444ProAsn: 2.444 ± 0.841
0.611ProPro: 0.611 ± 0.383
1.222ProGln: 1.222 ± 0.73
1.833ProArg: 1.833 ± 0.714
1.528ProSer: 1.528 ± 0.544
1.222ProThr: 1.222 ± 0.803
1.833ProVal: 1.833 ± 0.826
0.0ProTrp: 0.0 ± 0.0
2.444ProTyr: 2.444 ± 0.808
0.0ProXaa: 0.0 ± 0.0
Gln
3.361GlnAla: 3.361 ± 0.749
0.0GlnCys: 0.0 ± 0.0
1.222GlnAsp: 1.222 ± 0.56
2.75GlnGlu: 2.75 ± 0.863
1.833GlnPhe: 1.833 ± 0.657
2.444GlnGly: 2.444 ± 0.797
0.917GlnHis: 0.917 ± 0.4
3.055GlnIle: 3.055 ± 1.043
6.722GlnLys: 6.722 ± 1.594
4.277GlnLeu: 4.277 ± 1.191
0.917GlnMet: 0.917 ± 0.489
1.528GlnAsn: 1.528 ± 0.935
0.306GlnPro: 0.306 ± 0.348
2.75GlnGln: 2.75 ± 0.791
1.833GlnArg: 1.833 ± 0.764
3.055GlnSer: 3.055 ± 0.804
2.139GlnThr: 2.139 ± 0.777
1.833GlnVal: 1.833 ± 0.754
0.611GlnTrp: 0.611 ± 0.443
1.833GlnTyr: 1.833 ± 0.659
0.0GlnXaa: 0.0 ± 0.0
Arg
2.75ArgAla: 2.75 ± 0.636
0.0ArgCys: 0.0 ± 0.0
2.75ArgAsp: 2.75 ± 0.817
5.5ArgGlu: 5.5 ± 1.256
3.361ArgPhe: 3.361 ± 1.199
3.361ArgGly: 3.361 ± 0.901
1.222ArgHis: 1.222 ± 0.625
2.75ArgIle: 2.75 ± 0.703
4.888ArgLys: 4.888 ± 1.481
5.194ArgLeu: 5.194 ± 1.319
1.528ArgMet: 1.528 ± 0.661
3.055ArgAsn: 3.055 ± 1.239
1.528ArgPro: 1.528 ± 0.775
2.139ArgGln: 2.139 ± 0.886
2.75ArgArg: 2.75 ± 0.974
1.222ArgSer: 1.222 ± 0.651
1.528ArgThr: 1.528 ± 0.679
3.055ArgVal: 3.055 ± 1.048
0.0ArgTrp: 0.0 ± 0.0
2.75ArgTyr: 2.75 ± 1.397
0.0ArgXaa: 0.0 ± 0.0
Ser
2.139SerAla: 2.139 ± 0.62
0.306SerCys: 0.306 ± 0.296
3.361SerAsp: 3.361 ± 1.065
3.666SerGlu: 3.666 ± 0.853
1.833SerPhe: 1.833 ± 0.694
1.528SerGly: 1.528 ± 0.666
0.306SerHis: 0.306 ± 0.25
6.111SerIle: 6.111 ± 1.304
6.111SerLys: 6.111 ± 1.204
6.416SerLeu: 6.416 ± 1.37
1.528SerMet: 1.528 ± 0.688
1.528SerAsn: 1.528 ± 0.643
1.528SerPro: 1.528 ± 0.526
2.139SerGln: 2.139 ± 0.748
1.528SerArg: 1.528 ± 0.759
3.055SerSer: 3.055 ± 0.894
3.055SerThr: 3.055 ± 0.912
3.361SerVal: 3.361 ± 1.242
0.611SerTrp: 0.611 ± 0.409
3.055SerTyr: 3.055 ± 0.837
0.0SerXaa: 0.0 ± 0.0
Thr
4.583ThrAla: 4.583 ± 1.074
0.306ThrCys: 0.306 ± 0.332
3.055ThrAsp: 3.055 ± 0.908
3.361ThrGlu: 3.361 ± 0.747
3.055ThrPhe: 3.055 ± 1.324
4.888ThrGly: 4.888 ± 1.379
0.917ThrHis: 0.917 ± 0.605
2.444ThrIle: 2.444 ± 0.607
6.416ThrLys: 6.416 ± 1.451
7.027ThrLeu: 7.027 ± 1.228
1.833ThrMet: 1.833 ± 0.66
0.917ThrAsn: 0.917 ± 0.46
3.972ThrPro: 3.972 ± 0.95
3.666ThrGln: 3.666 ± 1.243
3.055ThrArg: 3.055 ± 0.587
3.055ThrSer: 3.055 ± 1.075
3.361ThrThr: 3.361 ± 1.46
3.361ThrVal: 3.361 ± 0.996
0.611ThrTrp: 0.611 ± 0.417
2.139ThrTyr: 2.139 ± 0.786
0.0ThrXaa: 0.0 ± 0.0
Val
3.666ValAla: 3.666 ± 0.887
0.306ValCys: 0.306 ± 0.322
1.528ValAsp: 1.528 ± 0.591
4.277ValGlu: 4.277 ± 1.579
0.611ValPhe: 0.611 ± 0.409
3.055ValGly: 3.055 ± 1.106
0.611ValHis: 0.611 ± 0.344
4.583ValIle: 4.583 ± 1.512
5.5ValLys: 5.5 ± 1.304
4.888ValLeu: 4.888 ± 1.4
1.528ValMet: 1.528 ± 0.741
2.139ValAsn: 2.139 ± 1.017
1.833ValPro: 1.833 ± 0.668
1.833ValGln: 1.833 ± 0.644
2.139ValArg: 2.139 ± 0.67
3.055ValSer: 3.055 ± 1.202
3.666ValThr: 3.666 ± 0.98
3.666ValVal: 3.666 ± 1.061
0.611ValTrp: 0.611 ± 0.448
3.361ValTyr: 3.361 ± 0.901
0.0ValXaa: 0.0 ± 0.0
Trp
0.306TrpAla: 0.306 ± 0.321
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.917TrpGlu: 0.917 ± 0.545
0.306TrpPhe: 0.306 ± 0.296
0.306TrpGly: 0.306 ± 0.359
0.0TrpHis: 0.0 ± 0.0
0.306TrpIle: 0.306 ± 0.296
1.528TrpLys: 1.528 ± 0.575
2.139TrpLeu: 2.139 ± 0.738
0.0TrpMet: 0.0 ± 0.0
0.306TrpAsn: 0.306 ± 0.294
0.306TrpPro: 0.306 ± 0.272
0.611TrpGln: 0.611 ± 0.573
0.0TrpArg: 0.0 ± 0.0
0.611TrpSer: 0.611 ± 0.344
0.611TrpThr: 0.611 ± 0.469
0.306TrpVal: 0.306 ± 0.287
0.306TrpTrp: 0.306 ± 0.296
0.306TrpTyr: 0.306 ± 0.296
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.528TyrAla: 1.528 ± 0.698
0.306TyrCys: 0.306 ± 0.287
2.444TyrAsp: 2.444 ± 1.209
3.666TyrGlu: 3.666 ± 1.334
2.139TyrPhe: 2.139 ± 0.861
2.139TyrGly: 2.139 ± 0.865
0.917TyrHis: 0.917 ± 0.565
3.361TyrIle: 3.361 ± 1.104
5.194TyrLys: 5.194 ± 1.408
3.972TyrLeu: 3.972 ± 1.123
1.833TyrMet: 1.833 ± 1.078
3.055TyrAsn: 3.055 ± 1.043
2.139TyrPro: 2.139 ± 0.907
1.833TyrGln: 1.833 ± 0.639
3.972TyrArg: 3.972 ± 1.247
1.222TyrSer: 1.222 ± 0.538
2.139TyrThr: 2.139 ± 0.682
1.833TyrVal: 1.833 ± 0.639
0.306TyrTrp: 0.306 ± 0.359
3.666TyrTyr: 3.666 ± 0.802
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (3274 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski