Amino acid dipepetide frequency for Xanthomonas phage XcP1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.607AlaAla: 12.607 ± 1.062
1.019AlaCys: 1.019 ± 0.245
6.062AlaAsp: 6.062 ± 0.565
6.33AlaGlu: 6.33 ± 0.818
4.077AlaPhe: 4.077 ± 0.532
7.296AlaGly: 7.296 ± 0.478
1.609AlaHis: 1.609 ± 0.275
6.223AlaIle: 6.223 ± 0.542
6.437AlaLys: 6.437 ± 0.757
8.476AlaLeu: 8.476 ± 0.631
2.575AlaMet: 2.575 ± 0.321
4.292AlaAsn: 4.292 ± 0.611
5.096AlaPro: 5.096 ± 0.662
3.862AlaGln: 3.862 ± 0.499
5.257AlaArg: 5.257 ± 0.465
7.188AlaSer: 7.188 ± 0.701
5.633AlaThr: 5.633 ± 0.698
5.901AlaVal: 5.901 ± 0.688
1.127AlaTrp: 1.127 ± 0.207
2.039AlaTyr: 2.039 ± 0.407
0.0AlaXaa: 0.0 ± 0.0
Cys
1.448CysAla: 1.448 ± 0.296
0.107CysCys: 0.107 ± 0.074
0.161CysAsp: 0.161 ± 0.08
0.644CysGlu: 0.644 ± 0.164
0.429CysPhe: 0.429 ± 0.125
0.858CysGly: 0.858 ± 0.228
0.322CysHis: 0.322 ± 0.133
0.483CysIle: 0.483 ± 0.167
0.376CysLys: 0.376 ± 0.136
0.697CysLeu: 0.697 ± 0.175
0.268CysMet: 0.268 ± 0.106
0.161CysAsn: 0.161 ± 0.08
0.536CysPro: 0.536 ± 0.152
0.376CysGln: 0.376 ± 0.169
0.483CysArg: 0.483 ± 0.159
0.59CysSer: 0.59 ± 0.206
0.858CysThr: 0.858 ± 0.17
0.751CysVal: 0.751 ± 0.172
0.054CysTrp: 0.054 ± 0.05
0.268CysTyr: 0.268 ± 0.11
0.0CysXaa: 0.0 ± 0.0
Asp
5.525AspAla: 5.525 ± 0.639
0.536AspCys: 0.536 ± 0.136
3.326AspAsp: 3.326 ± 0.432
3.541AspGlu: 3.541 ± 0.522
3.004AspPhe: 3.004 ± 0.437
5.418AspGly: 5.418 ± 0.52
0.858AspHis: 0.858 ± 0.228
3.97AspIle: 3.97 ± 0.535
3.111AspLys: 3.111 ± 0.464
4.292AspLeu: 4.292 ± 0.561
1.287AspMet: 1.287 ± 0.254
2.414AspAsn: 2.414 ± 0.406
3.219AspPro: 3.219 ± 0.377
1.931AspGln: 1.931 ± 0.336
3.433AspArg: 3.433 ± 0.447
3.326AspSer: 3.326 ± 0.406
3.648AspThr: 3.648 ± 0.356
3.648AspVal: 3.648 ± 0.459
0.805AspTrp: 0.805 ± 0.191
1.878AspTyr: 1.878 ± 0.259
0.0AspXaa: 0.0 ± 0.0
Glu
7.403GluAla: 7.403 ± 1.012
0.536GluCys: 0.536 ± 0.162
4.023GluAsp: 4.023 ± 0.493
4.989GluGlu: 4.989 ± 0.764
3.165GluPhe: 3.165 ± 0.395
4.023GluGly: 4.023 ± 0.494
1.073GluHis: 1.073 ± 0.231
3.004GluIle: 3.004 ± 0.415
3.165GluLys: 3.165 ± 0.566
5.365GluLeu: 5.365 ± 0.508
1.931GluMet: 1.931 ± 0.304
2.575GluAsn: 2.575 ± 0.334
1.824GluPro: 1.824 ± 0.295
3.058GluGln: 3.058 ± 0.418
3.38GluArg: 3.38 ± 0.625
4.721GluSer: 4.721 ± 0.529
2.414GluThr: 2.414 ± 0.373
4.023GluVal: 4.023 ± 0.391
0.858GluTrp: 0.858 ± 0.224
1.931GluTyr: 1.931 ± 0.282
0.0GluXaa: 0.0 ± 0.0
Phe
2.95PheAla: 2.95 ± 0.347
0.268PheCys: 0.268 ± 0.115
3.487PheAsp: 3.487 ± 0.451
2.95PheGlu: 2.95 ± 0.411
0.751PhePhe: 0.751 ± 0.2
3.165PheGly: 3.165 ± 0.384
0.429PheHis: 0.429 ± 0.147
2.79PheIle: 2.79 ± 0.319
2.79PheLys: 2.79 ± 0.268
2.253PheLeu: 2.253 ± 0.371
0.751PheMet: 0.751 ± 0.197
2.36PheAsn: 2.36 ± 0.368
1.18PhePro: 1.18 ± 0.263
1.448PheGln: 1.448 ± 0.272
1.985PheArg: 1.985 ± 0.31
2.36PheSer: 2.36 ± 0.367
2.629PheThr: 2.629 ± 0.397
2.629PheVal: 2.629 ± 0.347
0.644PheTrp: 0.644 ± 0.203
1.287PheTyr: 1.287 ± 0.205
0.0PheXaa: 0.0 ± 0.0
Gly
7.832GlyAla: 7.832 ± 1.027
1.019GlyCys: 1.019 ± 0.243
3.809GlyAsp: 3.809 ± 0.394
4.721GlyGlu: 4.721 ± 0.527
3.272GlyPhe: 3.272 ± 0.494
5.794GlyGly: 5.794 ± 1.433
1.77GlyHis: 1.77 ± 0.341
4.667GlyIle: 4.667 ± 0.554
4.506GlyLys: 4.506 ± 0.709
5.365GlyLeu: 5.365 ± 0.668
1.985GlyMet: 1.985 ± 0.288
2.736GlyAsn: 2.736 ± 0.46
2.146GlyPro: 2.146 ± 0.331
3.004GlyGln: 3.004 ± 0.508
4.131GlyArg: 4.131 ± 0.458
4.721GlySer: 4.721 ± 0.557
4.292GlyThr: 4.292 ± 0.638
7.349GlyVal: 7.349 ± 0.667
1.448GlyTrp: 1.448 ± 0.213
1.985GlyTyr: 1.985 ± 0.336
0.0GlyXaa: 0.0 ± 0.0
His
1.448HisAla: 1.448 ± 0.285
0.268HisCys: 0.268 ± 0.118
0.805HisAsp: 0.805 ± 0.224
1.127HisGlu: 1.127 ± 0.213
0.697HisPhe: 0.697 ± 0.181
1.609HisGly: 1.609 ± 0.328
0.429HisHis: 0.429 ± 0.177
1.127HisIle: 1.127 ± 0.281
0.644HisLys: 0.644 ± 0.177
1.609HisLeu: 1.609 ± 0.232
0.268HisMet: 0.268 ± 0.123
0.966HisAsn: 0.966 ± 0.225
0.644HisPro: 0.644 ± 0.197
0.805HisGln: 0.805 ± 0.229
0.805HisArg: 0.805 ± 0.196
0.966HisSer: 0.966 ± 0.209
0.751HisThr: 0.751 ± 0.199
0.966HisVal: 0.966 ± 0.233
0.054HisTrp: 0.054 ± 0.054
0.429HisTyr: 0.429 ± 0.138
0.0HisXaa: 0.0 ± 0.0
Ile
6.223IleAla: 6.223 ± 0.55
0.751IleCys: 0.751 ± 0.216
4.882IleAsp: 4.882 ± 0.68
3.97IleGlu: 3.97 ± 0.529
1.502IlePhe: 1.502 ± 0.247
3.702IleGly: 3.702 ± 0.423
0.751IleHis: 0.751 ± 0.204
2.736IleIle: 2.736 ± 0.403
4.774IleLys: 4.774 ± 0.575
4.292IleLeu: 4.292 ± 0.473
1.448IleMet: 1.448 ± 0.293
3.433IleAsn: 3.433 ± 0.417
2.629IlePro: 2.629 ± 0.392
2.468IleGln: 2.468 ± 0.31
2.79IleArg: 2.79 ± 0.384
4.292IleSer: 4.292 ± 0.618
3.702IleThr: 3.702 ± 0.574
4.828IleVal: 4.828 ± 0.561
0.376IleTrp: 0.376 ± 0.127
0.644IleTyr: 0.644 ± 0.162
0.0IleXaa: 0.0 ± 0.0
Lys
6.33LysAla: 6.33 ± 0.947
0.483LysCys: 0.483 ± 0.15
4.131LysAsp: 4.131 ± 0.467
3.272LysGlu: 3.272 ± 0.53
2.521LysPhe: 2.521 ± 0.366
3.38LysGly: 3.38 ± 0.392
1.073LysHis: 1.073 ± 0.247
3.326LysIle: 3.326 ± 0.509
4.667LysLys: 4.667 ± 0.749
3.648LysLeu: 3.648 ± 0.445
1.77LysMet: 1.77 ± 0.351
2.199LysAsn: 2.199 ± 0.308
2.736LysPro: 2.736 ± 0.418
1.824LysGln: 1.824 ± 0.338
3.702LysArg: 3.702 ± 0.386
3.755LysSer: 3.755 ± 0.451
3.326LysThr: 3.326 ± 0.414
4.506LysVal: 4.506 ± 0.429
0.805LysTrp: 0.805 ± 0.206
1.878LysTyr: 1.878 ± 0.364
0.0LysXaa: 0.0 ± 0.0
Leu
6.974LeuAla: 6.974 ± 0.631
0.858LeuCys: 0.858 ± 0.184
3.487LeuAsp: 3.487 ± 0.395
4.721LeuGlu: 4.721 ± 0.548
2.092LeuPhe: 2.092 ± 0.33
5.525LeuGly: 5.525 ± 0.514
0.858LeuHis: 0.858 ± 0.201
4.667LeuIle: 4.667 ± 0.5
3.594LeuLys: 3.594 ± 0.449
5.311LeuLeu: 5.311 ± 0.568
1.663LeuMet: 1.663 ± 0.266
3.755LeuAsn: 3.755 ± 0.334
3.272LeuPro: 3.272 ± 0.453
1.931LeuGln: 1.931 ± 0.313
4.774LeuArg: 4.774 ± 0.51
7.403LeuSer: 7.403 ± 0.62
4.667LeuThr: 4.667 ± 0.442
4.882LeuVal: 4.882 ± 0.423
0.912LeuTrp: 0.912 ± 0.217
1.77LeuTyr: 1.77 ± 0.289
0.0LeuXaa: 0.0 ± 0.0
Met
2.414MetAla: 2.414 ± 0.297
0.161MetCys: 0.161 ± 0.102
1.341MetAsp: 1.341 ± 0.228
1.717MetGlu: 1.717 ± 0.283
1.18MetPhe: 1.18 ± 0.211
1.663MetGly: 1.663 ± 0.307
0.429MetHis: 0.429 ± 0.135
0.966MetIle: 0.966 ± 0.227
1.878MetLys: 1.878 ± 0.269
2.146MetLeu: 2.146 ± 0.303
0.59MetMet: 0.59 ± 0.202
1.234MetAsn: 1.234 ± 0.209
1.448MetPro: 1.448 ± 0.349
1.127MetGln: 1.127 ± 0.24
1.931MetArg: 1.931 ± 0.278
2.521MetSer: 2.521 ± 0.374
1.556MetThr: 1.556 ± 0.358
1.502MetVal: 1.502 ± 0.32
0.429MetTrp: 0.429 ± 0.142
0.376MetTyr: 0.376 ± 0.127
0.0MetXaa: 0.0 ± 0.0
Asn
4.506AsnAla: 4.506 ± 0.44
0.322AsnCys: 0.322 ± 0.124
1.448AsnAsp: 1.448 ± 0.275
3.165AsnGlu: 3.165 ± 0.369
1.341AsnPhe: 1.341 ± 0.287
4.238AsnGly: 4.238 ± 0.5
0.751AsnHis: 0.751 ± 0.189
2.414AsnIle: 2.414 ± 0.338
2.629AsnLys: 2.629 ± 0.337
3.272AsnLeu: 3.272 ± 0.395
1.127AsnMet: 1.127 ± 0.241
1.234AsnAsn: 1.234 ± 0.254
2.629AsnPro: 2.629 ± 0.438
2.146AsnGln: 2.146 ± 0.445
2.199AsnArg: 2.199 ± 0.41
3.004AsnSer: 3.004 ± 0.468
2.146AsnThr: 2.146 ± 0.343
3.004AsnVal: 3.004 ± 0.433
0.966AsnTrp: 0.966 ± 0.198
1.234AsnTyr: 1.234 ± 0.275
0.0AsnXaa: 0.0 ± 0.0
Pro
5.043ProAla: 5.043 ± 0.641
0.483ProCys: 0.483 ± 0.158
3.165ProAsp: 3.165 ± 0.469
2.682ProGlu: 2.682 ± 0.431
1.502ProPhe: 1.502 ± 0.27
3.541ProGly: 3.541 ± 0.406
0.59ProHis: 0.59 ± 0.165
2.521ProIle: 2.521 ± 0.255
2.629ProLys: 2.629 ± 0.396
2.897ProLeu: 2.897 ± 0.373
1.234ProMet: 1.234 ± 0.291
2.575ProAsn: 2.575 ± 0.379
1.502ProPro: 1.502 ± 0.309
1.77ProGln: 1.77 ± 0.235
1.448ProArg: 1.448 ± 0.226
3.004ProSer: 3.004 ± 0.398
1.985ProThr: 1.985 ± 0.362
2.682ProVal: 2.682 ± 0.438
0.483ProTrp: 0.483 ± 0.151
0.858ProTyr: 0.858 ± 0.192
0.0ProXaa: 0.0 ± 0.0
Gln
3.702GlnAla: 3.702 ± 0.445
0.376GlnCys: 0.376 ± 0.141
1.717GlnAsp: 1.717 ± 0.314
2.146GlnGlu: 2.146 ± 0.32
2.253GlnPhe: 2.253 ± 0.253
2.897GlnGly: 2.897 ± 0.437
0.59GlnHis: 0.59 ± 0.191
3.541GlnIle: 3.541 ± 0.411
1.878GlnLys: 1.878 ± 0.266
3.433GlnLeu: 3.433 ± 0.335
1.127GlnMet: 1.127 ± 0.247
2.092GlnAsn: 2.092 ± 0.341
1.287GlnPro: 1.287 ± 0.257
1.609GlnGln: 1.609 ± 0.359
2.039GlnArg: 2.039 ± 0.308
3.004GlnSer: 3.004 ± 0.39
1.556GlnThr: 1.556 ± 0.303
2.79GlnVal: 2.79 ± 0.245
0.268GlnTrp: 0.268 ± 0.121
0.912GlnTyr: 0.912 ± 0.228
0.0GlnXaa: 0.0 ± 0.0
Arg
4.506ArgAla: 4.506 ± 0.422
0.483ArgCys: 0.483 ± 0.17
3.702ArgAsp: 3.702 ± 0.427
3.272ArgGlu: 3.272 ± 0.588
2.253ArgPhe: 2.253 ± 0.398
4.077ArgGly: 4.077 ± 0.488
0.644ArgHis: 0.644 ± 0.21
3.541ArgIle: 3.541 ± 0.435
2.843ArgLys: 2.843 ± 0.427
4.345ArgLeu: 4.345 ± 0.413
1.502ArgMet: 1.502 ± 0.264
2.575ArgAsn: 2.575 ± 0.364
2.146ArgPro: 2.146 ± 0.343
2.575ArgGln: 2.575 ± 0.435
3.165ArgArg: 3.165 ± 0.597
3.326ArgSer: 3.326 ± 0.437
2.146ArgThr: 2.146 ± 0.317
3.702ArgVal: 3.702 ± 0.353
0.322ArgTrp: 0.322 ± 0.115
2.36ArgTyr: 2.36 ± 0.319
0.0ArgXaa: 0.0 ± 0.0
Ser
7.028SerAla: 7.028 ± 0.752
0.376SerCys: 0.376 ± 0.142
4.077SerAsp: 4.077 ± 0.452
4.506SerGlu: 4.506 ± 0.433
2.897SerPhe: 2.897 ± 0.381
6.545SerGly: 6.545 ± 0.628
1.073SerHis: 1.073 ± 0.264
4.613SerIle: 4.613 ± 0.588
3.97SerLys: 3.97 ± 0.479
4.56SerLeu: 4.56 ± 0.444
1.824SerMet: 1.824 ± 0.334
2.897SerAsn: 2.897 ± 0.438
3.648SerPro: 3.648 ± 0.547
2.521SerGln: 2.521 ± 0.308
3.648SerArg: 3.648 ± 0.47
5.525SerSer: 5.525 ± 0.536
4.077SerThr: 4.077 ± 0.414
5.257SerVal: 5.257 ± 0.589
0.751SerTrp: 0.751 ± 0.219
1.931SerTyr: 1.931 ± 0.339
0.0SerXaa: 0.0 ± 0.0
Thr
6.491ThrAla: 6.491 ± 0.574
0.536ThrCys: 0.536 ± 0.164
2.682ThrAsp: 2.682 ± 0.374
2.414ThrGlu: 2.414 ± 0.318
2.682ThrPhe: 2.682 ± 0.466
4.506ThrGly: 4.506 ± 0.466
0.858ThrHis: 0.858 ± 0.235
3.541ThrIle: 3.541 ± 0.4
3.38ThrLys: 3.38 ± 0.417
3.702ThrLeu: 3.702 ± 0.365
1.18ThrMet: 1.18 ± 0.254
1.717ThrAsn: 1.717 ± 0.371
2.843ThrPro: 2.843 ± 0.394
1.609ThrGln: 1.609 ± 0.321
2.736ThrArg: 2.736 ± 0.386
4.667ThrSer: 4.667 ± 0.544
2.629ThrThr: 2.629 ± 0.352
3.702ThrVal: 3.702 ± 0.47
0.805ThrTrp: 0.805 ± 0.197
1.341ThrTyr: 1.341 ± 0.248
0.0ThrXaa: 0.0 ± 0.0
Val
6.759ValAla: 6.759 ± 0.772
0.912ValCys: 0.912 ± 0.235
4.989ValAsp: 4.989 ± 0.442
5.043ValGlu: 5.043 ± 0.556
2.253ValPhe: 2.253 ± 0.33
5.096ValGly: 5.096 ± 0.569
1.18ValHis: 1.18 ± 0.224
4.184ValIle: 4.184 ± 0.45
4.506ValLys: 4.506 ± 0.398
4.613ValLeu: 4.613 ± 0.432
2.736ValMet: 2.736 ± 0.402
2.521ValAsn: 2.521 ± 0.35
2.468ValPro: 2.468 ± 0.332
3.058ValGln: 3.058 ± 0.422
3.541ValArg: 3.541 ± 0.554
5.15ValSer: 5.15 ± 0.566
3.862ValThr: 3.862 ± 0.527
4.935ValVal: 4.935 ± 0.607
0.805ValTrp: 0.805 ± 0.179
1.556ValTyr: 1.556 ± 0.341
0.0ValXaa: 0.0 ± 0.0
Trp
1.234TrpAla: 1.234 ± 0.244
0.107TrpCys: 0.107 ± 0.061
0.751TrpAsp: 0.751 ± 0.219
0.805TrpGlu: 0.805 ± 0.227
0.429TrpPhe: 0.429 ± 0.134
0.697TrpGly: 0.697 ± 0.192
0.536TrpHis: 0.536 ± 0.22
0.697TrpIle: 0.697 ± 0.175
0.536TrpLys: 0.536 ± 0.157
1.019TrpLeu: 1.019 ± 0.222
0.483TrpMet: 0.483 ± 0.153
0.59TrpAsn: 0.59 ± 0.18
0.429TrpPro: 0.429 ± 0.139
0.59TrpGln: 0.59 ± 0.198
0.912TrpArg: 0.912 ± 0.184
0.644TrpSer: 0.644 ± 0.173
0.644TrpThr: 0.644 ± 0.215
0.805TrpVal: 0.805 ± 0.228
0.107TrpTrp: 0.107 ± 0.07
0.429TrpTyr: 0.429 ± 0.12
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.682TyrAla: 2.682 ± 0.405
0.268TyrCys: 0.268 ± 0.108
1.127TyrAsp: 1.127 ± 0.201
1.448TyrGlu: 1.448 ± 0.239
0.805TyrPhe: 0.805 ± 0.206
2.521TyrGly: 2.521 ± 0.411
0.59TyrHis: 0.59 ± 0.17
1.18TyrIle: 1.18 ± 0.282
1.019TyrLys: 1.019 ± 0.209
1.824TyrLeu: 1.824 ± 0.303
0.805TyrMet: 0.805 ± 0.173
1.448TyrAsn: 1.448 ± 0.224
0.912TyrPro: 0.912 ± 0.249
1.502TyrGln: 1.502 ± 0.272
1.127TyrArg: 1.127 ± 0.227
1.556TyrSer: 1.556 ± 0.25
1.502TyrThr: 1.502 ± 0.244
2.36TyrVal: 2.36 ± 0.406
0.429TyrTrp: 0.429 ± 0.162
0.536TyrTyr: 0.536 ± 0.156
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 81 proteins (18642 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski