Amino acid dipepetide frequency for Mycobacterium sp. 1274756.6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.328AlaAla: 24.328 ± 0.271	0.901AlaCys: 0.901 ± 0.028	9.583AlaAsp: 9.583 ± 0.096	9.1AlaGlu: 9.1 ± 0.113	3.309AlaPhe: 3.309 ± 0.052	13.616AlaGly: 13.616 ± 0.142	2.666AlaHis: 2.666 ± 0.056	4.896AlaIle: 4.896 ± 0.069	2.771AlaLys: 2.771 ± 0.072	14.115AlaLeu: 14.115 ± 0.159	2.741AlaMet: 2.741 ± 0.052	2.419AlaAsn: 2.419 ± 0.051	6.955AlaPro: 6.955 ± 0.105	4.051AlaGln: 4.051 ± 0.065	9.529AlaArg: 9.529 ± 0.102	5.101AlaSer: 5.101 ± 0.071	7.886AlaThr: 7.886 ± 0.091	12.824AlaVal: 12.824 ± 0.145	1.642AlaTrp: 1.642 ± 0.045	2.269AlaTyr: 2.269 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.093CysAla: 1.093 ± 0.031	0.077CysCys: 0.077 ± 0.008	0.5CysAsp: 0.5 ± 0.022	0.339CysGlu: 0.339 ± 0.02	0.223CysPhe: 0.223 ± 0.014	0.883CysGly: 0.883 ± 0.028	0.174CysHis: 0.174 ± 0.012	0.223CysIle: 0.223 ± 0.014	0.105CysLys: 0.105 ± 0.01	0.609CysLeu: 0.609 ± 0.023	0.113CysMet: 0.113 ± 0.01	0.14CysAsn: 0.14 ± 0.011	0.524CysPro: 0.524 ± 0.023	0.211CysGln: 0.211 ± 0.014	0.615CysArg: 0.615 ± 0.025	0.41CysSer: 0.41 ± 0.022	0.497CysThr: 0.497 ± 0.021	0.587CysVal: 0.587 ± 0.026	0.111CysTrp: 0.111 ± 0.011	0.184CysTyr: 0.184 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.344AspAla: 8.344 ± 0.108	0.459AspCys: 0.459 ± 0.021	4.327AspAsp: 4.327 ± 0.078	3.917AspGlu: 3.917 ± 0.067	1.752AspPhe: 1.752 ± 0.042	6.201AspGly: 6.201 ± 0.074	1.47AspHis: 1.47 ± 0.04	2.439AspIle: 2.439 ± 0.06	1.166AspLys: 1.166 ± 0.039	6.141AspLeu: 6.141 ± 0.089	0.895AspMet: 0.895 ± 0.03	1.183AspAsn: 1.183 ± 0.037	4.952AspPro: 4.952 ± 0.073	1.692AspGln: 1.692 ± 0.043	5.107AspArg: 5.107 ± 0.071	2.609AspSer: 2.609 ± 0.044	3.737AspThr: 3.737 ± 0.061	4.985AspVal: 4.985 ± 0.068	1.032AspTrp: 1.032 ± 0.032	1.578AspTyr: 1.578 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.308GluAla: 6.308 ± 0.086	0.325GluCys: 0.325 ± 0.02	2.399GluAsp: 2.399 ± 0.057	2.681GluGlu: 2.681 ± 0.063	1.836GluPhe: 1.836 ± 0.042	2.944GluGly: 2.944 ± 0.06	1.578GluHis: 1.578 ± 0.038	2.521GluIle: 2.521 ± 0.052	1.258GluLys: 1.258 ± 0.041	6.8GluLeu: 6.8 ± 0.089	1.0GluMet: 1.0 ± 0.035	1.068GluAsn: 1.068 ± 0.03	3.309GluPro: 3.309 ± 0.069	2.49GluGln: 2.49 ± 0.05	4.482GluArg: 4.482 ± 0.073	2.351GluSer: 2.351 ± 0.054	2.78GluThr: 2.78 ± 0.059	4.52GluVal: 4.52 ± 0.073	0.683GluTrp: 0.683 ± 0.026	1.07GluTyr: 1.07 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.131PheAla: 4.131 ± 0.063	0.298PheCys: 0.298 ± 0.018	2.489PheAsp: 2.489 ± 0.05	1.432PheGlu: 1.432 ± 0.042	0.975PhePhe: 0.975 ± 0.033	3.323PheGly: 3.323 ± 0.052	0.609PheHis: 0.609 ± 0.023	0.946PheIle: 0.946 ± 0.031	0.472PheLys: 0.472 ± 0.022	2.523PheLeu: 2.523 ± 0.052	0.42PheMet: 0.42 ± 0.023	0.71PheAsn: 0.71 ± 0.025	1.406PhePro: 1.406 ± 0.038	0.67PheGln: 0.67 ± 0.028	1.647PheArg: 1.647 ± 0.036	1.521PheSer: 1.521 ± 0.038	2.094PheThr: 2.094 ± 0.044	2.44PheVal: 2.44 ± 0.044	0.403PheTrp: 0.403 ± 0.022	0.692PheTyr: 0.692 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.084GlyAla: 11.084 ± 0.143	0.817GlyCys: 0.817 ± 0.027	4.972GlyAsp: 4.972 ± 0.069	4.59GlyGlu: 4.59 ± 0.068	2.963GlyPhe: 2.963 ± 0.058	7.834GlyGly: 7.834 ± 0.102	2.082GlyHis: 2.082 ± 0.043	3.764GlyIle: 3.764 ± 0.051	2.138GlyLys: 2.138 ± 0.051	8.833GlyLeu: 8.833 ± 0.094	2.16GlyMet: 2.16 ± 0.044	1.665GlyAsn: 1.665 ± 0.04	4.936GlyPro: 4.936 ± 0.069	2.79GlyGln: 2.79 ± 0.056	6.735GlyArg: 6.735 ± 0.082	4.799GlySer: 4.799 ± 0.078	5.146GlyThr: 5.146 ± 0.065	7.687GlyVal: 7.687 ± 0.09	1.657GlyTrp: 1.657 ± 0.041	2.553GlyTyr: 2.553 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.48HisAla: 2.48 ± 0.052	0.222HisCys: 0.222 ± 0.016	1.437HisAsp: 1.437 ± 0.037	0.956HisGlu: 0.956 ± 0.03	0.638HisPhe: 0.638 ± 0.027	2.133HisGly: 2.133 ± 0.054	0.646HisHis: 0.646 ± 0.027	0.774HisIle: 0.774 ± 0.025	0.319HisLys: 0.319 ± 0.017	2.094HisLeu: 2.094 ± 0.051	0.286HisMet: 0.286 ± 0.015	0.487HisAsn: 0.487 ± 0.019	1.739HisPro: 1.739 ± 0.044	0.642HisGln: 0.642 ± 0.023	2.062HisArg: 2.062 ± 0.045	0.996HisSer: 0.996 ± 0.033	1.273HisThr: 1.273 ± 0.035	1.513HisVal: 1.513 ± 0.036	0.365HisTrp: 0.365 ± 0.016	0.562HisTyr: 0.562 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.076IleAla: 6.076 ± 0.068	0.387IleCys: 0.387 ± 0.019	3.318IleAsp: 3.318 ± 0.057	2.448IleGlu: 2.448 ± 0.049	0.918IlePhe: 0.918 ± 0.035	4.267IleGly: 4.267 ± 0.063	0.752IleHis: 0.752 ± 0.026	1.326IleIle: 1.326 ± 0.037	0.833IleLys: 0.833 ± 0.03	2.662IleLeu: 2.662 ± 0.052	0.52IleMet: 0.52 ± 0.022	1.057IleAsn: 1.057 ± 0.033	2.211IlePro: 2.211 ± 0.054	0.883IleGln: 0.883 ± 0.026	2.555IleArg: 2.555 ± 0.048	1.921IleSer: 1.921 ± 0.043	2.796IleThr: 2.796 ± 0.056	3.248IleVal: 3.248 ± 0.057	0.423IleTrp: 0.423 ± 0.02	0.765IleTyr: 0.765 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.382LysAla: 2.382 ± 0.063	0.099LysCys: 0.099 ± 0.011	0.98LysAsp: 0.98 ± 0.034	0.821LysGlu: 0.821 ± 0.03	0.555LysPhe: 0.555 ± 0.026	1.325LysGly: 1.325 ± 0.039	0.446LysHis: 0.446 ± 0.021	0.939LysIle: 0.939 ± 0.035	0.625LysLys: 0.625 ± 0.04	2.091LysLeu: 2.091 ± 0.048	0.434LysMet: 0.434 ± 0.022	0.463LysAsn: 0.463 ± 0.023	1.28LysPro: 1.28 ± 0.038	0.708LysGln: 0.708 ± 0.028	1.423LysArg: 1.423 ± 0.041	1.025LysSer: 1.025 ± 0.03	1.331LysThr: 1.331 ± 0.042	1.674LysVal: 1.674 ± 0.047	0.253LysTrp: 0.253 ± 0.015	0.402LysTyr: 0.402 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.613LeuAla: 15.613 ± 0.135	0.766LeuCys: 0.766 ± 0.026	6.768LeuAsp: 6.768 ± 0.09	4.287LeuGlu: 4.287 ± 0.072	2.669LeuPhe: 2.669 ± 0.053	9.062LeuGly: 9.062 ± 0.105	2.109LeuHis: 2.109 ± 0.042	3.913LeuIle: 3.913 ± 0.063	1.604LeuLys: 1.604 ± 0.045	10.401LeuLeu: 10.401 ± 0.124	1.65LeuMet: 1.65 ± 0.039	1.985LeuAsn: 1.985 ± 0.043	6.186LeuPro: 6.186 ± 0.082	2.583LeuGln: 2.583 ± 0.052	8.078LeuArg: 8.078 ± 0.089	5.318LeuSer: 5.318 ± 0.076	6.754LeuThr: 6.754 ± 0.078	8.657LeuVal: 8.657 ± 0.097	1.195LeuTrp: 1.195 ± 0.038	1.665LeuTyr: 1.665 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.637MetAla: 2.637 ± 0.05	0.151MetCys: 0.151 ± 0.012	0.763MetAsp: 0.763 ± 0.026	0.688MetGlu: 0.688 ± 0.03	0.579MetPhe: 0.579 ± 0.022	1.413MetGly: 1.413 ± 0.035	0.401MetHis: 0.401 ± 0.019	0.808MetIle: 0.808 ± 0.031	0.387MetLys: 0.387 ± 0.019	2.004MetLeu: 2.004 ± 0.035	0.422MetMet: 0.422 ± 0.02	0.451MetAsn: 0.451 ± 0.02	1.104MetPro: 1.104 ± 0.038	0.483MetGln: 0.483 ± 0.02	1.427MetArg: 1.427 ± 0.034	1.381MetSer: 1.381 ± 0.036	1.702MetThr: 1.702 ± 0.039	1.547MetVal: 1.547 ± 0.043	0.249MetTrp: 0.249 ± 0.016	0.295MetTyr: 0.295 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.463AsnAla: 2.463 ± 0.048	0.18AsnCys: 0.18 ± 0.011	1.091AsnAsp: 1.091 ± 0.029	0.886AsnGlu: 0.886 ± 0.029	0.615AsnPhe: 0.615 ± 0.025	1.679AsnGly: 1.679 ± 0.04	0.421AsnHis: 0.421 ± 0.021	0.874AsnIle: 0.874 ± 0.036	0.393AsnLys: 0.393 ± 0.019	2.072AsnLeu: 2.072 ± 0.041	0.417AsnMet: 0.417 ± 0.019	0.498AsnAsn: 0.498 ± 0.025	1.689AsnPro: 1.689 ± 0.047	0.596AsnGln: 0.596 ± 0.024	1.505AsnArg: 1.505 ± 0.036	0.929AsnSer: 0.929 ± 0.031	1.267AsnThr: 1.267 ± 0.036	1.536AsnVal: 1.536 ± 0.034	0.332AsnTrp: 0.332 ± 0.017	0.558AsnTyr: 0.558 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	8.862ProAla: 8.862 ± 0.119	0.295ProCys: 0.295 ± 0.018	4.791ProAsp: 4.791 ± 0.067	3.785ProGlu: 3.785 ± 0.059	1.565ProPhe: 1.565 ± 0.036	6.03ProGly: 6.03 ± 0.086	1.19ProHis: 1.19 ± 0.036	2.052ProIle: 2.052 ± 0.047	1.112ProLys: 1.112 ± 0.035	5.214ProLeu: 5.214 ± 0.068	1.148ProMet: 1.148 ± 0.029	1.082ProAsn: 1.082 ± 0.032	4.125ProPro: 4.125 ± 0.124	1.877ProGln: 1.877 ± 0.047	3.809ProArg: 3.809 ± 0.064	2.637ProSer: 2.637 ± 0.051	3.509ProThr: 3.509 ± 0.061	5.379ProVal: 5.379 ± 0.067	0.826ProTrp: 0.826 ± 0.03	1.132ProTyr: 1.132 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.63GlnAla: 3.63 ± 0.063	0.203GlnCys: 0.203 ± 0.015	1.214GlnAsp: 1.214 ± 0.032	1.005GlnGlu: 1.005 ± 0.035	0.938GlnPhe: 0.938 ± 0.028	1.81GlnGly: 1.81 ± 0.041	0.739GlnHis: 0.739 ± 0.021	1.489GlnIle: 1.489 ± 0.038	0.556GlnLys: 0.556 ± 0.025	3.737GlnLeu: 3.737 ± 0.062	0.611GlnMet: 0.611 ± 0.024	0.568GlnAsn: 0.568 ± 0.02	1.95GlnPro: 1.95 ± 0.05	1.321GlnGln: 1.321 ± 0.041	2.984GlnArg: 2.984 ± 0.053	1.26GlnSer: 1.26 ± 0.035	1.615GlnThr: 1.615 ± 0.037	2.69GlnVal: 2.69 ± 0.054	0.539GlnTrp: 0.539 ± 0.027	0.596GlnTyr: 0.596 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.303ArgAla: 9.303 ± 0.103	0.617ArgCys: 0.617 ± 0.026	4.634ArgAsp: 4.634 ± 0.081	3.682ArgGlu: 3.682 ± 0.06	2.625ArgPhe: 2.625 ± 0.048	5.537ArgGly: 5.537 ± 0.081	1.81ArgHis: 1.81 ± 0.038	3.356ArgIle: 3.356 ± 0.064	1.391ArgLys: 1.391 ± 0.04	8.25ArgLeu: 8.25 ± 0.096	1.809ArgMet: 1.809 ± 0.042	1.505ArgAsn: 1.505 ± 0.038	4.371ArgPro: 4.371 ± 0.076	2.312ArgGln: 2.312 ± 0.048	7.365ArgArg: 7.365 ± 0.101	3.796ArgSer: 3.796 ± 0.061	4.214ArgThr: 4.214 ± 0.057	5.916ArgVal: 5.916 ± 0.074	1.507ArgTrp: 1.507 ± 0.035	2.013ArgTyr: 2.013 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.573SerAla: 6.573 ± 0.077	0.364SerCys: 0.364 ± 0.017	2.707SerAsp: 2.707 ± 0.05	2.22SerGlu: 2.22 ± 0.051	1.488SerPhe: 1.488 ± 0.038	5.065SerGly: 5.065 ± 0.077	0.89SerHis: 0.89 ± 0.027	1.797SerIle: 1.797 ± 0.047	0.897SerLys: 0.897 ± 0.029	4.285SerLeu: 4.285 ± 0.073	1.15SerMet: 1.15 ± 0.031	0.91SerAsn: 0.91 ± 0.029	2.897SerPro: 2.897 ± 0.059	1.279SerGln: 1.279 ± 0.037	3.435SerArg: 3.435 ± 0.056	2.478SerSer: 2.478 ± 0.059	2.955SerThr: 2.955 ± 0.059	4.032SerVal: 4.032 ± 0.066	0.859SerTrp: 0.859 ± 0.027	1.199SerTyr: 1.199 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	9.071ThrAla: 9.071 ± 0.105	0.378ThrCys: 0.378 ± 0.018	4.115ThrAsp: 4.115 ± 0.064	3.446ThrGlu: 3.446 ± 0.061	1.703ThrPhe: 1.703 ± 0.043	6.2ThrGly: 6.2 ± 0.073	1.053ThrHis: 1.053 ± 0.031	2.231ThrIle: 2.231 ± 0.049	1.149ThrLys: 1.149 ± 0.036	5.673ThrLeu: 5.673 ± 0.069	1.149ThrMet: 1.149 ± 0.033	1.121ThrAsn: 1.121 ± 0.036	3.8ThrPro: 3.8 ± 0.063	1.32ThrGln: 1.32 ± 0.034	3.814ThrArg: 3.814 ± 0.057	2.648ThrSer: 2.648 ± 0.052	3.79ThrThr: 3.79 ± 0.079	6.284ThrVal: 6.284 ± 0.09	0.815ThrTrp: 0.815 ± 0.027	1.163ThrTyr: 1.163 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	12.248ValAla: 12.248 ± 0.123	0.704ValCys: 0.704 ± 0.025	5.798ValAsp: 5.798 ± 0.078	4.536ValGlu: 4.536 ± 0.069	2.614ValPhe: 2.614 ± 0.05	6.912ValGly: 6.912 ± 0.088	1.797ValHis: 1.797 ± 0.043	3.864ValIle: 3.864 ± 0.063	1.513ValLys: 1.513 ± 0.041	9.398ValLeu: 9.398 ± 0.093	1.401ValMet: 1.401 ± 0.039	1.901ValAsn: 1.901 ± 0.045	4.824ValPro: 4.824 ± 0.066	2.157ValGln: 2.157 ± 0.047	6.038ValArg: 6.038 ± 0.08	4.288ValSer: 4.288 ± 0.067	5.483ValThr: 5.483 ± 0.068	8.352ValVal: 8.352 ± 0.101	1.076ValTrp: 1.076 ± 0.029	1.577ValTyr: 1.577 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.671TrpAla: 1.671 ± 0.036	0.159TrpCys: 0.159 ± 0.013	0.748TrpAsp: 0.748 ± 0.028	0.611TrpGlu: 0.611 ± 0.022	0.467TrpPhe: 0.467 ± 0.019	0.973TrpGly: 0.973 ± 0.027	0.349TrpHis: 0.349 ± 0.016	0.545TrpIle: 0.545 ± 0.024	0.238TrpLys: 0.238 ± 0.014	1.893TrpLeu: 1.893 ± 0.051	0.28TrpMet: 0.28 ± 0.015	0.348TrpAsn: 0.348 ± 0.019	0.828TrpPro: 0.828 ± 0.029	0.675TrpGln: 0.675 ± 0.025	1.341TrpArg: 1.341 ± 0.038	0.956TrpSer: 0.956 ± 0.034	0.832TrpThr: 0.832 ± 0.029	1.128TrpVal: 1.128 ± 0.037	0.355TrpTrp: 0.355 ± 0.019	0.288TrpTyr: 0.288 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.404TyrAla: 2.404 ± 0.043	0.216TyrCys: 0.216 ± 0.013	1.352TyrAsp: 1.352 ± 0.039	0.972TyrGlu: 0.972 ± 0.031	0.772TyrPhe: 0.772 ± 0.029	2.0TyrGly: 2.0 ± 0.049	0.445TyrHis: 0.445 ± 0.02	0.61TyrIle: 0.61 ± 0.024	0.329TyrLys: 0.329 ± 0.017	2.469TyrLeu: 2.469 ± 0.044	0.287TyrMet: 0.287 ± 0.017	0.437TyrAsn: 0.437 ± 0.02	1.332TyrPro: 1.332 ± 0.033	0.714TyrGln: 0.714 ± 0.026	2.059TyrArg: 2.059 ± 0.042	1.053TyrSer: 1.053 ± 0.034	1.265TyrThr: 1.265 ± 0.035	1.48TyrVal: 1.48 ± 0.039	0.364TyrTrp: 0.364 ± 0.017	0.469TyrTyr: 0.469 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3346 proteins (1103034 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---