Amino acid dipepetide frequency for Rubrivivax sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.227AlaAla: 17.227 ± 0.164	1.311AlaCys: 1.311 ± 0.034	6.693AlaAsp: 6.693 ± 0.078	6.314AlaGlu: 6.314 ± 0.08	4.053AlaPhe: 4.053 ± 0.065	10.631AlaGly: 10.631 ± 0.119	2.901AlaHis: 2.901 ± 0.051	4.718AlaIle: 4.718 ± 0.068	3.118AlaLys: 3.118 ± 0.062	16.024AlaLeu: 16.024 ± 0.133	3.58AlaMet: 3.58 ± 0.046	2.484AlaAsn: 2.484 ± 0.048	6.587AlaPro: 6.587 ± 0.078	6.195AlaGln: 6.195 ± 0.081	9.363AlaArg: 9.363 ± 0.106	7.46AlaSer: 7.46 ± 0.089	6.432AlaThr: 6.432 ± 0.077	9.422AlaVal: 9.422 ± 0.086	2.303AlaTrp: 2.303 ± 0.045	2.47AlaTyr: 2.47 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.095CysAla: 1.095 ± 0.031	0.107CysCys: 0.107 ± 0.01	0.484CysAsp: 0.484 ± 0.022	0.452CysGlu: 0.452 ± 0.021	0.279CysPhe: 0.279 ± 0.014	0.915CysGly: 0.915 ± 0.028	0.26CysHis: 0.26 ± 0.013	0.359CysIle: 0.359 ± 0.017	0.188CysLys: 0.188 ± 0.012	0.903CysLeu: 0.903 ± 0.027	0.198CysMet: 0.198 ± 0.013	0.19CysAsn: 0.19 ± 0.011	0.457CysPro: 0.457 ± 0.019	0.314CysGln: 0.314 ± 0.019	0.58CysArg: 0.58 ± 0.025	0.471CysSer: 0.471 ± 0.022	0.507CysThr: 0.507 ± 0.02	0.696CysVal: 0.696 ± 0.027	0.122CysTrp: 0.122 ± 0.012	0.184CysTyr: 0.184 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.143AspAla: 7.143 ± 0.089	0.417AspCys: 0.417 ± 0.018	3.018AspAsp: 3.018 ± 0.052	3.344AspGlu: 3.344 ± 0.051	1.783AspPhe: 1.783 ± 0.037	4.543AspGly: 4.543 ± 0.066	1.378AspHis: 1.378 ± 0.031	2.315AspIle: 2.315 ± 0.044	1.488AspLys: 1.488 ± 0.042	5.527AspLeu: 5.527 ± 0.078	1.129AspMet: 1.129 ± 0.032	1.142AspAsn: 1.142 ± 0.029	2.932AspPro: 2.932 ± 0.054	2.057AspGln: 2.057 ± 0.043	3.434AspArg: 3.434 ± 0.058	2.098AspSer: 2.098 ± 0.039	2.918AspThr: 2.918 ± 0.046	3.915AspVal: 3.915 ± 0.059	0.923AspTrp: 0.923 ± 0.031	1.181AspTyr: 1.181 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.979GluAla: 6.979 ± 0.085	0.323GluCys: 0.323 ± 0.016	2.012GluAsp: 2.012 ± 0.045	2.082GluGlu: 2.082 ± 0.047	1.532GluPhe: 1.532 ± 0.034	3.88GluGly: 3.88 ± 0.057	1.471GluHis: 1.471 ± 0.035	2.197GluIle: 2.197 ± 0.051	1.327GluLys: 1.327 ± 0.045	5.461GluLeu: 5.461 ± 0.078	1.09GluMet: 1.09 ± 0.029	0.946GluAsn: 0.946 ± 0.029	2.636GluPro: 2.636 ± 0.05	2.709GluGln: 2.709 ± 0.055	4.445GluArg: 4.445 ± 0.062	2.267GluSer: 2.267 ± 0.045	2.164GluThr: 2.164 ± 0.04	3.883GluVal: 3.883 ± 0.052	0.695GluTrp: 0.695 ± 0.024	0.792GluTyr: 0.792 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.722PheAla: 3.722 ± 0.061	0.366PheCys: 0.366 ± 0.017	2.368PheAsp: 2.368 ± 0.054	1.996PheGlu: 1.996 ± 0.04	1.317PhePhe: 1.317 ± 0.037	3.051PheGly: 3.051 ± 0.052	0.761PheHis: 0.761 ± 0.023	1.364PheIle: 1.364 ± 0.035	1.147PheLys: 1.147 ± 0.033	2.788PheLeu: 2.788 ± 0.053	0.835PheMet: 0.835 ± 0.028	1.027PheAsn: 1.027 ± 0.034	1.378PhePro: 1.378 ± 0.042	1.098PheGln: 1.098 ± 0.029	1.701PheArg: 1.701 ± 0.04	2.01PheSer: 2.01 ± 0.041	1.973PheThr: 1.973 ± 0.045	2.636PheVal: 2.636 ± 0.057	0.559PheTrp: 0.559 ± 0.023	0.81PheTyr: 0.81 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.208GlyAla: 9.208 ± 0.103	0.859GlyCys: 0.859 ± 0.028	4.024GlyAsp: 4.024 ± 0.055	4.136GlyGlu: 4.136 ± 0.057	3.183GlyPhe: 3.183 ± 0.047	7.088GlyGly: 7.088 ± 0.105	2.285GlyHis: 2.285 ± 0.045	3.589GlyIle: 3.589 ± 0.057	2.728GlyLys: 2.728 ± 0.056	10.199GlyLeu: 10.199 ± 0.118	2.279GlyMet: 2.279 ± 0.045	1.992GlyAsn: 1.992 ± 0.046	3.499GlyPro: 3.499 ± 0.054	4.218GlyGln: 4.218 ± 0.059	5.689GlyArg: 5.689 ± 0.074	4.636GlySer: 4.636 ± 0.077	4.47GlyThr: 4.47 ± 0.076	6.863GlyVal: 6.863 ± 0.074	1.66GlyTrp: 1.66 ± 0.038	2.075GlyTyr: 2.075 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	3.127HisAla: 3.127 ± 0.049	0.281HisCys: 0.281 ± 0.016	1.373HisAsp: 1.373 ± 0.036	1.328HisGlu: 1.328 ± 0.038	0.885HisPhe: 0.885 ± 0.026	2.447HisGly: 2.447 ± 0.048	0.866HisHis: 0.866 ± 0.03	0.825HisIle: 0.825 ± 0.026	0.556HisLys: 0.556 ± 0.023	2.597HisLeu: 2.597 ± 0.044	0.459HisMet: 0.459 ± 0.018	0.48HisAsn: 0.48 ± 0.02	1.636HisPro: 1.636 ± 0.033	0.972HisGln: 0.972 ± 0.025	1.78HisArg: 1.78 ± 0.041	1.01HisSer: 1.01 ± 0.028	1.195HisThr: 1.195 ± 0.033	1.7HisVal: 1.7 ± 0.031	0.491HisTrp: 0.491 ± 0.021	0.616HisTyr: 0.616 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.24IleAla: 5.24 ± 0.07	0.351IleCys: 0.351 ± 0.017	3.082IleAsp: 3.082 ± 0.05	2.829IleGlu: 2.829 ± 0.048	1.088IlePhe: 1.088 ± 0.031	3.905IleGly: 3.905 ± 0.059	0.861IleHis: 0.861 ± 0.025	1.351IleIle: 1.351 ± 0.035	1.317IleLys: 1.317 ± 0.038	3.174IleLeu: 3.174 ± 0.059	0.678IleMet: 0.678 ± 0.02	1.302IleAsn: 1.302 ± 0.036	1.816IlePro: 1.816 ± 0.042	1.338IleGln: 1.338 ± 0.033	2.249IleArg: 2.249 ± 0.043	2.147IleSer: 2.147 ± 0.039	2.577IleThr: 2.577 ± 0.046	3.166IleVal: 3.166 ± 0.05	0.451IleTrp: 0.451 ± 0.019	0.781IleTyr: 0.781 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.884LysAla: 3.884 ± 0.066	0.13LysCys: 0.13 ± 0.011	1.464LysAsp: 1.464 ± 0.035	1.18LysGlu: 1.18 ± 0.037	0.709LysPhe: 0.709 ± 0.026	2.328LysGly: 2.328 ± 0.052	0.54LysHis: 0.54 ± 0.021	1.064LysIle: 1.064 ± 0.033	0.936LysLys: 0.936 ± 0.033	2.949LysLeu: 2.949 ± 0.055	0.573LysMet: 0.573 ± 0.023	0.702LysAsn: 0.702 ± 0.027	1.914LysPro: 1.914 ± 0.043	1.053LysGln: 1.053 ± 0.032	1.863LysArg: 1.863 ± 0.044	1.342LysSer: 1.342 ± 0.038	1.5LysThr: 1.5 ± 0.036	2.204LysVal: 2.204 ± 0.042	0.275LysTrp: 0.275 ± 0.016	0.491LysTyr: 0.491 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.546LeuAla: 15.546 ± 0.146	1.019LeuCys: 1.019 ± 0.034	6.152LeuAsp: 6.152 ± 0.068	4.718LeuGlu: 4.718 ± 0.067	3.397LeuPhe: 3.397 ± 0.065	9.419LeuGly: 9.419 ± 0.1	2.484LeuHis: 2.484 ± 0.048	4.489LeuIle: 4.489 ± 0.066	3.537LeuLys: 3.537 ± 0.059	11.833LeuLeu: 11.833 ± 0.129	2.906LeuMet: 2.906 ± 0.051	2.834LeuAsn: 2.834 ± 0.049	6.722LeuPro: 6.722 ± 0.078	4.495LeuGln: 4.495 ± 0.061	7.724LeuArg: 7.724 ± 0.075	7.053LeuSer: 7.053 ± 0.079	5.762LeuThr: 5.762 ± 0.072	8.419LeuVal: 8.419 ± 0.09	1.607LeuTrp: 1.607 ± 0.039	2.039LeuTyr: 2.039 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.41MetAla: 3.41 ± 0.059	0.163MetCys: 0.163 ± 0.011	1.12MetAsp: 1.12 ± 0.031	0.87MetGlu: 0.87 ± 0.026	0.653MetPhe: 0.653 ± 0.024	2.084MetGly: 2.084 ± 0.04	0.475MetHis: 0.475 ± 0.019	0.905MetIle: 0.905 ± 0.029	0.824MetLys: 0.824 ± 0.027	2.691MetLeu: 2.691 ± 0.056	0.621MetMet: 0.621 ± 0.023	0.788MetAsn: 0.788 ± 0.023	1.57MetPro: 1.57 ± 0.034	1.017MetGln: 1.017 ± 0.033	1.596MetArg: 1.596 ± 0.035	1.755MetSer: 1.755 ± 0.04	1.444MetThr: 1.444 ± 0.03	1.882MetVal: 1.882 ± 0.046	0.251MetTrp: 0.251 ± 0.015	0.323MetTyr: 0.323 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.031AsnAla: 3.031 ± 0.058	0.217AsnCys: 0.217 ± 0.014	1.273AsnAsp: 1.273 ± 0.032	1.114AsnGlu: 1.114 ± 0.031	0.749AsnPhe: 0.749 ± 0.026	2.096AsnGly: 2.096 ± 0.052	0.567AsnHis: 0.567 ± 0.019	0.953AsnIle: 0.953 ± 0.027	0.601AsnLys: 0.601 ± 0.022	2.495AsnLeu: 2.495 ± 0.044	0.465AsnMet: 0.465 ± 0.02	0.634AsnAsn: 0.634 ± 0.025	1.646AsnPro: 1.646 ± 0.037	0.919AsnGln: 0.919 ± 0.03	1.53AsnArg: 1.53 ± 0.033	1.039AsnSer: 1.039 ± 0.033	1.366AsnThr: 1.366 ± 0.039	1.775AsnVal: 1.775 ± 0.037	0.355AsnTrp: 0.355 ± 0.017	0.568AsnTyr: 0.568 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.597ProAla: 7.597 ± 0.097	0.437ProCys: 0.437 ± 0.021	3.449ProAsp: 3.449 ± 0.058	3.195ProGlu: 3.195 ± 0.047	1.685ProPhe: 1.685 ± 0.036	5.062ProGly: 5.062 ± 0.072	1.26ProHis: 1.26 ± 0.028	1.806ProIle: 1.806 ± 0.041	1.306ProLys: 1.306 ± 0.036	5.821ProLeu: 5.821 ± 0.072	1.46ProMet: 1.46 ± 0.033	1.125ProAsn: 1.125 ± 0.03	3.127ProPro: 3.127 ± 0.068	2.327ProGln: 2.327 ± 0.045	3.269ProArg: 3.269 ± 0.053	3.197ProSer: 3.197 ± 0.047	2.784ProThr: 2.784 ± 0.05	4.711ProVal: 4.711 ± 0.057	0.97ProTrp: 0.97 ± 0.029	1.063ProTyr: 1.063 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	7.186GlnAla: 7.186 ± 0.096	0.283GlnCys: 0.283 ± 0.017	1.777GlnAsp: 1.777 ± 0.04	1.592GlnGlu: 1.592 ± 0.038	1.153GlnPhe: 1.153 ± 0.033	3.869GlnGly: 3.869 ± 0.052	1.138GlnHis: 1.138 ± 0.03	1.71GlnIle: 1.71 ± 0.041	0.911GlnLys: 0.911 ± 0.026	4.427GlnLeu: 4.427 ± 0.061	0.945GlnMet: 0.945 ± 0.028	0.75GlnAsn: 0.75 ± 0.024	2.682GlnPro: 2.682 ± 0.051	2.183GlnGln: 2.183 ± 0.049	3.917GlnArg: 3.917 ± 0.058	2.046GlnSer: 2.046 ± 0.045	2.003GlnThr: 2.003 ± 0.043	3.515GlnVal: 3.515 ± 0.059	0.845GlnTrp: 0.845 ± 0.027	0.729GlnTyr: 0.729 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.715ArgAla: 7.715 ± 0.078	0.598ArgCys: 0.598 ± 0.025	3.58ArgAsp: 3.58 ± 0.054	3.927ArgGlu: 3.927 ± 0.049	2.729ArgPhe: 2.729 ± 0.047	4.566ArgGly: 4.566 ± 0.054	2.193ArgHis: 2.193 ± 0.049	3.036ArgIle: 3.036 ± 0.048	1.622ArgLys: 1.622 ± 0.041	8.662ArgLeu: 8.662 ± 0.097	1.784ArgMet: 1.784 ± 0.041	1.561ArgAsn: 1.561 ± 0.039	3.58ArgPro: 3.58 ± 0.063	3.64ArgGln: 3.64 ± 0.06	5.381ArgArg: 5.381 ± 0.092	3.517ArgSer: 3.517 ± 0.05	3.276ArgThr: 3.276 ± 0.055	5.207ArgVal: 5.207 ± 0.067	1.428ArgTrp: 1.428 ± 0.035	1.719ArgTyr: 1.719 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.934SerAla: 6.934 ± 0.08	0.407SerCys: 0.407 ± 0.018	2.538SerAsp: 2.538 ± 0.043	2.341SerGlu: 2.341 ± 0.047	1.964SerPhe: 1.964 ± 0.044	5.147SerGly: 5.147 ± 0.074	1.28SerHis: 1.28 ± 0.033	2.226SerIle: 2.226 ± 0.046	1.237SerLys: 1.237 ± 0.032	6.25SerLeu: 6.25 ± 0.071	1.353SerMet: 1.353 ± 0.034	1.289SerAsn: 1.289 ± 0.032	3.322SerPro: 3.322 ± 0.053	2.196SerGln: 2.196 ± 0.04	3.673SerArg: 3.673 ± 0.054	3.449SerSer: 3.449 ± 0.062	3.18SerThr: 3.18 ± 0.062	4.066SerVal: 4.066 ± 0.062	0.823SerTrp: 0.823 ± 0.025	1.181SerTyr: 1.181 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.365ThrAla: 6.365 ± 0.075	0.414ThrCys: 0.414 ± 0.022	2.513ThrAsp: 2.513 ± 0.041	2.245ThrGlu: 2.245 ± 0.044	1.62ThrPhe: 1.62 ± 0.038	4.875ThrGly: 4.875 ± 0.078	1.231ThrHis: 1.231 ± 0.034	1.961ThrIle: 1.961 ± 0.038	1.07ThrLys: 1.07 ± 0.036	6.728ThrLeu: 6.728 ± 0.074	1.107ThrMet: 1.107 ± 0.034	1.07ThrAsn: 1.07 ± 0.036	3.803ThrPro: 3.803 ± 0.057	2.06ThrGln: 2.06 ± 0.038	3.384ThrArg: 3.384 ± 0.049	2.803ThrSer: 2.803 ± 0.051	2.951ThrThr: 2.951 ± 0.064	4.539ThrVal: 4.539 ± 0.06	0.801ThrTrp: 0.801 ± 0.023	1.031ThrTyr: 1.031 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.772ValAla: 9.772 ± 0.098	0.686ValCys: 0.686 ± 0.024	4.022ValAsp: 4.022 ± 0.063	3.701ValGlu: 3.701 ± 0.062	2.74ValPhe: 2.74 ± 0.043	5.817ValGly: 5.817 ± 0.076	1.788ValHis: 1.788 ± 0.038	3.5ValIle: 3.5 ± 0.06	2.254ValLys: 2.254 ± 0.049	8.955ValLeu: 8.955 ± 0.102	2.125ValMet: 2.125 ± 0.047	2.11ValAsn: 2.11 ± 0.039	4.356ValPro: 4.356 ± 0.068	3.048ValGln: 3.048 ± 0.054	5.078ValArg: 5.078 ± 0.073	4.578ValSer: 4.578 ± 0.071	4.105ValThr: 4.105 ± 0.055	6.657ValVal: 6.657 ± 0.093	1.19ValTrp: 1.19 ± 0.034	1.506ValTyr: 1.506 ± 0.036	0.001ValXaa: 0.001 ± 0.001
Trp	1.72TrpAla: 1.72 ± 0.044	0.189TrpCys: 0.189 ± 0.01	0.619TrpAsp: 0.619 ± 0.025	0.465TrpGlu: 0.465 ± 0.019	0.581TrpPhe: 0.581 ± 0.023	1.138TrpGly: 1.138 ± 0.032	0.456TrpHis: 0.456 ± 0.017	0.633TrpIle: 0.633 ± 0.021	0.405TrpLys: 0.405 ± 0.019	2.414TrpLeu: 2.414 ± 0.05	0.47TrpMet: 0.47 ± 0.022	0.387TrpAsn: 0.387 ± 0.018	0.962TrpPro: 0.962 ± 0.029	0.918TrpGln: 0.918 ± 0.031	1.536TrpArg: 1.536 ± 0.036	0.927TrpSer: 0.927 ± 0.028	0.798TrpThr: 0.798 ± 0.027	1.196TrpVal: 1.196 ± 0.033	0.425TrpTrp: 0.425 ± 0.022	0.312TrpTyr: 0.312 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.383TyrAla: 2.383 ± 0.048	0.202TyrCys: 0.202 ± 0.013	1.124TyrAsp: 1.124 ± 0.033	1.063TyrGlu: 1.063 ± 0.03	0.805TyrPhe: 0.805 ± 0.025	1.818TyrGly: 1.818 ± 0.04	0.431TyrHis: 0.431 ± 0.018	0.702TyrIle: 0.702 ± 0.026	0.531TyrLys: 0.531 ± 0.021	2.258TyrLeu: 2.258 ± 0.038	0.384TyrMet: 0.384 ± 0.017	0.579TyrAsn: 0.579 ± 0.02	1.027TyrPro: 1.027 ± 0.028	0.906TyrGln: 0.906 ± 0.03	1.526TyrArg: 1.526 ± 0.032	1.049TyrSer: 1.049 ± 0.029	1.167TyrThr: 1.167 ± 0.031	1.537TyrVal: 1.537 ± 0.036	0.377TyrTrp: 0.377 ± 0.018	0.498TyrTyr: 0.498 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4239 proteins (1279779 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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