Amino acid dipepetide frequency for Rotavirus A (isolate RVA/Dog/United States/Cu-1/1982/G3P5A[3]) (RV-A)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.623AlaAla: 3.623 ± 0.725
1.208AlaCys: 1.208 ± 0.47
3.106AlaAsp: 3.106 ± 0.486
1.898AlaGlu: 1.898 ± 0.698
2.415AlaPhe: 2.415 ± 0.614
2.243AlaGly: 2.243 ± 0.684
0.518AlaHis: 0.518 ± 0.268
2.761AlaIle: 2.761 ± 0.528
2.761AlaLys: 2.761 ± 1.072
5.176AlaLeu: 5.176 ± 0.307
1.38AlaMet: 1.38 ± 0.306
5.694AlaAsn: 5.694 ± 0.795
1.553AlaPro: 1.553 ± 0.467
1.898AlaGln: 1.898 ± 0.451
2.588AlaArg: 2.588 ± 1.003
3.623AlaSer: 3.623 ± 0.68
4.141AlaThr: 4.141 ± 0.876
4.313AlaVal: 4.313 ± 0.978
0.173AlaTrp: 0.173 ± 0.174
1.725AlaTyr: 1.725 ± 0.48
0.0AlaXaa: 0.0 ± 0.0
Cys
0.345CysAla: 0.345 ± 0.23
0.345CysCys: 0.345 ± 0.213
0.69CysAsp: 0.69 ± 0.304
0.345CysGlu: 0.345 ± 0.3
0.863CysPhe: 0.863 ± 0.424
0.0CysGly: 0.0 ± 0.0
0.173CysHis: 0.173 ± 0.157
1.553CysIle: 1.553 ± 0.778
0.863CysLys: 0.863 ± 0.47
0.69CysLeu: 0.69 ± 0.38
0.518CysMet: 0.518 ± 0.348
0.863CysAsn: 0.863 ± 0.271
0.173CysPro: 0.173 ± 0.189
0.69CysGln: 0.69 ± 0.353
0.69CysArg: 0.69 ± 0.349
0.863CysSer: 0.863 ± 0.354
0.863CysThr: 0.863 ± 0.442
0.173CysVal: 0.173 ± 0.154
0.0CysTrp: 0.0 ± 0.0
0.518CysTyr: 0.518 ± 0.246
0.0CysXaa: 0.0 ± 0.0
Asp
2.933AspAla: 2.933 ± 0.753
0.345AspCys: 0.345 ± 0.177
3.796AspAsp: 3.796 ± 0.987
2.761AspGlu: 2.761 ± 0.369
3.968AspPhe: 3.968 ± 0.567
2.588AspGly: 2.588 ± 0.304
0.345AspHis: 0.345 ± 0.213
4.831AspIle: 4.831 ± 0.779
2.933AspLys: 2.933 ± 0.584
4.486AspLeu: 4.486 ± 0.583
1.725AspMet: 1.725 ± 0.498
3.106AspAsn: 3.106 ± 0.726
1.553AspPro: 1.553 ± 0.466
2.933AspGln: 2.933 ± 0.747
2.07AspArg: 2.07 ± 0.755
5.176AspSer: 5.176 ± 1.092
3.451AspThr: 3.451 ± 0.767
5.521AspVal: 5.521 ± 0.527
1.035AspTrp: 1.035 ± 0.318
3.278AspTyr: 3.278 ± 0.524
0.0AspXaa: 0.0 ± 0.0
Glu
2.933GluAla: 2.933 ± 0.534
0.173GluCys: 0.173 ± 0.157
2.415GluAsp: 2.415 ± 0.482
4.313GluGlu: 4.313 ± 0.828
1.898GluPhe: 1.898 ± 0.369
1.553GluGly: 1.553 ± 0.414
0.69GluHis: 0.69 ± 0.336
4.831GluIle: 4.831 ± 0.673
5.003GluLys: 5.003 ± 1.074
5.866GluLeu: 5.866 ± 1.109
2.415GluMet: 2.415 ± 0.486
2.933GluAsn: 2.933 ± 0.556
1.553GluPro: 1.553 ± 0.622
2.243GluGln: 2.243 ± 0.57
2.588GluArg: 2.588 ± 0.529
3.278GluSer: 3.278 ± 0.692
2.761GluThr: 2.761 ± 0.789
2.933GluVal: 2.933 ± 0.535
0.69GluTrp: 0.69 ± 0.332
3.796GluTyr: 3.796 ± 0.914
0.0GluXaa: 0.0 ± 0.0
Phe
2.243PheAla: 2.243 ± 0.947
0.69PheCys: 0.69 ± 0.257
2.933PheAsp: 2.933 ± 0.843
3.451PheGlu: 3.451 ± 0.734
0.69PhePhe: 0.69 ± 0.291
1.553PheGly: 1.553 ± 0.46
1.553PheHis: 1.553 ± 0.552
4.831PheIle: 4.831 ± 0.834
3.968PheLys: 3.968 ± 0.58
2.588PheLeu: 2.588 ± 0.965
0.518PheMet: 0.518 ± 0.294
3.278PheAsn: 3.278 ± 0.715
2.243PhePro: 2.243 ± 0.751
1.725PheGln: 1.725 ± 0.804
2.415PheArg: 2.415 ± 0.424
3.451PheSer: 3.451 ± 0.86
2.761PheThr: 2.761 ± 0.685
1.725PheVal: 1.725 ± 0.552
0.173PheTrp: 0.173 ± 0.142
1.38PheTyr: 1.38 ± 0.357
0.0PheXaa: 0.0 ± 0.0
Gly
1.208GlyAla: 1.208 ± 0.406
0.863GlyCys: 0.863 ± 0.309
1.208GlyAsp: 1.208 ± 0.376
1.553GlyGlu: 1.553 ± 0.499
1.035GlyPhe: 1.035 ± 0.409
1.725GlyGly: 1.725 ± 0.789
1.035GlyHis: 1.035 ± 0.449
4.658GlyIle: 4.658 ± 0.571
2.933GlyLys: 2.933 ± 0.698
2.588GlyLeu: 2.588 ± 0.658
1.38GlyMet: 1.38 ± 0.423
1.553GlyAsn: 1.553 ± 0.499
1.38GlyPro: 1.38 ± 0.576
1.38GlyGln: 1.38 ± 0.289
1.553GlyArg: 1.553 ± 0.734
3.106GlySer: 3.106 ± 1.03
1.553GlyThr: 1.553 ± 0.74
2.415GlyVal: 2.415 ± 0.387
0.518GlyTrp: 0.518 ± 0.254
1.38GlyTyr: 1.38 ± 0.674
0.0GlyXaa: 0.0 ± 0.0
His
0.863HisAla: 0.863 ± 0.326
0.173HisCys: 0.173 ± 0.157
1.208HisAsp: 1.208 ± 0.341
0.518HisGlu: 0.518 ± 0.316
0.345HisPhe: 0.345 ± 0.221
0.345HisGly: 0.345 ± 0.243
0.69HisHis: 0.69 ± 0.368
0.69HisIle: 0.69 ± 0.295
1.208HisLys: 1.208 ± 0.486
1.208HisLeu: 1.208 ± 0.408
0.173HisMet: 0.173 ± 0.152
0.518HisAsn: 0.518 ± 0.294
0.345HisPro: 0.345 ± 0.19
0.69HisGln: 0.69 ± 0.365
0.173HisArg: 0.173 ± 0.139
1.725HisSer: 1.725 ± 0.38
0.863HisThr: 0.863 ± 0.377
1.208HisVal: 1.208 ± 0.353
0.518HisTrp: 0.518 ± 0.341
1.553HisTyr: 1.553 ± 0.436
0.0HisXaa: 0.0 ± 0.0
Ile
5.349IleAla: 5.349 ± 1.292
0.69IleCys: 0.69 ± 0.335
5.003IleAsp: 5.003 ± 1.14
5.694IleGlu: 5.694 ± 1.035
2.415IlePhe: 2.415 ± 0.486
2.243IleGly: 2.243 ± 0.452
0.345IleHis: 0.345 ± 0.221
5.349IleIle: 5.349 ± 0.615
3.968IleLys: 3.968 ± 0.778
5.694IleLeu: 5.694 ± 1.334
1.725IleMet: 1.725 ± 0.388
5.521IleAsn: 5.521 ± 0.547
4.141IlePro: 4.141 ± 0.853
4.141IleGln: 4.141 ± 0.601
3.796IleArg: 3.796 ± 0.649
6.384IleSer: 6.384 ± 1.301
6.384IleThr: 6.384 ± 0.804
4.486IleVal: 4.486 ± 0.388
0.345IleTrp: 0.345 ± 0.208
3.968IleTyr: 3.968 ± 1.186
0.0IleXaa: 0.0 ± 0.0
Lys
2.415LysAla: 2.415 ± 0.784
1.035LysCys: 1.035 ± 0.343
2.761LysAsp: 2.761 ± 0.575
4.141LysGlu: 4.141 ± 0.937
2.588LysPhe: 2.588 ± 0.771
2.07LysGly: 2.07 ± 0.587
1.38LysHis: 1.38 ± 0.54
5.521LysIle: 5.521 ± 1.256
3.106LysLys: 3.106 ± 0.611
7.764LysLeu: 7.764 ± 1.348
2.933LysMet: 2.933 ± 0.746
2.588LysAsn: 2.588 ± 0.718
2.243LysPro: 2.243 ± 0.491
3.451LysGln: 3.451 ± 0.648
3.968LysArg: 3.968 ± 0.671
4.486LysSer: 4.486 ± 1.215
3.278LysThr: 3.278 ± 0.738
4.313LysVal: 4.313 ± 0.727
0.518LysTrp: 0.518 ± 0.414
3.968LysTyr: 3.968 ± 1.211
0.0LysXaa: 0.0 ± 0.0
Leu
4.658LeuAla: 4.658 ± 0.644
0.69LeuCys: 0.69 ± 0.402
5.003LeuAsp: 5.003 ± 0.582
5.003LeuGlu: 5.003 ± 1.272
4.141LeuPhe: 4.141 ± 0.818
2.243LeuGly: 2.243 ± 0.334
2.243LeuHis: 2.243 ± 0.558
6.729LeuIle: 6.729 ± 0.56
6.039LeuLys: 6.039 ± 0.642
8.627LeuLeu: 8.627 ± 1.446
3.623LeuMet: 3.623 ± 0.839
7.074LeuAsn: 7.074 ± 1.03
4.831LeuPro: 4.831 ± 0.786
3.278LeuGln: 3.278 ± 0.738
4.831LeuArg: 4.831 ± 0.767
8.454LeuSer: 8.454 ± 1.177
6.729LeuThr: 6.729 ± 1.13
3.796LeuVal: 3.796 ± 0.947
0.69LeuTrp: 0.69 ± 0.213
4.486LeuTyr: 4.486 ± 0.78
0.0LeuXaa: 0.0 ± 0.0
Met
2.07MetAla: 2.07 ± 0.409
0.0MetCys: 0.0 ± 0.0
2.933MetAsp: 2.933 ± 0.68
1.553MetGlu: 1.553 ± 0.611
1.553MetPhe: 1.553 ± 0.389
1.035MetGly: 1.035 ± 0.402
0.518MetHis: 0.518 ± 0.298
1.035MetIle: 1.035 ± 0.333
2.588MetLys: 2.588 ± 0.391
3.623MetLeu: 3.623 ± 0.684
0.69MetMet: 0.69 ± 0.396
2.243MetAsn: 2.243 ± 0.369
0.69MetPro: 0.69 ± 0.368
1.725MetGln: 1.725 ± 0.81
1.725MetArg: 1.725 ± 0.518
2.415MetSer: 2.415 ± 0.632
1.38MetThr: 1.38 ± 0.383
0.69MetVal: 0.69 ± 0.291
0.69MetTrp: 0.69 ± 0.324
1.38MetTyr: 1.38 ± 0.331
0.0MetXaa: 0.0 ± 0.0
Asn
4.141AsnAla: 4.141 ± 0.785
0.69AsnCys: 0.69 ± 0.405
4.141AsnAsp: 4.141 ± 0.879
3.796AsnGlu: 3.796 ± 0.603
2.761AsnPhe: 2.761 ± 0.747
3.451AsnGly: 3.451 ± 0.631
1.208AsnHis: 1.208 ± 0.397
2.415AsnIle: 2.415 ± 0.725
4.141AsnLys: 4.141 ± 0.996
7.246AsnLeu: 7.246 ± 0.99
2.933AsnMet: 2.933 ± 0.5
5.176AsnAsn: 5.176 ± 1.329
1.898AsnPro: 1.898 ± 0.748
2.588AsnGln: 2.588 ± 0.683
2.415AsnArg: 2.415 ± 0.376
5.694AsnSer: 5.694 ± 1.226
3.106AsnThr: 3.106 ± 0.576
4.313AsnVal: 4.313 ± 0.637
1.38AsnTrp: 1.38 ± 0.56
5.003AsnTyr: 5.003 ± 0.672
0.0AsnXaa: 0.0 ± 0.0
Pro
1.553ProAla: 1.553 ± 0.407
0.0ProCys: 0.0 ± 0.0
1.898ProAsp: 1.898 ± 0.49
0.518ProGlu: 0.518 ± 0.324
1.898ProPhe: 1.898 ± 0.391
1.725ProGly: 1.725 ± 0.476
0.69ProHis: 0.69 ± 0.329
3.796ProIle: 3.796 ± 0.401
1.725ProLys: 1.725 ± 0.437
2.243ProLeu: 2.243 ± 0.565
0.345ProMet: 0.345 ± 0.223
2.243ProAsn: 2.243 ± 0.926
1.38ProPro: 1.38 ± 0.535
1.38ProGln: 1.38 ± 0.743
1.035ProArg: 1.035 ± 0.217
2.415ProSer: 2.415 ± 0.515
2.588ProThr: 2.588 ± 0.631
3.106ProVal: 3.106 ± 0.759
0.0ProTrp: 0.0 ± 0.0
2.243ProTyr: 2.243 ± 0.644
0.0ProXaa: 0.0 ± 0.0
Gln
1.898GlnAla: 1.898 ± 0.439
0.863GlnCys: 0.863 ± 0.365
2.243GlnAsp: 2.243 ± 0.733
2.243GlnGlu: 2.243 ± 0.459
2.243GlnPhe: 2.243 ± 0.619
0.345GlnGly: 0.345 ± 0.268
1.035GlnHis: 1.035 ± 0.342
3.796GlnIle: 3.796 ± 0.803
2.243GlnLys: 2.243 ± 0.558
5.694GlnLeu: 5.694 ± 1.251
1.208GlnMet: 1.208 ± 0.353
2.415GlnAsn: 2.415 ± 0.778
1.208GlnPro: 1.208 ± 0.317
2.588GlnGln: 2.588 ± 0.853
1.898GlnArg: 1.898 ± 0.773
2.588GlnSer: 2.588 ± 0.439
3.796GlnThr: 3.796 ± 0.866
2.933GlnVal: 2.933 ± 0.885
1.035GlnTrp: 1.035 ± 0.457
2.415GlnTyr: 2.415 ± 0.526
0.0GlnXaa: 0.0 ± 0.0
Arg
1.208ArgAla: 1.208 ± 0.406
0.69ArgCys: 0.69 ± 0.279
2.243ArgAsp: 2.243 ± 0.419
3.106ArgGlu: 3.106 ± 0.558
2.761ArgPhe: 2.761 ± 0.867
2.07ArgGly: 2.07 ± 0.461
0.518ArgHis: 0.518 ± 0.207
3.796ArgIle: 3.796 ± 0.347
2.761ArgLys: 2.761 ± 0.584
3.968ArgLeu: 3.968 ± 1.06
1.898ArgMet: 1.898 ± 0.53
4.141ArgAsn: 4.141 ± 1.2
1.035ArgPro: 1.035 ± 0.422
1.898ArgGln: 1.898 ± 0.638
2.243ArgArg: 2.243 ± 0.528
3.796ArgSer: 3.796 ± 0.681
1.898ArgThr: 1.898 ± 0.349
3.623ArgVal: 3.623 ± 0.762
1.035ArgTrp: 1.035 ± 0.304
1.38ArgTyr: 1.38 ± 0.264
0.0ArgXaa: 0.0 ± 0.0
Ser
3.623SerAla: 3.623 ± 0.872
0.518SerCys: 0.518 ± 0.29
4.486SerAsp: 4.486 ± 0.9
4.141SerGlu: 4.141 ± 0.706
3.796SerPhe: 3.796 ± 0.874
2.415SerGly: 2.415 ± 0.664
0.345SerHis: 0.345 ± 0.208
6.556SerIle: 6.556 ± 1.168
4.486SerLys: 4.486 ± 0.753
8.799SerLeu: 8.799 ± 1.596
2.415SerMet: 2.415 ± 0.513
6.039SerAsn: 6.039 ± 1.243
2.243SerPro: 2.243 ± 0.68
4.313SerGln: 4.313 ± 0.798
4.486SerArg: 4.486 ± 0.441
7.419SerSer: 7.419 ± 2.056
5.521SerThr: 5.521 ± 1.47
6.039SerVal: 6.039 ± 1.066
0.863SerTrp: 0.863 ± 0.335
3.278SerTyr: 3.278 ± 1.062
0.0SerXaa: 0.0 ± 0.0
Thr
3.451ThrAla: 3.451 ± 0.847
0.518ThrCys: 0.518 ± 0.256
4.831ThrAsp: 4.831 ± 1.093
3.623ThrGlu: 3.623 ± 0.744
3.796ThrPhe: 3.796 ± 0.636
2.243ThrGly: 2.243 ± 0.553
0.863ThrHis: 0.863 ± 0.304
5.003ThrIle: 5.003 ± 0.99
3.796ThrLys: 3.796 ± 0.751
7.074ThrLeu: 7.074 ± 1.495
1.553ThrMet: 1.553 ± 0.602
2.761ThrAsn: 2.761 ± 0.684
1.208ThrPro: 1.208 ± 0.413
3.451ThrGln: 3.451 ± 1.07
1.898ThrArg: 1.898 ± 0.439
5.349ThrSer: 5.349 ± 0.619
5.694ThrThr: 5.694 ± 1.462
3.796ThrVal: 3.796 ± 0.476
0.69ThrTrp: 0.69 ± 0.248
2.415ThrTyr: 2.415 ± 0.693
0.0ThrXaa: 0.0 ± 0.0
Val
4.141ValAla: 4.141 ± 0.911
0.863ValCys: 0.863 ± 0.348
3.796ValAsp: 3.796 ± 0.499
3.451ValGlu: 3.451 ± 0.73
2.933ValPhe: 2.933 ± 0.456
2.933ValGly: 2.933 ± 0.45
0.518ValHis: 0.518 ± 0.24
4.831ValIle: 4.831 ± 0.737
5.003ValLys: 5.003 ± 0.99
5.694ValLeu: 5.694 ± 0.823
1.208ValMet: 1.208 ± 0.496
5.521ValAsn: 5.521 ± 0.914
1.553ValPro: 1.553 ± 0.595
1.553ValGln: 1.553 ± 0.502
2.07ValArg: 2.07 ± 0.44
5.866ValSer: 5.866 ± 1.561
3.623ValThr: 3.623 ± 0.541
3.623ValVal: 3.623 ± 0.692
0.173ValTrp: 0.173 ± 0.157
2.933ValTyr: 2.933 ± 0.494
0.0ValXaa: 0.0 ± 0.0
Trp
0.345TrpAla: 0.345 ± 0.21
0.518TrpCys: 0.518 ± 0.472
1.208TrpAsp: 1.208 ± 0.291
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.173TrpGly: 0.173 ± 0.174
0.173TrpHis: 0.173 ± 0.157
0.863TrpIle: 0.863 ± 0.332
1.725TrpLys: 1.725 ± 0.345
1.38TrpLeu: 1.38 ± 0.259
0.518TrpMet: 0.518 ± 0.245
0.518TrpAsn: 0.518 ± 0.38
0.345TrpPro: 0.345 ± 0.255
0.863TrpGln: 0.863 ± 0.511
0.345TrpArg: 0.345 ± 0.204
0.345TrpSer: 0.345 ± 0.201
0.518TrpThr: 0.518 ± 0.25
0.345TrpVal: 0.345 ± 0.185
0.173TrpTrp: 0.173 ± 0.189
1.035TrpTyr: 1.035 ± 0.452
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.796TyrAla: 3.796 ± 0.749
0.345TyrCys: 0.345 ± 0.277
2.933TyrAsp: 2.933 ± 0.769
2.761TyrGlu: 2.761 ± 0.449
2.07TyrPhe: 2.07 ± 0.469
2.07TyrGly: 2.07 ± 0.752
0.173TyrHis: 0.173 ± 0.154
3.796TyrIle: 3.796 ± 0.733
3.278TyrLys: 3.278 ± 0.547
2.933TyrLeu: 2.933 ± 1.084
1.208TyrMet: 1.208 ± 0.409
4.313TyrAsn: 4.313 ± 0.704
1.208TyrPro: 1.208 ± 0.402
1.898TyrGln: 1.898 ± 0.434
3.278TyrArg: 3.278 ± 0.618
5.349TyrSer: 5.349 ± 1.37
3.106TyrThr: 3.106 ± 0.941
2.933TyrVal: 2.933 ± 0.502
0.69TyrTrp: 0.69 ± 0.316
2.588TyrTyr: 2.588 ± 0.824
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (5797 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski