Amino acid dipepetide frequency for Bradyrhizobium erythrophlei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.476AlaAla: 16.476 ± 0.096	1.159AlaCys: 1.159 ± 0.022	6.214AlaAsp: 6.214 ± 0.057	6.829AlaGlu: 6.829 ± 0.051	4.359AlaPhe: 4.359 ± 0.036	9.673AlaGly: 9.673 ± 0.066	2.269AlaHis: 2.269 ± 0.027	6.588AlaIle: 6.588 ± 0.055	4.713AlaLys: 4.713 ± 0.05	12.343AlaLeu: 12.343 ± 0.086	3.404AlaMet: 3.404 ± 0.035	3.221AlaAsn: 3.221 ± 0.036	5.627AlaPro: 5.627 ± 0.058	3.91AlaGln: 3.91 ± 0.035	8.351AlaArg: 8.351 ± 0.072	6.799AlaSer: 6.799 ± 0.053	6.259AlaThr: 6.259 ± 0.057	8.681AlaVal: 8.681 ± 0.061	1.479AlaTrp: 1.479 ± 0.024	2.577AlaTyr: 2.577 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	1.062CysAla: 1.062 ± 0.022	0.147CysCys: 0.147 ± 0.008	0.528CysAsp: 0.528 ± 0.015	0.472CysGlu: 0.472 ± 0.011	0.387CysPhe: 0.387 ± 0.012	0.968CysGly: 0.968 ± 0.019	0.265CysHis: 0.265 ± 0.01	0.447CysIle: 0.447 ± 0.013	0.267CysLys: 0.267 ± 0.01	0.876CysLeu: 0.876 ± 0.02	0.193CysMet: 0.193 ± 0.008	0.253CysAsn: 0.253 ± 0.01	0.473CysPro: 0.473 ± 0.013	0.272CysGln: 0.272 ± 0.009	0.739CysArg: 0.739 ± 0.016	0.588CysSer: 0.588 ± 0.014	0.463CysThr: 0.463 ± 0.012	0.671CysVal: 0.671 ± 0.014	0.149CysTrp: 0.149 ± 0.006	0.225CysTyr: 0.225 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	6.245AspAla: 6.245 ± 0.055	0.49AspCys: 0.49 ± 0.014	2.971AspAsp: 2.971 ± 0.031	3.073AspGlu: 3.073 ± 0.034	2.141AspPhe: 2.141 ± 0.029	4.684AspGly: 4.684 ± 0.047	1.284AspHis: 1.284 ± 0.023	2.958AspIle: 2.958 ± 0.033	1.865AspLys: 1.865 ± 0.028	5.513AspLeu: 5.513 ± 0.045	1.167AspMet: 1.167 ± 0.019	1.354AspAsn: 1.354 ± 0.021	3.342AspPro: 3.342 ± 0.034	1.821AspGln: 1.821 ± 0.023	4.26AspArg: 4.26 ± 0.04	2.257AspSer: 2.257 ± 0.028	2.427AspThr: 2.427 ± 0.037	3.986AspVal: 3.986 ± 0.033	0.914AspTrp: 0.914 ± 0.018	1.403AspTyr: 1.403 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.714GluAla: 6.714 ± 0.053	0.435GluCys: 0.435 ± 0.012	2.295GluAsp: 2.295 ± 0.029	2.608GluGlu: 2.608 ± 0.035	1.865GluPhe: 1.865 ± 0.026	3.584GluGly: 3.584 ± 0.04	1.232GluHis: 1.232 ± 0.022	3.412GluIle: 3.412 ± 0.038	2.298GluLys: 2.298 ± 0.026	5.206GluLeu: 5.206 ± 0.051	1.417GluMet: 1.417 ± 0.024	1.569GluAsn: 1.569 ± 0.024	2.544GluPro: 2.544 ± 0.034	2.14GluGln: 2.14 ± 0.029	4.608GluArg: 4.608 ± 0.052	2.393GluSer: 2.393 ± 0.027	3.057GluThr: 3.057 ± 0.033	3.549GluVal: 3.549 ± 0.034	0.76GluTrp: 0.76 ± 0.016	1.038GluTyr: 1.038 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	4.762PheAla: 4.762 ± 0.041	0.426PheCys: 0.426 ± 0.011	2.47PheAsp: 2.47 ± 0.03	2.122PheGlu: 2.122 ± 0.028	1.466PhePhe: 1.466 ± 0.025	3.785PheGly: 3.785 ± 0.042	0.757PheHis: 0.757 ± 0.018	1.787PheIle: 1.787 ± 0.029	1.181PheLys: 1.181 ± 0.019	3.395PheLeu: 3.395 ± 0.038	0.746PheMet: 0.746 ± 0.014	1.163PheAsn: 1.163 ± 0.018	1.722PhePro: 1.722 ± 0.024	1.042PheGln: 1.042 ± 0.021	2.439PheArg: 2.439 ± 0.028	2.339PheSer: 2.339 ± 0.031	2.032PheThr: 2.032 ± 0.03	3.137PheVal: 3.137 ± 0.037	0.545PheTrp: 0.545 ± 0.015	0.944PheTyr: 0.944 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	8.518GlyAla: 8.518 ± 0.067	0.877GlyCys: 0.877 ± 0.018	4.141GlyAsp: 4.141 ± 0.037	4.093GlyGlu: 4.093 ± 0.037	3.661GlyPhe: 3.661 ± 0.035	6.818GlyGly: 6.818 ± 0.074	1.888GlyHis: 1.888 ± 0.027	4.58GlyIle: 4.58 ± 0.043	3.495GlyLys: 3.495 ± 0.042	8.146GlyLeu: 8.146 ± 0.062	2.14GlyMet: 2.14 ± 0.031	2.341GlyAsn: 2.341 ± 0.034	3.541GlyPro: 3.541 ± 0.035	2.729GlyGln: 2.729 ± 0.029	5.652GlyArg: 5.652 ± 0.05	4.777GlySer: 4.777 ± 0.049	4.532GlyThr: 4.532 ± 0.052	5.891GlyVal: 5.891 ± 0.056	1.372GlyTrp: 1.372 ± 0.024	2.354GlyTyr: 2.354 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.345HisAla: 2.345 ± 0.029	0.276HisCys: 0.276 ± 0.011	1.25HisAsp: 1.25 ± 0.021	1.048HisGlu: 1.048 ± 0.02	0.879HisPhe: 0.879 ± 0.017	1.997HisGly: 1.997 ± 0.025	0.652HisHis: 0.652 ± 0.017	1.0HisIle: 1.0 ± 0.022	0.539HisLys: 0.539 ± 0.012	2.07HisLeu: 2.07 ± 0.027	0.48HisMet: 0.48 ± 0.013	0.52HisAsn: 0.52 ± 0.012	1.384HisPro: 1.384 ± 0.019	0.672HisGln: 0.672 ± 0.015	1.637HisArg: 1.637 ± 0.026	1.045HisSer: 1.045 ± 0.021	0.871HisThr: 0.871 ± 0.019	1.533HisVal: 1.533 ± 0.023	0.362HisTrp: 0.362 ± 0.012	0.57HisTyr: 0.57 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	7.576IleAla: 7.576 ± 0.058	0.566IleCys: 0.566 ± 0.015	3.62IleAsp: 3.62 ± 0.034	3.683IleGlu: 3.683 ± 0.032	1.803IlePhe: 1.803 ± 0.024	5.08IleGly: 5.08 ± 0.044	0.99IleHis: 0.99 ± 0.02	2.38IleIle: 2.38 ± 0.035	1.827IleLys: 1.827 ± 0.025	4.414IleLeu: 4.414 ± 0.045	1.046IleMet: 1.046 ± 0.019	1.587IleAsn: 1.587 ± 0.025	2.52IlePro: 2.52 ± 0.03	1.322IleGln: 1.322 ± 0.023	3.41IleArg: 3.41 ± 0.036	3.294IleSer: 3.294 ± 0.032	2.751IleThr: 2.751 ± 0.036	4.524IleVal: 4.524 ± 0.042	0.648IleTrp: 0.648 ± 0.015	1.209IleTyr: 1.209 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	4.505LysAla: 4.505 ± 0.044	0.237LysCys: 0.237 ± 0.009	1.907LysAsp: 1.907 ± 0.028	1.727LysGlu: 1.727 ± 0.026	1.228LysPhe: 1.228 ± 0.023	2.649LysGly: 2.649 ± 0.033	0.744LysHis: 0.744 ± 0.016	2.096LysIle: 2.096 ± 0.027	1.619LysLys: 1.619 ± 0.03	3.922LysLeu: 3.922 ± 0.04	0.937LysMet: 0.937 ± 0.019	1.056LysAsn: 1.056 ± 0.02	2.441LysPro: 2.441 ± 0.032	1.307LysGln: 1.307 ± 0.02	2.699LysArg: 2.699 ± 0.03	2.264LysSer: 2.264 ± 0.029	2.267LysThr: 2.267 ± 0.03	2.597LysVal: 2.597 ± 0.031	0.463LysTrp: 0.463 ± 0.012	0.842LysTyr: 0.842 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	12.898LeuAla: 12.898 ± 0.084	0.923LeuCys: 0.923 ± 0.018	5.38LeuAsp: 5.38 ± 0.045	4.758LeuGlu: 4.758 ± 0.049	3.662LeuPhe: 3.662 ± 0.043	7.805LeuGly: 7.805 ± 0.055	1.939LeuHis: 1.939 ± 0.024	5.217LeuIle: 5.217 ± 0.046	3.951LeuLys: 3.951 ± 0.036	9.353LeuLeu: 9.353 ± 0.082	2.276LeuMet: 2.276 ± 0.03	2.732LeuAsn: 2.732 ± 0.032	5.335LeuPro: 5.335 ± 0.044	2.896LeuGln: 2.896 ± 0.034	6.842LeuArg: 6.842 ± 0.054	6.222LeuSer: 6.222 ± 0.047	5.501LeuThr: 5.501 ± 0.052	7.258LeuVal: 7.258 ± 0.06	1.196LeuTrp: 1.196 ± 0.022	2.002LeuTyr: 2.002 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.81MetAla: 2.81 ± 0.031	0.178MetCys: 0.178 ± 0.007	1.022MetAsp: 1.022 ± 0.021	0.956MetGlu: 0.956 ± 0.017	0.817MetPhe: 0.817 ± 0.018	1.61MetGly: 1.61 ± 0.024	0.446MetHis: 0.446 ± 0.013	1.502MetIle: 1.502 ± 0.024	1.121MetLys: 1.121 ± 0.02	2.444MetLeu: 2.444 ± 0.031	0.662MetMet: 0.662 ± 0.015	0.776MetAsn: 0.776 ± 0.017	1.516MetPro: 1.516 ± 0.024	0.796MetGln: 0.796 ± 0.016	1.779MetArg: 1.779 ± 0.024	1.752MetSer: 1.752 ± 0.024	1.85MetThr: 1.85 ± 0.027	1.681MetVal: 1.681 ± 0.024	0.231MetTrp: 0.231 ± 0.009	0.351MetTyr: 0.351 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.335AsnAla: 3.335 ± 0.037	0.292AsnCys: 0.292 ± 0.01	1.55AsnAsp: 1.55 ± 0.027	1.397AsnGlu: 1.397 ± 0.022	1.145AsnPhe: 1.145 ± 0.023	2.522AsnGly: 2.522 ± 0.031	0.556AsnHis: 0.556 ± 0.015	1.556AsnIle: 1.556 ± 0.022	0.906AsnLys: 0.906 ± 0.019	2.742AsnLeu: 2.742 ± 0.033	0.654AsnMet: 0.654 ± 0.016	0.878AsnAsn: 0.878 ± 0.019	1.984AsnPro: 1.984 ± 0.028	0.856AsnGln: 0.856 ± 0.016	1.893AsnArg: 1.893 ± 0.028	1.553AsnSer: 1.553 ± 0.023	1.357AsnThr: 1.357 ± 0.025	2.13AsnVal: 2.13 ± 0.03	0.484AsnTrp: 0.484 ± 0.014	0.751AsnTyr: 0.751 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	6.304ProAla: 6.304 ± 0.053	0.364ProCys: 0.364 ± 0.01	3.525ProAsp: 3.525 ± 0.036	3.243ProGlu: 3.243 ± 0.039	2.021ProPhe: 2.021 ± 0.024	4.377ProGly: 4.377 ± 0.04	1.101ProHis: 1.101 ± 0.023	2.578ProIle: 2.578 ± 0.032	2.161ProLys: 2.161 ± 0.03	4.616ProLeu: 4.616 ± 0.045	1.195ProMet: 1.195 ± 0.02	1.701ProAsn: 1.701 ± 0.023	3.122ProPro: 3.122 ± 0.047	1.765ProGln: 1.765 ± 0.026	3.159ProArg: 3.159 ± 0.037	3.112ProSer: 3.112 ± 0.03	2.8ProThr: 2.8 ± 0.032	4.111ProVal: 4.111 ± 0.039	0.741ProTrp: 0.741 ± 0.016	1.205ProTyr: 1.205 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.89GlnAla: 3.89 ± 0.041	0.277GlnCys: 0.277 ± 0.009	1.33GlnAsp: 1.33 ± 0.021	1.399GlnGlu: 1.399 ± 0.021	1.24GlnPhe: 1.24 ± 0.019	2.268GlnGly: 2.268 ± 0.029	0.677GlnHis: 0.677 ± 0.015	1.986GlnIle: 1.986 ± 0.026	1.237GlnLys: 1.237 ± 0.022	3.151GlnLeu: 3.151 ± 0.034	0.908GlnMet: 0.908 ± 0.018	0.976GlnAsn: 0.976 ± 0.018	1.885GlnPro: 1.885 ± 0.028	1.365GlnGln: 1.365 ± 0.023	2.579GlnArg: 2.579 ± 0.029	1.926GlnSer: 1.926 ± 0.028	1.841GlnThr: 1.841 ± 0.029	2.197GlnVal: 2.197 ± 0.022	0.463GlnTrp: 0.463 ± 0.013	0.727GlnTyr: 0.727 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	7.751ArgAla: 7.751 ± 0.059	0.667ArgCys: 0.667 ± 0.017	4.078ArgAsp: 4.078 ± 0.043	4.089ArgGlu: 4.089 ± 0.044	2.774ArgPhe: 2.774 ± 0.031	4.797ArgGly: 4.797 ± 0.044	1.805ArgHis: 1.805 ± 0.03	4.068ArgIle: 4.068 ± 0.038	2.805ArgLys: 2.805 ± 0.033	7.499ArgLeu: 7.499 ± 0.065	1.808ArgMet: 1.808 ± 0.024	2.064ArgAsn: 2.064 ± 0.027	3.551ArgPro: 3.551 ± 0.037	2.596ArgGln: 2.596 ± 0.031	5.936ArgArg: 5.936 ± 0.054	4.113ArgSer: 4.113 ± 0.042	3.497ArgThr: 3.497 ± 0.033	4.622ArgVal: 4.622 ± 0.036	1.129ArgTrp: 1.129 ± 0.021	1.788ArgTyr: 1.788 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.598SerAla: 6.598 ± 0.05	0.533SerCys: 0.533 ± 0.015	3.179SerAsp: 3.179 ± 0.032	2.955SerGlu: 2.955 ± 0.031	2.374SerPhe: 2.374 ± 0.031	5.48SerGly: 5.48 ± 0.049	1.158SerHis: 1.158 ± 0.022	3.181SerIle: 3.181 ± 0.031	1.954SerLys: 1.954 ± 0.029	5.57SerLeu: 5.57 ± 0.047	1.398SerMet: 1.398 ± 0.022	1.631SerAsn: 1.631 ± 0.028	3.147SerPro: 3.147 ± 0.035	1.751SerGln: 1.751 ± 0.024	3.975SerArg: 3.975 ± 0.04	3.484SerSer: 3.484 ± 0.038	2.949SerThr: 2.949 ± 0.038	4.17SerVal: 4.17 ± 0.037	0.824SerTrp: 0.824 ± 0.015	1.422SerTyr: 1.422 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	6.279ThrAla: 6.279 ± 0.054	0.466ThrCys: 0.466 ± 0.013	2.716ThrAsp: 2.716 ± 0.035	2.599ThrGlu: 2.599 ± 0.03	2.136ThrPhe: 2.136 ± 0.026	4.881ThrGly: 4.881 ± 0.049	1.083ThrHis: 1.083 ± 0.021	3.134ThrIle: 3.134 ± 0.041	1.801ThrLys: 1.801 ± 0.022	5.5ThrLeu: 5.5 ± 0.057	1.262ThrMet: 1.262 ± 0.019	1.481ThrAsn: 1.481 ± 0.025	3.322ThrPro: 3.322 ± 0.039	1.492ThrGln: 1.492 ± 0.026	3.371ThrArg: 3.371 ± 0.037	3.167ThrSer: 3.167 ± 0.036	3.027ThrThr: 3.027 ± 0.046	4.189ThrVal: 4.189 ± 0.048	0.663ThrTrp: 0.663 ± 0.017	1.213ThrTyr: 1.213 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	9.131ValAla: 9.131 ± 0.057	0.689ValCys: 0.689 ± 0.014	3.955ValAsp: 3.955 ± 0.034	4.011ValGlu: 4.011 ± 0.035	2.689ValPhe: 2.689 ± 0.033	5.515ValGly: 5.515 ± 0.049	1.426ValHis: 1.426 ± 0.022	4.07ValIle: 4.07 ± 0.039	2.541ValLys: 2.541 ± 0.038	7.332ValLeu: 7.332 ± 0.057	1.76ValMet: 1.76 ± 0.027	2.102ValAsn: 2.102 ± 0.03	3.822ValPro: 3.822 ± 0.037	2.215ValGln: 2.215 ± 0.031	4.999ValArg: 4.999 ± 0.039	4.397ValSer: 4.397 ± 0.045	4.37ValThr: 4.37 ± 0.048	5.965ValVal: 5.965 ± 0.053	0.952ValTrp: 0.952 ± 0.018	1.498ValTyr: 1.498 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.192TrpAla: 1.192 ± 0.023	0.153TrpCys: 0.153 ± 0.008	0.646TrpAsp: 0.646 ± 0.016	0.538TrpGlu: 0.538 ± 0.014	0.594TrpPhe: 0.594 ± 0.016	0.94TrpGly: 0.94 ± 0.017	0.38TrpHis: 0.38 ± 0.013	0.778TrpIle: 0.778 ± 0.016	0.539TrpLys: 0.539 ± 0.015	1.679TrpLeu: 1.679 ± 0.027	0.377TrpMet: 0.377 ± 0.011	0.507TrpAsn: 0.507 ± 0.014	0.741TrpPro: 0.741 ± 0.017	0.599TrpGln: 0.599 ± 0.015	1.268TrpArg: 1.268 ± 0.024	0.935TrpSer: 0.935 ± 0.018	0.834TrpThr: 0.834 ± 0.018	0.807TrpVal: 0.807 ± 0.018	0.224TrpTrp: 0.224 ± 0.009	0.304TrpTyr: 0.304 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.539TyrAla: 2.539 ± 0.026	0.29TyrCys: 0.29 ± 0.011	1.377TyrAsp: 1.377 ± 0.022	1.127TyrGlu: 1.127 ± 0.02	1.019TyrPhe: 1.019 ± 0.019	2.117TyrGly: 2.117 ± 0.026	0.481TyrHis: 0.481 ± 0.013	0.933TyrIle: 0.933 ± 0.017	0.685TyrLys: 0.685 ± 0.017	2.374TyrLeu: 2.374 ± 0.031	0.47TyrMet: 0.47 ± 0.011	0.627TyrAsn: 0.627 ± 0.015	1.183TyrPro: 1.183 ± 0.02	0.773TyrGln: 0.773 ± 0.016	1.842TyrArg: 1.842 ± 0.024	1.316TyrSer: 1.316 ± 0.022	1.099TyrThr: 1.099 ± 0.021	1.74TyrVal: 1.74 ± 0.023	0.435TyrTrp: 0.435 ± 0.013	0.677TyrTyr: 0.677 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10605 proteins (2999090 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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