Amino acid dipepetide frequency for Streptococcus phage phiZJ20091101-4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.212AlaAla: 3.212 ± 0.615
0.548AlaCys: 0.548 ± 0.209
5.171AlaAsp: 5.171 ± 0.759
6.268AlaGlu: 6.268 ± 0.689
2.351AlaPhe: 2.351 ± 0.461
5.955AlaGly: 5.955 ± 1.044
0.548AlaHis: 0.548 ± 0.212
5.798AlaIle: 5.798 ± 0.618
7.365AlaLys: 7.365 ± 0.725
5.563AlaLeu: 5.563 ± 0.557
1.88AlaMet: 1.88 ± 0.601
4.153AlaAsn: 4.153 ± 0.507
2.037AlaPro: 2.037 ± 0.357
2.899AlaGln: 2.899 ± 0.511
3.291AlaArg: 3.291 ± 0.537
3.761AlaSer: 3.761 ± 0.671
5.406AlaThr: 5.406 ± 0.552
5.171AlaVal: 5.171 ± 0.831
0.862AlaTrp: 0.862 ± 0.318
2.899AlaTyr: 2.899 ± 0.545
0.0AlaXaa: 0.0 ± 0.0
Cys
0.235CysAla: 0.235 ± 0.134
0.0CysCys: 0.0 ± 0.0
0.548CysAsp: 0.548 ± 0.187
0.548CysGlu: 0.548 ± 0.226
0.313CysPhe: 0.313 ± 0.163
0.627CysGly: 0.627 ± 0.229
0.313CysHis: 0.313 ± 0.123
0.157CysIle: 0.157 ± 0.106
0.862CysLys: 0.862 ± 0.276
0.784CysLeu: 0.784 ± 0.295
0.157CysMet: 0.157 ± 0.113
0.157CysAsn: 0.157 ± 0.127
0.313CysPro: 0.313 ± 0.142
0.157CysGln: 0.157 ± 0.11
0.47CysArg: 0.47 ± 0.218
0.235CysSer: 0.235 ± 0.115
0.157CysThr: 0.157 ± 0.111
0.235CysVal: 0.235 ± 0.126
0.0CysTrp: 0.0 ± 0.0
0.313CysTyr: 0.313 ± 0.156
0.0CysXaa: 0.0 ± 0.0
Asp
4.388AspAla: 4.388 ± 0.486
0.157AspCys: 0.157 ± 0.104
3.526AspAsp: 3.526 ± 0.568
4.623AspGlu: 4.623 ± 0.682
3.056AspPhe: 3.056 ± 0.464
4.623AspGly: 4.623 ± 0.703
0.784AspHis: 0.784 ± 0.233
4.466AspIle: 4.466 ± 0.67
5.25AspLys: 5.25 ± 0.708
5.955AspLeu: 5.955 ± 0.562
1.489AspMet: 1.489 ± 0.366
3.918AspAsn: 3.918 ± 0.456
1.254AspPro: 1.254 ± 0.528
1.41AspGln: 1.41 ± 0.319
2.586AspArg: 2.586 ± 0.389
3.604AspSer: 3.604 ± 0.524
3.839AspThr: 3.839 ± 0.664
5.25AspVal: 5.25 ± 0.523
1.332AspTrp: 1.332 ± 0.37
2.664AspTyr: 2.664 ± 0.33
0.0AspXaa: 0.0 ± 0.0
Glu
6.817GluAla: 6.817 ± 0.8
0.548GluCys: 0.548 ± 0.21
3.212GluAsp: 3.212 ± 0.505
5.328GluGlu: 5.328 ± 0.981
2.977GluPhe: 2.977 ± 0.495
3.604GluGly: 3.604 ± 0.472
1.175GluHis: 1.175 ± 0.316
6.19GluIle: 6.19 ± 0.744
5.798GluLys: 5.798 ± 1.03
7.052GluLeu: 7.052 ± 0.661
1.489GluMet: 1.489 ± 0.423
3.761GluAsn: 3.761 ± 0.602
1.645GluPro: 1.645 ± 0.464
4.153GluGln: 4.153 ± 0.657
4.153GluArg: 4.153 ± 0.567
2.977GluSer: 2.977 ± 0.379
3.839GluThr: 3.839 ± 0.554
5.014GluVal: 5.014 ± 0.616
1.175GluTrp: 1.175 ± 0.325
3.056GluTyr: 3.056 ± 0.573
0.0GluXaa: 0.0 ± 0.0
Phe
3.056PheAla: 3.056 ± 0.478
0.157PheCys: 0.157 ± 0.116
3.369PheAsp: 3.369 ± 0.559
3.134PheGlu: 3.134 ± 0.477
1.645PhePhe: 1.645 ± 0.457
2.507PheGly: 2.507 ± 0.514
0.705PheHis: 0.705 ± 0.194
2.899PheIle: 2.899 ± 0.563
2.899PheLys: 2.899 ± 0.418
2.742PheLeu: 2.742 ± 0.526
0.548PheMet: 0.548 ± 0.191
2.664PheAsn: 2.664 ± 0.681
0.94PhePro: 0.94 ± 0.323
1.41PheGln: 1.41 ± 0.376
1.724PheArg: 1.724 ± 0.376
3.604PheSer: 3.604 ± 0.568
2.272PheThr: 2.272 ± 0.478
2.664PheVal: 2.664 ± 0.378
0.47PheTrp: 0.47 ± 0.189
1.724PheTyr: 1.724 ± 0.322
0.0PheXaa: 0.0 ± 0.0
Gly
3.604GlyAla: 3.604 ± 0.606
0.47GlyCys: 0.47 ± 0.23
3.056GlyAsp: 3.056 ± 0.474
3.918GlyGlu: 3.918 ± 0.55
3.447GlyPhe: 3.447 ± 0.629
3.918GlyGly: 3.918 ± 0.847
1.175GlyHis: 1.175 ± 0.281
4.309GlyIle: 4.309 ± 0.696
5.876GlyLys: 5.876 ± 0.754
5.093GlyLeu: 5.093 ± 0.691
1.645GlyMet: 1.645 ± 0.327
2.586GlyAsn: 2.586 ± 0.412
0.548GlyPro: 0.548 ± 0.229
2.821GlyGln: 2.821 ± 0.442
4.074GlyArg: 4.074 ± 0.509
2.977GlySer: 2.977 ± 0.633
3.291GlyThr: 3.291 ± 0.577
4.388GlyVal: 4.388 ± 0.542
0.862GlyTrp: 0.862 ± 0.263
2.272GlyTyr: 2.272 ± 0.34
0.0GlyXaa: 0.0 ± 0.0
His
0.862HisAla: 0.862 ± 0.268
0.0HisCys: 0.0 ± 0.0
0.705HisAsp: 0.705 ± 0.246
1.019HisGlu: 1.019 ± 0.296
1.019HisPhe: 1.019 ± 0.347
1.567HisGly: 1.567 ± 0.485
0.235HisHis: 0.235 ± 0.134
1.332HisIle: 1.332 ± 0.333
1.254HisLys: 1.254 ± 0.351
1.41HisLeu: 1.41 ± 0.339
0.235HisMet: 0.235 ± 0.197
0.627HisAsn: 0.627 ± 0.2
0.548HisPro: 0.548 ± 0.182
0.784HisGln: 0.784 ± 0.227
0.862HisArg: 0.862 ± 0.232
0.705HisSer: 0.705 ± 0.255
0.862HisThr: 0.862 ± 0.232
0.548HisVal: 0.548 ± 0.195
0.157HisTrp: 0.157 ± 0.112
0.94HisTyr: 0.94 ± 0.331
0.0HisXaa: 0.0 ± 0.0
Ile
4.701IleAla: 4.701 ± 0.527
0.548IleCys: 0.548 ± 0.203
5.093IleAsp: 5.093 ± 0.57
6.738IleGlu: 6.738 ± 0.842
2.194IlePhe: 2.194 ± 0.7
4.623IleGly: 4.623 ± 0.889
0.862IleHis: 0.862 ± 0.259
4.936IleIle: 4.936 ± 0.672
6.19IleLys: 6.19 ± 0.568
5.093IleLeu: 5.093 ± 0.622
1.175IleMet: 1.175 ± 0.364
4.074IleAsn: 4.074 ± 0.592
2.351IlePro: 2.351 ± 0.487
2.351IleGln: 2.351 ± 0.398
3.683IleArg: 3.683 ± 0.483
3.996IleSer: 3.996 ± 0.508
4.701IleThr: 4.701 ± 0.917
3.839IleVal: 3.839 ± 0.575
0.94IleTrp: 0.94 ± 0.235
2.664IleTyr: 2.664 ± 0.495
0.0IleXaa: 0.0 ± 0.0
Lys
6.268LysAla: 6.268 ± 0.716
0.235LysCys: 0.235 ± 0.124
4.231LysAsp: 4.231 ± 0.533
5.563LysGlu: 5.563 ± 0.784
1.802LysPhe: 1.802 ± 0.423
4.153LysGly: 4.153 ± 0.514
1.254LysHis: 1.254 ± 0.394
6.033LysIle: 6.033 ± 0.729
5.485LysLys: 5.485 ± 0.786
6.738LysLeu: 6.738 ± 0.608
2.115LysMet: 2.115 ± 0.503
3.761LysAsn: 3.761 ± 0.631
2.742LysPro: 2.742 ± 0.401
4.074LysGln: 4.074 ± 0.548
5.171LysArg: 5.171 ± 0.785
4.309LysSer: 4.309 ± 0.659
6.346LysThr: 6.346 ± 0.895
4.936LysVal: 4.936 ± 0.698
1.019LysTrp: 1.019 ± 0.292
4.074LysTyr: 4.074 ± 0.663
0.0LysXaa: 0.0 ± 0.0
Leu
8.305LeuAla: 8.305 ± 0.85
0.627LeuCys: 0.627 ± 0.299
6.503LeuAsp: 6.503 ± 0.697
6.19LeuGlu: 6.19 ± 0.814
4.074LeuPhe: 4.074 ± 0.872
4.544LeuGly: 4.544 ± 0.809
0.862LeuHis: 0.862 ± 0.229
5.563LeuIle: 5.563 ± 0.859
7.913LeuLys: 7.913 ± 0.724
6.346LeuLeu: 6.346 ± 1.017
1.724LeuMet: 1.724 ± 0.397
4.623LeuAsn: 4.623 ± 0.591
3.447LeuPro: 3.447 ± 0.844
3.369LeuGln: 3.369 ± 0.513
3.369LeuArg: 3.369 ± 0.572
4.779LeuSer: 4.779 ± 0.535
4.623LeuThr: 4.623 ± 0.848
4.701LeuVal: 4.701 ± 0.636
1.019LeuTrp: 1.019 ± 0.292
2.586LeuTyr: 2.586 ± 0.488
0.0LeuXaa: 0.0 ± 0.0
Met
1.645MetAla: 1.645 ± 0.451
0.078MetCys: 0.078 ± 0.077
1.019MetAsp: 1.019 ± 0.241
1.567MetGlu: 1.567 ± 0.4
0.784MetPhe: 0.784 ± 0.249
1.254MetGly: 1.254 ± 0.335
0.157MetHis: 0.157 ± 0.102
1.645MetIle: 1.645 ± 0.347
1.724MetLys: 1.724 ± 0.447
1.88MetLeu: 1.88 ± 0.37
0.235MetMet: 0.235 ± 0.134
1.254MetAsn: 1.254 ± 0.369
0.862MetPro: 0.862 ± 0.237
0.157MetGln: 0.157 ± 0.092
1.254MetArg: 1.254 ± 0.387
1.567MetSer: 1.567 ± 0.369
1.959MetThr: 1.959 ± 0.448
0.705MetVal: 0.705 ± 0.21
0.157MetTrp: 0.157 ± 0.095
0.392MetTyr: 0.392 ± 0.155
0.0MetXaa: 0.0 ± 0.0
Asn
3.996AsnAla: 3.996 ± 0.696
0.235AsnCys: 0.235 ± 0.118
3.918AsnAsp: 3.918 ± 0.638
2.899AsnGlu: 2.899 ± 0.445
1.802AsnPhe: 1.802 ± 0.383
3.918AsnGly: 3.918 ± 0.638
1.019AsnHis: 1.019 ± 0.24
3.761AsnIle: 3.761 ± 0.501
2.821AsnLys: 2.821 ± 0.462
5.171AsnLeu: 5.171 ± 0.671
0.94AsnMet: 0.94 ± 0.248
2.429AsnAsn: 2.429 ± 0.387
2.037AsnPro: 2.037 ± 0.455
1.959AsnGln: 1.959 ± 0.513
2.429AsnArg: 2.429 ± 0.45
2.429AsnSer: 2.429 ± 0.476
3.291AsnThr: 3.291 ± 0.618
3.604AsnVal: 3.604 ± 0.597
0.862AsnTrp: 0.862 ± 0.251
2.194AsnTyr: 2.194 ± 0.553
0.0AsnXaa: 0.0 ± 0.0
Pro
1.489ProAla: 1.489 ± 0.36
0.078ProCys: 0.078 ± 0.088
2.115ProAsp: 2.115 ± 0.42
2.272ProGlu: 2.272 ± 0.355
1.489ProPhe: 1.489 ± 0.277
1.019ProGly: 1.019 ± 0.288
0.392ProHis: 0.392 ± 0.161
2.037ProIle: 2.037 ± 0.406
2.429ProLys: 2.429 ± 0.487
1.959ProLeu: 1.959 ± 0.512
0.392ProMet: 0.392 ± 0.154
1.41ProAsn: 1.41 ± 0.428
0.705ProPro: 0.705 ± 0.232
0.862ProGln: 0.862 ± 0.229
1.41ProArg: 1.41 ± 0.424
2.115ProSer: 2.115 ± 0.483
2.351ProThr: 2.351 ± 0.344
2.037ProVal: 2.037 ± 0.368
0.392ProTrp: 0.392 ± 0.181
1.489ProTyr: 1.489 ± 0.36
0.0ProXaa: 0.0 ± 0.0
Gln
5.641GlnAla: 5.641 ± 0.669
0.157GlnCys: 0.157 ± 0.12
1.645GlnAsp: 1.645 ± 0.382
2.429GlnGlu: 2.429 ± 0.434
1.097GlnPhe: 1.097 ± 0.284
2.037GlnGly: 2.037 ± 0.431
0.313GlnHis: 0.313 ± 0.162
3.212GlnIle: 3.212 ± 0.415
2.507GlnLys: 2.507 ± 0.481
4.466GlnLeu: 4.466 ± 0.607
0.784GlnMet: 0.784 ± 0.273
2.429GlnAsn: 2.429 ± 0.487
1.254GlnPro: 1.254 ± 0.297
2.272GlnGln: 2.272 ± 0.374
1.489GlnArg: 1.489 ± 0.285
2.821GlnSer: 2.821 ± 0.732
2.742GlnThr: 2.742 ± 0.558
3.134GlnVal: 3.134 ± 0.435
0.548GlnTrp: 0.548 ± 0.179
1.41GlnTyr: 1.41 ± 0.353
0.0GlnXaa: 0.0 ± 0.0
Arg
3.683ArgAla: 3.683 ± 0.56
0.548ArgCys: 0.548 ± 0.189
2.821ArgAsp: 2.821 ± 0.401
3.761ArgGlu: 3.761 ± 0.687
2.742ArgPhe: 2.742 ± 0.761
1.645ArgGly: 1.645 ± 0.309
1.019ArgHis: 1.019 ± 0.244
3.134ArgIle: 3.134 ± 0.471
4.153ArgLys: 4.153 ± 0.706
4.858ArgLeu: 4.858 ± 0.654
1.254ArgMet: 1.254 ± 0.296
2.742ArgAsn: 2.742 ± 0.434
1.175ArgPro: 1.175 ± 0.36
2.272ArgGln: 2.272 ± 0.388
2.429ArgArg: 2.429 ± 0.581
2.742ArgSer: 2.742 ± 0.582
2.037ArgThr: 2.037 ± 0.575
2.507ArgVal: 2.507 ± 0.352
0.862ArgTrp: 0.862 ± 0.247
2.194ArgTyr: 2.194 ± 0.353
0.0ArgXaa: 0.0 ± 0.0
Ser
4.388SerAla: 4.388 ± 0.691
0.313SerCys: 0.313 ± 0.143
4.388SerAsp: 4.388 ± 0.622
3.918SerGlu: 3.918 ± 0.65
2.351SerPhe: 2.351 ± 0.544
3.447SerGly: 3.447 ± 0.63
1.645SerHis: 1.645 ± 0.507
3.212SerIle: 3.212 ± 0.457
4.936SerLys: 4.936 ± 0.925
5.485SerLeu: 5.485 ± 0.795
1.41SerMet: 1.41 ± 0.305
2.194SerAsn: 2.194 ± 0.438
1.254SerPro: 1.254 ± 0.208
2.899SerGln: 2.899 ± 0.544
2.507SerArg: 2.507 ± 0.462
3.291SerSer: 3.291 ± 0.46
2.821SerThr: 2.821 ± 0.667
2.586SerVal: 2.586 ± 0.303
0.784SerTrp: 0.784 ± 0.28
2.586SerTyr: 2.586 ± 0.479
0.0SerXaa: 0.0 ± 0.0
Thr
4.936ThrAla: 4.936 ± 1.17
0.47ThrCys: 0.47 ± 0.156
4.231ThrAsp: 4.231 ± 0.473
4.701ThrGlu: 4.701 ± 0.828
2.742ThrPhe: 2.742 ± 0.457
4.388ThrGly: 4.388 ± 0.588
0.94ThrHis: 0.94 ± 0.254
3.839ThrIle: 3.839 ± 0.474
5.171ThrLys: 5.171 ± 0.722
5.014ThrLeu: 5.014 ± 0.625
0.705ThrMet: 0.705 ± 0.378
2.977ThrAsn: 2.977 ± 0.418
1.724ThrPro: 1.724 ± 0.369
2.742ThrGln: 2.742 ± 0.895
2.115ThrArg: 2.115 ± 0.388
3.526ThrSer: 3.526 ± 0.661
4.309ThrThr: 4.309 ± 0.91
4.936ThrVal: 4.936 ± 1.039
0.392ThrTrp: 0.392 ± 0.194
2.037ThrTyr: 2.037 ± 0.459
0.0ThrXaa: 0.0 ± 0.0
Val
5.406ValAla: 5.406 ± 0.678
0.548ValCys: 0.548 ± 0.249
5.406ValAsp: 5.406 ± 0.612
5.171ValGlu: 5.171 ± 0.507
2.664ValPhe: 2.664 ± 0.494
3.447ValGly: 3.447 ± 0.656
1.175ValHis: 1.175 ± 0.296
3.761ValIle: 3.761 ± 0.572
3.996ValLys: 3.996 ± 0.477
4.779ValLeu: 4.779 ± 0.743
0.862ValMet: 0.862 ± 0.284
3.447ValAsn: 3.447 ± 0.557
1.959ValPro: 1.959 ± 0.363
2.664ValGln: 2.664 ± 0.406
2.899ValArg: 2.899 ± 0.457
4.388ValSer: 4.388 ± 0.756
3.918ValThr: 3.918 ± 0.537
4.388ValVal: 4.388 ± 0.736
0.627ValTrp: 0.627 ± 0.266
2.194ValTyr: 2.194 ± 0.411
0.0ValXaa: 0.0 ± 0.0
Trp
0.548TrpAla: 0.548 ± 0.239
0.157TrpCys: 0.157 ± 0.108
0.94TrpAsp: 0.94 ± 0.329
1.41TrpGlu: 1.41 ± 0.321
1.097TrpPhe: 1.097 ± 0.393
0.705TrpGly: 0.705 ± 0.24
0.313TrpHis: 0.313 ± 0.17
0.784TrpIle: 0.784 ± 0.236
0.627TrpLys: 0.627 ± 0.193
1.724TrpLeu: 1.724 ± 0.544
0.313TrpMet: 0.313 ± 0.149
0.784TrpAsn: 0.784 ± 0.342
0.078TrpPro: 0.078 ± 0.08
0.862TrpGln: 0.862 ± 0.272
0.392TrpArg: 0.392 ± 0.177
0.47TrpSer: 0.47 ± 0.193
0.784TrpThr: 0.784 ± 0.255
0.627TrpVal: 0.627 ± 0.279
0.078TrpTrp: 0.078 ± 0.086
0.47TrpTyr: 0.47 ± 0.175
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.959TyrAla: 1.959 ± 0.397
0.705TyrCys: 0.705 ± 0.257
2.272TyrAsp: 2.272 ± 0.328
2.507TyrGlu: 2.507 ± 0.625
1.567TyrPhe: 1.567 ± 0.35
2.351TyrGly: 2.351 ± 0.336
0.784TyrHis: 0.784 ± 0.262
3.683TyrIle: 3.683 ± 0.428
3.056TyrLys: 3.056 ± 0.661
3.056TyrLeu: 3.056 ± 0.532
0.862TyrMet: 0.862 ± 0.276
1.724TyrAsn: 1.724 ± 0.328
1.567TyrPro: 1.567 ± 0.336
2.272TyrGln: 2.272 ± 0.47
2.272TyrArg: 2.272 ± 0.512
2.115TyrSer: 2.115 ± 0.317
2.351TyrThr: 2.351 ± 0.314
2.429TyrVal: 2.429 ± 0.423
0.627TyrTrp: 0.627 ± 0.223
2.037TyrTyr: 2.037 ± 0.52
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 64 proteins (12764 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski