Amino acid dipepetide frequency for Micromonospora echinaurantiaca

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.814AlaAla: 24.814 ± 0.189	0.915AlaCys: 0.915 ± 0.023	9.142AlaAsp: 9.142 ± 0.074	9.121AlaGlu: 9.121 ± 0.08	3.297AlaPhe: 3.297 ± 0.047	15.648AlaGly: 15.648 ± 0.116	2.506AlaHis: 2.506 ± 0.037	3.865AlaIle: 3.865 ± 0.055	2.142AlaLys: 2.142 ± 0.048	15.037AlaLeu: 15.037 ± 0.136	2.37AlaMet: 2.37 ± 0.033	2.14AlaAsn: 2.14 ± 0.034	7.627AlaPro: 7.627 ± 0.079	3.445AlaGln: 3.445 ± 0.045	10.978AlaArg: 10.978 ± 0.082	5.23AlaSer: 5.23 ± 0.06	8.187AlaThr: 8.187 ± 0.079	13.282AlaVal: 13.282 ± 0.113	1.942AlaTrp: 1.942 ± 0.031	2.827AlaTyr: 2.827 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.009CysAla: 1.009 ± 0.023	0.114CysCys: 0.114 ± 0.008	0.478CysAsp: 0.478 ± 0.016	0.302CysGlu: 0.302 ± 0.012	0.202CysPhe: 0.202 ± 0.01	0.891CysGly: 0.891 ± 0.023	0.195CysHis: 0.195 ± 0.009	0.129CysIle: 0.129 ± 0.008	0.08CysLys: 0.08 ± 0.006	0.673CysLeu: 0.673 ± 0.018	0.089CysMet: 0.089 ± 0.006	0.121CysAsn: 0.121 ± 0.008	0.492CysPro: 0.492 ± 0.018	0.203CysGln: 0.203 ± 0.01	0.654CysArg: 0.654 ± 0.017	0.36CysSer: 0.36 ± 0.015	0.418CysThr: 0.418 ± 0.015	0.595CysVal: 0.595 ± 0.017	0.131CysTrp: 0.131 ± 0.008	0.17CysTyr: 0.17 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.681AspAla: 7.681 ± 0.067	0.385AspCys: 0.385 ± 0.014	3.711AspAsp: 3.711 ± 0.048	3.638AspGlu: 3.638 ± 0.048	1.426AspPhe: 1.426 ± 0.035	6.488AspGly: 6.488 ± 0.072	1.262AspHis: 1.262 ± 0.026	1.516AspIle: 1.516 ± 0.032	0.866AspLys: 0.866 ± 0.029	6.74AspLeu: 6.74 ± 0.059	0.658AspMet: 0.658 ± 0.018	0.892AspAsn: 0.892 ± 0.023	5.082AspPro: 5.082 ± 0.059	1.644AspGln: 1.644 ± 0.026	5.908AspArg: 5.908 ± 0.071	2.064AspSer: 2.064 ± 0.035	2.778AspThr: 2.778 ± 0.04	4.893AspVal: 4.893 ± 0.048	1.036AspTrp: 1.036 ± 0.02	1.099AspTyr: 1.099 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.52GluAla: 6.52 ± 0.06	0.326GluCys: 0.326 ± 0.014	1.959GluAsp: 1.959 ± 0.036	2.532GluGlu: 2.532 ± 0.045	1.434GluPhe: 1.434 ± 0.028	3.093GluGly: 3.093 ± 0.043	1.378GluHis: 1.378 ± 0.027	2.083GluIle: 2.083 ± 0.035	0.932GluLys: 0.932 ± 0.027	6.747GluLeu: 6.747 ± 0.073	0.754GluMet: 0.754 ± 0.019	0.755GluAsn: 0.755 ± 0.017	3.726GluPro: 3.726 ± 0.044	2.232GluGln: 2.232 ± 0.035	5.347GluArg: 5.347 ± 0.06	2.073GluSer: 2.073 ± 0.032	2.396GluThr: 2.396 ± 0.032	4.743GluVal: 4.743 ± 0.054	0.703GluTrp: 0.703 ± 0.019	1.029GluTyr: 1.029 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.859PheAla: 3.859 ± 0.049	0.238PheCys: 0.238 ± 0.011	1.887PheAsp: 1.887 ± 0.033	1.147PheGlu: 1.147 ± 0.025	0.81PhePhe: 0.81 ± 0.024	2.956PheGly: 2.956 ± 0.039	0.536PheHis: 0.536 ± 0.018	0.666PheIle: 0.666 ± 0.02	0.371PheLys: 0.371 ± 0.015	2.532PheLeu: 2.532 ± 0.036	0.299PheMet: 0.299 ± 0.013	0.536PheAsn: 0.536 ± 0.016	1.334PhePro: 1.334 ± 0.026	0.628PheGln: 0.628 ± 0.017	1.822PheArg: 1.822 ± 0.031	1.232PheSer: 1.232 ± 0.028	1.9PheThr: 1.9 ± 0.027	2.384PheVal: 2.384 ± 0.035	0.448PheTrp: 0.448 ± 0.016	0.568PheTyr: 0.568 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.496GlyAla: 11.496 ± 0.087	0.824GlyCys: 0.824 ± 0.022	5.329GlyAsp: 5.329 ± 0.063	4.752GlyGlu: 4.752 ± 0.05	2.791GlyPhe: 2.791 ± 0.038	9.025GlyGly: 9.025 ± 0.09	2.099GlyHis: 2.099 ± 0.036	3.063GlyIle: 3.063 ± 0.038	1.844GlyLys: 1.844 ± 0.037	9.733GlyLeu: 9.733 ± 0.091	1.941GlyMet: 1.941 ± 0.032	1.639GlyAsn: 1.639 ± 0.035	5.644GlyPro: 5.644 ± 0.061	2.828GlyGln: 2.828 ± 0.038	8.634GlyArg: 8.634 ± 0.08	4.74GlySer: 4.74 ± 0.058	5.677GlyThr: 5.677 ± 0.069	8.156GlyVal: 8.156 ± 0.075	2.078GlyTrp: 2.078 ± 0.032	2.476GlyTyr: 2.476 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.419HisAla: 2.419 ± 0.042	0.177HisCys: 0.177 ± 0.008	1.296HisAsp: 1.296 ± 0.026	1.018HisGlu: 1.018 ± 0.023	0.528HisPhe: 0.528 ± 0.016	2.074HisGly: 2.074 ± 0.034	0.602HisHis: 0.602 ± 0.018	0.499HisIle: 0.499 ± 0.018	0.238HisLys: 0.238 ± 0.012	2.447HisLeu: 2.447 ± 0.037	0.254HisMet: 0.254 ± 0.011	0.344HisAsn: 0.344 ± 0.013	1.766HisPro: 1.766 ± 0.033	0.6HisGln: 0.6 ± 0.017	2.199HisArg: 2.199 ± 0.034	0.814HisSer: 0.814 ± 0.022	1.073HisThr: 1.073 ± 0.023	1.644HisVal: 1.644 ± 0.028	0.355HisTrp: 0.355 ± 0.015	0.428HisTyr: 0.428 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.641IleAla: 4.641 ± 0.054	0.282IleCys: 0.282 ± 0.011	2.138IleAsp: 2.138 ± 0.036	1.835IleGlu: 1.835 ± 0.033	0.801IlePhe: 0.801 ± 0.021	3.386IleGly: 3.386 ± 0.044	0.523IleHis: 0.523 ± 0.015	0.857IleIle: 0.857 ± 0.023	0.543IleLys: 0.543 ± 0.018	2.341IleLeu: 2.341 ± 0.042	0.412IleMet: 0.412 ± 0.015	0.662IleAsn: 0.662 ± 0.018	1.606IlePro: 1.606 ± 0.028	0.664IleGln: 0.664 ± 0.022	2.396IleArg: 2.396 ± 0.034	1.558IleSer: 1.558 ± 0.03	1.944IleThr: 1.944 ± 0.032	2.681IleVal: 2.681 ± 0.041	0.408IleTrp: 0.408 ± 0.016	0.58IleTyr: 0.58 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.009LysAla: 2.009 ± 0.04	0.096LysCys: 0.096 ± 0.008	0.774LysAsp: 0.774 ± 0.027	0.709LysGlu: 0.709 ± 0.022	0.349LysPhe: 0.349 ± 0.014	1.148LysGly: 1.148 ± 0.029	0.318LysHis: 0.318 ± 0.013	0.696LysIle: 0.696 ± 0.021	0.481LysLys: 0.481 ± 0.02	1.689LysLeu: 1.689 ± 0.035	0.272LysMet: 0.272 ± 0.012	0.31LysAsn: 0.31 ± 0.016	1.076LysPro: 1.076 ± 0.024	0.571LysGln: 0.571 ± 0.019	1.203LysArg: 1.203 ± 0.029	0.81LysSer: 0.81 ± 0.019	0.923LysThr: 0.923 ± 0.023	1.486LysVal: 1.486 ± 0.03	0.198LysTrp: 0.198 ± 0.01	0.313LysTyr: 0.313 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	17.726LeuAla: 17.726 ± 0.151	0.742LeuCys: 0.742 ± 0.021	7.003LeuAsp: 7.003 ± 0.066	3.761LeuGlu: 3.761 ± 0.046	2.628LeuPhe: 2.628 ± 0.044	9.587LeuGly: 9.587 ± 0.086	2.285LeuHis: 2.285 ± 0.033	3.179LeuIle: 3.179 ± 0.047	1.331LeuLys: 1.331 ± 0.03	12.476LeuLeu: 12.476 ± 0.113	1.343LeuMet: 1.343 ± 0.023	1.593LeuAsn: 1.593 ± 0.029	6.952LeuPro: 6.952 ± 0.073	1.847LeuGln: 1.847 ± 0.03	9.658LeuArg: 9.658 ± 0.079	4.568LeuSer: 4.568 ± 0.048	7.129LeuThr: 7.129 ± 0.057	10.422LeuVal: 10.422 ± 0.09	1.314LeuTrp: 1.314 ± 0.027	1.721LeuTyr: 1.721 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.034MetAla: 2.034 ± 0.03	0.117MetCys: 0.117 ± 0.007	0.684MetAsp: 0.684 ± 0.018	0.556MetGlu: 0.556 ± 0.015	0.43MetPhe: 0.43 ± 0.016	1.06MetGly: 1.06 ± 0.021	0.278MetHis: 0.278 ± 0.011	0.646MetIle: 0.646 ± 0.017	0.312MetLys: 0.312 ± 0.013	1.641MetLeu: 1.641 ± 0.03	0.244MetMet: 0.244 ± 0.012	0.326MetAsn: 0.326 ± 0.011	1.041MetPro: 1.041 ± 0.022	0.406MetGln: 0.406 ± 0.013	1.337MetArg: 1.337 ± 0.028	1.163MetSer: 1.163 ± 0.024	1.53MetThr: 1.53 ± 0.029	1.253MetVal: 1.253 ± 0.023	0.192MetTrp: 0.192 ± 0.009	0.246MetTyr: 0.246 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.015AsnAla: 2.015 ± 0.029	0.157AsnCys: 0.157 ± 0.009	0.89AsnAsp: 0.89 ± 0.021	0.708AsnGlu: 0.708 ± 0.02	0.483AsnPhe: 0.483 ± 0.017	1.722AsnGly: 1.722 ± 0.04	0.361AsnHis: 0.361 ± 0.014	0.538AsnIle: 0.538 ± 0.018	0.288AsnLys: 0.288 ± 0.013	1.815AsnLeu: 1.815 ± 0.03	0.25AsnMet: 0.25 ± 0.012	0.424AsnAsn: 0.424 ± 0.016	1.441AsnPro: 1.441 ± 0.03	0.513AsnGln: 0.513 ± 0.017	1.375AsnArg: 1.375 ± 0.028	0.772AsnSer: 0.772 ± 0.022	0.952AsnThr: 0.952 ± 0.025	1.355AsnVal: 1.355 ± 0.027	0.303AsnTrp: 0.303 ± 0.014	0.413AsnTyr: 0.413 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	11.101ProAla: 11.101 ± 0.112	0.308ProCys: 0.308 ± 0.012	4.81ProAsp: 4.81 ± 0.05	4.03ProGlu: 4.03 ± 0.048	1.393ProPhe: 1.393 ± 0.028	6.909ProGly: 6.909 ± 0.066	1.185ProHis: 1.185 ± 0.027	1.521ProIle: 1.521 ± 0.028	0.941ProLys: 0.941 ± 0.022	5.529ProLeu: 5.529 ± 0.057	0.982ProMet: 0.982 ± 0.02	0.975ProAsn: 0.975 ± 0.024	4.646ProPro: 4.646 ± 0.086	1.516ProGln: 1.516 ± 0.028	4.253ProArg: 4.253 ± 0.046	2.807ProSer: 2.807 ± 0.043	4.065ProThr: 4.065 ± 0.051	6.261ProVal: 6.261 ± 0.068	0.952ProTrp: 0.952 ± 0.023	1.3ProTyr: 1.3 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.51GlnAla: 3.51 ± 0.044	0.143GlnCys: 0.143 ± 0.009	1.043GlnAsp: 1.043 ± 0.024	1.12GlnGlu: 1.12 ± 0.023	0.677GlnPhe: 0.677 ± 0.019	1.823GlnGly: 1.823 ± 0.031	0.579GlnHis: 0.579 ± 0.018	0.973GlnIle: 0.973 ± 0.022	0.397GlnLys: 0.397 ± 0.016	3.317GlnLeu: 3.317 ± 0.043	0.399GlnMet: 0.399 ± 0.015	0.442GlnAsn: 0.442 ± 0.015	1.938GlnPro: 1.938 ± 0.035	1.109GlnGln: 1.109 ± 0.024	2.816GlnArg: 2.816 ± 0.041	1.069GlnSer: 1.069 ± 0.027	1.289GlnThr: 1.289 ± 0.022	2.796GlnVal: 2.796 ± 0.035	0.465GlnTrp: 0.465 ± 0.014	0.519GlnTyr: 0.519 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	10.973ArgAla: 10.973 ± 0.088	0.647ArgCys: 0.647 ± 0.019	4.702ArgAsp: 4.702 ± 0.051	4.415ArgGlu: 4.415 ± 0.051	2.512ArgPhe: 2.512 ± 0.035	6.012ArgGly: 6.012 ± 0.056	2.191ArgHis: 2.191 ± 0.033	3.164ArgIle: 3.164 ± 0.037	1.283ArgLys: 1.283 ± 0.028	9.969ArgLeu: 9.969 ± 0.087	1.838ArgMet: 1.838 ± 0.032	1.413ArgAsn: 1.413 ± 0.027	6.059ArgPro: 6.059 ± 0.06	2.74ArgGln: 2.74 ± 0.039	9.472ArgArg: 9.472 ± 0.1	4.069ArgSer: 4.069 ± 0.044	4.927ArgThr: 4.927 ± 0.053	6.709ArgVal: 6.709 ± 0.073	1.805ArgTrp: 1.805 ± 0.031	2.145ArgTyr: 2.145 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.11SerAla: 6.11 ± 0.062	0.368SerCys: 0.368 ± 0.015	2.182SerAsp: 2.182 ± 0.034	1.785SerGlu: 1.785 ± 0.033	1.349SerPhe: 1.349 ± 0.028	5.145SerGly: 5.145 ± 0.062	0.835SerHis: 0.835 ± 0.022	1.412SerIle: 1.412 ± 0.03	0.664SerLys: 0.664 ± 0.019	4.112SerLeu: 4.112 ± 0.046	0.924SerMet: 0.924 ± 0.022	0.803SerAsn: 0.803 ± 0.02	2.962SerPro: 2.962 ± 0.04	1.048SerGln: 1.048 ± 0.024	3.598SerArg: 3.598 ± 0.045	2.21SerSer: 2.21 ± 0.043	2.9SerThr: 2.9 ± 0.038	3.879SerVal: 3.879 ± 0.04	0.893SerTrp: 0.893 ± 0.024	1.171SerTyr: 1.171 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.736ThrAla: 8.736 ± 0.071	0.419ThrCys: 0.419 ± 0.014	3.609ThrAsp: 3.609 ± 0.039	2.949ThrGlu: 2.949 ± 0.04	1.581ThrPhe: 1.581 ± 0.032	6.852ThrGly: 6.852 ± 0.066	1.003ThrHis: 1.003 ± 0.023	1.813ThrIle: 1.813 ± 0.03	0.843ThrLys: 0.843 ± 0.024	5.832ThrLeu: 5.832 ± 0.058	0.925ThrMet: 0.925 ± 0.024	1.01ThrAsn: 1.01 ± 0.026	4.236ThrPro: 4.236 ± 0.046	1.144ThrGln: 1.144 ± 0.023	4.119ThrArg: 4.119 ± 0.046	2.736ThrSer: 2.736 ± 0.042	3.634ThrThr: 3.634 ± 0.059	6.397ThrVal: 6.397 ± 0.066	0.911ThrTrp: 0.911 ± 0.02	1.217ThrTyr: 1.217 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	13.148ValAla: 13.148 ± 0.102	0.72ValCys: 0.72 ± 0.019	5.974ValAsp: 5.974 ± 0.061	4.808ValGlu: 4.808 ± 0.053	2.331ValPhe: 2.331 ± 0.035	7.838ValGly: 7.838 ± 0.064	1.777ValHis: 1.777 ± 0.031	2.736ValIle: 2.736 ± 0.04	1.355ValLys: 1.355 ± 0.029	10.178ValLeu: 10.178 ± 0.087	1.124ValMet: 1.124 ± 0.024	1.665ValAsn: 1.665 ± 0.03	5.663ValPro: 5.663 ± 0.057	1.97ValGln: 1.97 ± 0.029	7.487ValArg: 7.487 ± 0.068	4.188ValSer: 4.188 ± 0.041	6.152ValThr: 6.152 ± 0.065	9.117ValVal: 9.117 ± 0.083	1.15ValTrp: 1.15 ± 0.024	1.499ValTyr: 1.499 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.76TrpAla: 1.76 ± 0.032	0.152TrpCys: 0.152 ± 0.009	0.735TrpAsp: 0.735 ± 0.022	0.593TrpGlu: 0.593 ± 0.017	0.547TrpPhe: 0.547 ± 0.015	0.977TrpGly: 0.977 ± 0.021	0.409TrpHis: 0.409 ± 0.013	0.515TrpIle: 0.515 ± 0.015	0.251TrpLys: 0.251 ± 0.011	2.127TrpLeu: 2.127 ± 0.041	0.245TrpMet: 0.245 ± 0.011	0.368TrpAsn: 0.368 ± 0.012	0.956TrpPro: 0.956 ± 0.023	0.64TrpGln: 0.64 ± 0.018	1.746TrpArg: 1.746 ± 0.033	1.056TrpSer: 1.056 ± 0.021	1.02TrpThr: 1.02 ± 0.023	1.122TrpVal: 1.122 ± 0.024	0.423TrpTrp: 0.423 ± 0.017	0.401TrpTyr: 0.401 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.955TyrAla: 2.955 ± 0.04	0.174TyrCys: 0.174 ± 0.01	1.419TyrAsp: 1.419 ± 0.026	0.984TyrGlu: 0.984 ± 0.025	0.587TyrPhe: 0.587 ± 0.016	2.136TyrGly: 2.136 ± 0.032	0.452TyrHis: 0.452 ± 0.016	0.388TyrIle: 0.388 ± 0.015	0.268TyrLys: 0.268 ± 0.011	2.329TyrLeu: 2.329 ± 0.033	0.175TyrMet: 0.175 ± 0.009	0.358TyrAsn: 0.358 ± 0.013	1.238TyrPro: 1.238 ± 0.028	0.673TyrGln: 0.673 ± 0.02	2.04TyrArg: 2.04 ± 0.036	0.834TyrSer: 0.834 ± 0.018	1.069TyrThr: 1.069 ± 0.028	1.705TyrVal: 1.705 ± 0.028	0.337TyrTrp: 0.337 ± 0.014	0.423TyrTyr: 0.423 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6456 proteins (2094116 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---