Amino acid dipepetide frequency for Candidatus Accumulibacter sp. SK-12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.256AlaAla: 20.256 ± 0.203	1.525AlaCys: 1.525 ± 0.045	7.225AlaAsp: 7.225 ± 0.089	7.181AlaGlu: 7.181 ± 0.095	3.863AlaPhe: 3.863 ± 0.066	12.191AlaGly: 12.191 ± 0.13	2.579AlaHis: 2.579 ± 0.047	5.712AlaIle: 5.712 ± 0.081	2.672AlaLys: 2.672 ± 0.061	13.997AlaLeu: 13.997 ± 0.144	2.844AlaMet: 2.844 ± 0.049	2.895AlaAsn: 2.895 ± 0.056	5.37AlaPro: 5.37 ± 0.078	4.357AlaGln: 4.357 ± 0.067	10.331AlaArg: 10.331 ± 0.102	7.04AlaSer: 7.04 ± 0.082	6.22AlaThr: 6.22 ± 0.084	9.034AlaVal: 9.034 ± 0.085	1.721AlaTrp: 1.721 ± 0.041	2.367AlaTyr: 2.367 ± 0.046	0.01AlaXaa: 0.01 ± 0.003
Cys	1.305CysAla: 1.305 ± 0.033	0.194CysCys: 0.194 ± 0.013	0.606CysAsp: 0.606 ± 0.024	0.57CysGlu: 0.57 ± 0.019	0.385CysPhe: 0.385 ± 0.016	1.161CysGly: 1.161 ± 0.03	0.366CysHis: 0.366 ± 0.019	0.399CysIle: 0.399 ± 0.018	0.198CysLys: 0.198 ± 0.014	1.14CysLeu: 1.14 ± 0.031	0.179CysMet: 0.179 ± 0.013	0.257CysAsn: 0.257 ± 0.017	0.61CysPro: 0.61 ± 0.026	0.394CysGln: 0.394 ± 0.023	1.066CysArg: 1.066 ± 0.032	0.703CysSer: 0.703 ± 0.026	0.459CysThr: 0.459 ± 0.026	0.713CysVal: 0.713 ± 0.024	0.176CysTrp: 0.176 ± 0.012	0.219CysTyr: 0.219 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.643AspAla: 6.643 ± 0.098	0.638AspCys: 0.638 ± 0.025	3.319AspAsp: 3.319 ± 0.072	3.851AspGlu: 3.851 ± 0.054	2.294AspPhe: 2.294 ± 0.049	5.121AspGly: 5.121 ± 0.09	1.219AspHis: 1.219 ± 0.035	2.232AspIle: 2.232 ± 0.041	1.19AspLys: 1.19 ± 0.038	5.995AspLeu: 5.995 ± 0.078	0.879AspMet: 0.879 ± 0.029	1.125AspAsn: 1.125 ± 0.032	3.104AspPro: 3.104 ± 0.062	1.647AspGln: 1.647 ± 0.039	4.343AspArg: 4.343 ± 0.067	2.664AspSer: 2.664 ± 0.044	2.122AspThr: 2.122 ± 0.05	3.633AspVal: 3.633 ± 0.062	1.052AspTrp: 1.052 ± 0.029	1.421AspTyr: 1.421 ± 0.034	0.004AspXaa: 0.004 ± 0.002
Glu	6.772GluAla: 6.772 ± 0.092	0.483GluCys: 0.483 ± 0.023	2.243GluAsp: 2.243 ± 0.043	2.873GluGlu: 2.873 ± 0.065	1.811GluPhe: 1.811 ± 0.04	3.411GluGly: 3.411 ± 0.056	1.442GluHis: 1.442 ± 0.038	3.092GluIle: 3.092 ± 0.048	1.757GluLys: 1.757 ± 0.042	6.621GluLeu: 6.621 ± 0.086	1.358GluMet: 1.358 ± 0.031	1.274GluAsn: 1.274 ± 0.033	2.423GluPro: 2.423 ± 0.049	2.721GluGln: 2.721 ± 0.057	5.54GluArg: 5.54 ± 0.075	2.797GluSer: 2.797 ± 0.05	2.561GluThr: 2.561 ± 0.045	4.317GluVal: 4.317 ± 0.059	0.799GluTrp: 0.799 ± 0.03	1.161GluTyr: 1.161 ± 0.034	0.005GluXaa: 0.005 ± 0.002
Phe	4.749PheAla: 4.749 ± 0.063	0.458PheCys: 0.458 ± 0.018	2.378PheAsp: 2.378 ± 0.048	1.841PheGlu: 1.841 ± 0.039	1.416PhePhe: 1.416 ± 0.039	3.131PheGly: 3.131 ± 0.056	0.764PheHis: 0.764 ± 0.028	1.453PheIle: 1.453 ± 0.036	0.741PheLys: 0.741 ± 0.026	3.502PheLeu: 3.502 ± 0.051	0.644PheMet: 0.644 ± 0.024	0.926PheAsn: 0.926 ± 0.03	1.515PhePro: 1.515 ± 0.036	0.976PheGln: 0.976 ± 0.03	2.361PheArg: 2.361 ± 0.049	2.183PheSer: 2.183 ± 0.049	1.485PheThr: 1.485 ± 0.033	2.829PheVal: 2.829 ± 0.048	0.514PheTrp: 0.514 ± 0.021	0.781PheTyr: 0.781 ± 0.029	0.005PheXaa: 0.005 ± 0.002
Gly	8.269GlyAla: 8.269 ± 0.11	1.126GlyCys: 1.126 ± 0.029	4.778GlyAsp: 4.778 ± 0.079	5.347GlyGlu: 5.347 ± 0.072	3.072GlyPhe: 3.072 ± 0.049	7.276GlyGly: 7.276 ± 0.125	1.898GlyHis: 1.898 ± 0.038	4.095GlyIle: 4.095 ± 0.056	2.858GlyLys: 2.858 ± 0.055	8.596GlyLeu: 8.596 ± 0.096	2.096GlyMet: 2.096 ± 0.041	2.31GlyAsn: 2.31 ± 0.063	2.797GlyPro: 2.797 ± 0.054	3.152GlyGln: 3.152 ± 0.055	6.918GlyArg: 6.918 ± 0.084	5.421GlySer: 5.421 ± 0.096	3.776GlyThr: 3.776 ± 0.072	6.046GlyVal: 6.046 ± 0.079	1.337GlyTrp: 1.337 ± 0.035	1.987GlyTyr: 1.987 ± 0.04	0.003GlyXaa: 0.003 ± 0.002
His	2.787HisAla: 2.787 ± 0.054	0.34HisCys: 0.34 ± 0.018	1.311HisAsp: 1.311 ± 0.03	1.203HisGlu: 1.203 ± 0.028	0.979HisPhe: 0.979 ± 0.031	2.121HisGly: 2.121 ± 0.045	0.669HisHis: 0.669 ± 0.026	0.797HisIle: 0.797 ± 0.026	0.419HisLys: 0.419 ± 0.02	2.741HisLeu: 2.741 ± 0.048	0.351HisMet: 0.351 ± 0.016	0.433HisAsn: 0.433 ± 0.02	1.47HisPro: 1.47 ± 0.038	0.782HisGln: 0.782 ± 0.026	1.998HisArg: 1.998 ± 0.05	1.097HisSer: 1.097 ± 0.033	0.76HisThr: 0.76 ± 0.025	1.527HisVal: 1.527 ± 0.038	0.354HisTrp: 0.354 ± 0.016	0.642HisTyr: 0.642 ± 0.025	0.002HisXaa: 0.002 ± 0.001
Ile	6.098IleAla: 6.098 ± 0.072	0.463IleCys: 0.463 ± 0.021	3.454IleAsp: 3.454 ± 0.057	3.241IleGlu: 3.241 ± 0.051	1.247IlePhe: 1.247 ± 0.033	4.297IleGly: 4.297 ± 0.061	0.901IleHis: 0.901 ± 0.027	1.726IleIle: 1.726 ± 0.044	1.105IleLys: 1.105 ± 0.032	3.922IleLeu: 3.922 ± 0.063	0.647IleMet: 0.647 ± 0.028	1.314IleAsn: 1.314 ± 0.033	1.964IlePro: 1.964 ± 0.042	1.067IleGln: 1.067 ± 0.026	3.173IleArg: 3.173 ± 0.051	2.488IleSer: 2.488 ± 0.048	1.981IleThr: 1.981 ± 0.039	3.768IleVal: 3.768 ± 0.059	0.502IleTrp: 0.502 ± 0.019	0.886IleTyr: 0.886 ± 0.027	0.004IleXaa: 0.004 ± 0.002
Lys	2.931LysAla: 2.931 ± 0.062	0.152LysCys: 0.152 ± 0.011	1.192LysAsp: 1.192 ± 0.033	1.295LysGlu: 1.295 ± 0.037	0.643LysPhe: 0.643 ± 0.023	1.889LysGly: 1.889 ± 0.044	0.492LysHis: 0.492 ± 0.02	1.107LysIle: 1.107 ± 0.034	0.904LysLys: 0.904 ± 0.034	2.751LysLeu: 2.751 ± 0.047	0.573LysMet: 0.573 ± 0.025	0.623LysAsn: 0.623 ± 0.027	1.542LysPro: 1.542 ± 0.042	0.96LysGln: 0.96 ± 0.03	1.983LysArg: 1.983 ± 0.04	1.36LysSer: 1.36 ± 0.036	1.301LysThr: 1.301 ± 0.034	1.826LysVal: 1.826 ± 0.041	0.282LysTrp: 0.282 ± 0.014	0.517LysTyr: 0.517 ± 0.022	0.004LysXaa: 0.004 ± 0.002
Leu	17.523LeuAla: 17.523 ± 0.169	1.165LeuCys: 1.165 ± 0.037	6.308LeuAsp: 6.308 ± 0.081	5.26LeuGlu: 5.26 ± 0.073	3.652LeuPhe: 3.652 ± 0.06	8.492LeuGly: 8.492 ± 0.095	2.58LeuHis: 2.58 ± 0.048	4.676LeuIle: 4.676 ± 0.067	2.629LeuLys: 2.629 ± 0.051	14.669LeuLeu: 14.669 ± 0.162	2.027LeuMet: 2.027 ± 0.042	2.413LeuAsn: 2.413 ± 0.05	7.178LeuPro: 7.178 ± 0.084	4.602LeuGln: 4.602 ± 0.076	9.626LeuArg: 9.626 ± 0.09	6.167LeuSer: 6.167 ± 0.072	4.976LeuThr: 4.976 ± 0.068	7.881LeuVal: 7.881 ± 0.085	1.303LeuTrp: 1.303 ± 0.038	2.054LeuTyr: 2.054 ± 0.043	0.008LeuXaa: 0.008 ± 0.003
Met	2.479MetAla: 2.479 ± 0.042	0.136MetCys: 0.136 ± 0.011	0.856MetAsp: 0.856 ± 0.024	0.858MetGlu: 0.858 ± 0.03	0.588MetPhe: 0.588 ± 0.023	1.335MetGly: 1.335 ± 0.037	0.458MetHis: 0.458 ± 0.021	0.984MetIle: 0.984 ± 0.031	0.811MetLys: 0.811 ± 0.027	2.395MetLeu: 2.395 ± 0.056	0.451MetMet: 0.451 ± 0.019	0.719MetAsn: 0.719 ± 0.025	1.355MetPro: 1.355 ± 0.036	0.855MetGln: 0.855 ± 0.024	1.688MetArg: 1.688 ± 0.038	1.441MetSer: 1.441 ± 0.04	1.166MetThr: 1.166 ± 0.027	1.38MetVal: 1.38 ± 0.037	0.171MetTrp: 0.171 ± 0.011	0.292MetTyr: 0.292 ± 0.015	0.002MetXaa: 0.002 ± 0.001
Asn	2.738AsnAla: 2.738 ± 0.055	0.293AsnCys: 0.293 ± 0.018	1.253AsnAsp: 1.253 ± 0.035	1.236AsnGlu: 1.236 ± 0.035	0.834AsnPhe: 0.834 ± 0.028	2.049AsnGly: 2.049 ± 0.06	0.518AsnHis: 0.518 ± 0.024	1.036AsnIle: 1.036 ± 0.034	0.549AsnLys: 0.549 ± 0.021	2.628AsnLeu: 2.628 ± 0.049	0.436AsnMet: 0.436 ± 0.02	0.629AsnAsn: 0.629 ± 0.033	1.688AsnPro: 1.688 ± 0.044	0.799AsnGln: 0.799 ± 0.029	1.899AsnArg: 1.899 ± 0.036	1.187AsnSer: 1.187 ± 0.035	1.062AsnThr: 1.062 ± 0.034	1.651AsnVal: 1.651 ± 0.04	0.385AsnTrp: 0.385 ± 0.017	0.581AsnTyr: 0.581 ± 0.026	0.003AsnXaa: 0.003 ± 0.002
Pro	7.794ProAla: 7.794 ± 0.106	0.491ProCys: 0.491 ± 0.017	2.977ProAsp: 2.977 ± 0.055	3.247ProGlu: 3.247 ± 0.054	1.775ProPhe: 1.775 ± 0.037	4.618ProGly: 4.618 ± 0.069	0.983ProHis: 0.983 ± 0.029	1.82ProIle: 1.82 ± 0.038	1.119ProLys: 1.119 ± 0.03	5.946ProLeu: 5.946 ± 0.081	1.056ProMet: 1.056 ± 0.033	1.009ProAsn: 1.009 ± 0.029	3.313ProPro: 3.313 ± 0.059	2.035ProGln: 2.035 ± 0.043	3.46ProArg: 3.46 ± 0.056	2.423ProSer: 2.423 ± 0.051	2.291ProThr: 2.291 ± 0.047	3.96ProVal: 3.96 ± 0.058	0.779ProTrp: 0.779 ± 0.024	1.087ProTyr: 1.087 ± 0.033	0.003ProXaa: 0.003 ± 0.001
Gln	5.032GlnAla: 5.032 ± 0.071	0.315GlnCys: 0.315 ± 0.018	1.393GlnAsp: 1.393 ± 0.034	1.819GlnGlu: 1.819 ± 0.037	1.117GlnPhe: 1.117 ± 0.031	2.623GlnGly: 2.623 ± 0.047	0.929GlnHis: 0.929 ± 0.028	1.729GlnIle: 1.729 ± 0.041	1.001GlnLys: 1.001 ± 0.03	4.366GlnLeu: 4.366 ± 0.066	0.862GlnMet: 0.862 ± 0.028	0.712GlnAsn: 0.712 ± 0.027	2.386GlnPro: 2.386 ± 0.045	1.991GlnGln: 1.991 ± 0.047	3.952GlnArg: 3.952 ± 0.069	1.86GlnSer: 1.86 ± 0.04	1.679GlnThr: 1.679 ± 0.048	2.837GlnVal: 2.837 ± 0.046	0.502GlnTrp: 0.502 ± 0.022	0.635GlnTyr: 0.635 ± 0.021	0.002GlnXaa: 0.002 ± 0.001
Arg	8.493ArgAla: 8.493 ± 0.108	0.982ArgCys: 0.982 ± 0.028	4.145ArgAsp: 4.145 ± 0.059	4.764ArgGlu: 4.764 ± 0.069	3.214ArgPhe: 3.214 ± 0.048	5.123ArgGly: 5.123 ± 0.07	2.471ArgHis: 2.471 ± 0.052	4.149ArgIle: 4.149 ± 0.058	1.99ArgLys: 1.99 ± 0.043	10.71ArgLeu: 10.71 ± 0.105	1.928ArgMet: 1.928 ± 0.046	1.981ArgAsn: 1.981 ± 0.038	4.113ArgPro: 4.113 ± 0.063	4.33ArgGln: 4.33 ± 0.074	7.755ArgArg: 7.755 ± 0.103	4.607ArgSer: 4.607 ± 0.069	3.232ArgThr: 3.232 ± 0.05	5.713ArgVal: 5.713 ± 0.071	1.249ArgTrp: 1.249 ± 0.033	1.937ArgTyr: 1.937 ± 0.046	0.006ArgXaa: 0.006 ± 0.002
Ser	6.258SerAla: 6.258 ± 0.078	0.654SerCys: 0.654 ± 0.029	2.807SerAsp: 2.807 ± 0.055	3.114SerGlu: 3.114 ± 0.051	2.194SerPhe: 2.194 ± 0.046	5.832SerGly: 5.832 ± 0.09	1.108SerHis: 1.108 ± 0.031	2.393SerIle: 2.393 ± 0.053	1.178SerLys: 1.178 ± 0.031	6.449SerLeu: 6.449 ± 0.086	1.136SerMet: 1.136 ± 0.03	1.284SerAsn: 1.284 ± 0.039	3.088SerPro: 3.088 ± 0.06	1.706SerGln: 1.706 ± 0.038	4.307SerArg: 4.307 ± 0.065	3.281SerSer: 3.281 ± 0.066	2.503SerThr: 2.503 ± 0.056	3.768SerVal: 3.768 ± 0.057	0.773SerTrp: 0.773 ± 0.023	1.253SerTyr: 1.253 ± 0.033	0.006SerXaa: 0.006 ± 0.002
Thr	5.88ThrAla: 5.88 ± 0.079	0.378ThrCys: 0.378 ± 0.017	2.098ThrAsp: 2.098 ± 0.045	1.832ThrGlu: 1.832 ± 0.044	1.4ThrPhe: 1.4 ± 0.037	3.972ThrGly: 3.972 ± 0.067	0.982ThrHis: 0.982 ± 0.028	2.234ThrIle: 2.234 ± 0.047	0.786ThrLys: 0.786 ± 0.03	5.832ThrLeu: 5.832 ± 0.084	0.888ThrMet: 0.888 ± 0.028	0.964ThrAsn: 0.964 ± 0.033	2.914ThrPro: 2.914 ± 0.062	1.43ThrGln: 1.43 ± 0.037	3.389ThrArg: 3.389 ± 0.057	2.285ThrSer: 2.285 ± 0.054	2.44ThrThr: 2.44 ± 0.058	3.76ThrVal: 3.76 ± 0.048	0.591ThrTrp: 0.591 ± 0.025	0.884ThrTyr: 0.884 ± 0.037	0.005ThrXaa: 0.005 ± 0.002
Val	9.952ValAla: 9.952 ± 0.104	0.847ValCys: 0.847 ± 0.025	4.454ValAsp: 4.454 ± 0.071	4.303ValGlu: 4.303 ± 0.065	2.791ValPhe: 2.791 ± 0.047	5.879ValGly: 5.879 ± 0.082	1.527ValHis: 1.527 ± 0.034	3.326ValIle: 3.326 ± 0.055	1.655ValLys: 1.655 ± 0.039	8.117ValLeu: 8.117 ± 0.09	1.458ValMet: 1.458 ± 0.033	1.699ValAsn: 1.699 ± 0.036	3.524ValPro: 3.524 ± 0.054	2.118ValGln: 2.118 ± 0.042	5.563ValArg: 5.563 ± 0.063	4.105ValSer: 4.105 ± 0.061	3.4ValThr: 3.4 ± 0.063	6.354ValVal: 6.354 ± 0.08	0.883ValTrp: 0.883 ± 0.026	1.38ValTyr: 1.38 ± 0.034	0.002ValXaa: 0.002 ± 0.002
Trp	1.155TrpAla: 1.155 ± 0.032	0.174TrpCys: 0.174 ± 0.013	0.519TrpAsp: 0.519 ± 0.025	0.595TrpGlu: 0.595 ± 0.023	0.539TrpPhe: 0.539 ± 0.021	0.795TrpGly: 0.795 ± 0.03	0.35TrpHis: 0.35 ± 0.017	0.63TrpIle: 0.63 ± 0.025	0.345TrpLys: 0.345 ± 0.018	2.289TrpLeu: 2.289 ± 0.052	0.274TrpMet: 0.274 ± 0.014	0.38TrpAsn: 0.38 ± 0.018	0.731TrpPro: 0.731 ± 0.027	0.961TrpGln: 0.961 ± 0.031	1.471TrpArg: 1.471 ± 0.044	0.809TrpSer: 0.809 ± 0.03	0.584TrpThr: 0.584 ± 0.024	0.825TrpVal: 0.825 ± 0.026	0.242TrpTrp: 0.242 ± 0.016	0.291TrpTyr: 0.291 ± 0.017	0.002TrpXaa: 0.002 ± 0.001
Tyr	2.27TyrAla: 2.27 ± 0.045	0.282TyrCys: 0.282 ± 0.015	1.172TyrAsp: 1.172 ± 0.046	1.027TyrGlu: 1.027 ± 0.028	0.831TyrPhe: 0.831 ± 0.03	1.837TyrGly: 1.837 ± 0.04	0.546TyrHis: 0.546 ± 0.024	0.653TyrIle: 0.653 ± 0.021	0.417TyrLys: 0.417 ± 0.02	2.516TyrLeu: 2.516 ± 0.051	0.332TyrMet: 0.332 ± 0.016	0.511TyrAsn: 0.511 ± 0.024	1.095TyrPro: 1.095 ± 0.032	0.858TyrGln: 0.858 ± 0.026	2.064TyrArg: 2.064 ± 0.045	1.167TyrSer: 1.167 ± 0.035	0.941TyrThr: 0.941 ± 0.031	1.514TyrVal: 1.514 ± 0.033	0.346TyrTrp: 0.346 ± 0.017	0.561TyrTyr: 0.561 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.008XaaAla: 0.008 ± 0.003	0.003XaaCys: 0.003 ± 0.002	0.006XaaAsp: 0.006 ± 0.002	0.002XaaGlu: 0.002 ± 0.001	0.006XaaPhe: 0.006 ± 0.003	0.003XaaGly: 0.003 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.006XaaIle: 0.006 ± 0.002	0.002XaaLys: 0.002 ± 0.001	0.006XaaLeu: 0.006 ± 0.002	0.002XaaMet: 0.002 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.004XaaArg: 0.004 ± 0.002	0.006XaaSer: 0.006 ± 0.002	0.006XaaThr: 0.006 ± 0.002	0.005XaaVal: 0.005 ± 0.002	0.002XaaTrp: 0.002 ± 0.001	0.003XaaTyr: 0.003 ± 0.002	0.152XaaXaa: 0.152 ± 0.033

Statistics based on 3906 proteins (1261008 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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