Amino acid dipepetide frequency for Kockovaella imperatae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.548AlaAla: 8.548 ± 0.075	0.921AlaCys: 0.921 ± 0.017	4.143AlaAsp: 4.143 ± 0.041	5.215AlaGlu: 5.215 ± 0.056	3.045AlaPhe: 3.045 ± 0.031	6.065AlaGly: 6.065 ± 0.048	1.825AlaHis: 1.825 ± 0.024	4.103AlaIle: 4.103 ± 0.035	4.212AlaLys: 4.212 ± 0.043	7.867AlaLeu: 7.867 ± 0.054	2.131AlaMet: 2.131 ± 0.022	2.698AlaAsn: 2.698 ± 0.029	5.13AlaPro: 5.13 ± 0.056	3.487AlaGln: 3.487 ± 0.035	5.225AlaArg: 5.225 ± 0.043	8.306AlaSer: 8.306 ± 0.068	4.887AlaThr: 4.887 ± 0.044	5.145AlaVal: 5.145 ± 0.04	1.215AlaTrp: 1.215 ± 0.021	2.05AlaTyr: 2.05 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.79CysAla: 0.79 ± 0.015	0.201CysCys: 0.201 ± 0.009	0.564CysAsp: 0.564 ± 0.014	0.514CysGlu: 0.514 ± 0.011	0.44CysPhe: 0.44 ± 0.012	0.815CysGly: 0.815 ± 0.017	0.302CysHis: 0.302 ± 0.01	0.583CysIle: 0.583 ± 0.012	0.417CysLys: 0.417 ± 0.013	1.156CysLeu: 1.156 ± 0.021	0.236CysMet: 0.236 ± 0.008	0.325CysAsn: 0.325 ± 0.01	0.632CysPro: 0.632 ± 0.013	0.424CysGln: 0.424 ± 0.011	0.655CysArg: 0.655 ± 0.013	0.828CysSer: 0.828 ± 0.016	0.604CysThr: 0.604 ± 0.014	0.724CysVal: 0.724 ± 0.015	0.177CysTrp: 0.177 ± 0.007	0.271CysTyr: 0.271 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.563AspAla: 4.563 ± 0.039	0.539AspCys: 0.539 ± 0.012	4.313AspAsp: 4.313 ± 0.059	4.771AspGlu: 4.771 ± 0.05	1.925AspPhe: 1.925 ± 0.023	4.214AspGly: 4.214 ± 0.042	1.358AspHis: 1.358 ± 0.018	2.804AspIle: 2.804 ± 0.03	2.402AspLys: 2.402 ± 0.028	5.419AspLeu: 5.419 ± 0.042	1.298AspMet: 1.298 ± 0.02	1.535AspAsn: 1.535 ± 0.021	3.694AspPro: 3.694 ± 0.03	2.138AspGln: 2.138 ± 0.027	3.272AspArg: 3.272 ± 0.037	4.184AspSer: 4.184 ± 0.037	2.837AspThr: 2.837 ± 0.03	3.606AspVal: 3.606 ± 0.033	0.925AspTrp: 0.925 ± 0.015	1.424AspTyr: 1.424 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.457GluAla: 5.457 ± 0.051	0.531GluCys: 0.531 ± 0.014	4.457GluAsp: 4.457 ± 0.05	5.552GluGlu: 5.552 ± 0.068	1.573GluPhe: 1.573 ± 0.021	4.03GluGly: 4.03 ± 0.034	1.333GluHis: 1.333 ± 0.02	2.921GluIle: 2.921 ± 0.03	3.256GluLys: 3.256 ± 0.039	4.953GluLeu: 4.953 ± 0.044	1.582GluMet: 1.582 ± 0.021	1.83GluAsn: 1.83 ± 0.024	2.763GluPro: 2.763 ± 0.031	2.276GluGln: 2.276 ± 0.027	4.045GluArg: 4.045 ± 0.039	4.541GluSer: 4.541 ± 0.039	3.325GluThr: 3.325 ± 0.032	3.594GluVal: 3.594 ± 0.04	0.917GluTrp: 0.917 ± 0.016	1.414GluTyr: 1.414 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.956PheAla: 2.956 ± 0.026	0.457PheCys: 0.457 ± 0.012	2.171PheAsp: 2.171 ± 0.029	1.952PheGlu: 1.952 ± 0.021	1.411PhePhe: 1.411 ± 0.023	2.815PheGly: 2.815 ± 0.047	0.834PheHis: 0.834 ± 0.016	1.622PheIle: 1.622 ± 0.024	1.417PheLys: 1.417 ± 0.019	3.003PheLeu: 3.003 ± 0.036	0.705PheMet: 0.705 ± 0.013	1.235PheAsn: 1.235 ± 0.019	1.818PhePro: 1.818 ± 0.026	1.179PheGln: 1.179 ± 0.02	1.767PheArg: 1.767 ± 0.023	2.757PheSer: 2.757 ± 0.028	1.976PheThr: 1.976 ± 0.025	2.135PheVal: 2.135 ± 0.026	0.578PheTrp: 0.578 ± 0.014	0.919PheTyr: 0.919 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.307GlyAla: 5.307 ± 0.041	0.771GlyCys: 0.771 ± 0.016	3.834GlyAsp: 3.834 ± 0.039	3.952GlyGlu: 3.952 ± 0.04	2.491GlyPhe: 2.491 ± 0.029	6.656GlyGly: 6.656 ± 0.089	1.728GlyHis: 1.728 ± 0.021	3.403GlyIle: 3.403 ± 0.033	3.676GlyLys: 3.676 ± 0.037	6.122GlyLeu: 6.122 ± 0.052	1.8GlyMet: 1.8 ± 0.028	2.257GlyAsn: 2.257 ± 0.028	3.944GlyPro: 3.944 ± 0.041	2.956GlyGln: 2.956 ± 0.038	4.366GlyArg: 4.366 ± 0.038	6.786GlySer: 6.786 ± 0.057	4.023GlyThr: 4.023 ± 0.034	4.366GlyVal: 4.366 ± 0.04	1.262GlyTrp: 1.262 ± 0.023	2.023GlyTyr: 2.023 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.898HisAla: 1.898 ± 0.023	0.286HisCys: 0.286 ± 0.01	1.262HisAsp: 1.262 ± 0.019	1.273HisGlu: 1.273 ± 0.022	0.867HisPhe: 0.867 ± 0.017	1.718HisGly: 1.718 ± 0.022	0.942HisHis: 0.942 ± 0.023	1.098HisIle: 1.098 ± 0.018	0.798HisLys: 0.798 ± 0.017	2.528HisLeu: 2.528 ± 0.026	0.459HisMet: 0.459 ± 0.011	0.662HisAsn: 0.662 ± 0.012	1.911HisPro: 1.911 ± 0.026	0.967HisGln: 0.967 ± 0.018	1.666HisArg: 1.666 ± 0.025	2.031HisSer: 2.031 ± 0.026	1.281HisThr: 1.281 ± 0.02	1.467HisVal: 1.467 ± 0.018	0.337HisTrp: 0.337 ± 0.01	0.612HisTyr: 0.612 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.054IleAla: 4.054 ± 0.038	0.669IleCys: 0.669 ± 0.016	2.809IleAsp: 2.809 ± 0.027	2.697IleGlu: 2.697 ± 0.03	1.712IlePhe: 1.712 ± 0.025	3.281IleGly: 3.281 ± 0.031	1.206IleHis: 1.206 ± 0.018	2.408IleIle: 2.408 ± 0.033	2.191IleLys: 2.191 ± 0.03	4.492IleLeu: 4.492 ± 0.046	1.014IleMet: 1.014 ± 0.018	1.598IleAsn: 1.598 ± 0.025	3.265IlePro: 3.265 ± 0.033	1.793IleGln: 1.793 ± 0.021	2.813IleArg: 2.813 ± 0.031	3.863IleSer: 3.863 ± 0.037	2.668IleThr: 2.668 ± 0.028	3.052IleVal: 3.052 ± 0.031	0.701IleTrp: 0.701 ± 0.017	1.219IleTyr: 1.219 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.359LysAla: 4.359 ± 0.048	0.424LysCys: 0.424 ± 0.011	2.707LysAsp: 2.707 ± 0.031	3.131LysGlu: 3.131 ± 0.037	1.172LysPhe: 1.172 ± 0.019	3.242LysGly: 3.242 ± 0.039	1.025LysHis: 1.025 ± 0.017	2.13LysIle: 2.13 ± 0.029	2.894LysLys: 2.894 ± 0.043	3.733LysLeu: 3.733 ± 0.036	1.049LysMet: 1.049 ± 0.02	1.302LysAsn: 1.302 ± 0.019	2.526LysPro: 2.526 ± 0.035	1.632LysGln: 1.632 ± 0.023	3.629LysArg: 3.629 ± 0.038	3.637LysSer: 3.637 ± 0.038	2.729LysThr: 2.729 ± 0.035	2.867LysVal: 2.867 ± 0.032	0.682LysTrp: 0.682 ± 0.016	1.17LysTyr: 1.17 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.17LeuAla: 8.17 ± 0.058	1.094LeuCys: 1.094 ± 0.017	5.404LeuAsp: 5.404 ± 0.04	5.364LeuGlu: 5.364 ± 0.048	3.179LeuPhe: 3.179 ± 0.034	6.139LeuGly: 6.139 ± 0.049	2.194LeuHis: 2.194 ± 0.028	4.001LeuIle: 4.001 ± 0.039	4.007LeuLys: 4.007 ± 0.04	8.403LeuLeu: 8.403 ± 0.072	1.749LeuMet: 1.749 ± 0.023	3.003LeuAsn: 3.003 ± 0.032	6.286LeuPro: 6.286 ± 0.043	3.4LeuGln: 3.4 ± 0.034	5.698LeuArg: 5.698 ± 0.048	8.056LeuSer: 8.056 ± 0.057	4.926LeuThr: 4.926 ± 0.04	5.512LeuVal: 5.512 ± 0.046	1.14LeuTrp: 1.14 ± 0.02	2.181LeuTyr: 2.181 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.08MetAla: 2.08 ± 0.025	0.229MetCys: 0.229 ± 0.008	1.4MetAsp: 1.4 ± 0.02	1.334MetGlu: 1.334 ± 0.02	0.715MetPhe: 0.715 ± 0.015	1.588MetGly: 1.588 ± 0.024	0.386MetHis: 0.386 ± 0.01	1.079MetIle: 1.079 ± 0.017	0.947MetLys: 0.947 ± 0.017	1.831MetLeu: 1.831 ± 0.024	0.664MetMet: 0.664 ± 0.017	0.724MetAsn: 0.724 ± 0.014	1.403MetPro: 1.403 ± 0.023	0.76MetGln: 0.76 ± 0.014	1.325MetArg: 1.325 ± 0.021	2.308MetSer: 2.308 ± 0.025	1.558MetThr: 1.558 ± 0.023	1.26MetVal: 1.26 ± 0.02	0.265MetTrp: 0.265 ± 0.008	0.5MetTyr: 0.5 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.867AsnAla: 2.867 ± 0.033	0.332AsnCys: 0.332 ± 0.011	1.802AsnAsp: 1.802 ± 0.024	1.738AsnGlu: 1.738 ± 0.026	1.072AsnPhe: 1.072 ± 0.018	2.898AsnGly: 2.898 ± 0.033	0.793AsnHis: 0.793 ± 0.015	1.591AsnIle: 1.591 ± 0.023	1.228AsnLys: 1.228 ± 0.019	3.068AsnLeu: 3.068 ± 0.03	0.701AsnMet: 0.701 ± 0.013	1.042AsnAsn: 1.042 ± 0.022	2.175AsnPro: 2.175 ± 0.025	1.174AsnGln: 1.174 ± 0.021	1.786AsnArg: 1.786 ± 0.021	2.29AsnSer: 2.29 ± 0.026	1.819AsnThr: 1.819 ± 0.023	2.199AsnVal: 2.199 ± 0.026	0.457AsnTrp: 0.457 ± 0.013	0.789AsnTyr: 0.789 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.446ProAla: 5.446 ± 0.053	0.476ProCys: 0.476 ± 0.013	3.172ProAsp: 3.172 ± 0.031	3.612ProGlu: 3.612 ± 0.035	2.126ProPhe: 2.126 ± 0.029	4.121ProGly: 4.121 ± 0.045	1.517ProHis: 1.517 ± 0.023	2.925ProIle: 2.925 ± 0.029	2.608ProLys: 2.608 ± 0.031	5.514ProLeu: 5.514 ± 0.045	1.204ProMet: 1.204 ± 0.019	2.111ProAsn: 2.111 ± 0.028	6.343ProPro: 6.343 ± 0.087	2.312ProGln: 2.312 ± 0.032	3.816ProArg: 3.816 ± 0.04	7.919ProSer: 7.919 ± 0.072	4.385ProThr: 4.385 ± 0.046	3.826ProVal: 3.826 ± 0.037	0.774ProTrp: 0.774 ± 0.015	1.512ProTyr: 1.512 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.732GlnAla: 3.732 ± 0.036	0.408GlnCys: 0.408 ± 0.013	1.972GlnAsp: 1.972 ± 0.023	2.066GlnGlu: 2.066 ± 0.026	1.059GlnPhe: 1.059 ± 0.017	2.557GlnGly: 2.557 ± 0.028	0.977GlnHis: 0.977 ± 0.017	1.785GlnIle: 1.785 ± 0.024	1.592GlnLys: 1.592 ± 0.025	3.296GlnLeu: 3.296 ± 0.036	0.901GlnMet: 0.901 ± 0.016	1.275GlnAsn: 1.275 ± 0.021	2.494GlnPro: 2.494 ± 0.034	1.978GlnGln: 1.978 ± 0.062	2.544GlnArg: 2.544 ± 0.027	3.428GlnSer: 3.428 ± 0.033	2.354GlnThr: 2.354 ± 0.027	2.3GlnVal: 2.3 ± 0.026	0.539GlnTrp: 0.539 ± 0.012	1.018GlnTyr: 1.018 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	5.154ArgAla: 5.154 ± 0.042	0.607ArgCys: 0.607 ± 0.015	3.538ArgAsp: 3.538 ± 0.036	3.711ArgGlu: 3.711 ± 0.038	1.992ArgPhe: 1.992 ± 0.027	4.085ArgGly: 4.085 ± 0.043	1.629ArgHis: 1.629 ± 0.027	2.93ArgIle: 2.93 ± 0.028	3.369ArgLys: 3.369 ± 0.037	5.713ArgLeu: 5.713 ± 0.042	1.472ArgMet: 1.472 ± 0.021	1.874ArgAsn: 1.874 ± 0.025	4.054ArgPro: 4.054 ± 0.044	2.717ArgGln: 2.717 ± 0.027	5.449ArgArg: 5.449 ± 0.061	5.55ArgSer: 5.55 ± 0.048	3.348ArgThr: 3.348 ± 0.033	3.464ArgVal: 3.464 ± 0.035	0.904ArgTrp: 0.904 ± 0.017	1.552ArgTyr: 1.552 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	7.683SerAla: 7.683 ± 0.066	0.808SerCys: 0.808 ± 0.017	4.582SerAsp: 4.582 ± 0.038	4.384SerGlu: 4.384 ± 0.041	3.035SerPhe: 3.035 ± 0.029	6.454SerGly: 6.454 ± 0.049	2.226SerHis: 2.226 ± 0.028	4.157SerIle: 4.157 ± 0.038	3.835SerLys: 3.835 ± 0.039	8.047SerLeu: 8.047 ± 0.057	1.897SerMet: 1.897 ± 0.022	2.937SerAsn: 2.937 ± 0.029	6.632SerPro: 6.632 ± 0.077	3.319SerGln: 3.319 ± 0.035	5.908SerArg: 5.908 ± 0.05	12.05SerSer: 12.05 ± 0.125	6.642SerThr: 6.642 ± 0.063	4.892SerVal: 4.892 ± 0.036	1.123SerTrp: 1.123 ± 0.019	1.993SerTyr: 1.993 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.112ThrAla: 5.112 ± 0.047	0.658ThrCys: 0.658 ± 0.014	2.78ThrAsp: 2.78 ± 0.028	2.822ThrGlu: 2.822 ± 0.026	2.228ThrPhe: 2.228 ± 0.028	4.171ThrGly: 4.171 ± 0.037	1.354ThrHis: 1.354 ± 0.02	2.957ThrIle: 2.957 ± 0.03	2.342ThrLys: 2.342 ± 0.031	5.582ThrLeu: 5.582 ± 0.042	1.266ThrMet: 1.266 ± 0.018	1.813ThrAsn: 1.813 ± 0.027	4.801ThrPro: 4.801 ± 0.059	1.962ThrGln: 1.962 ± 0.028	3.253ThrArg: 3.253 ± 0.031	6.202ThrSer: 6.202 ± 0.059	3.983ThrThr: 3.983 ± 0.043	3.601ThrVal: 3.601 ± 0.038	0.826ThrTrp: 0.826 ± 0.016	1.467ThrTyr: 1.467 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	4.879ValAla: 4.879 ± 0.039	0.726ValCys: 0.726 ± 0.014	3.857ValAsp: 3.857 ± 0.036	4.003ValGlu: 4.003 ± 0.042	2.173ValPhe: 2.173 ± 0.026	4.002ValGly: 4.002 ± 0.033	1.401ValHis: 1.401 ± 0.019	3.042ValIle: 3.042 ± 0.03	3.142ValLys: 3.142 ± 0.036	5.436ValLeu: 5.436 ± 0.042	1.352ValMet: 1.352 ± 0.02	2.113ValAsn: 2.113 ± 0.029	3.808ValPro: 3.808 ± 0.034	2.326ValGln: 2.326 ± 0.028	3.414ValArg: 3.414 ± 0.031	4.829ValSer: 4.829 ± 0.04	3.35ValThr: 3.35 ± 0.033	4.045ValVal: 4.045 ± 0.037	0.908ValTrp: 0.908 ± 0.014	1.531ValTyr: 1.531 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.089TrpAla: 1.089 ± 0.018	0.194TrpCys: 0.194 ± 0.008	0.896TrpAsp: 0.896 ± 0.016	0.854TrpGlu: 0.854 ± 0.017	0.498TrpPhe: 0.498 ± 0.012	0.956TrpGly: 0.956 ± 0.019	0.31TrpHis: 0.31 ± 0.009	0.788TrpIle: 0.788 ± 0.015	0.741TrpLys: 0.741 ± 0.013	1.286TrpLeu: 1.286 ± 0.021	0.375TrpMet: 0.375 ± 0.009	0.558TrpAsn: 0.558 ± 0.012	0.577TrpPro: 0.577 ± 0.011	0.553TrpGln: 0.553 ± 0.013	0.999TrpArg: 0.999 ± 0.016	1.217TrpSer: 1.217 ± 0.02	0.995TrpThr: 0.995 ± 0.018	0.847TrpVal: 0.847 ± 0.014	0.314TrpTrp: 0.314 ± 0.01	0.391TrpTyr: 0.391 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.075TyrAla: 2.075 ± 0.027	0.325TyrCys: 0.325 ± 0.011	1.562TyrAsp: 1.562 ± 0.023	1.405TyrGlu: 1.405 ± 0.018	0.992TyrPhe: 0.992 ± 0.016	1.914TyrGly: 1.914 ± 0.028	0.724TyrHis: 0.724 ± 0.015	1.181TyrIle: 1.181 ± 0.02	0.964TyrLys: 0.964 ± 0.017	2.456TyrLeu: 2.456 ± 0.031	0.499TyrMet: 0.499 ± 0.013	0.93TyrAsn: 0.93 ± 0.016	1.463TyrPro: 1.463 ± 0.023	0.924TyrGln: 0.924 ± 0.017	1.484TyrArg: 1.484 ± 0.021	1.826TyrSer: 1.826 ± 0.024	1.486TyrThr: 1.486 ± 0.021	1.433TyrVal: 1.433 ± 0.022	0.393TyrTrp: 0.393 ± 0.012	0.726TyrTyr: 0.726 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7388 proteins (3644630 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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