Amino acid dipepetide frequency for Streptococcus satellite phage Javan753

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.384AlaAla: 1.384 ± 0.765
0.277AlaCys: 0.277 ± 0.32
3.32AlaAsp: 3.32 ± 0.998
4.704AlaGlu: 4.704 ± 1.354
1.66AlaPhe: 1.66 ± 0.647
2.49AlaGly: 2.49 ± 0.834
0.277AlaHis: 0.277 ± 0.335
3.874AlaIle: 3.874 ± 0.77
5.257AlaLys: 5.257 ± 1.009
6.364AlaLeu: 6.364 ± 1.024
1.384AlaMet: 1.384 ± 0.664
4.151AlaAsn: 4.151 ± 1.022
0.277AlaPro: 0.277 ± 0.251
2.49AlaGln: 2.49 ± 0.861
6.087AlaArg: 6.087 ± 0.982
2.214AlaSer: 2.214 ± 0.719
3.597AlaThr: 3.597 ± 1.007
4.981AlaVal: 4.981 ± 0.884
0.553AlaTrp: 0.553 ± 0.431
2.214AlaTyr: 2.214 ± 0.812
0.0AlaXaa: 0.0 ± 0.0
Cys
0.553CysAla: 0.553 ± 0.314
0.0CysCys: 0.0 ± 0.0
0.553CysAsp: 0.553 ± 0.369
0.277CysGlu: 0.277 ± 0.32
0.277CysPhe: 0.277 ± 0.264
0.83CysGly: 0.83 ± 0.527
0.553CysHis: 0.553 ± 0.289
1.384CysIle: 1.384 ± 0.509
0.553CysLys: 0.553 ± 0.337
1.107CysLeu: 1.107 ± 0.547
0.0CysMet: 0.0 ± 0.0
0.553CysAsn: 0.553 ± 0.357
0.83CysPro: 0.83 ± 0.509
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.277CysVal: 0.277 ± 0.314
0.0CysTrp: 0.0 ± 0.0
0.277CysTyr: 0.277 ± 0.314
0.0CysXaa: 0.0 ± 0.0
Asp
1.937AspAla: 1.937 ± 0.629
0.83AspCys: 0.83 ± 0.438
4.981AspAsp: 4.981 ± 1.104
4.981AspGlu: 4.981 ± 1.245
3.32AspPhe: 3.32 ± 1.024
2.49AspGly: 2.49 ± 0.659
0.0AspHis: 0.0 ± 0.0
6.364AspIle: 6.364 ± 1.039
5.534AspLys: 5.534 ± 0.84
7.194AspLeu: 7.194 ± 1.561
2.49AspMet: 2.49 ± 0.856
2.49AspAsn: 2.49 ± 0.809
1.107AspPro: 1.107 ± 0.547
1.384AspGln: 1.384 ± 0.597
2.49AspArg: 2.49 ± 0.685
1.937AspSer: 1.937 ± 0.664
2.49AspThr: 2.49 ± 0.97
2.214AspVal: 2.214 ± 0.681
0.553AspTrp: 0.553 ± 0.35
2.767AspTyr: 2.767 ± 0.951
0.0AspXaa: 0.0 ± 0.0
Glu
6.364GluAla: 6.364 ± 1.263
1.384GluCys: 1.384 ± 0.651
3.32GluAsp: 3.32 ± 1.127
7.194GluGlu: 7.194 ± 1.743
2.49GluPhe: 2.49 ± 0.989
3.044GluGly: 3.044 ± 0.937
1.384GluHis: 1.384 ± 0.641
9.131GluIle: 9.131 ± 1.584
7.471GluLys: 7.471 ± 1.505
8.854GluLeu: 8.854 ± 1.202
2.767GluMet: 2.767 ± 0.809
6.918GluAsn: 6.918 ± 1.615
1.384GluPro: 1.384 ± 0.692
4.151GluGln: 4.151 ± 0.924
5.257GluArg: 5.257 ± 1.224
4.151GluSer: 4.151 ± 1.305
3.597GluThr: 3.597 ± 0.888
5.534GluVal: 5.534 ± 1.481
0.553GluTrp: 0.553 ± 0.289
3.32GluTyr: 3.32 ± 0.859
0.0GluXaa: 0.0 ± 0.0
Phe
1.107PheAla: 1.107 ± 0.651
0.553PheCys: 0.553 ± 0.48
3.32PheAsp: 3.32 ± 0.839
2.767PheGlu: 2.767 ± 0.803
1.66PhePhe: 1.66 ± 0.798
1.937PheGly: 1.937 ± 0.654
0.277PheHis: 0.277 ± 0.227
3.874PheIle: 3.874 ± 1.002
3.874PheLys: 3.874 ± 0.953
3.32PheLeu: 3.32 ± 0.996
1.107PheMet: 1.107 ± 0.601
2.214PheAsn: 2.214 ± 0.59
0.277PhePro: 0.277 ± 0.322
3.32PheGln: 3.32 ± 0.79
2.214PheArg: 2.214 ± 0.714
3.044PheSer: 3.044 ± 0.719
1.384PheThr: 1.384 ± 0.473
1.107PheVal: 1.107 ± 0.547
0.277PheTrp: 0.277 ± 0.341
2.49PheTyr: 2.49 ± 0.781
0.0PheXaa: 0.0 ± 0.0
Gly
3.32GlyAla: 3.32 ± 1.208
0.553GlyCys: 0.553 ± 0.313
2.49GlyAsp: 2.49 ± 0.957
2.767GlyGlu: 2.767 ± 0.8
1.937GlyPhe: 1.937 ± 0.696
2.767GlyGly: 2.767 ± 1.181
1.107GlyHis: 1.107 ± 0.46
4.427GlyIle: 4.427 ± 1.045
4.151GlyLys: 4.151 ± 0.88
4.981GlyLeu: 4.981 ± 1.436
1.384GlyMet: 1.384 ± 0.536
2.767GlyAsn: 2.767 ± 0.86
0.553GlyPro: 0.553 ± 0.313
1.66GlyGln: 1.66 ± 0.515
2.214GlyArg: 2.214 ± 0.775
1.937GlySer: 1.937 ± 0.753
2.767GlyThr: 2.767 ± 0.794
4.427GlyVal: 4.427 ± 1.09
0.83GlyTrp: 0.83 ± 0.748
2.214GlyTyr: 2.214 ± 0.749
0.0GlyXaa: 0.0 ± 0.0
His
1.107HisAla: 1.107 ± 0.755
0.0HisCys: 0.0 ± 0.0
0.553HisAsp: 0.553 ± 0.38
1.66HisGlu: 1.66 ± 0.679
0.83HisPhe: 0.83 ± 0.493
1.107HisGly: 1.107 ± 0.52
0.0HisHis: 0.0 ± 0.0
0.277HisIle: 0.277 ± 0.227
0.553HisLys: 0.553 ± 0.335
1.384HisLeu: 1.384 ± 0.564
0.277HisMet: 0.277 ± 0.318
1.107HisAsn: 1.107 ± 0.622
0.277HisPro: 0.277 ± 0.251
0.277HisGln: 0.277 ± 0.314
1.66HisArg: 1.66 ± 0.789
1.107HisSer: 1.107 ± 0.693
0.83HisThr: 0.83 ± 0.482
0.277HisVal: 0.277 ± 0.249
0.0HisTrp: 0.0 ± 0.0
0.83HisTyr: 0.83 ± 0.38
0.0HisXaa: 0.0 ± 0.0
Ile
3.044IleAla: 3.044 ± 0.86
0.277IleCys: 0.277 ± 0.249
6.918IleAsp: 6.918 ± 1.785
8.301IleGlu: 8.301 ± 1.731
4.427IlePhe: 4.427 ± 0.848
4.427IleGly: 4.427 ± 1.099
1.107IleHis: 1.107 ± 0.627
4.427IleIle: 4.427 ± 0.916
8.024IleLys: 8.024 ± 1.276
3.597IleLeu: 3.597 ± 1.142
0.553IleMet: 0.553 ± 0.398
3.044IleAsn: 3.044 ± 1.077
3.044IlePro: 3.044 ± 1.003
3.32IleGln: 3.32 ± 1.024
3.32IleArg: 3.32 ± 0.847
6.364IleSer: 6.364 ± 1.539
2.767IleThr: 2.767 ± 0.772
3.32IleVal: 3.32 ± 0.754
0.553IleTrp: 0.553 ± 0.498
2.767IleTyr: 2.767 ± 0.897
0.0IleXaa: 0.0 ± 0.0
Lys
7.471LysAla: 7.471 ± 1.393
0.553LysCys: 0.553 ± 0.453
3.32LysAsp: 3.32 ± 1.192
9.685LysGlu: 9.685 ± 1.747
2.767LysPhe: 2.767 ± 0.765
2.214LysGly: 2.214 ± 0.659
2.214LysHis: 2.214 ± 0.768
5.257LysIle: 5.257 ± 0.958
7.748LysLys: 7.748 ± 1.422
8.024LysLeu: 8.024 ± 1.209
3.044LysMet: 3.044 ± 0.967
6.918LysAsn: 6.918 ± 1.028
3.597LysPro: 3.597 ± 1.102
3.597LysGln: 3.597 ± 0.956
6.918LysArg: 6.918 ± 1.606
4.704LysSer: 4.704 ± 0.926
7.194LysThr: 7.194 ± 1.556
3.874LysVal: 3.874 ± 0.957
1.107LysTrp: 1.107 ± 0.557
3.32LysTyr: 3.32 ± 1.069
0.0LysXaa: 0.0 ± 0.0
Leu
5.534LeuAla: 5.534 ± 1.327
0.553LeuCys: 0.553 ± 0.498
9.408LeuAsp: 9.408 ± 1.331
12.728LeuGlu: 12.728 ± 2.082
3.874LeuPhe: 3.874 ± 1.02
4.427LeuGly: 4.427 ± 1.195
0.277LeuHis: 0.277 ± 0.227
5.534LeuIle: 5.534 ± 1.349
6.918LeuLys: 6.918 ± 1.239
7.748LeuLeu: 7.748 ± 1.339
1.937LeuMet: 1.937 ± 0.693
6.641LeuAsn: 6.641 ± 1.442
3.044LeuPro: 3.044 ± 0.931
3.32LeuGln: 3.32 ± 0.821
3.32LeuArg: 3.32 ± 1.053
4.427LeuSer: 4.427 ± 1.072
5.534LeuThr: 5.534 ± 1.188
3.597LeuVal: 3.597 ± 1.107
0.83LeuTrp: 0.83 ± 0.409
4.151LeuTyr: 4.151 ± 0.928
0.0LeuXaa: 0.0 ± 0.0
Met
3.597MetAla: 3.597 ± 1.145
0.0MetCys: 0.0 ± 0.0
1.937MetAsp: 1.937 ± 0.804
3.044MetGlu: 3.044 ± 0.796
0.553MetPhe: 0.553 ± 0.361
1.937MetGly: 1.937 ± 0.607
0.0MetHis: 0.0 ± 0.0
0.277MetIle: 0.277 ± 0.261
2.214MetLys: 2.214 ± 0.616
1.384MetLeu: 1.384 ± 0.548
0.553MetMet: 0.553 ± 0.628
1.66MetAsn: 1.66 ± 0.61
0.83MetPro: 0.83 ± 0.574
0.553MetGln: 0.553 ± 0.408
1.66MetArg: 1.66 ± 0.75
1.66MetSer: 1.66 ± 0.589
3.044MetThr: 3.044 ± 1.027
1.384MetVal: 1.384 ± 0.622
0.277MetTrp: 0.277 ± 0.249
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.151AsnAla: 4.151 ± 1.013
0.553AsnCys: 0.553 ± 0.427
3.597AsnAsp: 3.597 ± 1.362
2.49AsnGlu: 2.49 ± 0.756
1.937AsnPhe: 1.937 ± 0.582
4.151AsnGly: 4.151 ± 1.02
1.107AsnHis: 1.107 ± 0.669
4.151AsnIle: 4.151 ± 1.246
6.087AsnLys: 6.087 ± 1.194
2.767AsnLeu: 2.767 ± 0.704
1.384AsnMet: 1.384 ± 0.511
1.937AsnAsn: 1.937 ± 0.717
2.767AsnPro: 2.767 ± 0.893
2.767AsnGln: 2.767 ± 0.884
1.937AsnArg: 1.937 ± 0.788
3.32AsnSer: 3.32 ± 0.792
4.427AsnThr: 4.427 ± 1.011
2.767AsnVal: 2.767 ± 1.085
0.277AsnTrp: 0.277 ± 0.227
2.214AsnTyr: 2.214 ± 0.941
0.0AsnXaa: 0.0 ± 0.0
Pro
1.384ProAla: 1.384 ± 0.746
0.277ProCys: 0.277 ± 0.249
2.214ProAsp: 2.214 ± 0.881
2.767ProGlu: 2.767 ± 0.674
1.66ProPhe: 1.66 ± 0.767
0.277ProGly: 0.277 ± 0.248
0.553ProHis: 0.553 ± 0.639
1.937ProIle: 1.937 ± 0.506
1.384ProLys: 1.384 ± 0.43
1.937ProLeu: 1.937 ± 0.535
0.277ProMet: 0.277 ± 0.249
1.66ProAsn: 1.66 ± 0.746
1.937ProPro: 1.937 ± 0.714
1.107ProGln: 1.107 ± 0.441
3.874ProArg: 3.874 ± 0.924
2.214ProSer: 2.214 ± 0.927
1.384ProThr: 1.384 ± 0.549
2.214ProVal: 2.214 ± 0.783
0.0ProTrp: 0.0 ± 0.0
1.384ProTyr: 1.384 ± 0.569
0.0ProXaa: 0.0 ± 0.0
Gln
3.597GlnAla: 3.597 ± 0.778
0.0GlnCys: 0.0 ± 0.0
1.384GlnAsp: 1.384 ± 0.648
3.597GlnGlu: 3.597 ± 0.874
0.83GlnPhe: 0.83 ± 0.48
2.767GlnGly: 2.767 ± 1.044
0.277GlnHis: 0.277 ± 0.245
1.937GlnIle: 1.937 ± 0.731
4.981GlnLys: 4.981 ± 0.84
4.981GlnLeu: 4.981 ± 1.404
1.384GlnMet: 1.384 ± 0.629
0.553GlnAsn: 0.553 ± 0.448
0.83GlnPro: 0.83 ± 0.553
1.384GlnGln: 1.384 ± 0.694
1.937GlnArg: 1.937 ± 0.588
2.214GlnSer: 2.214 ± 0.836
1.937GlnThr: 1.937 ± 0.586
3.597GlnVal: 3.597 ± 0.937
0.553GlnTrp: 0.553 ± 0.289
0.277GlnTyr: 0.277 ± 0.251
0.0GlnXaa: 0.0 ± 0.0
Arg
2.767ArgAla: 2.767 ± 0.787
0.277ArgCys: 0.277 ± 0.272
1.107ArgAsp: 1.107 ± 0.499
4.704ArgGlu: 4.704 ± 1.241
3.597ArgPhe: 3.597 ± 0.88
1.937ArgGly: 1.937 ± 1.098
1.66ArgHis: 1.66 ± 0.622
5.534ArgIle: 5.534 ± 1.003
6.087ArgLys: 6.087 ± 1.511
7.471ArgLeu: 7.471 ± 1.329
1.384ArgMet: 1.384 ± 0.746
2.49ArgAsn: 2.49 ± 0.739
0.553ArgPro: 0.553 ± 0.328
3.32ArgGln: 3.32 ± 1.024
1.937ArgArg: 1.937 ± 0.705
2.49ArgSer: 2.49 ± 0.764
3.044ArgThr: 3.044 ± 0.951
2.214ArgVal: 2.214 ± 0.728
0.553ArgTrp: 0.553 ± 0.342
2.767ArgTyr: 2.767 ± 0.924
0.0ArgXaa: 0.0 ± 0.0
Ser
1.937SerAla: 1.937 ± 0.638
0.277SerCys: 0.277 ± 0.248
2.214SerAsp: 2.214 ± 0.64
4.981SerGlu: 4.981 ± 1.609
2.767SerPhe: 2.767 ± 0.843
4.151SerGly: 4.151 ± 0.835
0.83SerHis: 0.83 ± 0.367
4.151SerIle: 4.151 ± 0.993
6.087SerLys: 6.087 ± 1.27
5.257SerLeu: 5.257 ± 1.292
2.767SerMet: 2.767 ± 0.806
4.151SerAsn: 4.151 ± 1.235
1.937SerPro: 1.937 ± 0.785
1.937SerGln: 1.937 ± 0.574
2.49SerArg: 2.49 ± 0.986
3.32SerSer: 3.32 ± 0.927
2.214SerThr: 2.214 ± 0.834
3.044SerVal: 3.044 ± 0.874
0.0SerTrp: 0.0 ± 0.0
2.767SerTyr: 2.767 ± 0.789
0.0SerXaa: 0.0 ± 0.0
Thr
2.214ThrAla: 2.214 ± 0.624
0.277ThrCys: 0.277 ± 0.275
1.66ThrAsp: 1.66 ± 0.948
2.214ThrGlu: 2.214 ± 0.568
1.66ThrPhe: 1.66 ± 0.674
3.597ThrGly: 3.597 ± 0.928
1.384ThrHis: 1.384 ± 0.444
3.32ThrIle: 3.32 ± 0.957
5.257ThrLys: 5.257 ± 1.239
5.811ThrLeu: 5.811 ± 1.139
1.66ThrMet: 1.66 ± 0.511
0.0ThrAsn: 0.0 ± 0.0
3.597ThrPro: 3.597 ± 1.172
1.66ThrGln: 1.66 ± 0.621
1.937ThrArg: 1.937 ± 0.568
4.427ThrSer: 4.427 ± 0.684
4.704ThrThr: 4.704 ± 1.054
4.981ThrVal: 4.981 ± 1.406
0.83ThrTrp: 0.83 ± 0.523
3.597ThrTyr: 3.597 ± 1.362
0.0ThrXaa: 0.0 ± 0.0
Val
4.704ValAla: 4.704 ± 1.58
0.553ValCys: 0.553 ± 0.367
2.49ValAsp: 2.49 ± 1.04
6.364ValGlu: 6.364 ± 1.46
1.66ValPhe: 1.66 ± 0.645
3.597ValGly: 3.597 ± 1.228
0.0ValHis: 0.0 ± 0.0
3.32ValIle: 3.32 ± 1.108
4.704ValLys: 4.704 ± 0.961
5.257ValLeu: 5.257 ± 1.454
1.384ValMet: 1.384 ± 0.567
3.32ValAsn: 3.32 ± 0.911
1.66ValPro: 1.66 ± 0.611
1.107ValGln: 1.107 ± 0.608
2.49ValArg: 2.49 ± 0.884
4.427ValSer: 4.427 ± 0.807
2.49ValThr: 2.49 ± 0.95
4.427ValVal: 4.427 ± 1.214
0.553ValTrp: 0.553 ± 0.404
2.214ValTyr: 2.214 ± 0.727
0.0ValXaa: 0.0 ± 0.0
Trp
0.277TrpAla: 0.277 ± 0.227
0.0TrpCys: 0.0 ± 0.0
0.83TrpAsp: 0.83 ± 0.514
1.107TrpGlu: 1.107 ± 0.584
0.277TrpPhe: 0.277 ± 0.249
0.553TrpGly: 0.553 ± 0.404
0.277TrpHis: 0.277 ± 0.249
0.553TrpIle: 0.553 ± 0.401
0.277TrpLys: 0.277 ± 0.314
0.83TrpLeu: 0.83 ± 0.401
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.553TrpGln: 0.553 ± 0.379
0.277TrpArg: 0.277 ± 0.249
0.83TrpSer: 0.83 ± 0.431
0.0TrpThr: 0.0 ± 0.0
1.107TrpVal: 1.107 ± 0.461
0.0TrpTrp: 0.0 ± 0.0
0.553TrpTyr: 0.553 ± 0.328
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.384TyrAla: 1.384 ± 0.804
0.83TyrCys: 0.83 ± 0.468
1.937TyrAsp: 1.937 ± 0.648
1.937TyrGlu: 1.937 ± 0.782
1.937TyrPhe: 1.937 ± 0.91
0.553TyrGly: 0.553 ± 0.462
0.83TyrHis: 0.83 ± 0.38
3.874TyrIle: 3.874 ± 1.277
6.364TyrLys: 6.364 ± 1.57
5.534TyrLeu: 5.534 ± 1.316
0.553TyrMet: 0.553 ± 0.384
2.214TyrAsn: 2.214 ± 0.552
1.937TyrPro: 1.937 ± 0.88
1.107TyrGln: 1.107 ± 0.494
3.874TyrArg: 3.874 ± 0.696
2.49TyrSer: 2.49 ± 0.781
1.384TyrThr: 1.384 ± 0.684
1.384TyrVal: 1.384 ± 0.604
0.0TyrTrp: 0.0 ± 0.0
0.277TyrTyr: 0.277 ± 0.335
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 27 proteins (3615 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski