Amino acid dipepetide frequency for Cryobacterium psychrophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.957AlaAla: 18.957 ± 0.178	0.729AlaCys: 0.729 ± 0.03	7.189AlaAsp: 7.189 ± 0.088	7.465AlaGlu: 7.465 ± 0.089	3.784AlaPhe: 3.784 ± 0.065	11.409AlaGly: 11.409 ± 0.108	2.457AlaHis: 2.457 ± 0.059	5.933AlaIle: 5.933 ± 0.085	2.729AlaLys: 2.729 ± 0.062	13.885AlaLeu: 13.885 ± 0.148	2.531AlaMet: 2.531 ± 0.05	2.714AlaAsn: 2.714 ± 0.052	5.906AlaPro: 5.906 ± 0.085	3.786AlaGln: 3.786 ± 0.06	8.38AlaArg: 8.38 ± 0.092	7.557AlaSer: 7.557 ± 0.083	7.664AlaThr: 7.664 ± 0.102	10.918AlaVal: 10.918 ± 0.129	1.707AlaTrp: 1.707 ± 0.046	2.116AlaTyr: 2.116 ± 0.047	0.003AlaXaa: 0.003 ± 0.001
Cys	0.728CysAla: 0.728 ± 0.033	0.069CysCys: 0.069 ± 0.009	0.337CysAsp: 0.337 ± 0.02	0.296CysGlu: 0.296 ± 0.021	0.191CysPhe: 0.191 ± 0.014	0.617CysGly: 0.617 ± 0.028	0.15CysHis: 0.15 ± 0.012	0.243CysIle: 0.243 ± 0.016	0.089CysLys: 0.089 ± 0.01	0.494CysLeu: 0.494 ± 0.022	0.11CysMet: 0.11 ± 0.01	0.125CysAsn: 0.125 ± 0.012	0.348CysPro: 0.348 ± 0.018	0.151CysGln: 0.151 ± 0.012	0.398CysArg: 0.398 ± 0.021	0.397CysSer: 0.397 ± 0.018	0.376CysThr: 0.376 ± 0.02	0.457CysVal: 0.457 ± 0.022	0.082CysTrp: 0.082 ± 0.01	0.126CysTyr: 0.126 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.708AspAla: 7.708 ± 0.095	0.292AspCys: 0.292 ± 0.016	3.366AspAsp: 3.366 ± 0.072	3.591AspGlu: 3.591 ± 0.072	1.892AspPhe: 1.892 ± 0.043	5.028AspGly: 5.028 ± 0.076	1.176AspHis: 1.176 ± 0.032	2.441AspIle: 2.441 ± 0.053	1.196AspLys: 1.196 ± 0.037	6.088AspLeu: 6.088 ± 0.084	0.913AspMet: 0.913 ± 0.032	1.192AspAsn: 1.192 ± 0.036	3.537AspPro: 3.537 ± 0.063	1.636AspGln: 1.636 ± 0.04	3.989AspArg: 3.989 ± 0.07	3.126AspSer: 3.126 ± 0.051	3.117AspThr: 3.117 ± 0.055	4.973AspVal: 4.973 ± 0.064	0.884AspTrp: 0.884 ± 0.032	1.252AspTyr: 1.252 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.421GluAla: 6.421 ± 0.086	0.294GluCys: 0.294 ± 0.019	2.281GluAsp: 2.281 ± 0.05	2.57GluGlu: 2.57 ± 0.05	1.776GluPhe: 1.776 ± 0.043	3.446GluGly: 3.446 ± 0.057	1.481GluHis: 1.481 ± 0.044	2.797GluIle: 2.797 ± 0.054	1.448GluLys: 1.448 ± 0.044	6.347GluLeu: 6.347 ± 0.087	1.084GluMet: 1.084 ± 0.029	1.396GluAsn: 1.396 ± 0.043	2.716GluPro: 2.716 ± 0.054	2.041GluGln: 2.041 ± 0.045	4.474GluArg: 4.474 ± 0.083	3.24GluSer: 3.24 ± 0.059	3.101GluThr: 3.101 ± 0.058	4.166GluVal: 4.166 ± 0.069	0.771GluTrp: 0.771 ± 0.03	1.133GluTyr: 1.133 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.201PheAla: 4.201 ± 0.066	0.224PheCys: 0.224 ± 0.015	2.259PheAsp: 2.259 ± 0.048	1.766PheGlu: 1.766 ± 0.04	1.146PhePhe: 1.146 ± 0.043	3.457PheGly: 3.457 ± 0.068	0.631PheHis: 0.631 ± 0.024	1.409PheIle: 1.409 ± 0.043	0.593PheLys: 0.593 ± 0.023	3.047PheLeu: 3.047 ± 0.063	0.505PheMet: 0.505 ± 0.02	0.836PheAsn: 0.836 ± 0.03	1.415PhePro: 1.415 ± 0.037	0.772PheGln: 0.772 ± 0.029	1.713PheArg: 1.713 ± 0.037	2.06PheSer: 2.06 ± 0.05	2.342PheThr: 2.342 ± 0.059	2.889PheVal: 2.889 ± 0.052	0.501PheTrp: 0.501 ± 0.025	0.742PheTyr: 0.742 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.818GlyAla: 9.818 ± 0.117	0.61GlyCys: 0.61 ± 0.027	4.452GlyAsp: 4.452 ± 0.072	4.405GlyGlu: 4.405 ± 0.061	3.245GlyPhe: 3.245 ± 0.066	7.053GlyGly: 7.053 ± 0.101	1.961GlyHis: 1.961 ± 0.051	4.864GlyIle: 4.864 ± 0.07	2.361GlyLys: 2.361 ± 0.051	9.24GlyLeu: 9.24 ± 0.122	1.925GlyMet: 1.925 ± 0.046	1.956GlyAsn: 1.956 ± 0.05	3.661GlyPro: 3.661 ± 0.059	2.62GlyGln: 2.62 ± 0.047	5.892GlyArg: 5.892 ± 0.072	5.423GlySer: 5.423 ± 0.078	5.843GlyThr: 5.843 ± 0.091	7.551GlyVal: 7.551 ± 0.093	1.498GlyTrp: 1.498 ± 0.031	2.236GlyTyr: 2.236 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.363HisAla: 2.363 ± 0.052	0.155HisCys: 0.155 ± 0.012	1.318HisAsp: 1.318 ± 0.039	1.194HisGlu: 1.194 ± 0.036	0.629HisPhe: 0.629 ± 0.025	1.967HisGly: 1.967 ± 0.049	0.569HisHis: 0.569 ± 0.029	0.877HisIle: 0.877 ± 0.028	0.361HisLys: 0.361 ± 0.021	2.11HisLeu: 2.11 ± 0.049	0.368HisMet: 0.368 ± 0.02	0.495HisAsn: 0.495 ± 0.025	1.485HisPro: 1.485 ± 0.038	0.558HisGln: 0.558 ± 0.024	1.545HisArg: 1.545 ± 0.042	1.25HisSer: 1.25 ± 0.031	1.167HisThr: 1.167 ± 0.035	1.689HisVal: 1.689 ± 0.042	0.27HisTrp: 0.27 ± 0.016	0.494HisTyr: 0.494 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.682IleAla: 6.682 ± 0.083	0.28IleCys: 0.28 ± 0.018	3.604IleAsp: 3.604 ± 0.066	2.914IleGlu: 2.914 ± 0.061	1.427IlePhe: 1.427 ± 0.039	4.645IleGly: 4.645 ± 0.08	0.807IleHis: 0.807 ± 0.027	2.224IleIle: 2.224 ± 0.06	1.017IleLys: 1.017 ± 0.033	4.211IleLeu: 4.211 ± 0.081	0.772IleMet: 0.772 ± 0.028	1.245IleAsn: 1.245 ± 0.031	2.548IlePro: 2.548 ± 0.048	1.056IleGln: 1.056 ± 0.027	2.936IleArg: 2.936 ± 0.048	2.749IleSer: 2.749 ± 0.049	3.265IleThr: 3.265 ± 0.062	4.896IleVal: 4.896 ± 0.073	0.529IleTrp: 0.529 ± 0.024	0.918IleTyr: 0.918 ± 0.031	0.001IleXaa: 0.001 ± 0.001
Lys	2.668LysAla: 2.668 ± 0.057	0.094LysCys: 0.094 ± 0.01	1.157LysAsp: 1.157 ± 0.038	1.039LysGlu: 1.039 ± 0.032	0.635LysPhe: 0.635 ± 0.026	1.714LysGly: 1.714 ± 0.045	0.502LysHis: 0.502 ± 0.023	1.195LysIle: 1.195 ± 0.035	0.871LysLys: 0.871 ± 0.042	2.11LysLeu: 2.11 ± 0.048	0.526LysMet: 0.526 ± 0.022	0.745LysAsn: 0.745 ± 0.029	1.367LysPro: 1.367 ± 0.042	0.769LysGln: 0.769 ± 0.03	1.751LysArg: 1.751 ± 0.042	1.464LysSer: 1.464 ± 0.045	1.544LysThr: 1.544 ± 0.049	1.775LysVal: 1.775 ± 0.042	0.291LysTrp: 0.291 ± 0.018	0.503LysTyr: 0.503 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.538LeuAla: 14.538 ± 0.148	0.573LeuCys: 0.573 ± 0.024	6.372LeuAsp: 6.372 ± 0.102	5.086LeuGlu: 5.086 ± 0.075	3.153LeuPhe: 3.153 ± 0.07	9.53LeuGly: 9.53 ± 0.12	2.076LeuHis: 2.076 ± 0.051	4.93LeuIle: 4.93 ± 0.081	2.122LeuLys: 2.122 ± 0.051	10.993LeuLeu: 10.993 ± 0.135	1.782LeuMet: 1.782 ± 0.036	2.457LeuAsn: 2.457 ± 0.045	5.477LeuPro: 5.477 ± 0.08	2.631LeuGln: 2.631 ± 0.049	7.261LeuArg: 7.261 ± 0.091	6.541LeuSer: 6.541 ± 0.079	6.799LeuThr: 6.799 ± 0.091	9.342LeuVal: 9.342 ± 0.112	1.241LeuTrp: 1.241 ± 0.04	1.731LeuTyr: 1.731 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.219MetAla: 2.219 ± 0.05	0.12MetCys: 0.12 ± 0.012	0.829MetAsp: 0.829 ± 0.028	0.704MetGlu: 0.704 ± 0.031	0.582MetPhe: 0.582 ± 0.026	1.393MetGly: 1.393 ± 0.035	0.371MetHis: 0.371 ± 0.018	1.003MetIle: 1.003 ± 0.033	0.557MetLys: 0.557 ± 0.024	2.138MetLeu: 2.138 ± 0.048	0.349MetMet: 0.349 ± 0.019	0.596MetAsn: 0.596 ± 0.023	1.127MetPro: 1.127 ± 0.031	0.599MetGln: 0.599 ± 0.025	1.344MetArg: 1.344 ± 0.034	1.497MetSer: 1.497 ± 0.037	1.86MetThr: 1.86 ± 0.039	1.5MetVal: 1.5 ± 0.037	0.206MetTrp: 0.206 ± 0.014	0.308MetTyr: 0.308 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.938AsnAla: 2.938 ± 0.061	0.139AsnCys: 0.139 ± 0.011	1.435AsnAsp: 1.435 ± 0.042	1.275AsnGlu: 1.275 ± 0.032	0.829AsnPhe: 0.829 ± 0.032	2.254AsnGly: 2.254 ± 0.051	0.455AsnHis: 0.455 ± 0.021	1.111AsnIle: 1.111 ± 0.034	0.528AsnLys: 0.528 ± 0.022	2.379AsnLeu: 2.379 ± 0.049	0.439AsnMet: 0.439 ± 0.02	0.654AsnAsn: 0.654 ± 0.028	1.775AsnPro: 1.775 ± 0.044	0.744AsnGln: 0.744 ± 0.029	1.616AsnArg: 1.616 ± 0.042	1.306AsnSer: 1.306 ± 0.041	1.47AsnThr: 1.47 ± 0.041	1.997AsnVal: 1.997 ± 0.045	0.388AsnTrp: 0.388 ± 0.019	0.603AsnTyr: 0.603 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.615ProAla: 6.615 ± 0.096	0.225ProCys: 0.225 ± 0.016	3.372ProAsp: 3.372 ± 0.056	3.512ProGlu: 3.512 ± 0.057	1.629ProPhe: 1.629 ± 0.038	4.913ProGly: 4.913 ± 0.063	1.098ProHis: 1.098 ± 0.038	2.249ProIle: 2.249 ± 0.049	1.127ProLys: 1.127 ± 0.036	4.894ProLeu: 4.894 ± 0.07	0.93ProMet: 0.93 ± 0.034	1.294ProAsn: 1.294 ± 0.037	2.127ProPro: 2.127 ± 0.051	1.461ProGln: 1.461 ± 0.039	3.176ProArg: 3.176 ± 0.057	3.107ProSer: 3.107 ± 0.06	3.542ProThr: 3.542 ± 0.06	4.854ProVal: 4.854 ± 0.082	0.784ProTrp: 0.784 ± 0.032	0.952ProTyr: 0.952 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.671GlnAla: 3.671 ± 0.058	0.125GlnCys: 0.125 ± 0.009	1.166GlnAsp: 1.166 ± 0.03	1.259GlnGlu: 1.259 ± 0.035	0.92GlnPhe: 0.92 ± 0.032	2.077GlnGly: 2.077 ± 0.048	0.655GlnHis: 0.655 ± 0.027	1.636GlnIle: 1.636 ± 0.037	0.763GlnLys: 0.763 ± 0.026	3.373GlnLeu: 3.373 ± 0.065	0.578GlnMet: 0.578 ± 0.023	0.798GlnAsn: 0.798 ± 0.028	1.484GlnPro: 1.484 ± 0.038	1.143GlnGln: 1.143 ± 0.038	2.278GlnArg: 2.278 ± 0.043	1.735GlnSer: 1.735 ± 0.047	1.602GlnThr: 1.602 ± 0.039	2.552GlnVal: 2.552 ± 0.047	0.432GlnTrp: 0.432 ± 0.019	0.62GlnTyr: 0.62 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.928ArgAla: 7.928 ± 0.106	0.355ArgCys: 0.355 ± 0.019	3.911ArgAsp: 3.911 ± 0.061	3.758ArgGlu: 3.758 ± 0.068	2.404ArgPhe: 2.404 ± 0.051	5.085ArgGly: 5.085 ± 0.081	1.58ArgHis: 1.58 ± 0.043	3.463ArgIle: 3.463 ± 0.053	1.629ArgLys: 1.629 ± 0.042	7.299ArgLeu: 7.299 ± 0.088	1.694ArgMet: 1.694 ± 0.044	1.596ArgAsn: 1.596 ± 0.041	3.339ArgPro: 3.339 ± 0.071	2.122ArgGln: 2.122 ± 0.048	5.603ArgArg: 5.603 ± 0.096	4.357ArgSer: 4.357 ± 0.071	4.157ArgThr: 4.157 ± 0.063	5.706ArgVal: 5.706 ± 0.074	1.045ArgTrp: 1.045 ± 0.034	1.539ArgTyr: 1.539 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.494SerAla: 7.494 ± 0.09	0.316SerCys: 0.316 ± 0.018	3.304SerAsp: 3.304 ± 0.063	2.975SerGlu: 2.975 ± 0.059	2.066SerPhe: 2.066 ± 0.048	5.962SerGly: 5.962 ± 0.09	1.162SerHis: 1.162 ± 0.033	2.957SerIle: 2.957 ± 0.059	1.313SerLys: 1.313 ± 0.035	6.156SerLeu: 6.156 ± 0.087	1.4SerMet: 1.4 ± 0.04	1.522SerAsn: 1.522 ± 0.037	3.243SerPro: 3.243 ± 0.061	1.61SerGln: 1.61 ± 0.042	4.023SerArg: 4.023 ± 0.067	3.923SerSer: 3.923 ± 0.074	4.207SerThr: 4.207 ± 0.069	5.327SerVal: 5.327 ± 0.071	0.916SerTrp: 0.916 ± 0.03	1.317SerTyr: 1.317 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	7.862ThrAla: 7.862 ± 0.1	0.312ThrCys: 0.312 ± 0.018	3.844ThrAsp: 3.844 ± 0.059	3.318ThrGlu: 3.318 ± 0.063	2.002ThrPhe: 2.002 ± 0.053	6.041ThrGly: 6.041 ± 0.089	1.263ThrHis: 1.263 ± 0.039	3.221ThrIle: 3.221 ± 0.059	1.369ThrLys: 1.369 ± 0.04	6.43ThrLeu: 6.43 ± 0.077	1.135ThrMet: 1.135 ± 0.032	1.588ThrAsn: 1.588 ± 0.038	3.997ThrPro: 3.997 ± 0.069	1.602ThrGln: 1.602 ± 0.043	3.967ThrArg: 3.967 ± 0.07	3.789ThrSer: 3.789 ± 0.068	4.023ThrThr: 4.023 ± 0.069	6.216ThrVal: 6.216 ± 0.096	0.849ThrTrp: 0.849 ± 0.027	1.241ThrTyr: 1.241 ± 0.038	0.001ThrXaa: 0.001 ± 0.001
Val	11.232ValAla: 11.232 ± 0.12	0.59ValCys: 0.59 ± 0.023	5.253ValAsp: 5.253 ± 0.071	4.26ValGlu: 4.26 ± 0.066	2.906ValPhe: 2.906 ± 0.059	7.078ValGly: 7.078 ± 0.092	1.848ValHis: 1.848 ± 0.048	4.749ValIle: 4.749 ± 0.071	1.879ValLys: 1.879 ± 0.05	9.386ValLeu: 9.386 ± 0.112	1.625ValMet: 1.625 ± 0.041	2.175ValAsn: 2.175 ± 0.051	4.51ValPro: 4.51 ± 0.078	2.414ValGln: 2.414 ± 0.048	5.54ValArg: 5.54 ± 0.072	5.476ValSer: 5.476 ± 0.08	6.03ValThr: 6.03 ± 0.088	8.073ValVal: 8.073 ± 0.108	1.075ValTrp: 1.075 ± 0.032	1.476ValTyr: 1.476 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.483TrpAla: 1.483 ± 0.038	0.121TrpCys: 0.121 ± 0.011	0.694TrpAsp: 0.694 ± 0.026	0.565TrpGlu: 0.565 ± 0.023	0.532TrpPhe: 0.532 ± 0.021	1.015TrpGly: 1.015 ± 0.034	0.332TrpHis: 0.332 ± 0.017	0.679TrpIle: 0.679 ± 0.025	0.37TrpLys: 0.37 ± 0.019	1.799TrpLeu: 1.799 ± 0.048	0.349TrpMet: 0.349 ± 0.019	0.434TrpAsn: 0.434 ± 0.021	0.732TrpPro: 0.732 ± 0.024	0.551TrpGln: 0.551 ± 0.026	1.08TrpArg: 1.08 ± 0.034	0.902TrpSer: 0.902 ± 0.03	0.789TrpThr: 0.789 ± 0.027	1.099TrpVal: 1.099 ± 0.032	0.337TrpTrp: 0.337 ± 0.021	0.279TrpTyr: 0.279 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.293TyrAla: 2.293 ± 0.041	0.16TyrCys: 0.16 ± 0.013	1.253TyrAsp: 1.253 ± 0.036	1.029TyrGlu: 1.029 ± 0.029	0.759TyrPhe: 0.759 ± 0.025	1.929TyrGly: 1.929 ± 0.046	0.292TyrHis: 0.292 ± 0.018	0.744TyrIle: 0.744 ± 0.024	0.398TyrLys: 0.398 ± 0.021	2.257TyrLeu: 2.257 ± 0.047	0.286TyrMet: 0.286 ± 0.017	0.518TyrAsn: 0.518 ± 0.028	1.067TyrPro: 1.067 ± 0.032	0.603TyrGln: 0.603 ± 0.027	1.603TyrArg: 1.603 ± 0.039	1.29TyrSer: 1.29 ± 0.035	1.172TyrThr: 1.172 ± 0.037	1.595TyrVal: 1.595 ± 0.041	0.338TyrTrp: 0.338 ± 0.018	0.452TyrTyr: 0.452 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3267 proteins (1042130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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