Amino acid dipepetide frequency for Microbulbifer agarilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.277AlaAla: 11.277 ± 0.14	1.061AlaCys: 1.061 ± 0.032	5.941AlaAsp: 5.941 ± 0.086	7.254AlaGlu: 7.254 ± 0.087	3.548AlaPhe: 3.548 ± 0.062	8.58AlaGly: 8.58 ± 0.115	1.922AlaHis: 1.922 ± 0.038	5.33AlaIle: 5.33 ± 0.073	3.799AlaLys: 3.799 ± 0.072	11.149AlaLeu: 11.149 ± 0.115	2.585AlaMet: 2.585 ± 0.047	3.455AlaAsn: 3.455 ± 0.062	4.205AlaPro: 4.205 ± 0.069	4.307AlaGln: 4.307 ± 0.059	5.792AlaArg: 5.792 ± 0.087	6.081AlaSer: 6.081 ± 0.078	4.883AlaThr: 4.883 ± 0.075	7.138AlaVal: 7.138 ± 0.086	1.224AlaTrp: 1.224 ± 0.033	2.455AlaTyr: 2.455 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.104CysAla: 1.104 ± 0.031	0.137CysCys: 0.137 ± 0.009	0.586CysAsp: 0.586 ± 0.021	0.576CysGlu: 0.576 ± 0.023	0.388CysPhe: 0.388 ± 0.019	1.023CysGly: 1.023 ± 0.028	0.303CysHis: 0.303 ± 0.02	0.432CysIle: 0.432 ± 0.019	0.293CysLys: 0.293 ± 0.014	0.896CysLeu: 0.896 ± 0.028	0.183CysMet: 0.183 ± 0.013	0.335CysAsn: 0.335 ± 0.016	0.476CysPro: 0.476 ± 0.021	0.311CysGln: 0.311 ± 0.016	0.538CysArg: 0.538 ± 0.021	0.639CysSer: 0.639 ± 0.02	0.456CysThr: 0.456 ± 0.02	0.652CysVal: 0.652 ± 0.022	0.142CysTrp: 0.142 ± 0.01	0.294CysTyr: 0.294 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.649AspAla: 5.649 ± 0.085	0.559AspCys: 0.559 ± 0.022	3.218AspAsp: 3.218 ± 0.067	3.709AspGlu: 3.709 ± 0.059	2.555AspPhe: 2.555 ± 0.048	4.957AspGly: 4.957 ± 0.077	1.157AspHis: 1.157 ± 0.031	3.348AspIle: 3.348 ± 0.062	2.347AspLys: 2.347 ± 0.046	5.849AspLeu: 5.849 ± 0.091	1.38AspMet: 1.38 ± 0.04	2.199AspAsn: 2.199 ± 0.051	2.752AspPro: 2.752 ± 0.047	2.167AspGln: 2.167 ± 0.042	3.061AspArg: 3.061 ± 0.057	3.607AspSer: 3.607 ± 0.064	3.064AspThr: 3.064 ± 0.057	3.94AspVal: 3.94 ± 0.077	1.004AspTrp: 1.004 ± 0.029	2.052AspTyr: 2.052 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.194GluAla: 6.194 ± 0.083	0.444GluCys: 0.444 ± 0.019	3.299GluAsp: 3.299 ± 0.059	4.361GluGlu: 4.361 ± 0.082	2.402GluPhe: 2.402 ± 0.045	4.256GluGly: 4.256 ± 0.068	1.473GluHis: 1.473 ± 0.037	3.531GluIle: 3.531 ± 0.055	3.192GluLys: 3.192 ± 0.061	6.665GluLeu: 6.665 ± 0.089	1.575GluMet: 1.575 ± 0.039	2.438GluAsn: 2.438 ± 0.043	2.502GluPro: 2.502 ± 0.053	3.696GluGln: 3.696 ± 0.06	4.302GluArg: 4.302 ± 0.064	3.808GluSer: 3.808 ± 0.065	3.127GluThr: 3.127 ± 0.05	4.585GluVal: 4.585 ± 0.068	0.839GluTrp: 0.839 ± 0.025	1.856GluTyr: 1.856 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.078PheAla: 4.078 ± 0.063	0.486PheCys: 0.486 ± 0.02	2.741PheAsp: 2.741 ± 0.052	2.289PheGlu: 2.289 ± 0.048	1.652PhePhe: 1.652 ± 0.04	3.368PheGly: 3.368 ± 0.056	0.821PheHis: 0.821 ± 0.027	1.892PheIle: 1.892 ± 0.044	1.226PheLys: 1.226 ± 0.036	3.338PheLeu: 3.338 ± 0.06	0.833PheMet: 0.833 ± 0.026	1.596PheAsn: 1.596 ± 0.039	1.587PhePro: 1.587 ± 0.038	1.189PheGln: 1.189 ± 0.028	1.98PheArg: 1.98 ± 0.035	3.045PheSer: 3.045 ± 0.062	2.285PheThr: 2.285 ± 0.045	2.717PheVal: 2.717 ± 0.045	0.554PheTrp: 0.554 ± 0.023	1.25PheTyr: 1.25 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.38GlyAla: 7.38 ± 0.106	0.953GlyCys: 0.953 ± 0.032	4.782GlyAsp: 4.782 ± 0.104	5.363GlyGlu: 5.363 ± 0.08	3.47GlyPhe: 3.47 ± 0.058	6.514GlyGly: 6.514 ± 0.116	1.669GlyHis: 1.669 ± 0.041	4.491GlyIle: 4.491 ± 0.072	3.637GlyLys: 3.637 ± 0.065	7.546GlyLeu: 7.546 ± 0.089	2.079GlyMet: 2.079 ± 0.05	2.961GlyAsn: 2.961 ± 0.07	2.456GlyPro: 2.456 ± 0.055	2.924GlyGln: 2.924 ± 0.05	4.292GlyArg: 4.292 ± 0.062	5.049GlySer: 5.049 ± 0.098	3.996GlyThr: 3.996 ± 0.078	6.028GlyVal: 6.028 ± 0.086	1.293GlyTrp: 1.293 ± 0.033	2.507GlyTyr: 2.507 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.742HisAla: 1.742 ± 0.043	0.313HisCys: 0.313 ± 0.015	1.003HisAsp: 1.003 ± 0.031	1.056HisGlu: 1.056 ± 0.032	1.012HisPhe: 1.012 ± 0.029	1.713HisGly: 1.713 ± 0.046	0.563HisHis: 0.563 ± 0.023	1.084HisIle: 1.084 ± 0.033	0.813HisLys: 0.813 ± 0.024	2.184HisLeu: 2.184 ± 0.048	0.475HisMet: 0.475 ± 0.021	0.771HisAsn: 0.771 ± 0.028	1.221HisPro: 1.221 ± 0.034	0.932HisGln: 0.932 ± 0.029	1.337HisArg: 1.337 ± 0.033	1.371HisSer: 1.371 ± 0.038	1.076HisThr: 1.076 ± 0.031	1.131HisVal: 1.131 ± 0.031	0.452HisTrp: 0.452 ± 0.02	0.763HisTyr: 0.763 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.872IleAla: 5.872 ± 0.076	0.56IleCys: 0.56 ± 0.02	3.613IleAsp: 3.613 ± 0.065	3.599IleGlu: 3.599 ± 0.057	1.821IlePhe: 1.821 ± 0.04	4.178IleGly: 4.178 ± 0.073	1.081IleHis: 1.081 ± 0.031	2.146IleIle: 2.146 ± 0.048	1.818IleLys: 1.818 ± 0.045	4.348IleLeu: 4.348 ± 0.059	0.866IleMet: 0.866 ± 0.028	2.057IleAsn: 2.057 ± 0.046	2.478IlePro: 2.478 ± 0.042	1.809IleGln: 1.809 ± 0.042	2.758IleArg: 2.758 ± 0.047	3.48IleSer: 3.48 ± 0.063	2.96IleThr: 2.96 ± 0.063	3.449IleVal: 3.449 ± 0.053	0.594IleTrp: 0.594 ± 0.021	1.464IleTyr: 1.464 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.804LysAla: 3.804 ± 0.077	0.234LysCys: 0.234 ± 0.016	2.042LysAsp: 2.042 ± 0.052	2.193LysGlu: 2.193 ± 0.042	1.294LysPhe: 1.294 ± 0.033	2.599LysGly: 2.599 ± 0.057	0.791LysHis: 0.791 ± 0.029	2.047LysIle: 2.047 ± 0.043	1.997LysLys: 1.997 ± 0.07	4.117LysLeu: 4.117 ± 0.069	0.972LysMet: 0.972 ± 0.029	1.488LysAsn: 1.488 ± 0.036	2.142LysPro: 2.142 ± 0.043	1.809LysGln: 1.809 ± 0.042	2.355LysArg: 2.355 ± 0.048	2.389LysSer: 2.389 ± 0.046	2.07LysThr: 2.07 ± 0.044	3.017LysVal: 3.017 ± 0.048	0.427LysTrp: 0.427 ± 0.02	1.001LysTyr: 1.001 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	11.241LeuAla: 11.241 ± 0.129	1.03LeuCys: 1.03 ± 0.032	5.989LeuAsp: 5.989 ± 0.08	6.327LeuGlu: 6.327 ± 0.081	3.727LeuPhe: 3.727 ± 0.073	7.661LeuGly: 7.661 ± 0.086	2.069LeuHis: 2.069 ± 0.043	4.846LeuIle: 4.846 ± 0.065	3.972LeuLys: 3.972 ± 0.061	10.816LeuLeu: 10.816 ± 0.143	2.306LeuMet: 2.306 ± 0.042	3.694LeuAsn: 3.694 ± 0.055	5.311LeuPro: 5.311 ± 0.072	4.427LeuGln: 4.427 ± 0.086	6.006LeuArg: 6.006 ± 0.089	6.651LeuSer: 6.651 ± 0.084	5.212LeuThr: 5.212 ± 0.085	7.236LeuVal: 7.236 ± 0.087	1.213LeuTrp: 1.213 ± 0.036	2.495LeuTyr: 2.495 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.587MetAla: 2.587 ± 0.048	0.167MetCys: 0.167 ± 0.013	1.292MetAsp: 1.292 ± 0.031	1.323MetGlu: 1.323 ± 0.03	0.731MetPhe: 0.731 ± 0.025	1.737MetGly: 1.737 ± 0.039	0.534MetHis: 0.534 ± 0.021	1.067MetIle: 1.067 ± 0.03	0.941MetLys: 0.941 ± 0.031	2.345MetLeu: 2.345 ± 0.047	0.517MetMet: 0.517 ± 0.019	0.839MetAsn: 0.839 ± 0.031	1.219MetPro: 1.219 ± 0.033	1.096MetGln: 1.096 ± 0.031	1.441MetArg: 1.441 ± 0.036	1.587MetSer: 1.587 ± 0.032	1.27MetThr: 1.27 ± 0.031	1.668MetVal: 1.668 ± 0.039	0.233MetTrp: 0.233 ± 0.015	0.462MetTyr: 0.462 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.299AsnAla: 3.299 ± 0.062	0.394AsnCys: 0.394 ± 0.018	1.889AsnAsp: 1.889 ± 0.043	1.8AsnGlu: 1.8 ± 0.041	1.487AsnPhe: 1.487 ± 0.038	3.118AsnGly: 3.118 ± 0.071	0.776AsnHis: 0.776 ± 0.025	1.981AsnIle: 1.981 ± 0.05	1.321AsnLys: 1.321 ± 0.037	3.702AsnLeu: 3.702 ± 0.067	0.811AsnMet: 0.811 ± 0.025	1.431AsnAsn: 1.431 ± 0.047	2.276AsnPro: 2.276 ± 0.042	1.475AsnGln: 1.475 ± 0.041	2.123AsnArg: 2.123 ± 0.045	2.193AsnSer: 2.193 ± 0.053	2.092AsnThr: 2.092 ± 0.051	2.32AsnVal: 2.32 ± 0.051	0.689AsnTrp: 0.689 ± 0.026	1.18AsnTyr: 1.18 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.735ProAla: 4.735 ± 0.071	0.309ProCys: 0.309 ± 0.016	2.862ProAsp: 2.862 ± 0.062	3.86ProGlu: 3.86 ± 0.06	1.727ProPhe: 1.727 ± 0.035	3.605ProGly: 3.605 ± 0.066	0.935ProHis: 0.935 ± 0.028	2.031ProIle: 2.031 ± 0.041	1.644ProLys: 1.644 ± 0.037	4.613ProLeu: 4.613 ± 0.073	1.045ProMet: 1.045 ± 0.029	1.583ProAsn: 1.583 ± 0.043	1.644ProPro: 1.644 ± 0.04	2.092ProGln: 2.092 ± 0.044	2.146ProArg: 2.146 ± 0.041	2.618ProSer: 2.618 ± 0.049	2.159ProThr: 2.159 ± 0.046	3.804ProVal: 3.804 ± 0.063	0.649ProTrp: 0.649 ± 0.023	1.234ProTyr: 1.234 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.239GlnAla: 4.239 ± 0.063	0.352GlnCys: 0.352 ± 0.02	1.865GlnAsp: 1.865 ± 0.042	2.494GlnGlu: 2.494 ± 0.05	1.639GlnPhe: 1.639 ± 0.039	2.968GlnGly: 2.968 ± 0.052	0.897GlnHis: 0.897 ± 0.028	2.066GlnIle: 2.066 ± 0.041	1.623GlnLys: 1.623 ± 0.04	5.143GlnLeu: 5.143 ± 0.086	1.043GlnMet: 1.043 ± 0.033	1.281GlnAsn: 1.281 ± 0.035	1.985GlnPro: 1.985 ± 0.045	2.775GlnGln: 2.775 ± 0.059	2.842GlnArg: 2.842 ± 0.06	2.517GlnSer: 2.517 ± 0.046	1.824GlnThr: 1.824 ± 0.05	3.192GlnVal: 3.192 ± 0.052	0.754GlnTrp: 0.754 ± 0.025	1.156GlnTyr: 1.156 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.598ArgAla: 5.598 ± 0.076	0.518ArgCys: 0.518 ± 0.022	3.526ArgAsp: 3.526 ± 0.058	4.252ArgGlu: 4.252 ± 0.07	2.509ArgPhe: 2.509 ± 0.049	4.038ArgGly: 4.038 ± 0.065	1.277ArgHis: 1.277 ± 0.033	3.124ArgIle: 3.124 ± 0.058	2.478ArgLys: 2.478 ± 0.048	5.821ArgLeu: 5.821 ± 0.087	1.351ArgMet: 1.351 ± 0.037	2.088ArgAsn: 2.088 ± 0.039	2.356ArgPro: 2.356 ± 0.046	2.533ArgGln: 2.533 ± 0.053	3.581ArgArg: 3.581 ± 0.067	3.229ArgSer: 3.229 ± 0.055	2.581ArgThr: 2.581 ± 0.048	4.014ArgVal: 4.014 ± 0.061	0.985ArgTrp: 0.985 ± 0.033	2.001ArgTyr: 2.001 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.714SerAla: 6.714 ± 0.091	0.57SerCys: 0.57 ± 0.027	3.816SerAsp: 3.816 ± 0.067	4.07SerGlu: 4.07 ± 0.061	2.355SerPhe: 2.355 ± 0.049	6.026SerGly: 6.026 ± 0.103	1.289SerHis: 1.289 ± 0.036	3.13SerIle: 3.13 ± 0.057	2.149SerLys: 2.149 ± 0.045	6.266SerLeu: 6.266 ± 0.086	1.423SerMet: 1.423 ± 0.03	2.177SerAsn: 2.177 ± 0.057	2.764SerPro: 2.764 ± 0.047	2.354SerGln: 2.354 ± 0.048	3.454SerArg: 3.454 ± 0.059	4.244SerSer: 4.244 ± 0.148	3.058SerThr: 3.058 ± 0.054	4.449SerVal: 4.449 ± 0.074	0.953SerTrp: 0.953 ± 0.027	1.866SerTyr: 1.866 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.309ThrAla: 5.309 ± 0.083	0.452ThrCys: 0.452 ± 0.022	3.096ThrAsp: 3.096 ± 0.064	2.997ThrGlu: 2.997 ± 0.053	2.005ThrPhe: 2.005 ± 0.043	4.601ThrGly: 4.601 ± 0.087	0.998ThrHis: 0.998 ± 0.03	2.607ThrIle: 2.607 ± 0.054	1.512ThrLys: 1.512 ± 0.045	5.904ThrLeu: 5.904 ± 0.085	0.952ThrMet: 0.952 ± 0.032	1.769ThrAsn: 1.769 ± 0.046	2.787ThrPro: 2.787 ± 0.05	1.847ThrGln: 1.847 ± 0.04	2.725ThrArg: 2.725 ± 0.049	3.167ThrSer: 3.167 ± 0.064	2.685ThrThr: 2.685 ± 0.062	3.789ThrVal: 3.789 ± 0.067	0.639ThrTrp: 0.639 ± 0.022	1.446ThrTyr: 1.446 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	7.621ValAla: 7.621 ± 0.085	0.715ValCys: 0.715 ± 0.029	4.599ValAsp: 4.599 ± 0.074	4.816ValGlu: 4.816 ± 0.066	2.715ValPhe: 2.715 ± 0.047	5.105ValGly: 5.105 ± 0.091	1.403ValHis: 1.403 ± 0.03	3.894ValIle: 3.894 ± 0.062	2.607ValLys: 2.607 ± 0.058	6.597ValLeu: 6.597 ± 0.098	1.677ValMet: 1.677 ± 0.039	2.657ValAsn: 2.657 ± 0.05	3.188ValPro: 3.188 ± 0.068	2.523ValGln: 2.523 ± 0.048	3.966ValArg: 3.966 ± 0.058	4.68ValSer: 4.68 ± 0.077	4.293ValThr: 4.293 ± 0.078	5.47ValVal: 5.47 ± 0.073	0.844ValTrp: 0.844 ± 0.03	1.868ValTyr: 1.868 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.069TrpAla: 1.069 ± 0.031	0.177TrpCys: 0.177 ± 0.013	0.731TrpAsp: 0.731 ± 0.026	0.695TrpGlu: 0.695 ± 0.027	0.578TrpPhe: 0.578 ± 0.022	1.005TrpGly: 1.005 ± 0.031	0.4TrpHis: 0.4 ± 0.019	0.655TrpIle: 0.655 ± 0.025	0.514TrpLys: 0.514 ± 0.02	1.887TrpLeu: 1.887 ± 0.049	0.431TrpMet: 0.431 ± 0.019	0.53TrpAsn: 0.53 ± 0.022	0.587TrpPro: 0.587 ± 0.026	0.94TrpGln: 0.94 ± 0.028	0.991TrpArg: 0.991 ± 0.028	0.869TrpSer: 0.869 ± 0.028	0.612TrpThr: 0.612 ± 0.024	0.893TrpVal: 0.893 ± 0.026	0.236TrpTrp: 0.236 ± 0.014	0.411TrpTyr: 0.411 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.476TyrAla: 2.476 ± 0.048	0.332TyrCys: 0.332 ± 0.015	1.683TyrAsp: 1.683 ± 0.054	1.512TyrGlu: 1.512 ± 0.044	1.312TyrPhe: 1.312 ± 0.031	2.339TyrGly: 2.339 ± 0.04	0.653TyrHis: 0.653 ± 0.021	1.251TyrIle: 1.251 ± 0.034	0.905TyrLys: 0.905 ± 0.03	3.04TyrLeu: 3.04 ± 0.049	0.55TyrMet: 0.55 ± 0.024	1.007TyrAsn: 1.007 ± 0.037	1.359TyrPro: 1.359 ± 0.033	1.451TyrGln: 1.451 ± 0.033	2.171TyrArg: 2.171 ± 0.047	1.905TyrSer: 1.905 ± 0.041	1.586TyrThr: 1.586 ± 0.043	1.742TyrVal: 1.742 ± 0.042	0.487TyrTrp: 0.487 ± 0.02	0.981TyrTyr: 0.981 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3454 proteins (1229174 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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