Amino acid dipepetide frequency for Freshwater phage uvFW-CGR-AMD-COM-C455

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.117AlaAla: 7.117 ± 1.003
0.527AlaCys: 0.527 ± 0.245
4.657AlaAsp: 4.657 ± 0.525
6.151AlaGlu: 6.151 ± 0.782
2.987AlaPhe: 2.987 ± 0.58
7.644AlaGly: 7.644 ± 0.891
1.582AlaHis: 1.582 ± 0.459
5.448AlaIle: 5.448 ± 0.589
5.448AlaLys: 5.448 ± 1.062
7.117AlaLeu: 7.117 ± 0.674
1.757AlaMet: 1.757 ± 0.467
4.657AlaAsn: 4.657 ± 0.779
3.251AlaPro: 3.251 ± 0.736
3.602AlaGln: 3.602 ± 0.604
4.833AlaArg: 4.833 ± 0.68
6.151AlaSer: 6.151 ± 0.982
7.293AlaThr: 7.293 ± 1.146
6.326AlaVal: 6.326 ± 0.656
1.494AlaTrp: 1.494 ± 0.333
2.812AlaTyr: 2.812 ± 0.471
0.0AlaXaa: 0.0 ± 0.0
Cys
0.791CysAla: 0.791 ± 0.302
0.0CysCys: 0.0 ± 0.0
0.351CysAsp: 0.351 ± 0.179
0.703CysGlu: 0.703 ± 0.303
0.176CysPhe: 0.176 ± 0.132
0.967CysGly: 0.967 ± 0.35
0.264CysHis: 0.264 ± 0.152
0.088CysIle: 0.088 ± 0.092
0.703CysLys: 0.703 ± 0.292
0.527CysLeu: 0.527 ± 0.211
0.088CysMet: 0.088 ± 0.091
0.088CysAsn: 0.088 ± 0.088
0.703CysPro: 0.703 ± 0.333
0.351CysGln: 0.351 ± 0.211
0.176CysArg: 0.176 ± 0.129
0.176CysSer: 0.176 ± 0.125
0.351CysThr: 0.351 ± 0.174
0.967CysVal: 0.967 ± 0.318
0.0CysTrp: 0.0 ± 0.0
0.088CysTyr: 0.088 ± 0.093
0.0CysXaa: 0.0 ± 0.0
Asp
4.218AspAla: 4.218 ± 0.668
0.176AspCys: 0.176 ± 0.135
3.339AspAsp: 3.339 ± 0.497
5.008AspGlu: 5.008 ± 0.663
2.987AspPhe: 2.987 ± 0.441
3.515AspGly: 3.515 ± 0.637
0.351AspHis: 0.351 ± 0.214
4.305AspIle: 4.305 ± 0.643
3.515AspLys: 3.515 ± 0.598
5.448AspLeu: 5.448 ± 0.707
0.967AspMet: 0.967 ± 0.43
2.636AspAsn: 2.636 ± 0.391
2.636AspPro: 2.636 ± 0.446
1.142AspGln: 1.142 ± 0.321
2.372AspArg: 2.372 ± 0.439
3.251AspSer: 3.251 ± 0.52
3.339AspThr: 3.339 ± 0.579
4.657AspVal: 4.657 ± 0.602
1.23AspTrp: 1.23 ± 0.274
2.285AspTyr: 2.285 ± 0.473
0.0AspXaa: 0.0 ± 0.0
Glu
5.096GluAla: 5.096 ± 0.781
0.351GluCys: 0.351 ± 0.167
3.954GluAsp: 3.954 ± 0.627
4.657GluGlu: 4.657 ± 0.646
2.636GluPhe: 2.636 ± 0.652
4.569GluGly: 4.569 ± 0.704
1.318GluHis: 1.318 ± 0.448
4.393GluIle: 4.393 ± 0.466
3.339GluLys: 3.339 ± 0.495
5.711GluLeu: 5.711 ± 0.692
1.494GluMet: 1.494 ± 0.354
3.075GluAsn: 3.075 ± 0.509
2.372GluPro: 2.372 ± 0.43
2.636GluGln: 2.636 ± 0.595
3.163GluArg: 3.163 ± 0.534
4.042GluSer: 4.042 ± 0.668
2.46GluThr: 2.46 ± 0.492
4.657GluVal: 4.657 ± 0.527
1.669GluTrp: 1.669 ± 0.372
2.724GluTyr: 2.724 ± 0.587
0.0GluXaa: 0.0 ± 0.0
Phe
3.69PheAla: 3.69 ± 0.599
0.351PheCys: 0.351 ± 0.199
2.636PheAsp: 2.636 ± 0.542
1.933PheGlu: 1.933 ± 0.485
0.879PhePhe: 0.879 ± 0.41
3.339PheGly: 3.339 ± 0.65
0.615PheHis: 0.615 ± 0.25
2.46PheIle: 2.46 ± 0.382
1.582PheLys: 1.582 ± 0.309
2.109PheLeu: 2.109 ± 0.423
0.879PheMet: 0.879 ± 0.324
2.285PheAsn: 2.285 ± 0.535
1.054PhePro: 1.054 ± 0.253
1.318PheGln: 1.318 ± 0.401
1.406PheArg: 1.406 ± 0.322
2.109PheSer: 2.109 ± 0.422
2.197PheThr: 2.197 ± 0.34
1.669PheVal: 1.669 ± 0.379
0.879PheTrp: 0.879 ± 0.32
1.142PheTyr: 1.142 ± 0.31
0.0PheXaa: 0.0 ± 0.0
Gly
6.414GlyAla: 6.414 ± 0.786
0.351GlyCys: 0.351 ± 0.183
3.954GlyAsp: 3.954 ± 0.613
5.008GlyGlu: 5.008 ± 0.719
2.724GlyPhe: 2.724 ± 0.39
4.481GlyGly: 4.481 ± 0.742
0.879GlyHis: 0.879 ± 0.336
4.745GlyIle: 4.745 ± 0.623
5.36GlyLys: 5.36 ± 0.776
5.536GlyLeu: 5.536 ± 0.59
0.879GlyMet: 0.879 ± 0.282
4.745GlyAsn: 4.745 ± 1.335
2.46GlyPro: 2.46 ± 0.55
2.9GlyGln: 2.9 ± 0.649
2.987GlyArg: 2.987 ± 0.543
5.008GlySer: 5.008 ± 0.744
6.151GlyThr: 6.151 ± 1.088
4.745GlyVal: 4.745 ± 0.838
1.406GlyTrp: 1.406 ± 0.39
2.548GlyTyr: 2.548 ± 0.521
0.0GlyXaa: 0.0 ± 0.0
His
1.054HisAla: 1.054 ± 0.399
0.264HisCys: 0.264 ± 0.195
0.791HisAsp: 0.791 ± 0.284
0.879HisGlu: 0.879 ± 0.306
0.439HisPhe: 0.439 ± 0.234
0.703HisGly: 0.703 ± 0.312
0.264HisHis: 0.264 ± 0.144
0.967HisIle: 0.967 ± 0.341
0.615HisLys: 0.615 ± 0.269
1.054HisLeu: 1.054 ± 0.367
0.615HisMet: 0.615 ± 0.286
0.967HisAsn: 0.967 ± 0.346
0.791HisPro: 0.791 ± 0.312
0.703HisGln: 0.703 ± 0.302
0.879HisArg: 0.879 ± 0.296
0.264HisSer: 0.264 ± 0.14
1.318HisThr: 1.318 ± 0.459
0.615HisVal: 0.615 ± 0.263
0.527HisTrp: 0.527 ± 0.221
0.791HisTyr: 0.791 ± 0.32
0.0HisXaa: 0.0 ± 0.0
Ile
5.184IleAla: 5.184 ± 0.601
0.615IleCys: 0.615 ± 0.244
4.393IleAsp: 4.393 ± 0.647
3.778IleGlu: 3.778 ± 0.522
2.109IlePhe: 2.109 ± 0.397
3.427IleGly: 3.427 ± 0.56
0.439IleHis: 0.439 ± 0.154
2.724IleIle: 2.724 ± 0.406
4.305IleLys: 4.305 ± 0.673
4.657IleLeu: 4.657 ± 0.74
1.757IleMet: 1.757 ± 0.469
3.427IleAsn: 3.427 ± 0.495
2.285IlePro: 2.285 ± 0.509
1.845IleGln: 1.845 ± 0.462
3.69IleArg: 3.69 ± 0.633
3.602IleSer: 3.602 ± 0.45
4.833IleThr: 4.833 ± 0.61
3.866IleVal: 3.866 ± 0.727
0.791IleTrp: 0.791 ± 0.241
2.46IleTyr: 2.46 ± 0.572
0.0IleXaa: 0.0 ± 0.0
Lys
7.029LysAla: 7.029 ± 0.98
0.527LysCys: 0.527 ± 0.325
3.075LysAsp: 3.075 ± 0.579
4.218LysGlu: 4.218 ± 0.58
1.845LysPhe: 1.845 ± 0.559
4.218LysGly: 4.218 ± 0.594
1.318LysHis: 1.318 ± 0.449
4.042LysIle: 4.042 ± 0.605
4.393LysLys: 4.393 ± 0.843
5.008LysLeu: 5.008 ± 0.852
1.669LysMet: 1.669 ± 0.361
3.954LysAsn: 3.954 ± 0.56
2.9LysPro: 2.9 ± 0.485
3.075LysGln: 3.075 ± 0.644
3.075LysArg: 3.075 ± 0.475
2.987LysSer: 2.987 ± 0.675
3.427LysThr: 3.427 ± 0.576
2.987LysVal: 2.987 ± 0.579
0.967LysTrp: 0.967 ± 0.372
1.669LysTyr: 1.669 ± 0.369
0.0LysXaa: 0.0 ± 0.0
Leu
8.259LeuAla: 8.259 ± 1.121
0.264LeuCys: 0.264 ± 0.165
5.184LeuAsp: 5.184 ± 0.708
3.866LeuGlu: 3.866 ± 0.706
3.427LeuPhe: 3.427 ± 0.628
5.096LeuGly: 5.096 ± 0.576
1.318LeuHis: 1.318 ± 0.336
5.36LeuIle: 5.36 ± 0.681
4.745LeuLys: 4.745 ± 0.698
5.711LeuLeu: 5.711 ± 0.971
1.669LeuMet: 1.669 ± 0.337
4.042LeuAsn: 4.042 ± 0.527
3.954LeuPro: 3.954 ± 0.649
3.602LeuGln: 3.602 ± 0.671
4.13LeuArg: 4.13 ± 0.939
5.711LeuSer: 5.711 ± 0.668
5.36LeuThr: 5.36 ± 1.309
4.745LeuVal: 4.745 ± 0.624
1.23LeuTrp: 1.23 ± 0.366
2.372LeuTyr: 2.372 ± 0.409
0.0LeuXaa: 0.0 ± 0.0
Met
2.812MetAla: 2.812 ± 0.569
0.176MetCys: 0.176 ± 0.132
0.791MetAsp: 0.791 ± 0.275
1.142MetGlu: 1.142 ± 0.327
0.264MetPhe: 0.264 ± 0.147
2.548MetGly: 2.548 ± 0.464
0.264MetHis: 0.264 ± 0.175
0.967MetIle: 0.967 ± 0.338
1.406MetLys: 1.406 ± 0.394
1.406MetLeu: 1.406 ± 0.332
0.703MetMet: 0.703 ± 0.3
0.879MetAsn: 0.879 ± 0.278
0.791MetPro: 0.791 ± 0.273
0.527MetGln: 0.527 ± 0.195
1.142MetArg: 1.142 ± 0.336
1.757MetSer: 1.757 ± 0.375
1.669MetThr: 1.669 ± 0.393
1.23MetVal: 1.23 ± 0.337
0.351MetTrp: 0.351 ± 0.17
0.615MetTyr: 0.615 ± 0.242
0.0MetXaa: 0.0 ± 0.0
Asn
4.481AsnAla: 4.481 ± 0.784
0.351AsnCys: 0.351 ± 0.218
3.075AsnAsp: 3.075 ± 0.446
3.778AsnGlu: 3.778 ± 0.531
1.318AsnPhe: 1.318 ± 0.349
4.13AsnGly: 4.13 ± 1.012
0.615AsnHis: 0.615 ± 0.257
2.987AsnIle: 2.987 ± 0.461
3.866AsnLys: 3.866 ± 0.449
4.569AsnLeu: 4.569 ± 0.736
1.494AsnMet: 1.494 ± 0.366
1.845AsnAsn: 1.845 ± 0.316
2.021AsnPro: 2.021 ± 0.439
1.406AsnGln: 1.406 ± 0.322
2.109AsnArg: 2.109 ± 0.396
3.515AsnSer: 3.515 ± 0.548
2.987AsnThr: 2.987 ± 0.621
3.866AsnVal: 3.866 ± 0.679
1.054AsnTrp: 1.054 ± 0.349
1.582AsnTyr: 1.582 ± 0.443
0.0AsnXaa: 0.0 ± 0.0
Pro
3.602ProAla: 3.602 ± 0.487
0.527ProCys: 0.527 ± 0.228
2.372ProAsp: 2.372 ± 0.591
3.954ProGlu: 3.954 ± 0.773
1.494ProPhe: 1.494 ± 0.314
2.636ProGly: 2.636 ± 0.484
0.615ProHis: 0.615 ± 0.262
2.724ProIle: 2.724 ± 0.677
2.285ProLys: 2.285 ± 0.481
2.724ProLeu: 2.724 ± 0.501
0.879ProMet: 0.879 ± 0.307
2.109ProAsn: 2.109 ± 0.648
2.021ProPro: 2.021 ± 0.539
1.054ProGln: 1.054 ± 0.277
1.845ProArg: 1.845 ± 0.368
3.69ProSer: 3.69 ± 0.504
3.427ProThr: 3.427 ± 0.656
2.636ProVal: 2.636 ± 0.374
0.615ProTrp: 0.615 ± 0.218
1.318ProTyr: 1.318 ± 0.318
0.0ProXaa: 0.0 ± 0.0
Gln
4.305GlnAla: 4.305 ± 0.796
0.176GlnCys: 0.176 ± 0.144
2.197GlnAsp: 2.197 ± 0.46
2.724GlnGlu: 2.724 ± 0.366
1.494GlnPhe: 1.494 ± 0.417
2.548GlnGly: 2.548 ± 0.389
0.527GlnHis: 0.527 ± 0.284
2.021GlnIle: 2.021 ± 0.373
2.021GlnLys: 2.021 ± 0.527
2.636GlnLeu: 2.636 ± 0.457
0.791GlnMet: 0.791 ± 0.32
1.23GlnAsn: 1.23 ± 0.358
2.109GlnPro: 2.109 ± 0.402
2.46GlnGln: 2.46 ± 0.459
2.548GlnArg: 2.548 ± 0.426
2.46GlnSer: 2.46 ± 0.377
2.285GlnThr: 2.285 ± 0.409
2.197GlnVal: 2.197 ± 0.529
0.264GlnTrp: 0.264 ± 0.155
1.318GlnTyr: 1.318 ± 0.348
0.0GlnXaa: 0.0 ± 0.0
Arg
4.305ArgAla: 4.305 ± 0.44
0.176ArgCys: 0.176 ± 0.126
2.285ArgAsp: 2.285 ± 0.461
2.812ArgGlu: 2.812 ± 0.686
0.967ArgPhe: 0.967 ± 0.257
3.778ArgGly: 3.778 ± 0.588
0.439ArgHis: 0.439 ± 0.233
2.724ArgIle: 2.724 ± 0.443
2.9ArgLys: 2.9 ± 0.564
5.096ArgLeu: 5.096 ± 0.729
0.791ArgMet: 0.791 ± 0.279
2.548ArgAsn: 2.548 ± 0.632
1.669ArgPro: 1.669 ± 0.335
2.021ArgGln: 2.021 ± 0.405
2.197ArgArg: 2.197 ± 0.657
3.515ArgSer: 3.515 ± 0.718
3.69ArgThr: 3.69 ± 0.496
2.372ArgVal: 2.372 ± 0.436
1.054ArgTrp: 1.054 ± 0.395
2.372ArgTyr: 2.372 ± 0.546
0.0ArgXaa: 0.0 ± 0.0
Ser
6.063SerAla: 6.063 ± 0.819
0.615SerCys: 0.615 ± 0.268
4.042SerAsp: 4.042 ± 0.66
3.69SerGlu: 3.69 ± 0.572
1.494SerPhe: 1.494 ± 0.346
5.536SerGly: 5.536 ± 0.934
0.703SerHis: 0.703 ± 0.319
4.218SerIle: 4.218 ± 0.618
4.569SerLys: 4.569 ± 0.542
5.711SerLeu: 5.711 ± 0.74
1.933SerMet: 1.933 ± 0.467
3.69SerAsn: 3.69 ± 0.903
3.163SerPro: 3.163 ± 0.648
2.9SerGln: 2.9 ± 0.55
2.46SerArg: 2.46 ± 0.475
4.218SerSer: 4.218 ± 0.888
5.36SerThr: 5.36 ± 1.124
3.954SerVal: 3.954 ± 0.541
1.318SerTrp: 1.318 ± 0.339
2.109SerTyr: 2.109 ± 0.32
0.0SerXaa: 0.0 ± 0.0
Thr
6.063ThrAla: 6.063 ± 0.974
0.615ThrCys: 0.615 ± 0.3
3.427ThrAsp: 3.427 ± 0.714
3.339ThrGlu: 3.339 ± 0.644
2.636ThrPhe: 2.636 ± 0.481
6.238ThrGly: 6.238 ± 1.448
1.23ThrHis: 1.23 ± 0.364
4.569ThrIle: 4.569 ± 0.73
4.745ThrLys: 4.745 ± 0.697
5.536ThrLeu: 5.536 ± 1.01
0.967ThrMet: 0.967 ± 0.269
3.251ThrAsn: 3.251 ± 0.63
3.778ThrPro: 3.778 ± 0.537
2.285ThrGln: 2.285 ± 0.463
2.548ThrArg: 2.548 ± 0.621
6.678ThrSer: 6.678 ± 1.593
5.711ThrThr: 5.711 ± 1.335
4.218ThrVal: 4.218 ± 0.67
1.757ThrTrp: 1.757 ± 0.716
1.933ThrTyr: 1.933 ± 0.497
0.0ThrXaa: 0.0 ± 0.0
Val
5.536ValAla: 5.536 ± 1.053
0.615ValCys: 0.615 ± 0.251
3.778ValAsp: 3.778 ± 0.631
4.305ValGlu: 4.305 ± 0.685
2.636ValPhe: 2.636 ± 0.571
3.954ValGly: 3.954 ± 0.499
0.879ValHis: 0.879 ± 0.312
2.812ValIle: 2.812 ± 0.489
3.427ValLys: 3.427 ± 0.571
4.833ValLeu: 4.833 ± 0.816
0.967ValMet: 0.967 ± 0.291
3.339ValAsn: 3.339 ± 0.528
2.372ValPro: 2.372 ± 0.421
2.285ValGln: 2.285 ± 0.691
3.515ValArg: 3.515 ± 0.529
4.569ValSer: 4.569 ± 0.656
5.711ValThr: 5.711 ± 0.845
4.305ValVal: 4.305 ± 0.769
0.791ValTrp: 0.791 ± 0.341
2.109ValTyr: 2.109 ± 0.77
0.0ValXaa: 0.0 ± 0.0
Trp
2.197TrpAla: 2.197 ± 0.436
0.439TrpCys: 0.439 ± 0.184
0.791TrpAsp: 0.791 ± 0.303
0.879TrpGlu: 0.879 ± 0.405
0.967TrpPhe: 0.967 ± 0.281
1.142TrpGly: 1.142 ± 0.298
0.0TrpHis: 0.0 ± 0.0
1.054TrpIle: 1.054 ± 0.269
1.142TrpLys: 1.142 ± 0.272
1.669TrpLeu: 1.669 ± 0.365
0.527TrpMet: 0.527 ± 0.225
0.791TrpAsn: 0.791 ± 0.345
0.264TrpPro: 0.264 ± 0.154
0.615TrpGln: 0.615 ± 0.226
0.967TrpArg: 0.967 ± 0.396
1.933TrpSer: 1.933 ± 0.395
1.23TrpThr: 1.23 ± 0.599
0.615TrpVal: 0.615 ± 0.231
0.264TrpTrp: 0.264 ± 0.149
0.615TrpTyr: 0.615 ± 0.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.636TyrAla: 2.636 ± 0.41
0.439TyrCys: 0.439 ± 0.204
2.285TyrAsp: 2.285 ± 0.55
1.494TyrGlu: 1.494 ± 0.39
1.054TyrPhe: 1.054 ± 0.291
2.812TyrGly: 2.812 ± 0.477
0.879TyrHis: 0.879 ± 0.276
1.582TyrIle: 1.582 ± 0.351
2.021TyrLys: 2.021 ± 0.408
2.987TyrLeu: 2.987 ± 0.448
0.527TyrMet: 0.527 ± 0.202
1.494TyrAsn: 1.494 ± 0.375
1.933TyrPro: 1.933 ± 0.375
1.582TyrGln: 1.582 ± 0.448
1.669TyrArg: 1.669 ± 0.388
2.109TyrSer: 2.109 ± 0.496
2.724TyrThr: 2.724 ± 0.535
2.109TyrVal: 2.109 ± 0.447
0.527TyrTrp: 0.527 ± 0.184
0.967TyrTyr: 0.967 ± 0.312
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 58 proteins (11382 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski