Amino acid dipepetide frequency for Juglans regia (English walnut)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.922AlaAla: 5.922 ± 0.029	1.266AlaCys: 1.266 ± 0.01	3.057AlaAsp: 3.057 ± 0.014	4.161AlaGlu: 4.161 ± 0.025	2.753AlaPhe: 2.753 ± 0.014	4.017AlaGly: 4.017 ± 0.018	1.367AlaHis: 1.367 ± 0.008	3.811AlaIle: 3.811 ± 0.017	3.808AlaLys: 3.808 ± 0.017	6.711AlaLeu: 6.711 ± 0.026	1.737AlaMet: 1.737 ± 0.01	2.595AlaAsn: 2.595 ± 0.014	2.761AlaPro: 2.761 ± 0.016	2.099AlaGln: 2.099 ± 0.014	3.419AlaArg: 3.419 ± 0.014	6.068AlaSer: 6.068 ± 0.021	3.52AlaThr: 3.52 ± 0.016	4.648AlaVal: 4.648 ± 0.017	0.79AlaTrp: 0.79 ± 0.007	1.831AlaTyr: 1.831 ± 0.011	0.0AlaXaa: 0.0 ± 0.0
Cys	1.012CysAla: 1.012 ± 0.008	0.526CysCys: 0.526 ± 0.006	0.867CysAsp: 0.867 ± 0.007	0.943CysGlu: 0.943 ± 0.008	0.888CysPhe: 0.888 ± 0.009	1.414CysGly: 1.414 ± 0.01	0.476CysHis: 0.476 ± 0.005	1.048CysIle: 1.048 ± 0.009	1.162CysLys: 1.162 ± 0.01	1.884CysLeu: 1.884 ± 0.01	0.472CysMet: 0.472 ± 0.005	0.899CysAsn: 0.899 ± 0.008	0.972CysPro: 0.972 ± 0.008	0.601CysGln: 0.601 ± 0.005	1.07CysArg: 1.07 ± 0.009	1.835CysSer: 1.835 ± 0.012	0.902CysThr: 0.902 ± 0.008	1.03CysVal: 1.03 ± 0.008	0.245CysTrp: 0.245 ± 0.004	0.534CysTyr: 0.534 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	3.46AspAla: 3.46 ± 0.016	0.997AspCys: 0.997 ± 0.007	3.564AspAsp: 3.564 ± 0.022	3.997AspGlu: 3.997 ± 0.023	2.366AspPhe: 2.366 ± 0.011	3.871AspGly: 3.871 ± 0.018	1.332AspHis: 1.332 ± 0.01	3.101AspIle: 3.101 ± 0.013	2.656AspLys: 2.656 ± 0.016	5.138AspLeu: 5.138 ± 0.018	1.343AspMet: 1.343 ± 0.009	2.149AspAsn: 2.149 ± 0.014	2.606AspPro: 2.606 ± 0.014	1.898AspGln: 1.898 ± 0.012	2.503AspArg: 2.503 ± 0.015	4.252AspSer: 4.252 ± 0.018	2.211AspThr: 2.211 ± 0.012	3.592AspVal: 3.592 ± 0.013	0.736AspTrp: 0.736 ± 0.007	1.512AspTyr: 1.512 ± 0.01	0.001AspXaa: 0.001 ± 0.0
Glu	4.78GluAla: 4.78 ± 0.026	0.992GluCys: 0.992 ± 0.008	4.154GluAsp: 4.154 ± 0.028	6.263GluGlu: 6.263 ± 0.045	2.375GluPhe: 2.375 ± 0.013	3.804GluGly: 3.804 ± 0.016	1.349GluHis: 1.349 ± 0.01	3.843GluIle: 3.843 ± 0.018	4.782GluLys: 4.782 ± 0.028	6.061GluLeu: 6.061 ± 0.022	1.763GluMet: 1.763 ± 0.011	3.254GluAsn: 3.254 ± 0.017	2.142GluPro: 2.142 ± 0.012	2.225GluGln: 2.225 ± 0.015	3.57GluArg: 3.57 ± 0.02	4.734GluSer: 4.734 ± 0.02	3.198GluThr: 3.198 ± 0.035	4.351GluVal: 4.351 ± 0.022	0.735GluTrp: 0.735 ± 0.007	1.677GluTyr: 1.677 ± 0.009	0.0GluXaa: 0.0 ± 0.0
Phe	2.435PheAla: 2.435 ± 0.013	0.906PheCys: 0.906 ± 0.007	2.32PheAsp: 2.32 ± 0.013	2.341PheGlu: 2.341 ± 0.013	1.952PhePhe: 1.952 ± 0.012	3.067PheGly: 3.067 ± 0.014	1.107PheHis: 1.107 ± 0.009	2.055PheIle: 2.055 ± 0.012	2.088PheLys: 2.088 ± 0.01	4.319PheLeu: 4.319 ± 0.02	0.949PheMet: 0.949 ± 0.007	1.763PheAsn: 1.763 ± 0.011	2.143PhePro: 2.143 ± 0.015	1.633PheGln: 1.633 ± 0.009	2.089PheArg: 2.089 ± 0.011	4.092PheSer: 4.092 ± 0.017	1.933PheThr: 1.933 ± 0.011	2.691PheVal: 2.691 ± 0.012	0.59PheTrp: 0.59 ± 0.006	1.231PheTyr: 1.231 ± 0.009	0.0PheXaa: 0.0 ± 0.0
Gly	3.776GlyAla: 3.776 ± 0.016	1.334GlyCys: 1.334 ± 0.01	3.361GlyAsp: 3.361 ± 0.015	3.708GlyGlu: 3.708 ± 0.017	3.153GlyPhe: 3.153 ± 0.015	5.061GlyGly: 5.061 ± 0.03	1.59GlyHis: 1.59 ± 0.01	3.684GlyIle: 3.684 ± 0.015	4.09GlyLys: 4.09 ± 0.018	6.013GlyLeu: 6.013 ± 0.02	1.534GlyMet: 1.534 ± 0.01	3.216GlyAsn: 3.216 ± 0.016	2.48GlyPro: 2.48 ± 0.014	2.185GlyGln: 2.185 ± 0.014	3.65GlyArg: 3.65 ± 0.018	6.147GlySer: 6.147 ± 0.025	3.365GlyThr: 3.365 ± 0.014	4.103GlyVal: 4.103 ± 0.017	0.904GlyTrp: 0.904 ± 0.009	2.036GlyTyr: 2.036 ± 0.014	0.001GlyXaa: 0.001 ± 0.0
His	1.493HisAla: 1.493 ± 0.01	0.534HisCys: 0.534 ± 0.006	1.236HisAsp: 1.236 ± 0.009	1.418HisGlu: 1.418 ± 0.009	1.062HisPhe: 1.062 ± 0.007	1.827HisGly: 1.827 ± 0.012	0.91HisHis: 0.91 ± 0.009	1.276HisIle: 1.276 ± 0.009	1.182HisLys: 1.182 ± 0.008	2.525HisLeu: 2.525 ± 0.013	0.573HisMet: 0.573 ± 0.005	0.998HisAsn: 0.998 ± 0.008	1.401HisPro: 1.401 ± 0.009	1.037HisGln: 1.037 ± 0.007	1.4HisArg: 1.4 ± 0.009	1.998HisSer: 1.998 ± 0.01	0.972HisThr: 0.972 ± 0.007	1.541HisVal: 1.541 ± 0.01	0.313HisTrp: 0.313 ± 0.004	0.69HisTyr: 0.69 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	3.493IleAla: 3.493 ± 0.014	1.112IleCys: 1.112 ± 0.009	2.886IleAsp: 2.886 ± 0.012	3.312IleGlu: 3.312 ± 0.014	2.325IlePhe: 2.325 ± 0.012	3.374IleGly: 3.374 ± 0.017	1.34IleHis: 1.34 ± 0.011	2.809IleIle: 2.809 ± 0.014	2.972IleLys: 2.972 ± 0.019	5.319IleLeu: 5.319 ± 0.018	1.137IleMet: 1.137 ± 0.009	2.221IleAsn: 2.221 ± 0.01	3.056IlePro: 3.056 ± 0.018	2.04IleGln: 2.04 ± 0.014	2.694IleArg: 2.694 ± 0.013	5.007IleSer: 5.007 ± 0.017	2.531IleThr: 2.531 ± 0.012	3.397IleVal: 3.397 ± 0.016	0.722IleTrp: 0.722 ± 0.008	1.508IleTyr: 1.508 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	4.081LysAla: 4.081 ± 0.019	1.004LysCys: 1.004 ± 0.008	3.271LysAsp: 3.271 ± 0.015	4.691LysGlu: 4.691 ± 0.032	2.147LysPhe: 2.147 ± 0.012	3.576LysGly: 3.576 ± 0.016	1.342LysHis: 1.342 ± 0.009	3.245LysIle: 3.245 ± 0.015	4.504LysLys: 4.504 ± 0.023	5.948LysLeu: 5.948 ± 0.019	1.496LysMet: 1.496 ± 0.01	2.694LysAsn: 2.694 ± 0.014	2.674LysPro: 2.674 ± 0.012	2.245LysGln: 2.245 ± 0.013	3.632LysArg: 3.632 ± 0.017	4.611LysSer: 4.611 ± 0.017	2.81LysThr: 2.81 ± 0.014	3.862LysVal: 3.862 ± 0.021	0.798LysTrp: 0.798 ± 0.007	1.615LysTyr: 1.615 ± 0.009	0.0LysXaa: 0.0 ± 0.0
Leu	6.478LeuAla: 6.478 ± 0.025	1.873LeuCys: 1.873 ± 0.011	5.26LeuAsp: 5.26 ± 0.019	6.631LeuGlu: 6.631 ± 0.027	3.792LeuPhe: 3.792 ± 0.019	5.893LeuGly: 5.893 ± 0.022	2.666LeuHis: 2.666 ± 0.015	4.586LeuIle: 4.586 ± 0.023	6.187LeuLys: 6.187 ± 0.021	9.869LeuLeu: 9.869 ± 0.032	2.111LeuMet: 2.111 ± 0.012	4.011LeuAsn: 4.011 ± 0.019	5.235LeuPro: 5.235 ± 0.02	4.492LeuGln: 4.492 ± 0.019	5.53LeuArg: 5.53 ± 0.02	8.762LeuSer: 8.762 ± 0.034	4.395LeuThr: 4.395 ± 0.018	6.312LeuVal: 6.312 ± 0.024	1.196LeuTrp: 1.196 ± 0.009	2.553LeuTyr: 2.553 ± 0.013	0.001LeuXaa: 0.001 ± 0.0
Met	2.129MetAla: 2.129 ± 0.012	0.315MetCys: 0.315 ± 0.004	1.474MetAsp: 1.474 ± 0.01	2.004MetGlu: 2.004 ± 0.011	0.799MetPhe: 0.799 ± 0.007	1.662MetGly: 1.662 ± 0.01	0.569MetHis: 0.569 ± 0.005	1.177MetIle: 1.177 ± 0.01	1.596MetLys: 1.596 ± 0.01	2.173MetLeu: 2.173 ± 0.01	0.625MetMet: 0.625 ± 0.006	1.037MetAsn: 1.037 ± 0.007	1.075MetPro: 1.075 ± 0.009	0.974MetGln: 0.974 ± 0.008	1.222MetArg: 1.222 ± 0.008	1.735MetSer: 1.735 ± 0.01	1.045MetThr: 1.045 ± 0.007	1.613MetVal: 1.613 ± 0.009	0.273MetTrp: 0.273 ± 0.003	0.558MetTyr: 0.558 ± 0.005	0.0MetXaa: 0.0 ± 0.0
Asn	2.726AsnAla: 2.726 ± 0.013	0.879AsnCys: 0.879 ± 0.008	2.154AsnAsp: 2.154 ± 0.013	2.6AsnGlu: 2.6 ± 0.014	1.932AsnPhe: 1.932 ± 0.01	3.268AsnGly: 3.268 ± 0.015	1.148AsnHis: 1.148 ± 0.009	2.546AsnIle: 2.546 ± 0.013	2.332AsnLys: 2.332 ± 0.011	4.756AsnLeu: 4.756 ± 0.025	1.122AsnMet: 1.122 ± 0.007	2.195AsnAsn: 2.195 ± 0.016	2.363AsnPro: 2.363 ± 0.014	1.746AsnGln: 1.746 ± 0.011	2.115AsnArg: 2.115 ± 0.011	4.0AsnSer: 4.0 ± 0.017	1.935AsnThr: 1.935 ± 0.011	2.788AsnVal: 2.788 ± 0.014	0.58AsnTrp: 0.58 ± 0.006	1.302AsnTyr: 1.302 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	2.999ProAla: 2.999 ± 0.016	0.807ProCys: 0.807 ± 0.007	2.458ProAsp: 2.458 ± 0.013	3.173ProGlu: 3.173 ± 0.016	2.008ProPhe: 2.008 ± 0.013	2.74ProGly: 2.74 ± 0.016	1.138ProHis: 1.138 ± 0.008	2.44ProIle: 2.44 ± 0.013	2.722ProLys: 2.722 ± 0.014	4.337ProLeu: 4.337 ± 0.018	0.981ProMet: 0.981 ± 0.008	2.314ProAsn: 2.314 ± 0.012	3.789ProPro: 3.789 ± 0.046	1.766ProGln: 1.766 ± 0.012	2.427ProArg: 2.427 ± 0.013	5.216ProSer: 5.216 ± 0.027	2.712ProThr: 2.712 ± 0.014	3.033ProVal: 3.033 ± 0.014	0.602ProTrp: 0.602 ± 0.006	1.347ProTyr: 1.347 ± 0.01	0.001ProXaa: 0.001 ± 0.0
Gln	2.421GlnAla: 2.421 ± 0.014	0.586GlnCys: 0.586 ± 0.006	1.755GlnAsp: 1.755 ± 0.011	2.572GlnGlu: 2.572 ± 0.019	1.431GlnPhe: 1.431 ± 0.009	2.174GlnGly: 2.174 ± 0.012	0.988GlnHis: 0.988 ± 0.008	1.995GlnIle: 1.995 ± 0.009	2.38GlnLys: 2.38 ± 0.013	3.692GlnLeu: 3.692 ± 0.018	0.977GlnMet: 0.977 ± 0.007	1.82GlnAsn: 1.82 ± 0.013	1.759GlnPro: 1.759 ± 0.014	2.149GlnGln: 2.149 ± 0.028	2.214GlnArg: 2.214 ± 0.013	2.964GlnSer: 2.964 ± 0.016	1.764GlnThr: 1.764 ± 0.011	2.347GlnVal: 2.347 ± 0.013	0.464GlnTrp: 0.464 ± 0.006	0.996GlnTyr: 0.996 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	3.276ArgAla: 3.276 ± 0.014	0.985ArgCys: 0.985 ± 0.009	2.746ArgAsp: 2.746 ± 0.015	3.517ArgGlu: 3.517 ± 0.019	2.206ArgPhe: 2.206 ± 0.013	3.283ArgGly: 3.283 ± 0.016	1.345ArgHis: 1.345 ± 0.009	2.883ArgIle: 2.883 ± 0.013	3.831ArgLys: 3.831 ± 0.019	5.149ArgLeu: 5.149 ± 0.02	1.363ArgMet: 1.363 ± 0.01	2.56ArgAsn: 2.56 ± 0.012	2.414ArgPro: 2.414 ± 0.013	1.893ArgGln: 1.893 ± 0.011	3.874ArgArg: 3.874 ± 0.018	4.511ArgSer: 4.511 ± 0.018	2.478ArgThr: 2.478 ± 0.013	3.314ArgVal: 3.314 ± 0.013	0.786ArgTrp: 0.786 ± 0.006	1.485ArgTyr: 1.485 ± 0.01	0.0ArgXaa: 0.0 ± 0.0
Ser	5.308SerAla: 5.308 ± 0.021	1.773SerCys: 1.773 ± 0.01	4.442SerAsp: 4.442 ± 0.018	4.984SerGlu: 4.984 ± 0.025	3.98SerPhe: 3.98 ± 0.018	5.991SerGly: 5.991 ± 0.024	2.08SerHis: 2.08 ± 0.012	4.617SerIle: 4.617 ± 0.017	4.954SerLys: 4.954 ± 0.016	8.885SerLeu: 8.885 ± 0.035	2.174SerMet: 2.174 ± 0.012	4.148SerAsn: 4.148 ± 0.02	4.629SerPro: 4.629 ± 0.029	3.148SerGln: 3.148 ± 0.018	4.634SerArg: 4.634 ± 0.017	11.099SerSer: 11.099 ± 0.046	4.836SerThr: 4.836 ± 0.018	5.145SerVal: 5.145 ± 0.022	1.189SerTrp: 1.189 ± 0.009	2.342SerTyr: 2.342 ± 0.013	0.0SerXaa: 0.0 ± 0.0
Thr	3.343ThrAla: 3.343 ± 0.013	0.919ThrCys: 0.919 ± 0.007	2.343ThrAsp: 2.343 ± 0.013	2.866ThrGlu: 2.866 ± 0.023	2.03ThrPhe: 2.03 ± 0.012	3.28ThrGly: 3.28 ± 0.015	1.06ThrHis: 1.06 ± 0.007	2.726ThrIle: 2.726 ± 0.014	2.705ThrLys: 2.705 ± 0.018	4.588ThrLeu: 4.588 ± 0.017	1.158ThrMet: 1.158 ± 0.009	2.113ThrAsn: 2.113 ± 0.011	2.537ThrPro: 2.537 ± 0.013	1.587ThrGln: 1.587 ± 0.01	2.419ThrArg: 2.419 ± 0.014	4.629ThrSer: 4.629 ± 0.019	2.909ThrThr: 2.909 ± 0.019	3.245ThrVal: 3.245 ± 0.015	0.645ThrTrp: 0.645 ± 0.006	1.373ThrTyr: 1.373 ± 0.01	0.0ThrXaa: 0.0 ± 0.0
Val	4.663ValAla: 4.663 ± 0.021	1.112ValCys: 1.112 ± 0.009	3.723ValAsp: 3.723 ± 0.016	4.494ValGlu: 4.494 ± 0.026	2.65ValPhe: 2.65 ± 0.015	4.222ValGly: 4.222 ± 0.016	1.522ValHis: 1.522 ± 0.011	3.283ValIle: 3.283 ± 0.016	3.752ValLys: 3.752 ± 0.018	6.387ValLeu: 6.387 ± 0.023	1.442ValMet: 1.442 ± 0.01	2.534ValAsn: 2.534 ± 0.012	3.214ValPro: 3.214 ± 0.014	2.33ValGln: 2.33 ± 0.014	3.088ValArg: 3.088 ± 0.014	5.398ValSer: 5.398 ± 0.019	3.047ValThr: 3.047 ± 0.013	4.694ValVal: 4.694 ± 0.019	0.792ValTrp: 0.792 ± 0.007	1.885ValTyr: 1.885 ± 0.011	0.001ValXaa: 0.001 ± 0.0
Trp	0.78TrpAla: 0.78 ± 0.007	0.244TrpCys: 0.244 ± 0.003	0.706TrpAsp: 0.706 ± 0.008	0.791TrpGlu: 0.791 ± 0.007	0.558TrpPhe: 0.558 ± 0.006	0.735TrpGly: 0.735 ± 0.008	0.324TrpHis: 0.324 ± 0.004	0.717TrpIle: 0.717 ± 0.007	0.999TrpLys: 0.999 ± 0.008	1.269TrpLeu: 1.269 ± 0.01	0.348TrpMet: 0.348 ± 0.005	0.692TrpAsn: 0.692 ± 0.006	0.504TrpPro: 0.504 ± 0.006	0.448TrpGln: 0.448 ± 0.005	0.853TrpArg: 0.853 ± 0.007	1.001TrpSer: 1.001 ± 0.008	0.64TrpThr: 0.64 ± 0.007	0.834TrpVal: 0.834 ± 0.008	0.251TrpTrp: 0.251 ± 0.004	0.327TrpTyr: 0.327 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.767TyrAla: 1.767 ± 0.011	0.614TyrCys: 0.614 ± 0.006	1.506TyrAsp: 1.506 ± 0.01	1.587TyrGlu: 1.587 ± 0.01	1.296TyrPhe: 1.296 ± 0.008	2.131TyrGly: 2.131 ± 0.013	0.732TyrHis: 0.732 ± 0.007	1.415TyrIle: 1.415 ± 0.009	1.543TyrLys: 1.543 ± 0.01	2.807TyrLeu: 2.807 ± 0.015	0.749TyrMet: 0.749 ± 0.008	1.276TyrAsn: 1.276 ± 0.009	1.255TyrPro: 1.255 ± 0.009	0.952TyrGln: 0.952 ± 0.007	1.497TyrArg: 1.497 ± 0.009	2.302TyrSer: 2.302 ± 0.012	1.273TyrThr: 1.273 ± 0.008	1.695TyrVal: 1.695 ± 0.011	0.407TyrTrp: 0.407 ± 0.006	0.931TyrTyr: 0.931 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 38418 proteins (18253930 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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