Amino acid dipepetide frequency for Apeu virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.992AlaAla: 1.992 ± 1.485
1.494AlaCys: 1.494 ± 0.702
1.494AlaAsp: 1.494 ± 1.382
2.987AlaGlu: 2.987 ± 0.606
3.236AlaPhe: 3.236 ± 0.417
1.743AlaGly: 1.743 ± 1.256
0.498AlaHis: 0.498 ± 0.15
4.481AlaIle: 4.481 ± 0.753
4.232AlaLys: 4.232 ± 3.403
5.726AlaLeu: 5.726 ± 1.157
0.249AlaMet: 0.249 ± 0.165
4.979AlaAsn: 4.979 ± 2.347
0.747AlaPro: 0.747 ± 0.351
1.494AlaGln: 1.494 ± 1.382
1.743AlaArg: 1.743 ± 0.632
2.24AlaSer: 2.24 ± 0.779
2.24AlaThr: 2.24 ± 0.554
1.245AlaVal: 1.245 ± 0.625
0.498AlaTrp: 0.498 ± 0.15
2.738AlaTyr: 2.738 ± 0.577
0.0AlaXaa: 0.0 ± 0.0
Cys
0.498CysAla: 0.498 ± 0.331
0.249CysCys: 0.249 ± 0.165
0.498CysAsp: 0.498 ± 0.15
1.494CysGlu: 1.494 ± 1.028
1.743CysPhe: 1.743 ± 0.923
3.485CysGly: 3.485 ± 1.846
0.249CysHis: 0.249 ± 0.229
2.489CysIle: 2.489 ± 1.6
1.992CysLys: 1.992 ± 1.147
2.738CysLeu: 2.738 ± 0.872
0.498CysMet: 0.498 ± 0.15
1.743CysAsn: 1.743 ± 0.472
0.996CysPro: 0.996 ± 0.301
1.245CysGln: 1.245 ± 0.8
0.498CysArg: 0.498 ± 0.459
3.485CysSer: 3.485 ± 1.369
2.24CysThr: 2.24 ± 1.053
1.743CysVal: 1.743 ± 0.923
0.249CysTrp: 0.249 ± 0.165
0.747CysTyr: 0.747 ± 0.351
0.0CysXaa: 0.0 ± 0.0
Asp
1.743AspAla: 1.743 ± 0.832
1.245AspCys: 1.245 ± 0.335
3.236AspAsp: 3.236 ± 1.22
2.738AspGlu: 2.738 ± 0.787
3.485AspPhe: 3.485 ± 1.375
1.992AspGly: 1.992 ± 0.753
0.249AspHis: 0.249 ± 0.229
4.481AspIle: 4.481 ± 1.557
3.236AspLys: 3.236 ± 0.417
4.979AspLeu: 4.979 ± 1.159
1.992AspMet: 1.992 ± 0.996
2.987AspAsn: 2.987 ± 0.903
1.992AspPro: 1.992 ± 0.682
1.245AspGln: 1.245 ± 0.511
2.987AspArg: 2.987 ± 1.068
2.24AspSer: 2.24 ± 0.779
3.485AspThr: 3.485 ± 1.484
3.983AspVal: 3.983 ± 1.176
0.249AspTrp: 0.249 ± 0.165
1.992AspTyr: 1.992 ± 0.545
0.0AspXaa: 0.0 ± 0.0
Glu
2.738GluAla: 2.738 ± 0.577
1.494GluCys: 1.494 ± 1.053
2.738GluAsp: 2.738 ± 1.18
4.73GluGlu: 4.73 ± 1.62
5.726GluPhe: 5.726 ± 2.427
0.747GluGly: 0.747 ± 0.218
1.743GluHis: 1.743 ± 1.601
8.215GluIle: 8.215 ± 0.632
5.477GluLys: 5.477 ± 1.574
5.477GluLeu: 5.477 ± 0.998
3.485GluMet: 3.485 ± 1.156
2.987GluAsn: 2.987 ± 1.267
1.245GluPro: 1.245 ± 0.827
1.743GluGln: 1.743 ± 0.566
2.987GluArg: 2.987 ± 0.921
3.983GluSer: 3.983 ± 0.951
3.734GluThr: 3.734 ± 1.223
3.485GluVal: 3.485 ± 1.133
0.249GluTrp: 0.249 ± 0.165
1.992GluTyr: 1.992 ± 0.545
0.0GluXaa: 0.0 ± 0.0
Phe
2.24PheAla: 2.24 ± 0.615
2.738PheCys: 2.738 ± 1.18
2.987PheAsp: 2.987 ± 1.088
3.983PheGlu: 3.983 ± 1.018
2.738PhePhe: 2.738 ± 1.386
2.489PheGly: 2.489 ± 1.25
0.747PheHis: 0.747 ± 0.218
2.24PheIle: 2.24 ± 1.159
5.477PheLys: 5.477 ± 1.646
3.485PheLeu: 3.485 ± 2.898
0.996PheMet: 0.996 ± 0.356
1.992PheAsn: 1.992 ± 1.323
1.245PhePro: 1.245 ± 0.625
1.743PheGln: 1.743 ± 0.566
2.489PheArg: 2.489 ± 1.283
3.734PheSer: 3.734 ± 1.023
2.738PheThr: 2.738 ± 0.926
3.485PheVal: 3.485 ± 1.006
0.498PheTrp: 0.498 ± 0.15
2.489PheTyr: 2.489 ± 0.978
0.0PheXaa: 0.0 ± 0.0
Gly
0.747GlyAla: 0.747 ± 0.218
2.489GlyCys: 2.489 ± 1.6
3.485GlyAsp: 3.485 ± 1.133
3.983GlyGlu: 3.983 ± 1.018
0.747GlyPhe: 0.747 ± 0.724
0.996GlyGly: 0.996 ± 0.356
0.498GlyHis: 0.498 ± 0.459
4.232GlyIle: 4.232 ± 0.826
2.738GlyLys: 2.738 ± 0.926
2.738GlyLeu: 2.738 ± 1.231
0.747GlyMet: 0.747 ± 0.351
3.734GlyAsn: 3.734 ± 1.088
0.996GlyPro: 0.996 ± 0.301
0.747GlyGln: 0.747 ± 0.724
2.489GlyArg: 2.489 ± 2.128
1.992GlySer: 1.992 ± 1.485
2.987GlyThr: 2.987 ± 1.945
2.738GlyVal: 2.738 ± 1.416
0.996GlyTrp: 0.996 ± 0.301
1.992GlyTyr: 1.992 ± 0.602
0.0GlyXaa: 0.0 ± 0.0
His
0.996HisAla: 0.996 ± 0.918
0.996HisCys: 0.996 ± 0.918
0.0HisAsp: 0.0 ± 0.0
1.245HisGlu: 1.245 ± 0.832
1.245HisPhe: 1.245 ± 0.827
1.245HisGly: 1.245 ± 0.511
0.498HisHis: 0.498 ± 0.15
1.245HisIle: 1.245 ± 0.511
0.996HisLys: 0.996 ± 0.356
1.494HisLeu: 1.494 ± 0.435
0.498HisMet: 0.498 ± 0.15
2.738HisAsn: 2.738 ± 0.759
1.245HisPro: 1.245 ± 0.8
0.498HisGln: 0.498 ± 0.459
1.245HisArg: 1.245 ± 2.402
1.494HisSer: 1.494 ± 0.451
0.996HisThr: 0.996 ± 1.092
0.498HisVal: 0.498 ± 0.331
0.498HisTrp: 0.498 ± 0.331
0.747HisTyr: 0.747 ± 0.707
0.0HisXaa: 0.0 ± 0.0
Ile
3.983IleAla: 3.983 ± 0.923
1.743IleCys: 1.743 ± 1.256
3.983IleAsp: 3.983 ± 1.123
5.975IleGlu: 5.975 ± 0.922
3.734IlePhe: 3.734 ± 1.466
2.489IleGly: 2.489 ± 1.654
1.245IleHis: 1.245 ± 0.511
6.721IleIle: 6.721 ± 2.36
9.211IleLys: 9.211 ± 2.907
10.207IleLeu: 10.207 ± 2.099
2.738IleMet: 2.738 ± 0.76
4.73IleAsn: 4.73 ± 0.943
3.485IlePro: 3.485 ± 0.975
3.236IleGln: 3.236 ± 1.299
4.979IleArg: 4.979 ± 2.385
4.979IleSer: 4.979 ± 1.121
4.73IleThr: 4.73 ± 1.785
4.232IleVal: 4.232 ± 1.206
0.996IleTrp: 0.996 ± 0.301
3.983IleTyr: 3.983 ± 2.116
0.0IleXaa: 0.0 ± 0.0
Lys
3.236LysAla: 3.236 ± 1.075
2.738LysCys: 2.738 ± 1.188
4.232LysAsp: 4.232 ± 1.14
6.721LysGlu: 6.721 ± 1.709
3.236LysPhe: 3.236 ± 1.271
4.232LysGly: 4.232 ± 0.906
1.992LysHis: 1.992 ± 0.953
6.721LysIle: 6.721 ± 1.17
4.481LysLys: 4.481 ± 0.844
7.966LysLeu: 7.966 ± 1.414
3.236LysMet: 3.236 ± 0.654
3.983LysAsn: 3.983 ± 0.49
2.738LysPro: 2.738 ± 0.499
2.738LysGln: 2.738 ± 1.122
2.489LysArg: 2.489 ± 1.021
4.481LysSer: 4.481 ± 1.108
5.975LysThr: 5.975 ± 1.805
3.983LysVal: 3.983 ± 1.32
0.996LysTrp: 0.996 ± 0.636
2.489LysTyr: 2.489 ± 0.671
0.0LysXaa: 0.0 ± 0.0
Leu
5.477LeuAla: 5.477 ± 2.67
2.489LeuCys: 2.489 ± 1.563
5.477LeuAsp: 5.477 ± 1.795
5.975LeuGlu: 5.975 ± 1.754
3.485LeuPhe: 3.485 ± 1.213
2.987LeuGly: 2.987 ± 1.314
2.987LeuHis: 2.987 ± 1.188
7.219LeuIle: 7.219 ± 1.481
6.721LeuLys: 6.721 ± 1.31
11.7LeuLeu: 11.7 ± 6.66
2.738LeuMet: 2.738 ± 1.162
7.966LeuAsn: 7.966 ± 3.292
3.485LeuPro: 3.485 ± 1.508
3.485LeuGln: 3.485 ± 0.975
4.481LeuArg: 4.481 ± 2.858
7.966LeuSer: 7.966 ± 1.403
6.472LeuThr: 6.472 ± 2.951
2.489LeuVal: 2.489 ± 0.781
0.249LeuTrp: 0.249 ± 0.165
3.236LeuTyr: 3.236 ± 0.468
0.0LeuXaa: 0.0 ± 0.0
Met
0.996MetAla: 0.996 ± 0.636
0.996MetCys: 0.996 ± 0.574
1.743MetAsp: 1.743 ± 0.832
1.245MetGlu: 1.245 ± 0.511
0.996MetPhe: 0.996 ± 0.636
0.747MetGly: 0.747 ± 0.351
0.498MetHis: 0.498 ± 0.15
3.485MetIle: 3.485 ± 0.543
3.734MetLys: 3.734 ± 0.945
2.489MetLeu: 2.489 ± 0.45
1.494MetMet: 1.494 ± 0.992
1.743MetAsn: 1.743 ± 1.268
1.743MetPro: 1.743 ± 0.472
0.498MetGln: 0.498 ± 0.15
2.24MetArg: 2.24 ± 0.897
2.738MetSer: 2.738 ± 0.936
2.489MetThr: 2.489 ± 0.752
1.743MetVal: 1.743 ± 1.056
0.0MetTrp: 0.0 ± 0.0
0.249MetTyr: 0.249 ± 0.165
0.0MetXaa: 0.0 ± 0.0
Asn
2.987AsnAla: 2.987 ± 0.805
1.245AsnCys: 1.245 ± 0.8
3.983AsnAsp: 3.983 ± 1.176
4.232AsnGlu: 4.232 ± 1.003
2.738AsnPhe: 2.738 ± 0.921
1.494AsnGly: 1.494 ± 0.702
2.24AsnHis: 2.24 ± 1.2
4.232AsnIle: 4.232 ± 1.003
4.232AsnLys: 4.232 ± 1.627
6.472AsnLeu: 6.472 ± 1.021
1.992AsnMet: 1.992 ± 0.545
3.485AsnAsn: 3.485 ± 0.829
2.489AsnPro: 2.489 ± 0.667
2.489AsnGln: 2.489 ± 1.021
1.992AsnArg: 1.992 ± 1.251
3.734AsnSer: 3.734 ± 0.49
4.232AsnThr: 4.232 ± 1.965
2.24AsnVal: 2.24 ± 0.615
0.747AsnTrp: 0.747 ± 0.496
2.489AsnTyr: 2.489 ± 0.671
0.0AsnXaa: 0.0 ± 0.0
Pro
2.489ProAla: 2.489 ± 0.989
0.0ProCys: 0.0 ± 0.0
1.245ProAsp: 1.245 ± 0.603
3.485ProGlu: 3.485 ± 0.578
0.996ProPhe: 0.996 ± 0.301
1.992ProGly: 1.992 ± 0.509
0.498ProHis: 0.498 ± 0.459
3.236ProIle: 3.236 ± 0.953
3.734ProLys: 3.734 ± 0.49
2.738ProLeu: 2.738 ± 2.159
0.747ProMet: 0.747 ± 0.351
1.494ProAsn: 1.494 ± 0.435
0.498ProPro: 0.498 ± 0.331
0.249ProGln: 0.249 ± 0.165
0.249ProArg: 0.249 ± 0.165
2.738ProSer: 2.738 ± 0.921
1.743ProThr: 1.743 ± 0.947
2.24ProVal: 2.24 ± 0.615
0.747ProTrp: 0.747 ± 0.724
0.747ProTyr: 0.747 ± 0.218
0.0ProXaa: 0.0 ± 0.0
Gln
2.489GlnAla: 2.489 ± 1.563
0.747GlnCys: 0.747 ± 0.496
1.494GlnAsp: 1.494 ± 0.67
1.743GlnGlu: 1.743 ± 0.923
1.494GlnPhe: 1.494 ± 0.67
1.992GlnGly: 1.992 ± 1.147
0.996GlnHis: 0.996 ± 0.918
2.987GlnIle: 2.987 ± 1.224
2.24GlnLys: 2.24 ± 1.228
2.24GlnLeu: 2.24 ± 0.897
1.245GlnMet: 1.245 ± 0.511
0.747GlnAsn: 0.747 ± 0.707
0.747GlnPro: 0.747 ± 0.351
1.494GlnGln: 1.494 ± 1.38
2.24GlnArg: 2.24 ± 0.865
4.73GlnSer: 4.73 ± 1.185
2.987GlnThr: 2.987 ± 0.805
0.747GlnVal: 0.747 ± 0.351
0.249GlnTrp: 0.249 ± 0.229
1.245GlnTyr: 1.245 ± 0.603
0.0GlnXaa: 0.0 ± 0.0
Arg
1.245ArgAla: 1.245 ± 1.44
1.743ArgCys: 1.743 ± 0.632
3.983ArgAsp: 3.983 ± 1.424
2.489ArgGlu: 2.489 ± 0.989
1.245ArgPhe: 1.245 ± 0.335
1.992ArgGly: 1.992 ± 1.227
0.747ArgHis: 0.747 ± 0.496
4.73ArgIle: 4.73 ± 2.175
2.738ArgLys: 2.738 ± 0.887
3.734ArgLeu: 3.734 ± 3.048
1.743ArgMet: 1.743 ± 0.947
2.987ArgAsn: 2.987 ± 1.068
0.249ArgPro: 0.249 ± 0.81
1.494ArgGln: 1.494 ± 1.38
1.245ArgArg: 1.245 ± 1.141
3.236ArgSer: 3.236 ± 4.325
1.992ArgThr: 1.992 ± 0.996
1.743ArgVal: 1.743 ± 1.245
0.249ArgTrp: 0.249 ± 0.229
2.24ArgTyr: 2.24 ± 1.159
0.0ArgXaa: 0.0 ± 0.0
Ser
3.983SerAla: 3.983 ± 1.709
1.992SerCys: 1.992 ± 1.147
3.734SerAsp: 3.734 ± 1.057
3.734SerGlu: 3.734 ± 1.088
2.987SerPhe: 2.987 ± 0.945
2.24SerGly: 2.24 ± 1.24
1.494SerHis: 1.494 ± 0.451
6.97SerIle: 6.97 ± 1.966
5.477SerLys: 5.477 ± 0.998
9.709SerLeu: 9.709 ± 4.885
2.489SerMet: 2.489 ± 1.727
3.734SerAsn: 3.734 ± 2.069
2.24SerPro: 2.24 ± 0.865
2.738SerGln: 2.738 ± 0.499
2.987SerArg: 2.987 ± 0.606
5.477SerSer: 5.477 ± 5.953
3.485SerThr: 3.485 ± 0.421
4.979SerVal: 4.979 ± 1.748
0.747SerTrp: 0.747 ± 1.102
1.992SerTyr: 1.992 ± 0.838
0.0SerXaa: 0.0 ± 0.0
Thr
4.481ThrAla: 4.481 ± 0.591
1.494ThrCys: 1.494 ± 1.028
2.489ThrAsp: 2.489 ± 0.978
3.485ThrGlu: 3.485 ± 1.484
3.236ThrPhe: 3.236 ± 0.468
3.734ThrGly: 3.734 ± 1.868
1.494ThrHis: 1.494 ± 0.702
4.481ThrIle: 4.481 ± 0.944
4.979ThrLys: 4.979 ± 1.163
3.983ThrLeu: 3.983 ± 3.505
1.245ThrMet: 1.245 ± 0.603
3.485ThrAsn: 3.485 ± 0.975
1.992ThrPro: 1.992 ± 1.323
2.489ThrGln: 2.489 ± 0.902
1.494ThrArg: 1.494 ± 0.67
5.228ThrSer: 5.228 ± 0.743
4.481ThrThr: 4.481 ± 1.231
4.232ThrVal: 4.232 ± 1.249
1.245ThrTrp: 1.245 ± 1.44
3.734ThrTyr: 3.734 ± 1.006
0.0ThrXaa: 0.0 ± 0.0
Val
1.992ValAla: 1.992 ± 0.99
2.24ValCys: 2.24 ± 0.779
1.743ValAsp: 1.743 ± 0.824
2.489ValGlu: 2.489 ± 0.667
3.983ValPhe: 3.983 ± 1.176
3.485ValGly: 3.485 ± 0.975
0.747ValHis: 0.747 ± 0.496
3.485ValIle: 3.485 ± 1.665
2.738ValLys: 2.738 ± 1.188
4.73ValLeu: 4.73 ± 1.824
1.494ValMet: 1.494 ± 0.54
1.743ValAsn: 1.743 ± 0.667
2.24ValPro: 2.24 ± 0.653
2.489ValGln: 2.489 ± 0.978
1.743ValArg: 1.743 ± 4.506
6.224ValSer: 6.224 ± 0.938
2.738ValThr: 2.738 ± 1.205
2.24ValVal: 2.24 ± 0.422
0.0ValTrp: 0.0 ± 0.0
0.498ValTyr: 0.498 ± 0.15
0.0ValXaa: 0.0 ± 0.0
Trp
0.249TrpAla: 0.249 ± 0.81
0.0TrpCys: 0.0 ± 0.0
0.498TrpAsp: 0.498 ± 0.331
0.747TrpGlu: 0.747 ± 0.496
0.747TrpPhe: 0.747 ± 0.218
0.996TrpGly: 0.996 ± 0.738
0.0TrpHis: 0.0 ± 0.0
0.498TrpIle: 0.498 ± 0.15
0.249TrpLys: 0.249 ± 0.81
1.992TrpLeu: 1.992 ± 0.838
0.249TrpMet: 0.249 ± 0.81
0.498TrpAsn: 0.498 ± 0.331
0.0TrpPro: 0.0 ± 0.0
0.996TrpGln: 0.996 ± 1.109
0.0TrpArg: 0.0 ± 0.0
1.245TrpSer: 1.245 ± 0.827
0.0TrpThr: 0.0 ± 0.0
0.747TrpVal: 0.747 ± 0.218
0.0TrpTrp: 0.0 ± 0.0
0.249TrpTyr: 0.249 ± 0.165
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.494TyrAla: 1.494 ± 0.973
0.747TyrCys: 0.747 ± 0.688
1.494TyrAsp: 1.494 ± 0.451
1.743TyrGlu: 1.743 ± 0.566
2.738TyrPhe: 2.738 ± 0.926
0.996TyrGly: 0.996 ± 0.356
0.996TyrHis: 0.996 ± 0.574
5.228TyrIle: 5.228 ± 0.842
3.983TyrLys: 3.983 ± 1.115
2.489TyrLeu: 2.489 ± 0.667
1.743TyrMet: 1.743 ± 0.566
1.992TyrAsn: 1.992 ± 0.545
1.494TyrPro: 1.494 ± 0.54
1.743TyrGln: 1.743 ± 0.472
1.245TyrArg: 1.245 ± 0.603
1.245TyrSer: 1.245 ± 0.335
3.734TyrThr: 3.734 ± 1.006
0.249TyrVal: 0.249 ± 0.165
0.498TyrTrp: 0.498 ± 0.331
1.743TyrTyr: 1.743 ± 0.632
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (4018 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski