Amino acid dipepetide frequency for Emiliania huxleyi virus 207

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.192AlaAla: 5.192 ± 0.292
1.077AlaCys: 1.077 ± 0.096
3.135AlaAsp: 3.135 ± 0.174
3.021AlaGlu: 3.021 ± 0.195
2.624AlaPhe: 2.624 ± 0.144
3.572AlaGly: 3.572 ± 0.195
1.62AlaHis: 1.62 ± 0.101
4.917AlaIle: 4.917 ± 0.244
3.337AlaLys: 3.337 ± 0.249
4.722AlaLeu: 4.722 ± 0.202
1.928AlaMet: 1.928 ± 0.139
3.248AlaAsn: 3.248 ± 0.197
3.353AlaPro: 3.353 ± 0.231
1.887AlaGln: 1.887 ± 0.114
3.256AlaArg: 3.256 ± 0.187
5.119AlaSer: 5.119 ± 0.248
4.163AlaThr: 4.163 ± 0.193
4.487AlaVal: 4.487 ± 0.233
0.721AlaTrp: 0.721 ± 0.092
2.6AlaTyr: 2.6 ± 0.167
0.0AlaXaa: 0.0 ± 0.0
Cys
1.118CysAla: 1.118 ± 0.112
0.502CysCys: 0.502 ± 0.075
1.004CysAsp: 1.004 ± 0.08
0.972CysGlu: 0.972 ± 0.12
0.64CysPhe: 0.64 ± 0.076
1.409CysGly: 1.409 ± 0.133
0.332CysHis: 0.332 ± 0.047
1.596CysIle: 1.596 ± 0.133
1.312CysLys: 1.312 ± 0.134
0.915CysLeu: 0.915 ± 0.094
0.697CysMet: 0.697 ± 0.084
1.353CysAsn: 1.353 ± 0.114
0.948CysPro: 0.948 ± 0.097
0.445CysGln: 0.445 ± 0.062
0.729CysArg: 0.729 ± 0.099
1.385CysSer: 1.385 ± 0.148
1.458CysThr: 1.458 ± 0.123
1.166CysVal: 1.166 ± 0.097
0.146CysTrp: 0.146 ± 0.035
0.575CysTyr: 0.575 ± 0.08
0.0CysXaa: 0.0 ± 0.0
Asp
4.277AspAla: 4.277 ± 0.216
0.786AspCys: 0.786 ± 0.087
4.244AspAsp: 4.244 ± 0.268
3.993AspGlu: 3.993 ± 0.244
2.26AspPhe: 2.26 ± 0.184
3.58AspGly: 3.58 ± 0.243
1.061AspHis: 1.061 ± 0.099
4.625AspIle: 4.625 ± 0.183
2.803AspLys: 2.803 ± 0.194
3.653AspLeu: 3.653 ± 0.214
1.741AspMet: 1.741 ± 0.139
2.973AspAsn: 2.973 ± 0.168
2.519AspPro: 2.519 ± 0.133
1.563AspGln: 1.563 ± 0.105
2.381AspArg: 2.381 ± 0.17
3.685AspSer: 3.685 ± 0.19
4.179AspThr: 4.179 ± 0.211
4.09AspVal: 4.09 ± 0.211
0.575AspTrp: 0.575 ± 0.064
2.09AspTyr: 2.09 ± 0.135
0.0AspXaa: 0.0 ± 0.0
Glu
2.414GluAla: 2.414 ± 0.173
1.231GluCys: 1.231 ± 0.111
2.568GluAsp: 2.568 ± 0.15
2.989GluGlu: 2.989 ± 0.248
2.284GluPhe: 2.284 ± 0.126
1.814GluGly: 1.814 ± 0.143
1.507GluHis: 1.507 ± 0.142
3.604GluIle: 3.604 ± 0.171
2.835GluLys: 2.835 ± 0.209
4.941GluLeu: 4.941 ± 0.223
1.806GluMet: 1.806 ± 0.136
3.224GluAsn: 3.224 ± 0.165
2.252GluPro: 2.252 ± 0.181
2.155GluGln: 2.155 ± 0.137
2.333GluArg: 2.333 ± 0.158
2.981GluSer: 2.981 ± 0.151
3.467GluThr: 3.467 ± 0.166
2.819GluVal: 2.819 ± 0.167
0.616GluTrp: 0.616 ± 0.07
2.964GluTyr: 2.964 ± 0.183
0.0GluXaa: 0.0 ± 0.0
Phe
2.624PheAla: 2.624 ± 0.16
0.729PheCys: 0.729 ± 0.086
2.551PheAsp: 2.551 ± 0.139
2.057PheGlu: 2.057 ± 0.142
1.353PhePhe: 1.353 ± 0.137
2.543PheGly: 2.543 ± 0.147
0.931PheHis: 0.931 ± 0.095
3.305PheIle: 3.305 ± 0.177
1.782PheLys: 1.782 ± 0.146
2.819PheLeu: 2.819 ± 0.17
1.571PheMet: 1.571 ± 0.125
2.365PheAsn: 2.365 ± 0.129
1.839PhePro: 1.839 ± 0.124
0.81PheGln: 0.81 ± 0.074
1.345PheArg: 1.345 ± 0.084
2.811PheSer: 2.811 ± 0.149
2.632PheThr: 2.632 ± 0.137
2.673PheVal: 2.673 ± 0.14
0.413PheTrp: 0.413 ± 0.054
1.498PheTyr: 1.498 ± 0.104
0.0PheXaa: 0.0 ± 0.0
Gly
3.637GlyAla: 3.637 ± 0.211
1.045GlyCys: 1.045 ± 0.092
3.459GlyAsp: 3.459 ± 0.213
2.349GlyGlu: 2.349 ± 0.16
2.195GlyPhe: 2.195 ± 0.136
3.58GlyGly: 3.58 ± 0.277
1.11GlyHis: 1.11 ± 0.116
4.779GlyIle: 4.779 ± 0.252
3.313GlyLys: 3.313 ± 0.17
3.621GlyLeu: 3.621 ± 0.198
1.596GlyMet: 1.596 ± 0.116
3.078GlyAsn: 3.078 ± 0.2
1.669GlyPro: 1.669 ± 0.114
1.547GlyGln: 1.547 ± 0.13
2.219GlyArg: 2.219 ± 0.132
4.074GlySer: 4.074 ± 0.251
4.066GlyThr: 4.066 ± 0.272
3.839GlyVal: 3.839 ± 0.24
0.632GlyTrp: 0.632 ± 0.068
2.495GlyTyr: 2.495 ± 0.166
0.0GlyXaa: 0.0 ± 0.0
His
1.798HisAla: 1.798 ± 0.133
0.47HisCys: 0.47 ± 0.062
1.385HisAsp: 1.385 ± 0.122
1.296HisGlu: 1.296 ± 0.108
0.891HisPhe: 0.891 ± 0.089
1.458HisGly: 1.458 ± 0.144
1.166HisHis: 1.166 ± 0.266
1.895HisIle: 1.895 ± 0.144
1.312HisLys: 1.312 ± 0.105
1.733HisLeu: 1.733 ± 0.143
0.81HisMet: 0.81 ± 0.079
1.361HisAsn: 1.361 ± 0.117
1.369HisPro: 1.369 ± 0.136
0.818HisGln: 0.818 ± 0.076
1.426HisArg: 1.426 ± 0.183
1.579HisSer: 1.579 ± 0.131
1.652HisThr: 1.652 ± 0.134
1.822HisVal: 1.822 ± 0.138
0.211HisTrp: 0.211 ± 0.038
0.899HisTyr: 0.899 ± 0.079
0.0HisXaa: 0.0 ± 0.0
Ile
5.006IleAla: 5.006 ± 0.202
1.523IleCys: 1.523 ± 0.116
4.455IleAsp: 4.455 ± 0.18
3.653IleGlu: 3.653 ± 0.188
2.616IlePhe: 2.616 ± 0.172
4.366IleGly: 4.366 ± 0.222
1.806IleHis: 1.806 ± 0.152
5.654IleIle: 5.654 ± 0.265
4.074IleLys: 4.074 ± 0.268
5.646IleLeu: 5.646 ± 0.233
1.855IleMet: 1.855 ± 0.147
3.945IleAsn: 3.945 ± 0.166
3.629IlePro: 3.629 ± 0.198
2.325IleGln: 2.325 ± 0.129
3.329IleArg: 3.329 ± 0.161
5.184IleSer: 5.184 ± 0.205
5.038IleThr: 5.038 ± 0.208
5.394IleVal: 5.394 ± 0.205
0.753IleTrp: 0.753 ± 0.086
2.835IleTyr: 2.835 ± 0.155
0.0IleXaa: 0.0 ± 0.0
Lys
2.608LysAla: 2.608 ± 0.195
1.118LysCys: 1.118 ± 0.121
2.495LysAsp: 2.495 ± 0.173
2.827LysGlu: 2.827 ± 0.224
2.252LysPhe: 2.252 ± 0.131
1.912LysGly: 1.912 ± 0.179
1.928LysHis: 1.928 ± 0.159
3.531LysIle: 3.531 ± 0.213
4.9LysLys: 4.9 ± 0.327
4.471LysLeu: 4.471 ± 0.233
1.596LysMet: 1.596 ± 0.137
3.766LysAsn: 3.766 ± 0.225
2.333LysPro: 2.333 ± 0.155
2.074LysGln: 2.074 ± 0.143
3.677LysArg: 3.677 ± 0.287
3.548LysSer: 3.548 ± 0.217
3.904LysThr: 3.904 ± 0.201
2.908LysVal: 2.908 ± 0.217
0.705LysTrp: 0.705 ± 0.082
3.369LysTyr: 3.369 ± 0.19
0.0LysXaa: 0.0 ± 0.0
Leu
4.795LeuAla: 4.795 ± 0.249
1.458LeuCys: 1.458 ± 0.107
3.637LeuAsp: 3.637 ± 0.183
3.523LeuGlu: 3.523 ± 0.208
3.216LeuPhe: 3.216 ± 0.198
3.734LeuGly: 3.734 ± 0.162
2.106LeuHis: 2.106 ± 0.122
5.305LeuIle: 5.305 ± 0.217
4.082LeuLys: 4.082 ± 0.233
6.245LeuLeu: 6.245 ± 0.302
2.276LeuMet: 2.276 ± 0.167
3.75LeuAsn: 3.75 ± 0.187
4.204LeuPro: 4.204 ± 0.193
2.317LeuGln: 2.317 ± 0.133
3.256LeuArg: 3.256 ± 0.191
6.156LeuSer: 6.156 ± 0.223
5.014LeuThr: 5.014 ± 0.219
4.439LeuVal: 4.439 ± 0.188
0.786LeuTrp: 0.786 ± 0.08
3.232LeuTyr: 3.232 ± 0.171
0.0LeuXaa: 0.0 ± 0.0
Met
2.041MetAla: 2.041 ± 0.168
0.478MetCys: 0.478 ± 0.057
1.758MetAsp: 1.758 ± 0.146
1.628MetGlu: 1.628 ± 0.152
1.547MetPhe: 1.547 ± 0.132
1.32MetGly: 1.32 ± 0.103
0.834MetHis: 0.834 ± 0.097
1.669MetIle: 1.669 ± 0.14
1.66MetLys: 1.66 ± 0.128
2.381MetLeu: 2.381 ± 0.17
1.069MetMet: 1.069 ± 0.093
1.571MetAsn: 1.571 ± 0.111
1.539MetPro: 1.539 ± 0.125
1.077MetGln: 1.077 ± 0.09
1.385MetArg: 1.385 ± 0.104
2.487MetSer: 2.487 ± 0.165
2.082MetThr: 2.082 ± 0.115
1.628MetVal: 1.628 ± 0.119
0.356MetTrp: 0.356 ± 0.053
1.677MetTyr: 1.677 ± 0.13
0.0MetXaa: 0.0 ± 0.0
Asn
4.09AsnAla: 4.09 ± 0.241
0.721AsnCys: 0.721 ± 0.077
3.758AsnAsp: 3.758 ± 0.186
2.778AsnGlu: 2.778 ± 0.168
1.636AsnPhe: 1.636 ± 0.095
4.026AsnGly: 4.026 ± 0.249
1.134AsnHis: 1.134 ± 0.091
4.269AsnIle: 4.269 ± 0.192
3.507AsnLys: 3.507 ± 0.181
3.515AsnLeu: 3.515 ± 0.165
1.831AsnMet: 1.831 ± 0.135
3.507AsnAsn: 3.507 ± 0.193
2.803AsnPro: 2.803 ± 0.158
1.458AsnGln: 1.458 ± 0.096
2.543AsnArg: 2.543 ± 0.159
3.386AsnSer: 3.386 ± 0.167
4.293AsnThr: 4.293 ± 0.205
3.783AsnVal: 3.783 ± 0.172
0.607AsnTrp: 0.607 ± 0.088
1.993AsnTyr: 1.993 ± 0.146
0.0AsnXaa: 0.0 ± 0.0
Pro
2.649ProAla: 2.649 ± 0.175
0.778ProCys: 0.778 ± 0.078
2.924ProAsp: 2.924 ± 0.173
2.624ProGlu: 2.624 ± 0.148
1.75ProPhe: 1.75 ± 0.144
2.689ProGly: 2.689 ± 0.196
1.11ProHis: 1.11 ± 0.112
3.337ProIle: 3.337 ± 0.168
2.211ProLys: 2.211 ± 0.164
3.548ProLeu: 3.548 ± 0.186
1.223ProMet: 1.223 ± 0.086
2.244ProAsn: 2.244 ± 0.148
12.87ProPro: 12.87 ± 2.613
1.32ProGln: 1.32 ± 0.113
2.025ProArg: 2.025 ± 0.123
7.201ProSer: 7.201 ± 0.906
3.523ProThr: 3.523 ± 0.197
3.855ProVal: 3.855 ± 0.219
0.421ProTrp: 0.421 ± 0.05
1.871ProTyr: 1.871 ± 0.121
0.0ProXaa: 0.0 ± 0.0
Gln
1.822GlnAla: 1.822 ± 0.124
0.81GlnCys: 0.81 ± 0.119
1.32GlnAsp: 1.32 ± 0.11
1.45GlnGlu: 1.45 ± 0.124
1.385GlnPhe: 1.385 ± 0.104
1.166GlnGly: 1.166 ± 0.092
0.883GlnHis: 0.883 ± 0.091
2.227GlnIle: 2.227 ± 0.149
1.79GlnLys: 1.79 ± 0.154
2.576GlnLeu: 2.576 ± 0.132
0.972GlnMet: 0.972 ± 0.096
1.482GlnAsn: 1.482 ± 0.095
1.434GlnPro: 1.434 ± 0.111
1.345GlnGln: 1.345 ± 0.115
1.839GlnArg: 1.839 ± 0.146
2.09GlnSer: 2.09 ± 0.135
2.333GlnThr: 2.333 ± 0.17
1.879GlnVal: 1.879 ± 0.116
0.429GlnTrp: 0.429 ± 0.053
1.401GlnTyr: 1.401 ± 0.119
0.0GlnXaa: 0.0 ± 0.0
Arg
3.013ArgAla: 3.013 ± 0.155
0.761ArgCys: 0.761 ± 0.077
2.681ArgAsp: 2.681 ± 0.154
2.527ArgGlu: 2.527 ± 0.159
1.669ArgPhe: 1.669 ± 0.135
2.187ArgGly: 2.187 ± 0.143
1.401ArgHis: 1.401 ± 0.209
3.345ArgIle: 3.345 ± 0.186
2.997ArgLys: 2.997 ± 0.204
3.224ArgLeu: 3.224 ± 0.174
1.579ArgMet: 1.579 ± 0.126
2.964ArgAsn: 2.964 ± 0.168
1.984ArgPro: 1.984 ± 0.12
1.766ArgGln: 1.766 ± 0.134
3.783ArgArg: 3.783 ± 0.351
3.499ArgSer: 3.499 ± 0.227
2.916ArgThr: 2.916 ± 0.174
3.037ArgVal: 3.037 ± 0.166
0.397ArgTrp: 0.397 ± 0.048
1.903ArgTyr: 1.903 ± 0.104
0.0ArgXaa: 0.0 ± 0.0
Ser
4.593SerAla: 4.593 ± 0.197
1.353SerCys: 1.353 ± 0.141
4.228SerAsp: 4.228 ± 0.192
3.726SerGlu: 3.726 ± 0.178
2.867SerPhe: 2.867 ± 0.141
4.536SerGly: 4.536 ± 0.367
1.774SerHis: 1.774 ± 0.13
5.038SerIle: 5.038 ± 0.222
3.815SerLys: 3.815 ± 0.223
5.07SerLeu: 5.07 ± 0.197
2.082SerMet: 2.082 ± 0.118
3.815SerAsn: 3.815 ± 0.185
6.099SerPro: 6.099 ± 0.875
2.017SerGln: 2.017 ± 0.12
3.637SerArg: 3.637 ± 0.223
6.237SerSer: 6.237 ± 0.305
5.411SerThr: 5.411 ± 0.257
4.949SerVal: 4.949 ± 0.219
0.794SerTrp: 0.794 ± 0.08
3.167SerTyr: 3.167 ± 0.185
0.0SerXaa: 0.0 ± 0.0
Thr
4.682ThrAla: 4.682 ± 0.211
1.507ThrCys: 1.507 ± 0.195
4.082ThrAsp: 4.082 ± 0.193
3.669ThrGlu: 3.669 ± 0.199
2.819ThrPhe: 2.819 ± 0.147
4.017ThrGly: 4.017 ± 0.235
1.782ThrHis: 1.782 ± 0.148
4.779ThrIle: 4.779 ± 0.208
3.742ThrLys: 3.742 ± 0.203
5.662ThrLeu: 5.662 ± 0.214
1.863ThrMet: 1.863 ± 0.118
3.507ThrAsn: 3.507 ± 0.182
3.953ThrPro: 3.953 ± 0.183
2.252ThrGln: 2.252 ± 0.128
3.329ThrArg: 3.329 ± 0.219
5.095ThrSer: 5.095 ± 0.206
5.467ThrThr: 5.467 ± 0.273
4.568ThrVal: 4.568 ± 0.203
0.802ThrTrp: 0.802 ± 0.088
2.657ThrTyr: 2.657 ± 0.17
0.0ThrXaa: 0.0 ± 0.0
Val
4.431ValAla: 4.431 ± 0.186
1.255ValCys: 1.255 ± 0.128
3.896ValAsp: 3.896 ± 0.217
3.191ValGlu: 3.191 ± 0.195
2.511ValPhe: 2.511 ± 0.145
3.637ValGly: 3.637 ± 0.219
1.547ValHis: 1.547 ± 0.124
4.9ValIle: 4.9 ± 0.215
3.386ValLys: 3.386 ± 0.245
5.022ValLeu: 5.022 ± 0.203
2.017ValMet: 2.017 ± 0.129
3.483ValAsn: 3.483 ± 0.193
3.45ValPro: 3.45 ± 0.175
1.96ValGln: 1.96 ± 0.141
2.835ValArg: 2.835 ± 0.145
4.949ValSer: 4.949 ± 0.25
4.755ValThr: 4.755 ± 0.256
4.852ValVal: 4.852 ± 0.267
0.697ValTrp: 0.697 ± 0.075
2.875ValTyr: 2.875 ± 0.163
0.0ValXaa: 0.0 ± 0.0
Trp
0.624TrpAla: 0.624 ± 0.073
0.243TrpCys: 0.243 ± 0.053
0.64TrpAsp: 0.64 ± 0.067
0.405TrpGlu: 0.405 ± 0.064
0.567TrpPhe: 0.567 ± 0.072
0.64TrpGly: 0.64 ± 0.077
0.267TrpHis: 0.267 ± 0.048
0.664TrpIle: 0.664 ± 0.071
0.721TrpLys: 0.721 ± 0.077
0.915TrpLeu: 0.915 ± 0.092
0.332TrpMet: 0.332 ± 0.058
0.705TrpAsn: 0.705 ± 0.076
0.389TrpPro: 0.389 ± 0.057
0.348TrpGln: 0.348 ± 0.05
0.502TrpArg: 0.502 ± 0.058
0.769TrpSer: 0.769 ± 0.064
0.583TrpThr: 0.583 ± 0.068
0.599TrpVal: 0.599 ± 0.065
0.202TrpTrp: 0.202 ± 0.043
0.583TrpTyr: 0.583 ± 0.068
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.568TyrAla: 2.568 ± 0.172
0.859TyrCys: 0.859 ± 0.09
2.859TyrAsp: 2.859 ± 0.143
2.122TyrGlu: 2.122 ± 0.142
1.571TyrPhe: 1.571 ± 0.12
2.114TyrGly: 2.114 ± 0.127
1.053TyrHis: 1.053 ± 0.128
3.645TyrIle: 3.645 ± 0.166
2.341TyrLys: 2.341 ± 0.173
2.851TyrLeu: 2.851 ± 0.17
1.336TyrMet: 1.336 ± 0.106
3.297TyrAsn: 3.297 ± 0.147
1.539TyrPro: 1.539 ± 0.127
1.15TyrGln: 1.15 ± 0.108
1.814TyrArg: 1.814 ± 0.126
2.973TyrSer: 2.973 ± 0.146
3.297TyrThr: 3.297 ± 0.181
2.859TyrVal: 2.859 ± 0.148
0.437TyrTrp: 0.437 ± 0.072
1.863TyrTyr: 1.863 ± 0.154
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 467 proteins (123462 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski