Amino acid dipepetide frequency for Micromonospora inositola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.294AlaAla: 23.294 ± 0.185	0.982AlaCys: 0.982 ± 0.027	8.847AlaAsp: 8.847 ± 0.076	8.675AlaGlu: 8.675 ± 0.103	3.368AlaPhe: 3.368 ± 0.043	14.759AlaGly: 14.759 ± 0.108	2.51AlaHis: 2.51 ± 0.036	4.053AlaIle: 4.053 ± 0.058	2.487AlaLys: 2.487 ± 0.051	14.528AlaLeu: 14.528 ± 0.127	2.452AlaMet: 2.452 ± 0.038	2.174AlaAsn: 2.174 ± 0.038	7.291AlaPro: 7.291 ± 0.082	3.582AlaGln: 3.582 ± 0.048	10.536AlaArg: 10.536 ± 0.099	5.48AlaSer: 5.48 ± 0.054	8.051AlaThr: 8.051 ± 0.074	12.99AlaVal: 12.99 ± 0.109	1.996AlaTrp: 1.996 ± 0.035	2.759AlaTyr: 2.759 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.988CysAla: 0.988 ± 0.022	0.104CysCys: 0.104 ± 0.008	0.482CysAsp: 0.482 ± 0.016	0.304CysGlu: 0.304 ± 0.013	0.217CysPhe: 0.217 ± 0.01	0.907CysGly: 0.907 ± 0.024	0.196CysHis: 0.196 ± 0.01	0.133CysIle: 0.133 ± 0.009	0.083CysLys: 0.083 ± 0.006	0.69CysLeu: 0.69 ± 0.017	0.105CysMet: 0.105 ± 0.007	0.119CysAsn: 0.119 ± 0.008	0.492CysPro: 0.492 ± 0.017	0.188CysGln: 0.188 ± 0.011	0.597CysArg: 0.597 ± 0.016	0.355CysSer: 0.355 ± 0.014	0.416CysThr: 0.416 ± 0.015	0.606CysVal: 0.606 ± 0.02	0.139CysTrp: 0.139 ± 0.009	0.164CysTyr: 0.164 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.569AspAla: 7.569 ± 0.07	0.38AspCys: 0.38 ± 0.016	3.679AspAsp: 3.679 ± 0.04	3.824AspGlu: 3.824 ± 0.055	1.533AspPhe: 1.533 ± 0.027	6.308AspGly: 6.308 ± 0.077	1.289AspHis: 1.289 ± 0.033	1.626AspIle: 1.626 ± 0.032	1.003AspLys: 1.003 ± 0.028	6.618AspLeu: 6.618 ± 0.059	0.711AspMet: 0.711 ± 0.018	0.938AspAsn: 0.938 ± 0.027	4.868AspPro: 4.868 ± 0.054	1.742AspGln: 1.742 ± 0.032	5.752AspArg: 5.752 ± 0.073	2.2AspSer: 2.2 ± 0.036	2.735AspThr: 2.735 ± 0.038	4.975AspVal: 4.975 ± 0.064	1.018AspTrp: 1.018 ± 0.021	1.106AspTyr: 1.106 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	6.485GluAla: 6.485 ± 0.075	0.32GluCys: 0.32 ± 0.014	2.123GluAsp: 2.123 ± 0.038	2.641GluGlu: 2.641 ± 0.049	1.418GluPhe: 1.418 ± 0.026	3.327GluGly: 3.327 ± 0.056	1.371GluHis: 1.371 ± 0.031	2.181GluIle: 2.181 ± 0.04	1.072GluLys: 1.072 ± 0.031	6.711GluLeu: 6.711 ± 0.068	0.834GluMet: 0.834 ± 0.023	0.864GluAsn: 0.864 ± 0.022	3.444GluPro: 3.444 ± 0.055	2.166GluGln: 2.166 ± 0.042	5.2GluArg: 5.2 ± 0.068	2.182GluSer: 2.182 ± 0.035	2.528GluThr: 2.528 ± 0.04	4.696GluVal: 4.696 ± 0.054	0.736GluTrp: 0.736 ± 0.02	1.064GluTyr: 1.064 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.847PheAla: 3.847 ± 0.049	0.25PheCys: 0.25 ± 0.011	1.883PheAsp: 1.883 ± 0.034	1.212PheGlu: 1.212 ± 0.025	0.885PhePhe: 0.885 ± 0.02	3.018PheGly: 3.018 ± 0.041	0.561PheHis: 0.561 ± 0.018	0.767PheIle: 0.767 ± 0.022	0.413PheLys: 0.413 ± 0.014	2.552PheLeu: 2.552 ± 0.042	0.338PheMet: 0.338 ± 0.015	0.557PheAsn: 0.557 ± 0.02	1.345PhePro: 1.345 ± 0.028	0.64PheGln: 0.64 ± 0.018	1.88PheArg: 1.88 ± 0.036	1.334PheSer: 1.334 ± 0.029	1.906PheThr: 1.906 ± 0.038	2.46PheVal: 2.46 ± 0.038	0.453PheTrp: 0.453 ± 0.016	0.581PheTyr: 0.581 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.073GlyAla: 11.073 ± 0.093	0.801GlyCys: 0.801 ± 0.024	5.2GlyAsp: 5.2 ± 0.05	4.812GlyGlu: 4.812 ± 0.048	2.86GlyPhe: 2.86 ± 0.048	8.801GlyGly: 8.801 ± 0.104	2.138GlyHis: 2.138 ± 0.032	3.227GlyIle: 3.227 ± 0.045	2.023GlyLys: 2.023 ± 0.047	9.856GlyLeu: 9.856 ± 0.077	1.963GlyMet: 1.963 ± 0.03	1.707GlyAsn: 1.707 ± 0.038	5.449GlyPro: 5.449 ± 0.066	2.854GlyGln: 2.854 ± 0.046	8.371GlyArg: 8.371 ± 0.077	4.746GlySer: 4.746 ± 0.067	5.619GlyThr: 5.619 ± 0.065	8.071GlyVal: 8.071 ± 0.071	2.007GlyTrp: 2.007 ± 0.037	2.433GlyTyr: 2.433 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.513HisAla: 2.513 ± 0.035	0.188HisCys: 0.188 ± 0.009	1.331HisAsp: 1.331 ± 0.028	1.021HisGlu: 1.021 ± 0.023	0.559HisPhe: 0.559 ± 0.019	2.146HisGly: 2.146 ± 0.037	0.6HisHis: 0.6 ± 0.02	0.537HisIle: 0.537 ± 0.016	0.271HisLys: 0.271 ± 0.012	2.435HisLeu: 2.435 ± 0.034	0.266HisMet: 0.266 ± 0.013	0.363HisAsn: 0.363 ± 0.015	1.748HisPro: 1.748 ± 0.031	0.618HisGln: 0.618 ± 0.019	2.116HisArg: 2.116 ± 0.033	0.841HisSer: 0.841 ± 0.022	1.085HisThr: 1.085 ± 0.023	1.691HisVal: 1.691 ± 0.031	0.364HisTrp: 0.364 ± 0.012	0.446HisTyr: 0.446 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.916IleAla: 4.916 ± 0.056	0.299IleCys: 0.299 ± 0.014	2.315IleAsp: 2.315 ± 0.035	1.879IleGlu: 1.879 ± 0.041	0.91IlePhe: 0.91 ± 0.022	3.512IleGly: 3.512 ± 0.051	0.588IleHis: 0.588 ± 0.019	0.998IleIle: 0.998 ± 0.03	0.654IleLys: 0.654 ± 0.022	2.513IleLeu: 2.513 ± 0.043	0.452IleMet: 0.452 ± 0.017	0.717IleAsn: 0.717 ± 0.021	1.669IlePro: 1.669 ± 0.032	0.719IleGln: 0.719 ± 0.018	2.445IleArg: 2.445 ± 0.041	1.727IleSer: 1.727 ± 0.03	2.057IleThr: 2.057 ± 0.031	2.876IleVal: 2.876 ± 0.041	0.433IleTrp: 0.433 ± 0.016	0.63IleTyr: 0.63 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.305LysAla: 2.305 ± 0.047	0.096LysCys: 0.096 ± 0.008	0.903LysAsp: 0.903 ± 0.032	0.811LysGlu: 0.811 ± 0.027	0.406LysPhe: 0.406 ± 0.016	1.389LysGly: 1.389 ± 0.032	0.354LysHis: 0.354 ± 0.013	0.816LysIle: 0.816 ± 0.023	0.565LysLys: 0.565 ± 0.022	1.865LysLeu: 1.865 ± 0.032	0.329LysMet: 0.329 ± 0.014	0.373LysAsn: 0.373 ± 0.016	1.188LysPro: 1.188 ± 0.031	0.643LysGln: 0.643 ± 0.021	1.305LysArg: 1.305 ± 0.028	0.885LysSer: 0.885 ± 0.022	1.07LysThr: 1.07 ± 0.026	1.682LysVal: 1.682 ± 0.036	0.227LysTrp: 0.227 ± 0.011	0.36LysTyr: 0.36 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.928LeuAla: 16.928 ± 0.127	0.738LeuCys: 0.738 ± 0.021	6.89LeuAsp: 6.89 ± 0.064	3.889LeuGlu: 3.889 ± 0.057	2.646LeuPhe: 2.646 ± 0.047	9.504LeuGly: 9.504 ± 0.086	2.233LeuHis: 2.233 ± 0.034	3.501LeuIle: 3.501 ± 0.051	1.506LeuLys: 1.506 ± 0.034	11.91LeuLeu: 11.91 ± 0.112	1.422LeuMet: 1.422 ± 0.028	1.633LeuAsn: 1.633 ± 0.027	6.69LeuPro: 6.69 ± 0.066	2.024LeuGln: 2.024 ± 0.035	9.303LeuArg: 9.303 ± 0.084	4.813LeuSer: 4.813 ± 0.056	6.863LeuThr: 6.863 ± 0.065	10.14LeuVal: 10.14 ± 0.085	1.328LeuTrp: 1.328 ± 0.028	1.7LeuTyr: 1.7 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.122MetAla: 2.122 ± 0.032	0.109MetCys: 0.109 ± 0.007	0.763MetAsp: 0.763 ± 0.02	0.596MetGlu: 0.596 ± 0.017	0.447MetPhe: 0.447 ± 0.015	1.126MetGly: 1.126 ± 0.026	0.315MetHis: 0.315 ± 0.013	0.683MetIle: 0.683 ± 0.018	0.352MetLys: 0.352 ± 0.014	1.772MetLeu: 1.772 ± 0.03	0.281MetMet: 0.281 ± 0.012	0.367MetAsn: 0.367 ± 0.012	1.069MetPro: 1.069 ± 0.021	0.437MetGln: 0.437 ± 0.015	1.426MetArg: 1.426 ± 0.031	1.227MetSer: 1.227 ± 0.025	1.598MetThr: 1.598 ± 0.026	1.331MetVal: 1.331 ± 0.028	0.203MetTrp: 0.203 ± 0.01	0.264MetTyr: 0.264 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.163AsnAla: 2.163 ± 0.033	0.151AsnCys: 0.151 ± 0.009	0.973AsnAsp: 0.973 ± 0.022	0.762AsnGlu: 0.762 ± 0.022	0.502AsnPhe: 0.502 ± 0.019	1.788AsnGly: 1.788 ± 0.041	0.405AsnHis: 0.405 ± 0.018	0.592AsnIle: 0.592 ± 0.019	0.329AsnLys: 0.329 ± 0.014	1.836AsnLeu: 1.836 ± 0.03	0.283AsnMet: 0.283 ± 0.014	0.452AsnAsn: 0.452 ± 0.02	1.429AsnPro: 1.429 ± 0.032	0.554AsnGln: 0.554 ± 0.017	1.382AsnArg: 1.382 ± 0.025	0.858AsnSer: 0.858 ± 0.022	0.99AsnThr: 0.99 ± 0.025	1.416AsnVal: 1.416 ± 0.025	0.306AsnTrp: 0.306 ± 0.013	0.414AsnTyr: 0.414 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	10.136ProAla: 10.136 ± 0.117	0.311ProCys: 0.311 ± 0.013	4.636ProAsp: 4.636 ± 0.059	3.96ProGlu: 3.96 ± 0.053	1.379ProPhe: 1.379 ± 0.027	6.65ProGly: 6.65 ± 0.078	1.193ProHis: 1.193 ± 0.029	1.621ProIle: 1.621 ± 0.03	1.04ProLys: 1.04 ± 0.023	5.289ProLeu: 5.289 ± 0.053	1.062ProMet: 1.062 ± 0.022	1.026ProAsn: 1.026 ± 0.025	4.303ProPro: 4.303 ± 0.083	1.573ProGln: 1.573 ± 0.031	4.112ProArg: 4.112 ± 0.051	2.954ProSer: 2.954 ± 0.043	3.986ProThr: 3.986 ± 0.054	5.987ProVal: 5.987 ± 0.062	0.957ProTrp: 0.957 ± 0.023	1.312ProTyr: 1.312 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.626GlnAla: 3.626 ± 0.049	0.148GlnCys: 0.148 ± 0.009	1.14GlnAsp: 1.14 ± 0.027	1.208GlnGlu: 1.208 ± 0.026	0.725GlnPhe: 0.725 ± 0.019	1.934GlnGly: 1.934 ± 0.034	0.627GlnHis: 0.627 ± 0.02	1.07GlnIle: 1.07 ± 0.023	0.485GlnLys: 0.485 ± 0.017	3.31GlnLeu: 3.31 ± 0.041	0.445GlnMet: 0.445 ± 0.015	0.465GlnAsn: 0.465 ± 0.016	1.961GlnPro: 1.961 ± 0.035	1.206GlnGln: 1.206 ± 0.032	2.758GlnArg: 2.758 ± 0.041	1.094GlnSer: 1.094 ± 0.023	1.338GlnThr: 1.338 ± 0.027	2.821GlnVal: 2.821 ± 0.038	0.461GlnTrp: 0.461 ± 0.015	0.537GlnTyr: 0.537 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.507ArgAla: 10.507 ± 0.094	0.608ArgCys: 0.608 ± 0.019	4.667ArgAsp: 4.667 ± 0.049	4.464ArgGlu: 4.464 ± 0.067	2.435ArgPhe: 2.435 ± 0.038	6.041ArgGly: 6.041 ± 0.066	2.209ArgHis: 2.209 ± 0.039	3.179ArgIle: 3.179 ± 0.048	1.408ArgLys: 1.408 ± 0.029	9.546ArgLeu: 9.546 ± 0.089	1.888ArgMet: 1.888 ± 0.03	1.446ArgAsn: 1.446 ± 0.027	5.672ArgPro: 5.672 ± 0.064	2.688ArgGln: 2.688 ± 0.041	9.249ArgArg: 9.249 ± 0.11	4.087ArgSer: 4.087 ± 0.046	4.761ArgThr: 4.761 ± 0.045	6.497ArgVal: 6.497 ± 0.067	1.766ArgTrp: 1.766 ± 0.033	2.099ArgTyr: 2.099 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.151SerAla: 6.151 ± 0.066	0.362SerCys: 0.362 ± 0.014	2.358SerAsp: 2.358 ± 0.037	1.951SerGlu: 1.951 ± 0.039	1.424SerPhe: 1.424 ± 0.032	5.275SerGly: 5.275 ± 0.063	0.882SerHis: 0.882 ± 0.024	1.529SerIle: 1.529 ± 0.032	0.797SerLys: 0.797 ± 0.022	4.205SerLeu: 4.205 ± 0.05	0.992SerMet: 0.992 ± 0.021	0.83SerAsn: 0.83 ± 0.024	3.091SerPro: 3.091 ± 0.041	1.152SerGln: 1.152 ± 0.025	3.729SerArg: 3.729 ± 0.045	2.384SerSer: 2.384 ± 0.042	2.991SerThr: 2.991 ± 0.041	3.975SerVal: 3.975 ± 0.05	0.94SerTrp: 0.94 ± 0.021	1.186SerTyr: 1.186 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.575ThrAla: 8.575 ± 0.074	0.415ThrCys: 0.415 ± 0.016	3.599ThrAsp: 3.599 ± 0.051	2.88ThrGlu: 2.88 ± 0.043	1.625ThrPhe: 1.625 ± 0.032	6.497ThrGly: 6.497 ± 0.073	1.049ThrHis: 1.049 ± 0.026	1.892ThrIle: 1.892 ± 0.035	0.999ThrLys: 0.999 ± 0.025	5.718ThrLeu: 5.718 ± 0.065	0.995ThrMet: 0.995 ± 0.024	1.033ThrAsn: 1.033 ± 0.024	4.149ThrPro: 4.149 ± 0.055	1.191ThrGln: 1.191 ± 0.027	4.04ThrArg: 4.04 ± 0.051	2.875ThrSer: 2.875 ± 0.044	3.661ThrThr: 3.661 ± 0.062	6.253ThrVal: 6.253 ± 0.063	0.91ThrTrp: 0.91 ± 0.023	1.233ThrTyr: 1.233 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	12.949ValAla: 12.949 ± 0.108	0.702ValCys: 0.702 ± 0.021	5.86ValAsp: 5.86 ± 0.051	4.832ValGlu: 4.832 ± 0.059	2.364ValPhe: 2.364 ± 0.036	7.9ValGly: 7.9 ± 0.075	1.792ValHis: 1.792 ± 0.031	2.929ValIle: 2.929 ± 0.04	1.474ValLys: 1.474 ± 0.035	9.984ValLeu: 9.984 ± 0.095	1.204ValMet: 1.204 ± 0.024	1.78ValAsn: 1.78 ± 0.03	5.425ValPro: 5.425 ± 0.052	2.027ValGln: 2.027 ± 0.036	7.345ValArg: 7.345 ± 0.062	4.256ValSer: 4.256 ± 0.05	5.906ValThr: 5.906 ± 0.061	9.028ValVal: 9.028 ± 0.082	1.167ValTrp: 1.167 ± 0.024	1.485ValTyr: 1.485 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.787TrpAla: 1.787 ± 0.032	0.153TrpCys: 0.153 ± 0.008	0.757TrpAsp: 0.757 ± 0.021	0.613TrpGlu: 0.613 ± 0.02	0.543TrpPhe: 0.543 ± 0.017	0.998TrpGly: 0.998 ± 0.023	0.391TrpHis: 0.391 ± 0.016	0.556TrpIle: 0.556 ± 0.015	0.294TrpLys: 0.294 ± 0.015	2.06TrpLeu: 2.06 ± 0.033	0.278TrpMet: 0.278 ± 0.012	0.366TrpAsn: 0.366 ± 0.014	0.951TrpPro: 0.951 ± 0.025	0.658TrpGln: 0.658 ± 0.022	1.7TrpArg: 1.7 ± 0.031	1.051TrpSer: 1.051 ± 0.025	1.031TrpThr: 1.031 ± 0.024	1.16TrpVal: 1.16 ± 0.026	0.417TrpTrp: 0.417 ± 0.017	0.406TrpTyr: 0.406 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.882TyrAla: 2.882 ± 0.047	0.166TyrCys: 0.166 ± 0.01	1.469TyrAsp: 1.469 ± 0.03	1.028TyrGlu: 1.028 ± 0.024	0.635TyrPhe: 0.635 ± 0.02	2.13TyrGly: 2.13 ± 0.037	0.439TyrHis: 0.439 ± 0.017	0.419TyrIle: 0.419 ± 0.016	0.317TyrLys: 0.317 ± 0.015	2.265TyrLeu: 2.265 ± 0.039	0.187TyrMet: 0.187 ± 0.01	0.376TyrAsn: 0.376 ± 0.017	1.253TyrPro: 1.253 ± 0.029	0.698TyrGln: 0.698 ± 0.019	1.97TyrArg: 1.97 ± 0.035	0.855TyrSer: 0.855 ± 0.022	0.997TyrThr: 0.997 ± 0.027	1.753TyrVal: 1.753 ± 0.031	0.343TyrTrp: 0.343 ± 0.014	0.403TyrTyr: 0.403 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6104 proteins (1917864 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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