Amino acid dipepetide frequency for Jannaschia donghaensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.632AlaAla: 17.632 ± 0.181	1.191AlaCys: 1.191 ± 0.037	8.283AlaAsp: 8.283 ± 0.092	7.381AlaGlu: 7.381 ± 0.117	4.459AlaPhe: 4.459 ± 0.077	11.142AlaGly: 11.142 ± 0.113	2.347AlaHis: 2.347 ± 0.051	6.133AlaIle: 6.133 ± 0.086	3.433AlaLys: 3.433 ± 0.073	13.756AlaLeu: 13.756 ± 0.173	4.075AlaMet: 4.075 ± 0.065	2.653AlaAsn: 2.653 ± 0.06	6.308AlaPro: 6.308 ± 0.105	4.414AlaGln: 4.414 ± 0.076	9.683AlaArg: 9.683 ± 0.124	5.424AlaSer: 5.424 ± 0.073	7.233AlaThr: 7.233 ± 0.099	8.974AlaVal: 8.974 ± 0.116	1.593AlaTrp: 1.593 ± 0.041	2.369AlaTyr: 2.369 ± 0.053	0.001AlaXaa: 0.001 ± 0.001
Cys	1.162CysAla: 1.162 ± 0.033	0.088CysCys: 0.088 ± 0.01	0.666CysAsp: 0.666 ± 0.025	0.393CysGlu: 0.393 ± 0.021	0.316CysPhe: 0.316 ± 0.017	0.916CysGly: 0.916 ± 0.032	0.253CysHis: 0.253 ± 0.016	0.433CysIle: 0.433 ± 0.021	0.172CysLys: 0.172 ± 0.013	0.828CysLeu: 0.828 ± 0.027	0.158CysMet: 0.158 ± 0.013	0.194CysAsn: 0.194 ± 0.014	0.494CysPro: 0.494 ± 0.023	0.192CysGln: 0.192 ± 0.013	0.541CysArg: 0.541 ± 0.024	0.381CysSer: 0.381 ± 0.019	0.504CysThr: 0.504 ± 0.027	0.625CysVal: 0.625 ± 0.028	0.092CysTrp: 0.092 ± 0.008	0.189CysTyr: 0.189 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.482AspAla: 9.482 ± 0.127	0.535AspCys: 0.535 ± 0.025	4.585AspAsp: 4.585 ± 0.115	3.181AspGlu: 3.181 ± 0.061	2.38AspPhe: 2.38 ± 0.052	7.075AspGly: 7.075 ± 0.115	1.557AspHis: 1.557 ± 0.041	3.361AspIle: 3.361 ± 0.058	1.439AspLys: 1.439 ± 0.037	7.397AspLeu: 7.397 ± 0.096	1.867AspMet: 1.867 ± 0.047	1.193AspAsn: 1.193 ± 0.038	4.164AspPro: 4.164 ± 0.068	1.723AspGln: 1.723 ± 0.04	5.501AspArg: 5.501 ± 0.078	1.918AspSer: 1.918 ± 0.046	3.557AspThr: 3.557 ± 0.08	5.183AspVal: 5.183 ± 0.087	1.365AspTrp: 1.365 ± 0.038	1.466AspTyr: 1.466 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.313GluAla: 7.313 ± 0.1	0.298GluCys: 0.298 ± 0.017	3.349GluAsp: 3.349 ± 0.059	3.049GluGlu: 3.049 ± 0.069	1.542GluPhe: 1.542 ± 0.046	4.475GluGly: 4.475 ± 0.074	0.928GluHis: 0.928 ± 0.032	3.171GluIle: 3.171 ± 0.063	1.592GluLys: 1.592 ± 0.047	4.185GluLeu: 4.185 ± 0.075	1.849GluMet: 1.849 ± 0.048	1.399GluAsn: 1.399 ± 0.036	2.196GluPro: 2.196 ± 0.05	1.598GluGln: 1.598 ± 0.039	3.897GluArg: 3.897 ± 0.065	1.916GluSer: 1.916 ± 0.047	3.676GluThr: 3.676 ± 0.071	4.054GluVal: 4.054 ± 0.069	0.683GluTrp: 0.683 ± 0.025	0.964GluTyr: 0.964 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.741PheAla: 4.741 ± 0.073	0.373PheCys: 0.373 ± 0.02	3.105PheAsp: 3.105 ± 0.062	2.008PheGlu: 2.008 ± 0.045	1.269PhePhe: 1.269 ± 0.043	3.626PheGly: 3.626 ± 0.065	0.756PheHis: 0.756 ± 0.025	1.473PheIle: 1.473 ± 0.045	0.779PheLys: 0.779 ± 0.028	3.298PheLeu: 3.298 ± 0.064	0.797PheMet: 0.797 ± 0.031	0.844PheAsn: 0.844 ± 0.032	1.531PhePro: 1.531 ± 0.04	0.938PheGln: 0.938 ± 0.03	2.239PheArg: 2.239 ± 0.047	1.722PheSer: 1.722 ± 0.045	2.087PheThr: 2.087 ± 0.042	2.847PheVal: 2.847 ± 0.058	0.547PheTrp: 0.547 ± 0.024	0.831PheTyr: 0.831 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.142GlyAla: 10.142 ± 0.103	0.892GlyCys: 0.892 ± 0.032	5.588GlyAsp: 5.588 ± 0.111	4.316GlyGlu: 4.316 ± 0.07	3.691GlyPhe: 3.691 ± 0.064	7.887GlyGly: 7.887 ± 0.135	2.014GlyHis: 2.014 ± 0.052	4.499GlyIle: 4.499 ± 0.075	2.81GlyLys: 2.81 ± 0.059	9.513GlyLeu: 9.513 ± 0.13	2.611GlyMet: 2.611 ± 0.057	1.983GlyAsn: 1.983 ± 0.066	4.23GlyPro: 4.23 ± 0.073	3.076GlyGln: 3.076 ± 0.062	6.165GlyArg: 6.165 ± 0.088	3.996GlySer: 3.996 ± 0.067	5.695GlyThr: 5.695 ± 0.08	6.714GlyVal: 6.714 ± 0.093	1.586GlyTrp: 1.586 ± 0.042	2.162GlyTyr: 2.162 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.462HisAla: 2.462 ± 0.057	0.202HisCys: 0.202 ± 0.016	1.503HisAsp: 1.503 ± 0.04	0.933HisGlu: 0.933 ± 0.031	0.735HisPhe: 0.735 ± 0.028	1.982HisGly: 1.982 ± 0.052	0.598HisHis: 0.598 ± 0.027	0.916HisIle: 0.916 ± 0.027	0.389HisLys: 0.389 ± 0.02	2.164HisLeu: 2.164 ± 0.05	0.525HisMet: 0.525 ± 0.023	0.38HisAsn: 0.38 ± 0.019	1.352HisPro: 1.352 ± 0.038	0.506HisGln: 0.506 ± 0.019	1.416HisArg: 1.416 ± 0.043	0.836HisSer: 0.836 ± 0.03	0.824HisThr: 0.824 ± 0.027	1.589HisVal: 1.589 ± 0.043	0.341HisTrp: 0.341 ± 0.017	0.482HisTyr: 0.482 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.278IleAla: 7.278 ± 0.096	0.569IleCys: 0.569 ± 0.023	3.818IleAsp: 3.818 ± 0.066	3.309IleGlu: 3.309 ± 0.064	1.675IlePhe: 1.675 ± 0.049	4.832IleGly: 4.832 ± 0.084	0.918IleHis: 0.918 ± 0.031	1.942IleIle: 1.942 ± 0.05	1.079IleLys: 1.079 ± 0.035	4.948IleLeu: 4.948 ± 0.081	1.03IleMet: 1.03 ± 0.031	1.092IleAsn: 1.092 ± 0.035	2.32IlePro: 2.32 ± 0.047	1.047IleGln: 1.047 ± 0.029	3.106IleArg: 3.106 ± 0.061	2.433IleSer: 2.433 ± 0.047	2.823IleThr: 2.823 ± 0.056	4.227IleVal: 4.227 ± 0.072	0.747IleTrp: 0.747 ± 0.027	1.005IleTyr: 1.005 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.365LysAla: 3.365 ± 0.067	0.146LysCys: 0.146 ± 0.013	1.636LysAsp: 1.636 ± 0.045	1.088LysGlu: 1.088 ± 0.042	0.788LysPhe: 0.788 ± 0.028	2.352LysGly: 2.352 ± 0.05	0.518LysHis: 0.518 ± 0.025	1.361LysIle: 1.361 ± 0.039	0.933LysLys: 0.933 ± 0.04	2.43LysLeu: 2.43 ± 0.05	0.786LysMet: 0.786 ± 0.027	0.599LysAsn: 0.599 ± 0.027	1.552LysPro: 1.552 ± 0.051	0.682LysGln: 0.682 ± 0.029	1.986LysArg: 1.986 ± 0.048	1.525LysSer: 1.525 ± 0.042	1.816LysThr: 1.816 ± 0.05	2.052LysVal: 2.052 ± 0.054	0.366LysTrp: 0.366 ± 0.018	0.501LysTyr: 0.501 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.958LeuAla: 12.958 ± 0.148	0.871LeuCys: 0.871 ± 0.033	6.6LeuAsp: 6.6 ± 0.09	4.717LeuGlu: 4.717 ± 0.077	3.319LeuPhe: 3.319 ± 0.061	8.308LeuGly: 8.308 ± 0.112	1.917LeuHis: 1.917 ± 0.05	5.241LeuIle: 5.241 ± 0.084	2.645LeuLys: 2.645 ± 0.054	8.979LeuLeu: 8.979 ± 0.12	2.687LeuMet: 2.687 ± 0.051	2.491LeuAsn: 2.491 ± 0.047	5.697LeuPro: 5.697 ± 0.093	2.534LeuGln: 2.534 ± 0.054	7.573LeuArg: 7.573 ± 0.091	6.455LeuSer: 6.455 ± 0.083	6.928LeuThr: 6.928 ± 0.097	6.641LeuVal: 6.641 ± 0.085	1.359LeuTrp: 1.359 ± 0.032	1.727LeuTyr: 1.727 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.704MetAla: 3.704 ± 0.058	0.19MetCys: 0.19 ± 0.013	1.626MetAsp: 1.626 ± 0.042	1.366MetGlu: 1.366 ± 0.037	0.79MetPhe: 0.79 ± 0.028	2.382MetGly: 2.382 ± 0.052	0.463MetHis: 0.463 ± 0.022	1.611MetIle: 1.611 ± 0.042	0.984MetLys: 0.984 ± 0.034	2.545MetLeu: 2.545 ± 0.054	0.76MetMet: 0.76 ± 0.03	0.805MetAsn: 0.805 ± 0.026	1.554MetPro: 1.554 ± 0.04	0.861MetGln: 0.861 ± 0.029	1.934MetArg: 1.934 ± 0.044	1.528MetSer: 1.528 ± 0.035	2.346MetThr: 2.346 ± 0.042	1.933MetVal: 1.933 ± 0.046	0.254MetTrp: 0.254 ± 0.017	0.311MetTyr: 0.311 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.009AsnAla: 3.009 ± 0.053	0.243AsnCys: 0.243 ± 0.016	1.433AsnAsp: 1.433 ± 0.05	0.919AsnGlu: 0.919 ± 0.035	0.88AsnPhe: 0.88 ± 0.031	2.138AsnGly: 2.138 ± 0.061	0.44AsnHis: 0.44 ± 0.022	1.149AsnIle: 1.149 ± 0.035	0.5AsnLys: 0.5 ± 0.023	2.33AsnLeu: 2.33 ± 0.053	0.611AsnMet: 0.611 ± 0.025	0.526AsnAsn: 0.526 ± 0.027	1.673AsnPro: 1.673 ± 0.044	0.569AsnGln: 0.569 ± 0.027	1.687AsnArg: 1.687 ± 0.04	0.921AsnSer: 0.921 ± 0.031	1.25AsnThr: 1.25 ± 0.056	1.852AsnVal: 1.852 ± 0.05	0.381AsnTrp: 0.381 ± 0.022	0.554AsnTyr: 0.554 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.062ProAla: 6.062 ± 0.098	0.396ProCys: 0.396 ± 0.022	4.683ProAsp: 4.683 ± 0.072	3.486ProGlu: 3.486 ± 0.056	1.995ProPhe: 1.995 ± 0.043	4.894ProGly: 4.894 ± 0.084	1.044ProHis: 1.044 ± 0.034	2.314ProIle: 2.314 ± 0.048	1.59ProLys: 1.59 ± 0.044	4.709ProLeu: 4.709 ± 0.073	1.349ProMet: 1.349 ± 0.037	1.257ProAsn: 1.257 ± 0.038	2.423ProPro: 2.423 ± 0.06	1.641ProGln: 1.641 ± 0.036	3.099ProArg: 3.099 ± 0.061	2.429ProSer: 2.429 ± 0.047	2.871ProThr: 2.871 ± 0.054	4.427ProVal: 4.427 ± 0.079	0.733ProTrp: 0.733 ± 0.03	1.063ProTyr: 1.063 ± 0.033	0.001ProXaa: 0.001 ± 0.001
Gln	4.163GlnAla: 4.163 ± 0.078	0.172GlnCys: 0.172 ± 0.012	1.774GlnAsp: 1.774 ± 0.044	1.312GlnGlu: 1.312 ± 0.039	0.939GlnPhe: 0.939 ± 0.03	2.501GlnGly: 2.501 ± 0.055	0.492GlnHis: 0.492 ± 0.022	1.798GlnIle: 1.798 ± 0.032	0.793GlnLys: 0.793 ± 0.029	2.455GlnLeu: 2.455 ± 0.053	0.996GlnMet: 0.996 ± 0.028	0.712GlnAsn: 0.712 ± 0.026	1.522GlnPro: 1.522 ± 0.034	0.923GlnGln: 0.923 ± 0.037	1.945GlnArg: 1.945 ± 0.049	1.526GlnSer: 1.526 ± 0.044	1.923GlnThr: 1.923 ± 0.044	2.404GlnVal: 2.404 ± 0.052	0.329GlnTrp: 0.329 ± 0.018	0.492GlnTyr: 0.492 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.177ArgAla: 9.177 ± 0.119	0.492ArgCys: 0.492 ± 0.026	5.372ArgAsp: 5.372 ± 0.086	3.261ArgGlu: 3.261 ± 0.059	2.582ArgPhe: 2.582 ± 0.052	5.023ArgGly: 5.023 ± 0.077	1.6ArgHis: 1.6 ± 0.042	4.004ArgIle: 4.004 ± 0.061	1.925ArgLys: 1.925 ± 0.048	7.536ArgLeu: 7.536 ± 0.114	2.199ArgMet: 2.199 ± 0.054	1.652ArgAsn: 1.652 ± 0.039	3.46ArgPro: 3.46 ± 0.058	2.188ArgGln: 2.188 ± 0.048	5.353ArgArg: 5.353 ± 0.092	3.305ArgSer: 3.305 ± 0.061	3.719ArgThr: 3.719 ± 0.066	5.026ArgVal: 5.026 ± 0.064	1.006ArgTrp: 1.006 ± 0.033	1.458ArgTyr: 1.458 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.321SerAla: 5.321 ± 0.07	0.385SerCys: 0.385 ± 0.02	3.652SerAsp: 3.652 ± 0.07	2.479SerGlu: 2.479 ± 0.059	1.901SerPhe: 1.901 ± 0.043	5.03SerGly: 5.03 ± 0.074	0.89SerHis: 0.89 ± 0.03	2.388SerIle: 2.388 ± 0.056	1.342SerLys: 1.342 ± 0.037	4.474SerLeu: 4.474 ± 0.07	1.28SerMet: 1.28 ± 0.035	1.228SerAsn: 1.228 ± 0.037	2.35SerPro: 2.35 ± 0.051	1.391SerGln: 1.391 ± 0.031	2.999SerArg: 2.999 ± 0.057	2.214SerSer: 2.214 ± 0.053	2.388SerThr: 2.388 ± 0.045	3.686SerVal: 3.686 ± 0.06	0.609SerTrp: 0.609 ± 0.026	1.065SerTyr: 1.065 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.993ThrAla: 6.993 ± 0.094	0.579ThrCys: 0.579 ± 0.029	3.992ThrAsp: 3.992 ± 0.079	2.879ThrGlu: 2.879 ± 0.059	2.306ThrPhe: 2.306 ± 0.051	6.111ThrGly: 6.111 ± 0.095	1.222ThrHis: 1.222 ± 0.037	2.933ThrIle: 2.933 ± 0.069	1.349ThrLys: 1.349 ± 0.036	6.767ThrLeu: 6.767 ± 0.097	1.432ThrMet: 1.432 ± 0.042	1.272ThrAsn: 1.272 ± 0.049	3.887ThrPro: 3.887 ± 0.073	1.731ThrGln: 1.731 ± 0.045	4.001ThrArg: 4.001 ± 0.061	2.763ThrSer: 2.763 ± 0.056	3.26ThrThr: 3.26 ± 0.058	4.763ThrVal: 4.763 ± 0.096	0.771ThrTrp: 0.771 ± 0.026	1.239ThrTyr: 1.239 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.611ValAla: 9.611 ± 0.109	0.646ValCys: 0.646 ± 0.025	4.728ValAsp: 4.728 ± 0.075	4.383ValGlu: 4.383 ± 0.072	2.882ValPhe: 2.882 ± 0.059	5.846ValGly: 5.846 ± 0.083	1.371ValHis: 1.371 ± 0.039	3.969ValIle: 3.969 ± 0.067	1.861ValLys: 1.861 ± 0.049	7.559ValLeu: 7.559 ± 0.106	2.076ValMet: 2.076 ± 0.049	1.883ValAsn: 1.883 ± 0.046	4.09ValPro: 4.09 ± 0.07	2.066ValGln: 2.066 ± 0.042	4.611ValArg: 4.611 ± 0.072	4.041ValSer: 4.041 ± 0.069	5.442ValThr: 5.442 ± 0.1	5.894ValVal: 5.894 ± 0.09	1.061ValTrp: 1.061 ± 0.036	1.307ValTyr: 1.307 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.46TrpAla: 1.46 ± 0.041	0.13TrpCys: 0.13 ± 0.012	0.878TrpAsp: 0.878 ± 0.029	0.63TrpGlu: 0.63 ± 0.025	0.581TrpPhe: 0.581 ± 0.024	1.034TrpGly: 1.034 ± 0.033	0.335TrpHis: 0.335 ± 0.019	0.731TrpIle: 0.731 ± 0.026	0.422TrpLys: 0.422 ± 0.021	1.681TrpLeu: 1.681 ± 0.041	0.457TrpMet: 0.457 ± 0.022	0.426TrpAsn: 0.426 ± 0.021	0.743TrpPro: 0.743 ± 0.028	0.549TrpGln: 0.549 ± 0.023	1.145TrpArg: 1.145 ± 0.032	0.825TrpSer: 0.825 ± 0.029	0.947TrpThr: 0.947 ± 0.031	0.937TrpVal: 0.937 ± 0.032	0.282TrpTrp: 0.282 ± 0.018	0.247TrpTyr: 0.247 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.452TyrAla: 2.452 ± 0.055	0.197TyrCys: 0.197 ± 0.014	1.658TyrAsp: 1.658 ± 0.04	1.045TyrGlu: 1.045 ± 0.034	0.78TyrPhe: 0.78 ± 0.028	2.012TyrGly: 2.012 ± 0.051	0.472TyrHis: 0.472 ± 0.019	0.771TyrIle: 0.771 ± 0.028	0.444TyrLys: 0.444 ± 0.022	2.092TyrLeu: 2.092 ± 0.049	0.402TyrMet: 0.402 ± 0.019	0.477TyrAsn: 0.477 ± 0.023	0.921TyrPro: 0.921 ± 0.033	0.544TyrGln: 0.544 ± 0.026	1.456TyrArg: 1.456 ± 0.04	0.913TyrSer: 0.913 ± 0.03	0.961TyrThr: 0.961 ± 0.04	1.5TyrVal: 1.5 ± 0.04	0.336TyrTrp: 0.336 ± 0.019	0.489TyrTyr: 0.489 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.004

Statistics based on 3480 proteins (1044310 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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