Amino acid dipepetide frequency for Portunus trituberculatus (Swimming crab) (Neptunus trituberculatus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.052AlaAla: 8.052 ± 0.038	1.599AlaCys: 1.599 ± 0.012	2.37AlaAsp: 2.37 ± 0.014	3.361AlaGlu: 3.361 ± 0.021	1.885AlaPhe: 1.885 ± 0.012	5.423AlaGly: 5.423 ± 0.026	1.984AlaHis: 1.984 ± 0.013	2.334AlaIle: 2.334 ± 0.013	2.56AlaLys: 2.56 ± 0.016	6.101AlaLeu: 6.101 ± 0.022	1.577AlaMet: 1.577 ± 0.011	1.787AlaAsn: 1.787 ± 0.012	4.719AlaPro: 4.719 ± 0.024	2.345AlaGln: 2.345 ± 0.015	4.915AlaArg: 4.915 ± 0.02	6.812AlaSer: 6.812 ± 0.026	4.827AlaThr: 4.827 ± 0.022	5.017AlaVal: 5.017 ± 0.023	1.06AlaTrp: 1.06 ± 0.01	1.184AlaTyr: 1.184 ± 0.011	0.0AlaXaa: 0.0 ± 0.0
Cys	1.307CysAla: 1.307 ± 0.012	1.022CysCys: 1.022 ± 0.012	0.98CysAsp: 0.98 ± 0.011	1.078CysGlu: 1.078 ± 0.01	0.919CysPhe: 0.919 ± 0.008	2.016CysGly: 2.016 ± 0.015	0.958CysHis: 0.958 ± 0.008	0.904CysIle: 0.904 ± 0.009	0.85CysLys: 0.85 ± 0.008	2.794CysLeu: 2.794 ± 0.017	0.583CysMet: 0.583 ± 0.007	0.724CysAsn: 0.724 ± 0.008	1.735CysPro: 1.735 ± 0.013	0.959CysGln: 0.959 ± 0.01	1.848CysArg: 1.848 ± 0.014	2.345CysSer: 2.345 ± 0.015	1.313CysThr: 1.313 ± 0.011	1.985CysVal: 1.985 ± 0.016	0.436CysTrp: 0.436 ± 0.005	0.63CysTyr: 0.63 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	2.595AspAla: 2.595 ± 0.016	0.821AspCys: 0.821 ± 0.009	2.504AspAsp: 2.504 ± 0.025	2.71AspGlu: 2.71 ± 0.021	1.272AspPhe: 1.272 ± 0.01	2.978AspGly: 2.978 ± 0.017	1.143AspHis: 1.143 ± 0.011	1.773AspIle: 1.773 ± 0.012	1.959AspLys: 1.959 ± 0.015	3.529AspLeu: 3.529 ± 0.022	1.044AspMet: 1.044 ± 0.01	1.452AspAsn: 1.452 ± 0.012	2.159AspPro: 2.159 ± 0.016	1.295AspGln: 1.295 ± 0.011	2.243AspArg: 2.243 ± 0.017	3.472AspSer: 3.472 ± 0.019	2.683AspThr: 2.683 ± 0.024	2.672AspVal: 2.672 ± 0.016	0.514AspTrp: 0.514 ± 0.008	0.981AspTyr: 0.981 ± 0.011	0.0AspXaa: 0.0 ± 0.0
Glu	4.449GluAla: 4.449 ± 0.022	1.202GluCys: 1.202 ± 0.013	3.096GluAsp: 3.096 ± 0.026	8.401GluGlu: 8.401 ± 0.072	1.196GluPhe: 1.196 ± 0.01	4.898GluGly: 4.898 ± 0.023	1.279GluHis: 1.279 ± 0.01	1.922GluIle: 1.922 ± 0.012	3.601GluLys: 3.601 ± 0.03	3.622GluLeu: 3.622 ± 0.02	1.469GluMet: 1.469 ± 0.01	1.921GluAsn: 1.921 ± 0.016	2.164GluPro: 2.164 ± 0.016	2.009GluGln: 2.009 ± 0.015	3.992GluArg: 3.992 ± 0.022	3.527GluSer: 3.527 ± 0.022	2.835GluThr: 2.835 ± 0.018	4.065GluVal: 4.065 ± 0.02	0.726GluTrp: 0.726 ± 0.008	1.091GluTyr: 1.091 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	1.508PheAla: 1.508 ± 0.012	0.85PheCys: 0.85 ± 0.008	1.01PheAsp: 1.01 ± 0.01	1.112PheGlu: 1.112 ± 0.01	1.506PhePhe: 1.506 ± 0.014	1.578PheGly: 1.578 ± 0.012	1.073PheHis: 1.073 ± 0.01	1.567PheIle: 1.567 ± 0.011	1.242PheLys: 1.242 ± 0.011	3.749PheLeu: 3.749 ± 0.02	0.818PheMet: 0.818 ± 0.008	1.017PheAsn: 1.017 ± 0.009	2.282PhePro: 2.282 ± 0.015	1.034PheGln: 1.034 ± 0.009	1.773PheArg: 1.773 ± 0.013	3.24PheSer: 3.24 ± 0.016	2.264PheThr: 2.264 ± 0.014	1.848PheVal: 1.848 ± 0.012	0.39PheTrp: 0.39 ± 0.006	0.878PheTyr: 0.878 ± 0.008	0.0PheXaa: 0.0 ± 0.0
Gly	4.599GlyAla: 4.599 ± 0.02	1.588GlyCys: 1.588 ± 0.011	3.077GlyAsp: 3.077 ± 0.017	4.425GlyGlu: 4.425 ± 0.019	1.666GlyPhe: 1.666 ± 0.016	8.123GlyGly: 8.123 ± 0.05	1.976GlyHis: 1.976 ± 0.013	2.182GlyIle: 2.182 ± 0.012	3.321GlyLys: 3.321 ± 0.019	4.926GlyLeu: 4.926 ± 0.023	1.647GlyMet: 1.647 ± 0.014	2.097GlyAsn: 2.097 ± 0.013	3.015GlyPro: 3.015 ± 0.022	2.487GlyGln: 2.487 ± 0.018	6.265GlyArg: 6.265 ± 0.03	5.664GlySer: 5.664 ± 0.027	3.665GlyThr: 3.665 ± 0.019	4.913GlyVal: 4.913 ± 0.026	1.139GlyTrp: 1.139 ± 0.01	1.32GlyTyr: 1.32 ± 0.016	0.0GlyXaa: 0.0 ± 0.0
His	2.068HisAla: 2.068 ± 0.013	0.992HisCys: 0.992 ± 0.009	1.173HisAsp: 1.173 ± 0.01	1.255HisGlu: 1.255 ± 0.01	1.184HisPhe: 1.184 ± 0.011	1.81HisGly: 1.81 ± 0.013	2.642HisHis: 2.642 ± 0.025	1.408HisIle: 1.408 ± 0.01	1.281HisLys: 1.281 ± 0.011	3.67HisLeu: 3.67 ± 0.022	0.756HisMet: 0.756 ± 0.009	1.215HisAsn: 1.215 ± 0.01	2.522HisPro: 2.522 ± 0.017	1.601HisGln: 1.601 ± 0.013	2.322HisArg: 2.322 ± 0.014	3.357HisSer: 3.357 ± 0.018	2.628HisThr: 2.628 ± 0.022	1.804HisVal: 1.804 ± 0.012	0.395HisTrp: 0.395 ± 0.006	1.05HisTyr: 1.05 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	2.118IleAla: 2.118 ± 0.014	0.857IleCys: 0.857 ± 0.008	1.374IleAsp: 1.374 ± 0.011	1.617IleGlu: 1.617 ± 0.012	1.499IlePhe: 1.499 ± 0.011	1.756IleGly: 1.756 ± 0.013	1.335IleHis: 1.335 ± 0.012	2.119IleIle: 2.119 ± 0.023	1.951IleLys: 1.951 ± 0.014	3.663IleLeu: 3.663 ± 0.018	1.064IleMet: 1.064 ± 0.01	1.625IleAsn: 1.625 ± 0.014	2.471IlePro: 2.471 ± 0.016	1.43IleGln: 1.43 ± 0.011	2.188IleArg: 2.188 ± 0.013	3.427IleSer: 3.427 ± 0.016	3.247IleThr: 3.247 ± 0.018	2.177IleVal: 2.177 ± 0.013	0.418IleTrp: 0.418 ± 0.006	1.022IleTyr: 1.022 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	2.925LysAla: 2.925 ± 0.018	0.982LysCys: 0.982 ± 0.01	2.086LysAsp: 2.086 ± 0.018	3.931LysGlu: 3.931 ± 0.03	1.195LysPhe: 1.195 ± 0.012	2.925LysGly: 2.925 ± 0.015	1.269LysHis: 1.269 ± 0.01	1.933LysIle: 1.933 ± 0.014	4.036LysLys: 4.036 ± 0.04	3.444LysLeu: 3.444 ± 0.019	1.355LysMet: 1.355 ± 0.011	1.785LysAsn: 1.785 ± 0.013	2.178LysPro: 2.178 ± 0.017	1.871LysGln: 1.871 ± 0.014	3.353LysArg: 3.353 ± 0.021	3.062LysSer: 3.062 ± 0.021	2.806LysThr: 2.806 ± 0.018	2.879LysVal: 2.879 ± 0.016	0.535LysTrp: 0.535 ± 0.006	1.121LysTyr: 1.121 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	6.493LeuAla: 6.493 ± 0.025	2.418LeuCys: 2.418 ± 0.015	3.297LeuAsp: 3.297 ± 0.018	4.278LeuGlu: 4.278 ± 0.025	3.066LeuPhe: 3.066 ± 0.017	5.088LeuGly: 5.088 ± 0.023	3.557LeuHis: 3.557 ± 0.018	3.272LeuIle: 3.272 ± 0.019	3.757LeuLys: 3.757 ± 0.02	10.058LeuLeu: 10.058 ± 0.046	2.247LeuMet: 2.247 ± 0.015	2.709LeuAsn: 2.709 ± 0.016	7.759LeuPro: 7.759 ± 0.034	3.945LeuGln: 3.945 ± 0.021	6.195LeuArg: 6.195 ± 0.021	8.357LeuSer: 8.357 ± 0.032	6.039LeuThr: 6.039 ± 0.026	5.81LeuVal: 5.81 ± 0.024	1.213LeuTrp: 1.213 ± 0.011	2.195LeuTyr: 2.195 ± 0.016	0.0LeuXaa: 0.0 ± 0.0
Met	1.938MetAla: 1.938 ± 0.012	0.611MetCys: 0.611 ± 0.007	1.044MetAsp: 1.044 ± 0.008	1.699MetGlu: 1.699 ± 0.011	0.755MetPhe: 0.755 ± 0.009	1.488MetGly: 1.488 ± 0.013	0.605MetHis: 0.605 ± 0.007	0.865MetIle: 0.865 ± 0.009	1.516MetLys: 1.516 ± 0.011	1.978MetLeu: 1.978 ± 0.014	0.854MetMet: 0.854 ± 0.013	0.913MetAsn: 0.913 ± 0.009	1.243MetPro: 1.243 ± 0.011	0.913MetGln: 0.913 ± 0.009	1.669MetArg: 1.669 ± 0.013	1.981MetSer: 1.981 ± 0.012	1.609MetThr: 1.609 ± 0.011	1.936MetVal: 1.936 ± 0.013	0.385MetTrp: 0.385 ± 0.005	0.59MetTyr: 0.59 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	1.745AsnAla: 1.745 ± 0.013	0.651AsnCys: 0.651 ± 0.007	1.319AsnAsp: 1.319 ± 0.011	1.65AsnGlu: 1.65 ± 0.013	1.17AsnPhe: 1.17 ± 0.012	1.843AsnGly: 1.843 ± 0.013	1.045AsnHis: 1.045 ± 0.011	1.808AsnIle: 1.808 ± 0.014	1.879AsnLys: 1.879 ± 0.014	2.901AsnLeu: 2.901 ± 0.018	0.937AsnMet: 0.937 ± 0.008	1.95AsnAsn: 1.95 ± 0.029	1.784AsnPro: 1.784 ± 0.013	1.132AsnGln: 1.132 ± 0.01	1.639AsnArg: 1.639 ± 0.012	2.759AsnSer: 2.759 ± 0.018	2.812AsnThr: 2.812 ± 0.017	1.907AsnVal: 1.907 ± 0.012	0.328AsnTrp: 0.328 ± 0.005	0.887AsnTyr: 0.887 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	5.631ProAla: 5.631 ± 0.024	1.62ProCys: 1.62 ± 0.013	2.358ProAsp: 2.358 ± 0.018	2.734ProGlu: 2.734 ± 0.02	1.999ProPhe: 1.999 ± 0.014	4.009ProGly: 4.009 ± 0.024	2.908ProHis: 2.908 ± 0.021	1.988ProIle: 1.988 ± 0.013	2.044ProLys: 2.044 ± 0.016	6.603ProLeu: 6.603 ± 0.025	1.197ProMet: 1.197 ± 0.01	1.657ProAsn: 1.657 ± 0.011	8.789ProPro: 8.789 ± 0.05	2.898ProGln: 2.898 ± 0.021	5.185ProArg: 5.185 ± 0.023	7.685ProSer: 7.685 ± 0.034	4.245ProThr: 4.245 ± 0.021	3.806ProVal: 3.806 ± 0.018	0.79ProTrp: 0.79 ± 0.008	1.393ProTyr: 1.393 ± 0.011	0.0ProXaa: 0.0 ± 0.0
Gln	2.746GlnAla: 2.746 ± 0.015	1.008GlnCys: 1.008 ± 0.009	1.828GlnAsp: 1.828 ± 0.013	2.743GlnGlu: 2.743 ± 0.017	0.928GlnPhe: 0.928 ± 0.01	2.672GlnGly: 2.672 ± 0.018	1.816GlnHis: 1.816 ± 0.016	1.232GlnIle: 1.232 ± 0.011	1.651GlnLys: 1.651 ± 0.014	3.314GlnLeu: 3.314 ± 0.019	0.938GlnMet: 0.938 ± 0.008	1.234GlnAsn: 1.234 ± 0.012	2.851GlnPro: 2.851 ± 0.02	2.869GlnGln: 2.869 ± 0.034	2.927GlnArg: 2.927 ± 0.013	2.751GlnSer: 2.751 ± 0.017	2.205GlnThr: 2.205 ± 0.015	2.67GlnVal: 2.67 ± 0.015	0.511GlnTrp: 0.511 ± 0.006	0.982GlnTyr: 0.982 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	4.42ArgAla: 4.42 ± 0.019	1.933ArgCys: 1.933 ± 0.015	2.969ArgAsp: 2.969 ± 0.018	4.391ArgGlu: 4.391 ± 0.024	1.759ArgPhe: 1.759 ± 0.01	5.836ArgGly: 5.836 ± 0.027	2.863ArgHis: 2.863 ± 0.016	2.204ArgIle: 2.204 ± 0.015	3.703ArgLys: 3.703 ± 0.023	6.236ArgLeu: 6.236 ± 0.025	1.737ArgMet: 1.737 ± 0.011	2.184ArgAsn: 2.184 ± 0.013	4.768ArgPro: 4.768 ± 0.022	3.213ArgGln: 3.213 ± 0.017	7.572ArgArg: 7.572 ± 0.037	5.407ArgSer: 5.407 ± 0.024	3.571ArgThr: 3.571 ± 0.018	4.361ArgVal: 4.361 ± 0.021	1.1ArgTrp: 1.1 ± 0.009	1.581ArgTyr: 1.581 ± 0.012	0.0ArgXaa: 0.0 ± 0.0
Ser	5.703SerAla: 5.703 ± 0.024	2.394SerCys: 2.394 ± 0.015	3.291SerAsp: 3.291 ± 0.018	3.952SerGlu: 3.952 ± 0.023	3.169SerPhe: 3.169 ± 0.018	5.865SerGly: 5.865 ± 0.027	3.136SerHis: 3.136 ± 0.019	3.172SerIle: 3.172 ± 0.017	3.167SerLys: 3.167 ± 0.019	9.367SerLeu: 9.367 ± 0.034	1.836SerMet: 1.836 ± 0.013	2.535SerAsn: 2.535 ± 0.017	7.682SerPro: 7.682 ± 0.04	3.528SerGln: 3.528 ± 0.018	6.09SerArg: 6.09 ± 0.026	11.536SerSer: 11.536 ± 0.06	5.808SerThr: 5.808 ± 0.031	5.577SerVal: 5.577 ± 0.021	1.13SerTrp: 1.13 ± 0.009	1.897SerTyr: 1.897 ± 0.014	0.0SerXaa: 0.0 ± 0.0
Thr	4.751ThrAla: 4.751 ± 0.024	1.661ThrCys: 1.661 ± 0.012	2.256ThrAsp: 2.256 ± 0.014	2.824ThrGlu: 2.824 ± 0.018	2.002ThrPhe: 2.002 ± 0.012	3.57ThrGly: 3.57 ± 0.018	2.475ThrHis: 2.475 ± 0.016	2.624ThrIle: 2.624 ± 0.019	2.562ThrLys: 2.562 ± 0.016	6.143ThrLeu: 6.143 ± 0.024	1.43ThrMet: 1.43 ± 0.011	2.092ThrAsn: 2.092 ± 0.015	5.518ThrPro: 5.518 ± 0.029	2.662ThrGln: 2.662 ± 0.019	4.365ThrArg: 4.365 ± 0.021	6.482ThrSer: 6.482 ± 0.028	7.447ThrThr: 7.447 ± 0.061	3.918ThrVal: 3.918 ± 0.019	0.788ThrTrp: 0.788 ± 0.008	1.361ThrTyr: 1.361 ± 0.01	0.0ThrXaa: 0.0 ± 0.0
Val	4.894ValAla: 4.894 ± 0.025	1.966ValCys: 1.966 ± 0.015	2.363ValAsp: 2.363 ± 0.014	3.516ValGlu: 3.516 ± 0.019	2.231ValPhe: 2.231 ± 0.011	4.036ValGly: 4.036 ± 0.018	1.769ValHis: 1.769 ± 0.012	2.516ValIle: 2.516 ± 0.014	2.893ValLys: 2.893 ± 0.017	6.003ValLeu: 6.003 ± 0.027	2.043ValMet: 2.043 ± 0.014	1.952ValAsn: 1.952 ± 0.014	3.876ValPro: 3.876 ± 0.018	2.25ValGln: 2.25 ± 0.014	4.258ValArg: 4.258 ± 0.019	5.79ValSer: 5.79 ± 0.024	4.694ValThr: 4.694 ± 0.022	6.81ValVal: 6.81 ± 0.051	1.061ValTrp: 1.061 ± 0.01	1.435ValTyr: 1.435 ± 0.011	0.0ValXaa: 0.0 ± 0.0
Trp	0.826TrpAla: 0.826 ± 0.008	0.526TrpCys: 0.526 ± 0.006	0.49TrpAsp: 0.49 ± 0.007	0.751TrpGlu: 0.751 ± 0.007	0.378TrpPhe: 0.378 ± 0.005	0.899TrpGly: 0.899 ± 0.008	0.372TrpHis: 0.372 ± 0.004	0.422TrpIle: 0.422 ± 0.006	0.665TrpLys: 0.665 ± 0.007	1.276TrpLeu: 1.276 ± 0.011	0.427TrpMet: 0.427 ± 0.006	0.452TrpAsn: 0.452 ± 0.007	0.749TrpPro: 0.749 ± 0.008	0.574TrpGln: 0.574 ± 0.006	1.498TrpArg: 1.498 ± 0.011	1.062TrpSer: 1.062 ± 0.009	0.681TrpThr: 0.681 ± 0.008	0.874TrpVal: 0.874 ± 0.008	0.414TrpTrp: 0.414 ± 0.006	0.316TrpTyr: 0.316 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.143TyrAla: 1.143 ± 0.01	0.683TyrCys: 0.683 ± 0.007	0.912TyrAsp: 0.912 ± 0.009	1.04TyrGlu: 1.04 ± 0.01	0.959TyrPhe: 0.959 ± 0.008	1.281TyrGly: 1.281 ± 0.011	0.927TyrHis: 0.927 ± 0.008	1.112TyrIle: 1.112 ± 0.009	1.033TyrLys: 1.033 ± 0.009	2.376TyrLeu: 2.376 ± 0.015	0.628TyrMet: 0.628 ± 0.006	0.848TyrAsn: 0.848 ± 0.008	1.275TyrPro: 1.275 ± 0.01	0.864TyrGln: 0.864 ± 0.009	1.514TyrArg: 1.514 ± 0.011	2.121TyrSer: 2.121 ± 0.014	1.553TyrThr: 1.553 ± 0.017	1.327TyrVal: 1.327 ± 0.01	0.318TyrTrp: 0.318 ± 0.006	0.965TyrTyr: 0.965 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.06XaaXaa: 0.06 ± 0.021

Statistics based on 99420 proteins (13516514 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---