Amino acid dipepetide frequency for Halioglobus japonicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.453AlaAla: 11.453 ± 0.115	1.215AlaCys: 1.215 ± 0.029	5.863AlaAsp: 5.863 ± 0.076	6.133AlaGlu: 6.133 ± 0.084	3.474AlaPhe: 3.474 ± 0.05	7.971AlaGly: 7.971 ± 0.088	1.944AlaHis: 1.944 ± 0.037	5.561AlaIle: 5.561 ± 0.065	3.349AlaLys: 3.349 ± 0.061	11.333AlaLeu: 11.333 ± 0.105	2.915AlaMet: 2.915 ± 0.047	3.177AlaAsn: 3.177 ± 0.055	4.149AlaPro: 4.149 ± 0.055	4.514AlaGln: 4.514 ± 0.062	5.702AlaArg: 5.702 ± 0.077	6.091AlaSer: 6.091 ± 0.071	5.216AlaThr: 5.216 ± 0.073	7.348AlaVal: 7.348 ± 0.082	1.247AlaTrp: 1.247 ± 0.033	2.631AlaTyr: 2.631 ± 0.043	0.007AlaXaa: 0.007 ± 0.002
Cys	1.129CysAla: 1.129 ± 0.032	0.176CysCys: 0.176 ± 0.011	0.696CysAsp: 0.696 ± 0.023	0.669CysGlu: 0.669 ± 0.022	0.415CysPhe: 0.415 ± 0.017	0.951CysGly: 0.951 ± 0.027	0.35CysHis: 0.35 ± 0.019	0.571CysIle: 0.571 ± 0.02	0.317CysLys: 0.317 ± 0.016	1.042CysLeu: 1.042 ± 0.028	0.245CysMet: 0.245 ± 0.013	0.369CysAsn: 0.369 ± 0.016	0.571CysPro: 0.571 ± 0.021	0.361CysGln: 0.361 ± 0.02	0.618CysArg: 0.618 ± 0.021	0.789CysSer: 0.789 ± 0.026	0.555CysThr: 0.555 ± 0.02	0.721CysVal: 0.721 ± 0.024	0.15CysTrp: 0.15 ± 0.009	0.322CysTyr: 0.322 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.652AspAla: 5.652 ± 0.067	0.652AspCys: 0.652 ± 0.022	3.538AspAsp: 3.538 ± 0.059	3.832AspGlu: 3.832 ± 0.056	2.414AspPhe: 2.414 ± 0.04	4.61AspGly: 4.61 ± 0.09	1.204AspHis: 1.204 ± 0.025	3.875AspIle: 3.875 ± 0.055	2.264AspLys: 2.264 ± 0.046	5.388AspLeu: 5.388 ± 0.061	1.45AspMet: 1.45 ± 0.033	2.308AspAsn: 2.308 ± 0.041	2.966AspPro: 2.966 ± 0.052	1.935AspGln: 1.935 ± 0.039	3.027AspArg: 3.027 ± 0.044	3.725AspSer: 3.725 ± 0.053	3.366AspThr: 3.366 ± 0.051	4.022AspVal: 4.022 ± 0.056	1.01AspTrp: 1.01 ± 0.026	2.122AspTyr: 2.122 ± 0.04	0.001AspXaa: 0.001 ± 0.001
Glu	5.961GluAla: 5.961 ± 0.072	0.516GluCys: 0.516 ± 0.02	3.205GluAsp: 3.205 ± 0.046	3.89GluGlu: 3.89 ± 0.065	2.379GluPhe: 2.379 ± 0.041	4.009GluGly: 4.009 ± 0.055	1.532GluHis: 1.532 ± 0.035	3.427GluIle: 3.427 ± 0.049	2.635GluLys: 2.635 ± 0.053	6.909GluLeu: 6.909 ± 0.077	1.551GluMet: 1.551 ± 0.034	2.227GluAsn: 2.227 ± 0.039	2.569GluPro: 2.569 ± 0.051	3.346GluGln: 3.346 ± 0.052	3.984GluArg: 3.984 ± 0.057	3.526GluSer: 3.526 ± 0.053	3.057GluThr: 3.057 ± 0.052	4.248GluVal: 4.248 ± 0.059	0.76GluTrp: 0.76 ± 0.027	1.827GluTyr: 1.827 ± 0.039	0.005GluXaa: 0.005 ± 0.002
Phe	3.534PheAla: 3.534 ± 0.055	0.543PheCys: 0.543 ± 0.02	2.741PheAsp: 2.741 ± 0.044	2.419PheGlu: 2.419 ± 0.046	1.63PhePhe: 1.63 ± 0.039	3.27PheGly: 3.27 ± 0.048	0.796PheHis: 0.796 ± 0.022	1.971PheIle: 1.971 ± 0.04	1.203PheLys: 1.203 ± 0.029	3.422PheLeu: 3.422 ± 0.055	0.937PheMet: 0.937 ± 0.026	1.487PheAsn: 1.487 ± 0.03	1.604PhePro: 1.604 ± 0.038	1.194PheGln: 1.194 ± 0.026	1.859PheArg: 1.859 ± 0.034	2.992PheSer: 2.992 ± 0.046	2.178PheThr: 2.178 ± 0.043	2.582PheVal: 2.582 ± 0.043	0.547PheTrp: 0.547 ± 0.021	1.268PheTyr: 1.268 ± 0.03	0.003PheXaa: 0.003 ± 0.001
Gly	7.041GlyAla: 7.041 ± 0.1	0.928GlyCys: 0.928 ± 0.028	4.601GlyAsp: 4.601 ± 0.083	4.879GlyGlu: 4.879 ± 0.064	3.307GlyPhe: 3.307 ± 0.05	6.121GlyGly: 6.121 ± 0.143	1.624GlyHis: 1.624 ± 0.037	4.629GlyIle: 4.629 ± 0.056	3.237GlyLys: 3.237 ± 0.049	7.519GlyLeu: 7.519 ± 0.072	2.241GlyMet: 2.241 ± 0.049	2.732GlyAsn: 2.732 ± 0.072	2.546GlyPro: 2.546 ± 0.051	2.724GlyGln: 2.724 ± 0.045	4.086GlyArg: 4.086 ± 0.056	4.928GlySer: 4.928 ± 0.066	4.093GlyThr: 4.093 ± 0.085	5.866GlyVal: 5.866 ± 0.07	1.203GlyTrp: 1.203 ± 0.03	2.607GlyTyr: 2.607 ± 0.035	0.004GlyXaa: 0.004 ± 0.001
His	1.807HisAla: 1.807 ± 0.032	0.346HisCys: 0.346 ± 0.016	1.101HisAsp: 1.101 ± 0.027	1.056HisGlu: 1.056 ± 0.03	1.0HisPhe: 1.0 ± 0.029	1.697HisGly: 1.697 ± 0.04	0.636HisHis: 0.636 ± 0.023	1.185HisIle: 1.185 ± 0.03	0.701HisLys: 0.701 ± 0.021	2.206HisLeu: 2.206 ± 0.04	0.536HisMet: 0.536 ± 0.018	0.783HisAsn: 0.783 ± 0.023	1.327HisPro: 1.327 ± 0.029	0.847HisGln: 0.847 ± 0.025	1.401HisArg: 1.401 ± 0.031	1.413HisSer: 1.413 ± 0.028	1.153HisThr: 1.153 ± 0.032	1.256HisVal: 1.256 ± 0.029	0.418HisTrp: 0.418 ± 0.015	0.838HisTyr: 0.838 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.117IleAla: 6.117 ± 0.072	0.614IleCys: 0.614 ± 0.021	3.816IleAsp: 3.816 ± 0.051	3.719IleGlu: 3.719 ± 0.048	1.898IlePhe: 1.898 ± 0.039	4.169IleGly: 4.169 ± 0.062	1.07IleHis: 1.07 ± 0.025	2.583IleIle: 2.583 ± 0.047	1.876IleLys: 1.876 ± 0.044	4.61IleLeu: 4.61 ± 0.073	1.062IleMet: 1.062 ± 0.027	2.092IleAsn: 2.092 ± 0.039	2.63IlePro: 2.63 ± 0.041	1.669IleGln: 1.669 ± 0.038	2.865IleArg: 2.865 ± 0.041	3.571IleSer: 3.571 ± 0.051	3.197IleThr: 3.197 ± 0.047	3.902IleVal: 3.902 ± 0.055	0.62IleTrp: 0.62 ± 0.023	1.532IleTyr: 1.532 ± 0.033	0.003IleXaa: 0.003 ± 0.001
Lys	3.607LysAla: 3.607 ± 0.07	0.25LysCys: 0.25 ± 0.012	1.798LysAsp: 1.798 ± 0.041	1.928LysGlu: 1.928 ± 0.043	1.101LysPhe: 1.101 ± 0.026	2.399LysGly: 2.399 ± 0.043	0.816LysHis: 0.816 ± 0.025	1.849LysIle: 1.849 ± 0.039	1.594LysLys: 1.594 ± 0.041	3.767LysLeu: 3.767 ± 0.059	0.893LysMet: 0.893 ± 0.028	1.322LysAsn: 1.322 ± 0.03	1.933LysPro: 1.933 ± 0.04	1.507LysGln: 1.507 ± 0.034	2.355LysArg: 2.355 ± 0.042	2.136LysSer: 2.136 ± 0.042	1.954LysThr: 1.954 ± 0.038	2.594LysVal: 2.594 ± 0.044	0.452LysTrp: 0.452 ± 0.017	0.969LysTyr: 0.969 ± 0.03	0.003LysXaa: 0.003 ± 0.001
Leu	11.47LeuAla: 11.47 ± 0.115	1.231LeuCys: 1.231 ± 0.035	6.095LeuAsp: 6.095 ± 0.069	6.177LeuGlu: 6.177 ± 0.071	3.796LeuPhe: 3.796 ± 0.064	7.662LeuGly: 7.662 ± 0.071	2.202LeuHis: 2.202 ± 0.045	4.962LeuIle: 4.962 ± 0.071	3.613LeuLys: 3.613 ± 0.057	11.328LeuLeu: 11.328 ± 0.127	2.424LeuMet: 2.424 ± 0.046	3.478LeuAsn: 3.478 ± 0.053	5.354LeuPro: 5.354 ± 0.07	4.706LeuGln: 4.706 ± 0.061	5.891LeuArg: 5.891 ± 0.071	7.071LeuSer: 7.071 ± 0.078	5.251LeuThr: 5.251 ± 0.066	7.112LeuVal: 7.112 ± 0.075	1.276LeuTrp: 1.276 ± 0.03	2.656LeuTyr: 2.656 ± 0.044	0.008LeuXaa: 0.008 ± 0.002
Met	2.685MetAla: 2.685 ± 0.041	0.216MetCys: 0.216 ± 0.013	1.343MetAsp: 1.343 ± 0.031	1.367MetGlu: 1.367 ± 0.032	0.768MetPhe: 0.768 ± 0.024	1.904MetGly: 1.904 ± 0.036	0.516MetHis: 0.516 ± 0.018	1.202MetIle: 1.202 ± 0.03	1.031MetLys: 1.031 ± 0.026	2.546MetLeu: 2.546 ± 0.045	0.636MetMet: 0.636 ± 0.023	0.981MetAsn: 0.981 ± 0.027	1.332MetPro: 1.332 ± 0.031	1.06MetGln: 1.06 ± 0.03	1.547MetArg: 1.547 ± 0.027	1.809MetSer: 1.809 ± 0.032	1.515MetThr: 1.515 ± 0.028	1.7MetVal: 1.7 ± 0.039	0.258MetTrp: 0.258 ± 0.012	0.514MetTyr: 0.514 ± 0.018	0.001MetXaa: 0.001 ± 0.001
Asn	3.424AsnAla: 3.424 ± 0.054	0.42AsnCys: 0.42 ± 0.017	1.871AsnAsp: 1.871 ± 0.038	1.831AsnGlu: 1.831 ± 0.037	1.391AsnPhe: 1.391 ± 0.029	2.752AsnGly: 2.752 ± 0.06	0.715AsnHis: 0.715 ± 0.023	2.057AsnIle: 2.057 ± 0.039	1.182AsnLys: 1.182 ± 0.03	3.378AsnLeu: 3.378 ± 0.051	0.799AsnMet: 0.799 ± 0.028	1.383AsnAsn: 1.383 ± 0.039	2.215AsnPro: 2.215 ± 0.04	1.201AsnGln: 1.201 ± 0.028	2.023AsnArg: 2.023 ± 0.036	2.213AsnSer: 2.213 ± 0.042	2.146AsnThr: 2.146 ± 0.043	2.233AsnVal: 2.233 ± 0.039	0.584AsnTrp: 0.584 ± 0.022	1.17AsnTyr: 1.17 ± 0.031	0.004AsnXaa: 0.004 ± 0.002
Pro	4.67ProAla: 4.67 ± 0.057	0.382ProCys: 0.382 ± 0.016	3.304ProAsp: 3.304 ± 0.051	3.644ProGlu: 3.644 ± 0.051	1.705ProPhe: 1.705 ± 0.039	4.013ProGly: 4.013 ± 0.06	0.984ProHis: 0.984 ± 0.026	2.157ProIle: 2.157 ± 0.038	1.397ProLys: 1.397 ± 0.033	4.693ProLeu: 4.693 ± 0.062	1.178ProMet: 1.178 ± 0.03	1.532ProAsn: 1.532 ± 0.035	2.105ProPro: 2.105 ± 0.044	2.061ProGln: 2.061 ± 0.038	2.226ProArg: 2.226 ± 0.042	2.572ProSer: 2.572 ± 0.04	2.349ProThr: 2.349 ± 0.042	3.792ProVal: 3.792 ± 0.053	0.691ProTrp: 0.691 ± 0.02	1.25ProTyr: 1.25 ± 0.031	0.003ProXaa: 0.003 ± 0.001
Gln	4.306GlnAla: 4.306 ± 0.057	0.411GlnCys: 0.411 ± 0.017	1.876GlnAsp: 1.876 ± 0.037	2.245GlnGlu: 2.245 ± 0.043	1.472GlnPhe: 1.472 ± 0.035	2.765GlnGly: 2.765 ± 0.044	1.036GlnHis: 1.036 ± 0.029	1.994GlnIle: 1.994 ± 0.037	1.349GlnLys: 1.349 ± 0.031	4.85GlnLeu: 4.85 ± 0.057	0.979GlnMet: 0.979 ± 0.024	1.139GlnAsn: 1.139 ± 0.032	1.87GlnPro: 1.87 ± 0.037	2.402GlnGln: 2.402 ± 0.059	3.019GlnArg: 3.019 ± 0.049	2.482GlnSer: 2.482 ± 0.043	1.935GlnThr: 1.935 ± 0.038	2.791GlnVal: 2.791 ± 0.044	0.762GlnTrp: 0.762 ± 0.022	1.172GlnTyr: 1.172 ± 0.028	0.001GlnXaa: 0.001 ± 0.001
Arg	5.208ArgAla: 5.208 ± 0.065	0.608ArgCys: 0.608 ± 0.02	3.449ArgAsp: 3.449 ± 0.051	4.171ArgGlu: 4.171 ± 0.061	2.373ArgPhe: 2.373 ± 0.045	3.729ArgGly: 3.729 ± 0.055	1.357ArgHis: 1.357 ± 0.03	3.197ArgIle: 3.197 ± 0.052	2.276ArgLys: 2.276 ± 0.038	5.998ArgLeu: 5.998 ± 0.078	1.513ArgMet: 1.513 ± 0.034	2.09ArgAsn: 2.09 ± 0.035	2.248ArgPro: 2.248 ± 0.042	2.47ArgGln: 2.47 ± 0.048	3.621ArgArg: 3.621 ± 0.061	3.481ArgSer: 3.481 ± 0.049	2.686ArgThr: 2.686 ± 0.04	3.958ArgVal: 3.958 ± 0.052	1.001ArgTrp: 1.001 ± 0.027	2.034ArgTyr: 2.034 ± 0.033	0.005ArgXaa: 0.005 ± 0.002
Ser	6.517SerAla: 6.517 ± 0.066	0.692SerCys: 0.692 ± 0.023	3.873SerAsp: 3.873 ± 0.052	3.726SerGlu: 3.726 ± 0.054	2.426SerPhe: 2.426 ± 0.04	5.848SerGly: 5.848 ± 0.082	1.324SerHis: 1.324 ± 0.026	3.414SerIle: 3.414 ± 0.053	2.119SerLys: 2.119 ± 0.04	6.533SerLeu: 6.533 ± 0.075	1.628SerMet: 1.628 ± 0.029	2.233SerAsn: 2.233 ± 0.039	2.867SerPro: 2.867 ± 0.049	2.332SerGln: 2.332 ± 0.039	3.537SerArg: 3.537 ± 0.052	4.196SerSer: 4.196 ± 0.082	3.489SerThr: 3.489 ± 0.054	4.412SerVal: 4.412 ± 0.059	0.92SerTrp: 0.92 ± 0.024	1.84SerTyr: 1.84 ± 0.037	0.005SerXaa: 0.005 ± 0.002
Thr	5.551ThrAla: 5.551 ± 0.083	0.493ThrCys: 0.493 ± 0.019	3.132ThrAsp: 3.132 ± 0.045	3.032ThrGlu: 3.032 ± 0.046	1.933ThrPhe: 1.933 ± 0.037	4.814ThrGly: 4.814 ± 0.082	1.077ThrHis: 1.077 ± 0.026	2.868ThrIle: 2.868 ± 0.047	1.375ThrLys: 1.375 ± 0.031	6.087ThrLeu: 6.087 ± 0.064	1.154ThrMet: 1.154 ± 0.027	1.592ThrAsn: 1.592 ± 0.038	3.097ThrPro: 3.097 ± 0.05	1.94ThrGln: 1.94 ± 0.032	2.943ThrArg: 2.943 ± 0.042	3.167ThrSer: 3.167 ± 0.058	3.049ThrThr: 3.049 ± 0.052	4.211ThrVal: 4.211 ± 0.057	0.685ThrTrp: 0.685 ± 0.022	1.481ThrTyr: 1.481 ± 0.046	0.003ThrXaa: 0.003 ± 0.001
Val	7.485ValAla: 7.485 ± 0.074	0.794ValCys: 0.794 ± 0.027	4.486ValAsp: 4.486 ± 0.058	4.537ValGlu: 4.537 ± 0.072	2.842ValPhe: 2.842 ± 0.046	4.993ValGly: 4.993 ± 0.07	1.415ValHis: 1.415 ± 0.033	4.02ValIle: 4.02 ± 0.046	2.312ValLys: 2.312 ± 0.044	7.156ValLeu: 7.156 ± 0.078	1.782ValMet: 1.782 ± 0.034	2.5ValAsn: 2.5 ± 0.042	3.309ValPro: 3.309 ± 0.047	2.355ValGln: 2.355 ± 0.038	3.692ValArg: 3.692 ± 0.055	4.898ValSer: 4.898 ± 0.068	4.163ValThr: 4.163 ± 0.06	5.506ValVal: 5.506 ± 0.075	0.881ValTrp: 0.881 ± 0.026	1.864ValTyr: 1.864 ± 0.037	0.007ValXaa: 0.007 ± 0.002
Trp	1.085TrpAla: 1.085 ± 0.026	0.165TrpCys: 0.165 ± 0.01	0.781TrpAsp: 0.781 ± 0.024	0.747TrpGlu: 0.747 ± 0.022	0.553TrpPhe: 0.553 ± 0.02	0.963TrpGly: 0.963 ± 0.028	0.393TrpHis: 0.393 ± 0.015	0.661TrpIle: 0.661 ± 0.023	0.464TrpLys: 0.464 ± 0.019	1.828TrpLeu: 1.828 ± 0.036	0.387TrpMet: 0.387 ± 0.017	0.478TrpAsn: 0.478 ± 0.016	0.628TrpPro: 0.628 ± 0.023	0.892TrpGln: 0.892 ± 0.025	0.987TrpArg: 0.987 ± 0.027	0.915TrpSer: 0.915 ± 0.023	0.667TrpThr: 0.667 ± 0.022	0.945TrpVal: 0.945 ± 0.029	0.234TrpTrp: 0.234 ± 0.013	0.397TrpTyr: 0.397 ± 0.015	0.002TrpXaa: 0.002 ± 0.001
Tyr	2.586TyrAla: 2.586 ± 0.036	0.367TyrCys: 0.367 ± 0.015	1.789TyrAsp: 1.789 ± 0.044	1.553TyrGlu: 1.553 ± 0.036	1.302TyrPhe: 1.302 ± 0.034	2.269TyrGly: 2.269 ± 0.042	0.714TyrHis: 0.714 ± 0.023	1.426TyrIle: 1.426 ± 0.032	0.932TyrLys: 0.932 ± 0.027	3.166TyrLeu: 3.166 ± 0.05	0.62TyrMet: 0.62 ± 0.018	1.085TyrAsn: 1.085 ± 0.031	1.377TyrPro: 1.377 ± 0.031	1.339TyrGln: 1.339 ± 0.033	2.085TyrArg: 2.085 ± 0.041	1.957TyrSer: 1.957 ± 0.039	1.665TyrThr: 1.665 ± 0.039	1.792TyrVal: 1.792 ± 0.036	0.469TyrTrp: 0.469 ± 0.017	1.04TyrTyr: 1.04 ± 0.028	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.007XaaAla: 0.007 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.007XaaGlu: 0.007 ± 0.002	0.001XaaPhe: 0.001 ± 0.001	0.006XaaGly: 0.006 ± 0.002	0.003XaaHis: 0.003 ± 0.001	0.005XaaIle: 0.005 ± 0.002	0.001XaaLys: 0.001 ± 0.001	0.005XaaLeu: 0.005 ± 0.002	0.003XaaMet: 0.003 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.007XaaPro: 0.007 ± 0.002	0.003XaaGln: 0.003 ± 0.001	0.003XaaArg: 0.003 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.003XaaThr: 0.003 ± 0.002	0.006XaaVal: 0.006 ± 0.002	0.001XaaTrp: 0.001 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.007XaaXaa: 0.007 ± 0.005

Statistics based on 4451 proteins (1492785 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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