Amino acid dipepetide frequency for Wenzhou hepe-like virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.692AlaAla: 6.692 ± 1.92
0.418AlaCys: 0.418 ± 0.661
2.091AlaAsp: 2.091 ± 0.708
0.418AlaGlu: 0.418 ± 0.661
5.019AlaPhe: 5.019 ± 1.592
4.182AlaGly: 4.182 ± 0.55
0.836AlaHis: 0.836 ± 0.41
5.019AlaIle: 5.019 ± 0.14
3.764AlaLys: 3.764 ± 0.978
4.182AlaLeu: 4.182 ± 1.183
0.836AlaMet: 0.836 ± 1.323
4.182AlaAsn: 4.182 ± 0.55
4.182AlaPro: 4.182 ± 0.55
0.836AlaGln: 0.836 ± 0.41
2.928AlaArg: 2.928 ± 1.165
7.528AlaSer: 7.528 ± 1.51
6.692AlaThr: 6.692 ± 1.92
6.274AlaVal: 6.274 ± 2.991
1.255AlaTrp: 1.255 ± 0.615
1.255AlaTyr: 1.255 ± 0.252
0.0AlaXaa: 0.0 ± 0.0
Cys
1.255CysAla: 1.255 ± 0.615
0.0CysCys: 0.0 ± 0.0
0.418CysAsp: 0.418 ± 0.205
0.836CysGlu: 0.836 ± 0.41
1.255CysPhe: 1.255 ± 0.615
0.836CysGly: 0.836 ± 0.41
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
2.091CysLeu: 2.091 ± 1.024
0.0CysMet: 0.0 ± 0.0
1.673CysAsn: 1.673 ± 0.047
1.255CysPro: 1.255 ± 0.615
1.255CysGln: 1.255 ± 0.615
1.255CysArg: 1.255 ± 0.615
1.673CysSer: 1.673 ± 0.047
0.0CysThr: 0.0 ± 0.0
2.091CysVal: 2.091 ± 1.024
0.418CysTrp: 0.418 ± 0.205
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.346AspAla: 3.346 ± 0.773
1.673AspCys: 1.673 ± 0.047
5.019AspAsp: 5.019 ± 0.14
3.346AspGlu: 3.346 ± 0.773
5.019AspPhe: 5.019 ± 2.459
2.928AspGly: 2.928 ± 0.298
1.673AspHis: 1.673 ± 0.82
5.019AspIle: 5.019 ± 0.726
3.346AspLys: 3.346 ± 0.093
3.764AspLeu: 3.764 ± 0.111
1.255AspMet: 1.255 ± 0.615
1.255AspAsn: 1.255 ± 0.615
2.091AspPro: 2.091 ± 1.024
0.836AspGln: 0.836 ± 0.41
2.091AspArg: 2.091 ± 1.024
6.692AspSer: 6.692 ± 1.053
1.673AspThr: 1.673 ± 0.82
5.855AspVal: 5.855 ± 2.002
0.418AspTrp: 0.418 ± 0.661
3.346AspTyr: 3.346 ± 0.773
0.0AspXaa: 0.0 ± 0.0
Glu
1.255GluAla: 1.255 ± 0.615
0.836GluCys: 0.836 ± 0.41
2.509GluAsp: 2.509 ± 0.503
2.091GluGlu: 2.091 ± 0.158
1.255GluPhe: 1.255 ± 0.615
2.509GluGly: 2.509 ± 1.37
1.673GluHis: 1.673 ± 0.82
1.673GluIle: 1.673 ± 1.779
2.091GluLys: 2.091 ± 0.158
5.437GluLeu: 5.437 ± 0.065
0.836GluMet: 0.836 ± 0.41
2.509GluAsn: 2.509 ± 0.503
0.418GluPro: 0.418 ± 0.661
1.673GluGln: 1.673 ± 0.82
2.509GluArg: 2.509 ± 1.229
2.928GluSer: 2.928 ± 0.568
1.673GluThr: 1.673 ± 0.82
2.509GluVal: 2.509 ± 1.229
1.255GluTrp: 1.255 ± 0.252
3.346GluTyr: 3.346 ± 0.773
0.0GluXaa: 0.0 ± 0.0
Phe
5.019PheAla: 5.019 ± 2.459
0.418PheCys: 0.418 ± 0.205
1.673PheAsp: 1.673 ± 0.82
2.928PheGlu: 2.928 ± 0.298
2.509PhePhe: 2.509 ± 1.229
1.673PheGly: 1.673 ± 0.047
1.255PheHis: 1.255 ± 0.615
3.346PheIle: 3.346 ± 0.96
3.346PheLys: 3.346 ± 0.093
1.673PheLeu: 1.673 ± 0.82
2.091PheMet: 2.091 ± 0.708
3.346PheAsn: 3.346 ± 0.96
3.346PhePro: 3.346 ± 0.093
3.346PheGln: 3.346 ± 0.773
2.091PheArg: 2.091 ± 1.024
4.182PheSer: 4.182 ± 0.316
5.855PheThr: 5.855 ± 0.597
4.601PheVal: 4.601 ± 1.388
0.418PheTrp: 0.418 ± 0.205
0.836PheTyr: 0.836 ± 0.41
0.0PheXaa: 0.0 ± 0.0
Gly
3.346GlyAla: 3.346 ± 1.826
0.836GlyCys: 0.836 ± 0.41
3.764GlyAsp: 3.764 ± 0.111
2.091GlyGlu: 2.091 ± 1.024
4.182GlyPhe: 4.182 ± 1.183
2.509GlyGly: 2.509 ± 1.229
2.091GlyHis: 2.091 ± 1.024
3.346GlyIle: 3.346 ± 0.96
1.673GlyLys: 1.673 ± 0.047
7.11GlyLeu: 7.11 ± 0.884
0.0GlyMet: 0.0 ± 0.0
3.764GlyAsn: 3.764 ± 0.111
0.836GlyPro: 0.836 ± 0.457
1.673GlyGln: 1.673 ± 1.779
2.091GlyArg: 2.091 ± 0.158
3.764GlySer: 3.764 ± 1.621
2.091GlyThr: 2.091 ± 0.708
4.601GlyVal: 4.601 ± 0.345
1.673GlyTrp: 1.673 ± 0.047
1.255GlyTyr: 1.255 ± 0.252
0.0GlyXaa: 0.0 ± 0.0
His
1.255HisAla: 1.255 ± 1.118
0.836HisCys: 0.836 ± 0.41
1.673HisAsp: 1.673 ± 0.82
1.255HisGlu: 1.255 ± 0.615
2.091HisPhe: 2.091 ± 1.024
1.255HisGly: 1.255 ± 0.252
0.418HisHis: 0.418 ± 0.205
0.836HisIle: 0.836 ± 0.41
1.255HisLys: 1.255 ± 0.615
1.673HisLeu: 1.673 ± 0.82
0.418HisMet: 0.418 ± 0.205
1.673HisAsn: 1.673 ± 0.82
1.673HisPro: 1.673 ± 0.047
1.255HisGln: 1.255 ± 0.252
1.255HisArg: 1.255 ± 0.252
5.019HisSer: 5.019 ± 1.592
1.673HisThr: 1.673 ± 0.82
1.673HisVal: 1.673 ± 0.82
0.418HisTrp: 0.418 ± 0.205
0.836HisTyr: 0.836 ± 0.41
0.0HisXaa: 0.0 ± 0.0
Ile
4.182IleAla: 4.182 ± 0.55
0.836IleCys: 0.836 ± 0.41
3.764IleAsp: 3.764 ± 0.111
0.836IleGlu: 0.836 ± 0.41
3.346IlePhe: 3.346 ± 0.96
3.346IleGly: 3.346 ± 0.093
0.836IleHis: 0.836 ± 0.41
3.346IleIle: 3.346 ± 0.773
4.182IleLys: 4.182 ± 0.316
4.182IleLeu: 4.182 ± 0.316
0.836IleMet: 0.836 ± 0.457
3.346IleAsn: 3.346 ± 0.773
3.346IlePro: 3.346 ± 0.96
5.437IleGln: 5.437 ± 0.065
1.673IleArg: 1.673 ± 0.82
4.601IleSer: 4.601 ± 1.388
3.764IleThr: 3.764 ± 0.111
4.601IleVal: 4.601 ± 0.521
0.418IleTrp: 0.418 ± 0.661
1.673IleTyr: 1.673 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.601LysAla: 4.601 ± 1.211
0.0LysCys: 0.0 ± 0.0
2.509LysAsp: 2.509 ± 0.363
2.091LysGlu: 2.091 ± 0.708
6.274LysPhe: 6.274 ± 0.474
5.019LysGly: 5.019 ± 1.592
1.673LysHis: 1.673 ± 0.82
3.764LysIle: 3.764 ± 1.844
2.928LysLys: 2.928 ± 2.031
6.692LysLeu: 6.692 ± 1.546
2.509LysMet: 2.509 ± 0.363
2.091LysAsn: 2.091 ± 0.158
1.673LysPro: 1.673 ± 0.913
0.836LysGln: 0.836 ± 0.457
5.855LysArg: 5.855 ± 0.27
5.019LysSer: 5.019 ± 1.007
4.601LysThr: 4.601 ± 0.345
3.764LysVal: 3.764 ± 1.621
0.418LysTrp: 0.418 ± 0.205
1.673LysTyr: 1.673 ± 0.82
0.0LysXaa: 0.0 ± 0.0
Leu
4.182LeuAla: 4.182 ± 0.316
1.255LeuCys: 1.255 ± 0.615
5.437LeuAsp: 5.437 ± 0.931
3.346LeuGlu: 3.346 ± 0.773
5.019LeuPhe: 5.019 ± 0.726
4.182LeuGly: 4.182 ± 0.316
2.091LeuHis: 2.091 ± 1.024
3.346LeuIle: 3.346 ± 0.093
4.601LeuLys: 4.601 ± 0.521
5.437LeuLeu: 5.437 ± 0.931
1.255LeuMet: 1.255 ± 0.385
4.182LeuAsn: 4.182 ± 0.316
5.855LeuPro: 5.855 ± 3.196
2.928LeuGln: 2.928 ± 0.298
2.509LeuArg: 2.509 ± 1.229
7.11LeuSer: 7.11 ± 0.848
3.346LeuThr: 3.346 ± 0.96
4.182LeuVal: 4.182 ± 1.183
0.418LeuTrp: 0.418 ± 0.205
2.509LeuTyr: 2.509 ± 1.229
0.0LeuXaa: 0.0 ± 0.0
Met
1.255MetAla: 1.255 ± 0.252
0.0MetCys: 0.0 ± 0.0
0.836MetAsp: 0.836 ± 0.41
1.255MetGlu: 1.255 ± 0.252
0.418MetPhe: 0.418 ± 0.661
0.836MetGly: 0.836 ± 0.457
0.836MetHis: 0.836 ± 0.457
0.418MetIle: 0.418 ± 0.205
0.836MetLys: 0.836 ± 0.457
0.0MetLeu: 0.0 ± 0.0
1.255MetMet: 1.255 ± 0.252
2.509MetAsn: 2.509 ± 0.363
0.836MetPro: 0.836 ± 0.457
1.255MetGln: 1.255 ± 1.118
2.091MetArg: 2.091 ± 0.708
2.928MetSer: 2.928 ± 0.298
2.509MetThr: 2.509 ± 1.229
0.0MetVal: 0.0 ± 0.0
0.836MetTrp: 0.836 ± 0.457
1.255MetTyr: 1.255 ± 0.615
0.0MetXaa: 0.0 ± 0.0
Asn
3.764AsnAla: 3.764 ± 0.111
2.091AsnCys: 2.091 ± 1.024
3.764AsnAsp: 3.764 ± 0.978
1.673AsnGlu: 1.673 ± 0.82
2.091AsnPhe: 2.091 ± 0.708
1.673AsnGly: 1.673 ± 0.047
1.673AsnHis: 1.673 ± 0.047
3.764AsnIle: 3.764 ± 1.844
2.509AsnLys: 2.509 ± 0.503
2.928AsnLeu: 2.928 ± 0.568
0.836AsnMet: 0.836 ± 0.165
5.019AsnAsn: 5.019 ± 0.726
2.509AsnPro: 2.509 ± 0.503
1.673AsnGln: 1.673 ± 1.779
2.509AsnArg: 2.509 ± 1.229
3.764AsnSer: 3.764 ± 0.978
2.928AsnThr: 2.928 ± 1.165
5.019AsnVal: 5.019 ± 0.14
0.0AsnTrp: 0.0 ± 0.0
0.836AsnTyr: 0.836 ± 1.323
0.0AsnXaa: 0.0 ± 0.0
Pro
5.019ProAla: 5.019 ± 4.472
0.418ProCys: 0.418 ± 0.205
3.764ProAsp: 3.764 ± 1.621
2.509ProGlu: 2.509 ± 1.229
2.091ProPhe: 2.091 ± 0.708
2.509ProGly: 2.509 ± 0.503
0.836ProHis: 0.836 ± 0.41
0.836ProIle: 0.836 ± 0.457
4.182ProLys: 4.182 ± 0.55
2.091ProLeu: 2.091 ± 0.708
0.836ProMet: 0.836 ± 1.323
2.509ProAsn: 2.509 ± 0.503
2.509ProPro: 2.509 ± 0.363
2.091ProGln: 2.091 ± 0.158
2.091ProArg: 2.091 ± 0.158
5.437ProSer: 5.437 ± 0.802
3.346ProThr: 3.346 ± 1.826
4.601ProVal: 4.601 ± 1.388
0.836ProTrp: 0.836 ± 1.323
0.836ProTyr: 0.836 ± 0.457
0.0ProXaa: 0.0 ± 0.0
Gln
2.509GlnAla: 2.509 ± 0.363
0.836GlnCys: 0.836 ± 0.41
2.091GlnAsp: 2.091 ± 1.024
2.509GlnGlu: 2.509 ± 0.503
1.255GlnPhe: 1.255 ± 0.252
2.928GlnGly: 2.928 ± 2.031
0.836GlnHis: 0.836 ± 0.41
1.255GlnIle: 1.255 ± 1.118
2.928GlnLys: 2.928 ± 0.298
2.091GlnLeu: 2.091 ± 0.158
0.836GlnMet: 0.836 ± 0.457
1.673GlnAsn: 1.673 ± 0.047
2.509GlnPro: 2.509 ± 2.236
2.091GlnGln: 2.091 ± 1.574
1.673GlnArg: 1.673 ± 0.82
4.182GlnSer: 4.182 ± 1.416
2.091GlnThr: 2.091 ± 0.708
1.255GlnVal: 1.255 ± 0.252
0.418GlnTrp: 0.418 ± 0.661
2.509GlnTyr: 2.509 ± 1.229
0.0GlnXaa: 0.0 ± 0.0
Arg
2.928ArgAla: 2.928 ± 0.568
2.091ArgCys: 2.091 ± 1.024
3.764ArgAsp: 3.764 ± 0.978
2.928ArgGlu: 2.928 ± 0.298
2.509ArgPhe: 2.509 ± 1.229
1.255ArgGly: 1.255 ± 0.615
1.255ArgHis: 1.255 ± 0.615
4.601ArgIle: 4.601 ± 1.388
3.764ArgLys: 3.764 ± 0.755
1.673ArgLeu: 1.673 ± 0.82
0.418ArgMet: 0.418 ± 0.205
2.091ArgAsn: 2.091 ± 1.024
2.928ArgPro: 2.928 ± 2.031
1.673ArgGln: 1.673 ± 0.82
1.673ArgArg: 1.673 ± 1.779
1.673ArgSer: 1.673 ± 0.913
4.182ArgThr: 4.182 ± 1.183
1.673ArgVal: 1.673 ± 0.82
0.418ArgTrp: 0.418 ± 0.205
2.928ArgTyr: 2.928 ± 0.568
0.0ArgXaa: 0.0 ± 0.0
Ser
8.783SerAla: 8.783 ± 4.36
0.0SerCys: 0.0 ± 0.0
7.11SerAsp: 7.11 ± 1.751
4.601SerGlu: 4.601 ± 0.521
2.928SerPhe: 2.928 ± 2.031
5.019SerGly: 5.019 ± 1.007
3.346SerHis: 3.346 ± 0.093
5.855SerIle: 5.855 ± 2.002
8.783SerLys: 8.783 ± 0.838
6.692SerLeu: 6.692 ± 1.92
1.255SerMet: 1.255 ± 0.252
1.255SerAsn: 1.255 ± 0.615
3.346SerPro: 3.346 ± 0.093
2.091SerGln: 2.091 ± 0.708
4.601SerArg: 4.601 ± 2.254
11.711SerSer: 11.711 ± 7.258
4.601SerThr: 4.601 ± 4.677
5.019SerVal: 5.019 ± 0.726
0.836SerTrp: 0.836 ± 0.41
3.764SerTyr: 3.764 ± 0.755
0.0SerXaa: 0.0 ± 0.0
Thr
2.509ThrAla: 2.509 ± 1.37
2.091ThrCys: 2.091 ± 1.024
3.346ThrAsp: 3.346 ± 1.639
2.091ThrGlu: 2.091 ± 0.708
2.928ThrPhe: 2.928 ± 1.165
4.601ThrGly: 4.601 ± 0.345
2.928ThrHis: 2.928 ± 0.568
4.182ThrIle: 4.182 ± 1.416
3.346ThrLys: 3.346 ± 0.773
5.437ThrLeu: 5.437 ± 0.802
1.255ThrMet: 1.255 ± 0.615
2.509ThrAsn: 2.509 ± 0.503
4.601ThrPro: 4.601 ± 1.211
1.673ThrGln: 1.673 ± 0.913
2.091ThrArg: 2.091 ± 0.708
4.601ThrSer: 4.601 ± 2.944
4.182ThrThr: 4.182 ± 0.316
4.182ThrVal: 4.182 ± 1.416
0.418ThrTrp: 0.418 ± 0.661
2.928ThrTyr: 2.928 ± 0.298
0.0ThrXaa: 0.0 ± 0.0
Val
6.274ValAla: 6.274 ± 1.341
1.255ValCys: 1.255 ± 0.615
3.764ValAsp: 3.764 ± 1.844
2.091ValGlu: 2.091 ± 1.024
1.673ValPhe: 1.673 ± 0.82
1.673ValGly: 1.673 ± 0.82
2.509ValHis: 2.509 ± 0.503
3.346ValIle: 3.346 ± 0.773
5.855ValLys: 5.855 ± 0.597
4.601ValLeu: 4.601 ± 0.521
4.601ValMet: 4.601 ± 0.345
3.346ValAsn: 3.346 ± 0.093
4.601ValPro: 4.601 ± 0.345
3.346ValGln: 3.346 ± 0.96
3.346ValArg: 3.346 ± 0.96
5.437ValSer: 5.437 ± 0.931
2.509ValThr: 2.509 ± 2.236
7.528ValVal: 7.528 ± 0.223
0.0ValTrp: 0.0 ± 0.0
4.601ValTyr: 4.601 ± 1.388
0.0ValXaa: 0.0 ± 0.0
Trp
0.418TrpAla: 0.418 ± 0.205
0.0TrpCys: 0.0 ± 0.0
0.418TrpAsp: 0.418 ± 0.205
0.418TrpGlu: 0.418 ± 0.661
1.255TrpPhe: 1.255 ± 0.615
1.673TrpGly: 1.673 ± 0.913
0.418TrpHis: 0.418 ± 0.205
0.0TrpIle: 0.0 ± 0.0
0.836TrpLys: 0.836 ± 0.41
2.091TrpLeu: 2.091 ± 1.574
0.0TrpMet: 0.0 ± 0.0
0.836TrpAsn: 0.836 ± 0.457
0.0TrpPro: 0.0 ± 0.0
1.255TrpGln: 1.255 ± 0.252
0.0TrpArg: 0.0 ± 0.0
0.836TrpSer: 0.836 ± 0.457
0.418TrpThr: 0.418 ± 0.205
0.836TrpVal: 0.836 ± 0.457
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.418TyrCys: 0.418 ± 0.205
2.928TyrAsp: 2.928 ± 1.434
1.673TyrGlu: 1.673 ± 0.047
0.836TyrPhe: 0.836 ± 0.41
2.091TyrGly: 2.091 ± 1.024
1.255TyrHis: 1.255 ± 0.615
4.601TyrIle: 4.601 ± 0.345
3.764TyrLys: 3.764 ± 0.978
3.346TyrLeu: 3.346 ± 0.093
0.418TyrMet: 0.418 ± 0.205
1.673TyrAsn: 1.673 ± 0.047
0.836TyrPro: 0.836 ± 0.41
1.255TyrGln: 1.255 ± 1.118
2.091TyrArg: 2.091 ± 1.024
2.509TyrSer: 2.509 ± 0.363
3.764TyrThr: 3.764 ± 0.111
2.091TyrVal: 2.091 ± 0.158
0.836TyrTrp: 0.836 ± 0.457
1.255TyrTyr: 1.255 ± 0.252
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2392 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski